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Home Amines 446292-07-5
446292-07-5,MFCD11977664
Catalog No.:AA00I8DL

446292-07-5 | (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
97%
1 week  
$12.00   $9.00
- +
250mg
97%
1 week  
$20.00   $14.00
- +
1g
97%
1 week  
$51.00   $36.00
- +
5g
97%
1 week  
$173.00   $121.00
- +
25g
97%
1 week  
$597.00   $418.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I8DL
Chemical Name:
(R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione
CAS Number:
446292-07-5
Molecular Formula:
C21H21N3O5
Molecular Weight:
395.4085
MDL Number:
MFCD11977664
SMILES:
O[C@@H](CN1C(=O)c2c(C1=O)cccc2)CNc1ccc(cc1)N1CCOCC1=O
Properties
Properties
 
BP:
734.9°C at 760 mmHg  
Form:
Solid  
MP:
208-211°C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
610  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
1  

Upstream Synthesis Route

[1]Patent:WO2012/51692,2012,A1,.Locationinpatent:Page/Pagecolumn42-43

[2]Patent:CN103951661,2017,B,.Locationinpatent:Paragraph0043-0044

[3]Patent:CN104974105,2017,B,.Locationinpatent:Paragraph0073

[4]Patent:CN104974149,2018,B,.Locationinpatent:Paragraph0074;0075;0077;0081;0083

[5]Patent:WO2012/32533,2012,A2,.Locationinpatent:Page/Pagecolumn15

[6]Patent:CN104974148,2017,B,.Locationinpatent:Paragraph0073;0074;0076;0082

[1]JournalofMedicinalChemistry,2005,vol.48,#19,p.5900-5908

[2]Patent:WO2018/127762,2018,A1,.Locationinpatent:Page/Pagecolumn12

[3]Patent:CN108164519,2018,A,.Locationinpatent:Paragraph0014;0015;0016;0017

[4]Patent:CN106588905,2017,A,.Locationinpatent:Paragraph0044;0046-0047

[5]Patent:WO2014/102820,2014,A2,.Locationinpatent:Paragraph047

[6]Patent:WO2016/199027,2016,A1,.Locationinpatent:Page/Pagecolumn18

[7]Patent:WO2013/121436,2013,A2,.Locationinpatent:Page/Pagecolumn26

[8]Patent:US2015/11756,2015,A1,.Locationinpatent:Paragraph0117

[9]Patent:WO2015/198259,2015,A1,.Locationinpatent:Page/Pagecolumn6

[10]Patent:US2005/182055,2005,A1,.Locationinpatent:Page/Pagecolumn1;3

[11]Patent:WO2005/68456,2005,A1,.Locationinpatent:Page/Pagecolumn7

[12]Patent:WO2013/53739,2013,A1,.Locationinpatent:Page/Pagecolumn31

[13]Patent:WO2011/12321,2011,A1,.Locationinpatent:Page/Pagecolumn31

[14]Patent:WO2013/98833,2013,A2,.Locationinpatent:Page/Pagecolumn41

[15]Patent:US2014/378682,2014,A1,.Locationinpatent:Paragraph0209;0210

[16]Patent:WO2016/30669,2016,A1,.Locationinpatent:Page/Pagecolumn28

[1]Patent:WO2012/41263,2012,A2,.Locationinpatent:Page/Pagecolumn10

[1]Patent:US2008/306070,2008,A1,

[2]Patent:US2010/120718,2010,A1,

[3]Patent:US2010/160301,2010,A1,

[1]Patent:WO2011/12321,2011,A1,

[2]Patent:WO2013/98833,2013,A2,

[3]Patent:US2014/378682,2014,A1,

[4]Patent:WO2016/30669,2016,A1,

Downstream Synthesis Route

[1]Patent:US2005/182055,2005,A1.Locationinpatent:Page/Pagecolumn1;3

[2]Patent:WO2014/102820,2014,A2.Locationinpatent:Paragraph058

[3]Patent:WO2015/198259,2015,A1.Locationinpatent:Page/Pagecolumn6

[4]Patent:WO2016/199027,2016,A1.Locationinpatent:Page/Pagecolumn18-19

[5]Patent:CN109553611,2019,A.Locationinpatent:Paragraph0028;0029

[6]Patent:WO2013/53739,2013,A1.Locationinpatent:Page/Pagecolumn31

[7]Patent:CN110818700,2020,A.Locationinpatent:Paragraph0018-0019

[8]Patent:WO2011/12321,2011,A1.Locationinpatent:Page/Pagecolumn31

[9]Patent:WO2013/121436,2013,A2.Locationinpatent:Page/Pagecolumn26;27

[10]Patent:US2015/11756,2015,A1.Locationinpatent:Paragraph0118

[11]JournalofMedicinalChemistry,2005,vol.48,p.5900-5908

[12]Patent:WO2012/41263,2012,A2.Locationinpatent:Page/Pagecolumn9

[13]Patent:WO2013/120464,2013,A1.Locationinpatent:Page/Pagecolumn8-9

[14]Patent:WO2012/32533,2012,A2.Locationinpatent:Page/Pagecolumn15-16

[15]Patent:WO2013/98833,2013,A2.Locationinpatent:Page/Pagecolumn41-42

[16]Patent:US2014/378682,2014,A1.Locationinpatent:Paragraph0211;0212

[17]Patent:WO2016/30669,2016,A1.Locationinpatent:Page/Pagecolumn28;29

[1]JournalofMedicinalChemistry,2005,vol.48,p.5900-5908

[2]Patent:WO2018/127762,2018,A1.Locationinpatent:Page/Pagecolumn12

[3]Patent:CN108164519,2018,A.Locationinpatent:Paragraph0014;0015;0016;0017

[4]Patent:CN106588905,2017,A.Locationinpatent:Paragraph0044;0046-0047

[5]Patent:CN110818700,2020,A.Locationinpatent:Paragraph0018

[6]Patent:WO2014/102820,2014,A2.Locationinpatent:Paragraph047

[7]Patent:WO2016/199027,2016,A1.Locationinpatent:Page/Pagecolumn18

[8]Patent:WO2013/121436,2013,A2.Locationinpatent:Page/Pagecolumn26

[9]Patent:US2015/11756,2015,A1.Locationinpatent:Paragraph0117

[10]Patent:WO2015/198259,2015,A1.Locationinpatent:Page/Pagecolumn6

[11]Patent:US2005/182055,2005,A1.Locationinpatent:Page/Pagecolumn1;3

[12]Patent:WO2005/68456,2005,A1.Locationinpatent:Page/Pagecolumn7

[13]Patent:WO2013/53739,2013,A1.Locationinpatent:Page/Pagecolumn31

[14]Patent:WO2011/12321,2011,A1.Locationinpatent:Page/Pagecolumn31

[15]Patent:WO2013/98833,2013,A2.Locationinpatent:Page/Pagecolumn41

[16]Patent:US2014/378682,2014,A1.Locationinpatent:Paragraph0209;0210

[17]Patent:WO2016/30669,2016,A1.Locationinpatent:Page/Pagecolumn28

[18]Patent:CN109553611,2019,A.Locationinpatent:Paragraph0020;0021;0022;0023;0024-0027

[1]JournalofMedicinalChemistry,2005,vol.48,p.5900-5908

[2]Patent:WO2011/12321,2011,A1

[3]Patent:WO2012/32533,2012,A2

[4]Patent:WO2013/121436,2013,A2

[5]Patent:US2015/11756,2015,A1

[6]Patent:WO2016/30669,2016,A1

[7]Patent:WO2016/199027,2016,A1

[8]Patent:CN104974105,2017,B

[9]Patent:CN103951661,2017,B

[10]Patent:CN110818700,2020,A

[1]Roehrig,Susanne;Straub,Alexander;Pohlmann,Jens;Lampe,Thomas;Pernerstorfer,Josef;Schlemmer,Karl-Heinz;Reinemer,Peter;Perzborn,Elisabeth[JournalofMedicinalChemistry,2005,vol.48,#19,p.5900-5908]

