444912-48-5,MFCD11045986
Catalog No.:AA00DA6W

444912-48-5 | (R,S)-AM1241

This product is typically in stock,please click "Inquire" below or
contact us at [email protected] for pricing and availability information.
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DA6W
Chemical Name:
(R,S)-AM1241
CAS Number:
444912-48-5
Molecular Formula:
C22H22IN3O3
Molecular Weight:
503.3328
MDL Number:
MFCD11045986
SMILES:
CN1CCCCC1Cn1cc(c2c1cccc2)C(=O)c1cc(ccc1I)[N+](=O)[O-]
Properties
Properties
 
BP:
630.709 °C at 760 mmHg  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
613  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.7  

Literature

Title: Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.

Journal: Journal of medicinal chemistry 20131114

Title: Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.

Journal: Journal of neuroimmunology 20120301

Title: Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking.

Journal: PloS one 20120101

Title: Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists.

Journal: Journal of medicinal chemistry 20111027

Title: Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice.

Journal: European journal of pharmacology 20111001

Title: CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain.

Journal: Behavioural pharmacology 20110901

Title: Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy.

Journal: Diabetes 20110901

Title: Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.

Journal: European journal of medicinal chemistry 20110201

Title: Cannabinoids attenuate cancer pain and proliferation in a mouse model.

Journal: Neuroscience letters 20110125

Title: Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.

Journal: Blood 20110120

Title: Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20101101

Title: Cross-regulation of cannabinoid CB₁ and CB₂ receptors governs hepatic steatosis.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20101101

Title: Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: lack of dependence upon opioid receptor activation.

Journal: The AAPS journal 20100601

Title: Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.

Journal: Journal of medicinal chemistry 20100114

Title: Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.

Journal: Inflammatory bowel diseases 20091101

Title: Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242.

Journal: British journal of pharmacology 20090901

Title: Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.

Journal: The Journal of pharmacology and experimental therapeutics 20090101

Title: Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20081101

Title: Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain.

Journal: Journal of medicinal chemistry 20080828

Title: Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.

Journal: Journal of medicinal chemistry 20080327

Title: Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action.

Journal: Bioorganic & medicinal chemistry 20080201

Title: Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080130

Title: Effect of cannabinoid receptor agonists on streptozotocin-induced hyperalgesia in diabetic neuropathy.

Journal: Pharmacology 20080101

Title: Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.

Journal: British journal of pharmacology 20071101

Title: Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis.

Journal: British journal of pharmacology 20070101

Title: Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?

Journal: British journal of pharmacology 20060901

Title: CB2 cannabinoid receptor mediation of antinociception.

Journal: Pain 20060501

Title: Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation.

Journal: Journal of neurophysiology 20041201

Title: Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin.

Journal: The Journal of pharmacology and experimental therapeutics 20040201

Title: Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors.

Journal: Anesthesiology 20031001

Title: Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.

Journal: Neuroscience 20030101

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Related Products of 444912-48-5
Tags:444912-48-5 Molecular Formula|444912-48-5 MDL|444912-48-5 SMILES|444912-48-5 (R,S)-AM1241
Catalog No.: AA00DA6W
444912-48-5,MFCD11045986
444912-48-5 | (R,S)-AM1241
This product is typically in stock,please click "Inquire" below or contact us at [email protected]for pricing and availability information.
Inquire
Technical Information
Catalog Number: AA00DA6W
Chemical Name: (R,S)-AM1241
CAS Number: 444912-48-5
Molecular Formula: C22H22IN3O3
Molecular Weight: 503.3328
MDL Number: MFCD11045986
SMILES: CN1CCCCC1Cn1cc(c2c1cccc2)C(=O)c1cc(ccc1I)[N+](=O)[O-]
Properties
BP: 630.709 °C at 760 mmHg  
Storage: -20 ℃;  
Complexity: 613  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.7  
Literature fold

Title: Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.

Journal: Journal of medicinal chemistry20131114

Title: Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.

Journal: Journal of neuroimmunology20120301

Title: Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking.

Journal: PloS one20120101

Title: Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists.

Journal: Journal of medicinal chemistry20111027

Title: Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice.

Journal: European journal of pharmacology20111001

Title: CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain.

Journal: Behavioural pharmacology20110901

Title: Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy.

Journal: Diabetes20110901

Title: Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.

Journal: European journal of medicinal chemistry20110201

Title: Cannabinoids attenuate cancer pain and proliferation in a mouse model.

Journal: Neuroscience letters20110125

Title: Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.

Journal: Blood20110120

Title: Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes.

Journal: Liver international : official journal of the International Association for the Study of the Liver20101101

Title: Cross-regulation of cannabinoid CB₁ and CB₂ receptors governs hepatic steatosis.

Journal: Liver international : official journal of the International Association for the Study of the Liver20101101

Title: Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: lack of dependence upon opioid receptor activation.

Journal: The AAPS journal20100601

Title: Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.

Journal: Journal of medicinal chemistry20100114

Title: Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.

Journal: Inflammatory bowel diseases20091101

Title: Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242.

Journal: British journal of pharmacology20090901

Title: Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.

Journal: The Journal of pharmacology and experimental therapeutics20090101

Title: Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats.

Journal: The Journal of pharmacology and experimental therapeutics20081101

Title: Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain.

Journal: Journal of medicinal chemistry20080828

Title: Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.

Journal: Journal of medicinal chemistry20080327

Title: Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action.

Journal: Bioorganic & medicinal chemistry20080201

Title: Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080130

Title: Effect of cannabinoid receptor agonists on streptozotocin-induced hyperalgesia in diabetic neuropathy.

Journal: Pharmacology20080101

Title: Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.

Journal: British journal of pharmacology20071101

Title: Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis.

Journal: British journal of pharmacology20070101

Title: Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.

Journal: The Journal of pharmacology and experimental therapeutics20061201

Title: In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?

Journal: British journal of pharmacology20060901

Title: CB2 cannabinoid receptor mediation of antinociception.

Journal: Pain20060501

Title: Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation.

Journal: Journal of neurophysiology20041201

Title: Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin.

Journal: The Journal of pharmacology and experimental therapeutics20040201

Title: Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors.

Journal: Anesthesiology20031001

Title: Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.

Journal: Neuroscience20030101

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