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4547-24-4,MFCD06794973
Catalog No.:AA00DE86

4547-24-4 | Corosolic acid

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1mg
95%
in stock  
$53.00   $37.00
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5mg
95%
in stock  
$115.00   $80.00
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10mg
95%
in stock  
$208.00   $146.00
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25mg
95%
in stock  
$412.00   $288.00
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50mg
98% by HPLC
in stock  
$808.00   $565.00
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100mg
98% by HPLC
in stock  
$1,350.00   $945.00
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500mg
98% by HPLC
in stock  
$4,218.00   $2,952.00
- +
1000mg
98% by HPLC
in stock  
$6,710.00   $4,697.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DE86
Chemical Name:
Corosolic acid
CAS Number:
4547-24-4
Molecular Formula:
C30H48O4
Molecular Weight:
472.6997
MDL Number:
MFCD06794973
SMILES:
C[C@@H]1CC[C@]2([C@@H]([C@H]1C)C1=CC[C@H]3[C@@]([C@@]1(CC2)C)(C)CC[C@@H]1[C@]3(C)C[C@@H](O)[C@@H](C1(C)C)O)C(=O)O
Properties
Computed Properties
 
Complexity:
908  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
6.4  

Literature

Title: CRA(Crosolic Acid) isolated from Actinidia valvata Dunn.Radix induces apoptosis of human gastric cancer cell line BGC823 in vitro via down-regulation of the NF-κB pathway.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170701

Title: Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

Journal: Oncotarget 20151117

Title: Blockade of store-operated calcium entry alleviates ethanol-induced hepatotoxicity via inhibiting apoptosis.

Journal: Toxicology and applied pharmacology 20150815

Title: Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140501

Title: A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients.

Journal: Food chemistry 20130115

Title: [Chemical constituents from Sambucus chinensis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

Title: A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid.

Journal: Phytotherapy research : PTR 20120301

Title: Determination of corosolic acid, a natural potential anti-diabetes compound, in rat plasma by high-performance liquid chromatography-mass spectrometry and its application to pharmacokinetic and bioavailability studies.

Journal: Planta medica 20111001

Title: [Chemical constituents from Exochorda racemosa].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

Title: Triterpenoid saponins from Symplocos lancifolia.

Journal: Journal of natural products 20110225

Title: Bioprocess and bioreactor: next generation technology for production of potential plant-based antidiabetic and antioxidant molecules.

Journal: Current medicinal chemistry 20110101

Title: Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis.

Journal: Phytotherapy research : PTR 20101201

Title: Corosolic acid-induced acute kidney injury and lactic acidosis in a patient with impaired kidney function.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20100801

Title: Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice.

Journal: Biomedical research (Tokyo, Japan) 20100801

Title: 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.

Journal: Bioorganic & medicinal chemistry 20100215

Title: Stimulation of glucose uptake by triterpenoids from Weigela subsessilis.

Journal: Phytotherapy research : PTR 20100101

Title: Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.

Journal: Journal of natural products 20090801

Title: Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors.

Journal: Phytotherapy research : PTR 20090501

Title: Cytotoxic, antioxidant activities and structure activity relationship of some newly synthesized terpenoidal oxaliplatin analogs.

Journal: European journal of medicinal chemistry 20090201

Title: Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase.

Journal: Journal of natural products 20081101

Title: [Triterpenoids and steroids of root of Rubus biflorus].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081101

Title: Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.

Journal: Bioorganic & medicinal chemistry 20080915

Title: [Studies on the triterpenes from loquat leaf (Eriobotrya japonica)].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080901

Title: Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.

Journal: Journal of medicinal chemistry 20080626

Title: Effect of corosolic acid on the hydrolysis of disaccharides.

Journal: Journal of nutritional science and vitaminology 20080601

Title: Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.

Journal: European journal of pharmacology 20080414

Title: Effect of corosolic acid on gluconeogenesis in rat liver.

Journal: Diabetes research and clinical practice 20080401

Title: Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice.

Journal: Biological & pharmaceutical bulletin 20080401

Title: Ursolic acid: a potent inhibitor of superoxides produced in the cellular system.

Journal: Phytotherapy research : PTR 20070601

Title: [Studies on chemical constituents from Serissa serissoides].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Corosolic acid isolation from the leaves of Eriobotrta japonica showing the effects on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes.

Journal: Asia Pacific journal of clinical nutrition 20070101

Title: Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome.

Journal: Life sciences 20061125

Title: [Triterpenes from herb of Potentilla chinesis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061101

Title: [Determination of corosolic acid in Eriobotrya japonica leaves by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20060901

Title: Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae.

Journal: Bioorganic & medicinal chemistry 20060815

Title: Effect of corosolic acid on postchallenge plasma glucose levels.

Journal: Diabetes research and clinical practice 20060801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Chemical constituents of Glechoma longituba.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060501

Title: Antidiabetic effects of corosolic acid in KK-Ay diabetic mice.

Journal: Biological & pharmaceutical bulletin 20060301

Title: [Study on chemical constituents of Potentilla chinensis Ser].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060301

Title: Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases.

Journal: Bioorganic & medicinal chemistry letters 20051115

Title: Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice.

Journal: Biological & pharmaceutical bulletin 20040701

Title: A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase.

Journal: Journal of natural products 20040501

Title: Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study.

Journal: Journal of ethnopharmacology 20030701

Title: [Studies on chemical constituents in fruit of Eucalyptus globulus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020801

Title: Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.

Journal: Journal of natural products 19980901

Title: Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64(5):468-70.

Title: LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine,2015-08

Title: Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015, 29 (5): 14–723

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