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4450-98-0,MFCD00179167
Catalog No.:AA003DX8

4450-98-0 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$133.00   $93.00
- +
10mg
≥98%
in stock  
$199.00   $139.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003DX8
Chemical Name:
1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester
CAS Number:
4450-98-0
Molecular Formula:
C14H15NO4
Molecular Weight:
261.2732
MDL Number:
MFCD00179167
SMILES:
CCOC(=O)C1=C(O)C(=O)N(C1)Cc1ccccc1
NSC Number:
229530
Properties
Properties
 
BP:
408.5°C at 760 mmHg  
Form:
Solid  
MP:
132-134°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
396  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
1.7  

Downstream Synthesis Route

[1]Heterocycles,1998,vol.48,p.465-480

[2]BioorganicandMedicinalChemistryLetters,2008,vol.18,p.1623-1627

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Cancer biomarker AKR1B10 and carbonyl metabolism.

Journal: Chemico-biological interactions 20090316

Title: Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.

Journal: European journal of pharmacology 20080428

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation.

Journal: Cellular and molecular life sciences : CMLS 20050501

Title: Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases.

Journal: Anti-cancer drugs 20020901

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SDS
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Tags:4450-98-0 Molecular Formula|4450-98-0 MDL|4450-98-0 SMILES|4450-98-0 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester