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4498-74-2,MFCD01565718
Catalog No.:AA00DBO5

4498-74-2 | 3-Benzyl-1h-indazole

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250mg
95%
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$71.00   $50.00
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1g
95%
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$188.00   $132.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DBO5
Chemical Name:
3-Benzyl-1h-indazole
CAS Number:
4498-74-2
Molecular Formula:
C14H12N2
Molecular Weight:
208.2585
MDL Number:
MFCD01565718
SMILES:
c1ccc(cc1)Cc1n[nH]c2c1cccc2
Properties
Properties
 
BP:
277.6°C at 760 mmHg  
Form:
Solid  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
223  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
3.5  

Literature

Title: Relaxant effect of a water soluble carbon monoxide-releasing molecule (CORM-3) on spontaneously hypertensive rat aortas.

Journal: Cardiovascular drugs and therapy 20120801

Title: Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.

Journal: Bioorganic & medicinal chemistry letters 20120701

Title: Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.

Journal: Critical care research and practice 20120101

Title: Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils.

Journal: Biochemical pharmacology 20110115

Title: Guanylate cyclase activators, cell volume changes and IOP reduction.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The mechanism of (R,R) ZX-5 on increasing NO release.

Journal: International journal of molecular sciences 20100101

Title: Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells.

Journal: Molecular pharmacology 20090101

Title: NO-independent, haem-dependent soluble guanylate cyclase stimulators.

Journal: Handbook of experimental pharmacology 20090101

Title: Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.

Journal: Bioorganic & medicinal chemistry letters 20070901

Title: YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9.

Journal: The Journal of pharmacology and experimental therapeutics 20060101

Title: Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase.

Journal: Biochemistry 20051213

Title: Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1.

Journal: The European journal of neuroscience 20050301

Title: Salutary properties of YC-1 in the cardiovascular and hematological systems.

Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20041001

Title: Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule.

Journal: British journal of pharmacology 20040601

Title: Functional characterization of nitric oxide and YC-1 activation of soluble guanylyl cyclase: structural implication for the YC-1 binding site?

Journal: Biochemistry 20040323

Title: The inhibitory mechanism of YC-1, a benzyl indazole, on smooth muscle cell proliferation: an in vitro and in vivo study.

Journal: Journal of pharmacological sciences 20040301

Title: YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase.

Journal: The Journal of biological chemistry 20030328

Title: YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function.

Journal: Biochemical and biophysical research communications 20020308

Title: Prolonged exposure to YC-1 induces apoptosis in adrenomedullary endothelial and chromaffin cells through a cGMP-independent mechanism.

Journal: Neuropharmacology 20011201

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