Catalog No.:AA00DB25

451492-95-8 | Av-412

Name: Name:Av-412
Brand: AABLOCKS
SKU: AA00DB25
Availability: InStock
Rating: 90 (10 reviews)

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10mg

≥98%(HPLC)

in stock

$375.00 $263.00

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50mg

≥98%(HPLC)

in stock

$1,011.00 $708.00

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250mg

≥98%(HPLC)

in stock

$4,350.00 $3,045.00

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA00DB25

Chemical Name:

Av-412

CAS Number:

451492-95-8

Molecular Formula:

C27H28ClFN6O

Molecular Weight:

507.0022

MDL Number:

MFCD16038939

SMILES:

C=CC(=O)Nc1cc2c(ncnc2cc1C#CC(N1CCN(CC1)C)(C)C)Nc1ccc(c(c1)Cl)F

Properties

Computed Properties

Complexity:

850

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

4.5

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells.

Journal: Journal of cellular biochemistry 20110901

Title: Antitumor activity of a dual epidermal growth factor receptor and ErbB2 kinase inhibitor MP-412 (AV-412) in mouse xenograft models.

Journal: Cancer science 20090801

Title: Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptor and ErbB2 tyrosine kinase inhibitor.

Journal: Cancer science 20071201

Title: Suzuki T, et al. Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptorand ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98(12):1977-84.

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