[2]CurrentPatentAssignee:KRKADDNOVOMESTO-WO2011/12321,2011,A1

[3]CurrentPatentAssignee:APOTEXINC-WO2012/51692,2012,A1

[4]CurrentPatentAssignee:PERMIRAHOLDINGSLIMITED-WO2013/53739,2013,A1

[5]CurrentPatentAssignee:PERMIRAHOLDINGSLIMITED-WO2013/53739,2013,A1

[6]CurrentPatentAssignee:PERMIRAHOLDINGSLIMITED-WO2013/53739,2013,A1

[7]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-WO2013/98833,2013,A2

[8]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-WO2013/98833,2013,A2

[9]CurrentPatentAssignee:MEGAFINEPHARMA(P)LTD.-WO2013/121436,2013,A2

[10]CurrentPatentAssignee:MEGAFINEPHARMA(P)LTD.-WO2013/121436,2013,A2

[11]CurrentPatentAssignee:WANBURYLIMITED-WO2014/102820,2014,A2

[12]CurrentPatentAssignee:WANBURYLIMITED-WO2014/102820,2014,A2

[13]CurrentPatentAssignee:WANBURYLIMITED-WO2014/102820,2014,A2

[14]CurrentPatentAssignee:WANBURYLIMITED-WO2014/102820,2014,A2

[15]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-US2014/378682,2014,A1

[16]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-US2014/378682,2014,A1

[17]CurrentPatentAssignee:MEGAFINEPHARMA(P)LTD.-US2015/11756,2015,A1

[18]CurrentPatentAssignee:MEGAFINEPHARMA(P)LTD.-US2015/11756,2015,A1

[19]CurrentPatentAssignee:MEGAFINEPHARMA(P)LTD.-US2015/11756,2015,A1

[20]CurrentPatentAssignee:ERREGIERRESPA.-WO2015/198259,2015,A1

[21]CurrentPatentAssignee:CIPLALTD-WO2016/30669,2016,A1

[22]CurrentPatentAssignee:MEHTAAPIPVT-WO2016/199027,2016,A1

[23]CurrentPatentAssignee:HYBIOPHARMACEUTICALCO.,LTD.-CN104016975,2017,B

[24]CurrentPatentAssignee:PEKINGUNIVERSITY-CN104974105,2017,B

[25]CurrentPatentAssignee:SPRINGPHARMA-CN103951661,2017,B

[26]CurrentPatentAssignee:CHONGQINGENSKYCHEMICAL;CHONGQINGKERUIPHARMACEUTICALGROUP-CN106588905,2017,A

[27]CurrentPatentAssignee:CHONGQINGENSKYCHEMICAL;CHONGQINGKERUIPHARMACEUTICALGROUP-CN106588905,2017,A

[28]CurrentPatentAssignee:UNICHEMLABORATORIESLIMITED-WO2018/127762,2018,A1

[29]CurrentPatentAssignee:QILUPHARMACEUTICALGROUPCOLTD-CN109553611,2019,A

[30]CurrentPatentAssignee:HUNANJIUDIANPHARMACEUTICAL-CN110818700,2020,A

[31]CurrentPatentAssignee:NANJINGCHICOPHARMACEUTICAL-CN110938069,2020,A

[32]-CN114105970,2022,A

[33]CurrentPatentAssignee:BEIJINGXINKAIYUANPHARMACEUTICALS-CN114031617,2022,A

446292-07-5   
1,1'-carbonyldiimidazole 
  446292-08-6 

[1]Patent:WO2005/68456,2005,A1.Locationinpatent:Page/Pagecolumn7

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Tags:446292-07-5 Molecular Formula|446292-07-5 MDL|446292-07-5 SMILES|446292-07-5 (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione