Name: Name:4-Benzyl-4-hydroxypiperidine
Brand: AABLOCKS
SKU: AA003KR7
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA003KR7

Chemical Name: 4-Benzyl-4-hydroxypiperidine

CAS Number: 51135-96-7

Molecular Formula: C12H17NO

Molecular Weight: 191.2695

MDL Number: MFCD00023147

SMILES: OC1(CCNCC1)Cc1ccccc1

NSC Number: 83237

Properties

BP: 329°C at 760 mmHg

Form: Solid

MP: 80-85 °C

Refractive Index: 1.5212 (estimate)

Stability: Hygroscopic

Storage: Keep in dry area;2-8℃;

Complexity: 169

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 14

Hydrogen Bond Acceptor Count: 2

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 2

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.4

Downstream Synthesis Route

51135-96-7

ethyl2-(naphthalene-2-yl)acetimidatehydrochloride

4-Benzyl-1-(1-imino-2-naphthalen-2-yl-ethyl)-piperidin-4-ol;hydrochloride

[1]McCarthy;Wright;Schuster;Abdallah;Shea;Eyster[JournalofMedicinalChemistry,1985,vol.28,#11,p.1721-1727]

51135-96-7

134136-66-6

134136-74-6

[1]Chenard;Bordner;Butler;Chambers;Collins;DeCosta;Ducat;Dumont;Fox;Mena;Menniti;Nielsen;Pagnozzi;Richter;Ronau;Shalaby;Stemple;White[JournalofMedicinalChemistry,1995,vol.38,#16,p.3138-3145]

[2]CurrentPatentAssignee:PFIZERINC-US5185343,1993,A

[3]CurrentPatentAssignee:PFIZERINC-US5710168,1998,A

51135-96-7

24424-99-5

191327-87-4

[1]VanNiel,MoniqueB.;Collins,Ian;Beer,MargaretS.;Broughton,HowardB.;Cheng,SusanK.F.;Goodacre,SimonC.;Heald,Anne;Locker,KarenL.;MacLeod,AngusM.;Morrison,Denise;Moyes,ChristopherR.;O'Connor,Desmond;Pike,Andrew;Rowley,Michael;Russell,MichaelG.N.;Sohal,Baibinder;Stanton,JosephineA.;Thomas,Steven;Verrier,Hugh;Watt,AlanP.;Castro,JoséL.[JournalofMedicinalChemistry,1999,vol.42,#12,p.2087-2104]

[2]CurrentPatentAssignee:ABBVIEINC-US2002/55631,2002,A1

[3]CurrentPatentAssignee:ABBVIEINC-US2002/86887,2002,A1

[4]CurrentPatentAssignee:MERCK&COINC-US6048878,2000,A

51135-96-7

toluene-4-sulfonicacid4-(1-benzenesulfonyl-1<i>H</i>-imidazol-4-yl)-but-3-ynylester

4-benzyl-1-4-(1<i>H</i>-imidazol-4-yl)-but-3-ynyl-piperidin-4-ol

[1]Wright,JonL.;Gregory,TracyF.;Boxer,PeterA.;Meltzer,LeonardT.;Serpa,KevinA.;Wise,LawrenceD.;Hong-Bae,Soo;Huang,JinCheng;Konkoy,ChristopherS.;Upasani,RavindraB.;Whittemore,EdwardR.;Woodward,RichardM.;Yang,KevinC.;Zhou,Zhang-Lin[BioorganicandMedicinalChemistryLetters,1999,vol.9,#19,p.2815-2818]

51135-96-7

87997-56-6

6,11-Dihydro-11-3-4-hydroxy-4-(phenylmethyl)-1-piperidinylpropyldibenzob,ethiepin-11-carbonitrile

[1]Ng,HowardP.;Karen,May;Bauman,JohnG.;Ghannam,Ameen;Islam,Imadul;Liang,Meina;Horuk,Richard;Hesselgesser,Joseph;Snider,R.Michael;Perez,H.Daniel;Morrissey,MichaelM.[JournalofMedicinalChemistry,1999,vol.42,#22,p.4680-4694]

Literature fold

Title: 2-Aryl indole NK(1) antagonists: optimisation of the amide substituent.

Journal: Bioorganic & medicinal chemistry letters20011203

51135-96-7 | 4-Benzyl-4-hydroxypiperidine