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451470-34-1,MFCD11040855
Catalog No.:AA00DLRO

451470-34-1 | Gw 427353b

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2.5mg
2 weeks  
$786.00   $550.00
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10mg
2 weeks  
$1,129.00   $790.00
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DLRO
Chemical Name:
Gw 427353b
CAS Number:
451470-34-1
Molecular Formula:
C23H23ClN2O3
Molecular Weight:
410.8933
MDL Number:
MFCD11040855
SMILES:
C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNCC(C3=CC(=CC=C3)Cl)O
Properties
Computed Properties
 
Complexity:
507  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
XLogP3:
1.8  

Literature

Title: β3-Adrenoceptor agonists for overactive bladder syndrome: Role of translational pharmacology in a repositioning clinical drug development project.

Journal: Pharmacology & therapeutics 20160301

Title: A multicenter, double-blind, randomized, placebo-controlled trial of the β3-adrenoceptor agonist solabegron for overactive bladder.

Journal: European urology 20121101

Title: An aryloxypropanolamine hβ3-adrenoceptor agonist as bladder smooth muscle relaxant.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815

Title: Treatment of overactive bladder symptoms beyond antimuscarinics: current and future therapies.

Journal: Postgraduate medicine 20120501

Title: The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin.

Journal: Gastroenterology 20100101

Title: Investigations into the presence of functional Beta1, Beta2 and Beta3-adrenoceptors in urothelium and detrusor of human bladder.

Journal: International braz j urol : official journal of the Brazilian Society of Urology 20090101

Title: Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety.

Journal: Journal of medicinal chemistry 20080814

Title: Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080501

Title: Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I.

Journal: Journal of medicinal chemistry 20080327

Title: GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog.

Journal: The Journal of pharmacology and experimental therapeutics 20071001

Title: The effects of a new selective beta3-adrenoceptor agonist (GW427353) on spontaneous activity and detrusor relaxation in human bladder.

Journal: BJU international 20061201

Title: Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists.

Journal: Journal of medicinal chemistry 20060504

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