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Home Amines 4572-03-6
4572-03-6,MFCD00014616
Catalog No.:AA0039O6

4572-03-6 | 3-(4-Methylpiperazin-1-yl)propan-1-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%
in stock  
$17.00   $12.00
- +
5g
98%
in stock  
$83.00   $58.00
- +
100g
97%
in stock  
$1,407.00   $985.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0039O6
Chemical Name:
3-(4-Methylpiperazin-1-yl)propan-1-amine
CAS Number:
4572-03-6
Molecular Formula:
C8H19N3
Molecular Weight:
157.2566
MDL Number:
MFCD00014616
SMILES:
NCCCN1CCN(CC1)C
NSC Number:
60215
Properties
Computed Properties
 
Complexity:
97.5  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
-0.8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/144404,2017,A1Locationinpatent:Page/Pagecolumn8

[2]Ma,Lichao;Yuan,Liwei;Xu,Changzhu;Li,Guowei;Tao,Minli;Zhang,Wenqin[Synthesis,2013,vol.45,#1,p.45-52]

[3]Hamilton,ChrisJ.;Saravanamuthu,Ahilan;Fairlamb,AlanH.;Eggleston,IanM.[BioorganicandMedicinalChemistry,2003,vol.11,#17,p.3683-3693]

[4]Fujii;Watanabe[Tanabeseiyakukenkyunenpo=AnnualreportofGoheiTanabeCo.,1956,vol.1,p.7][Chem.Abstr.,1957,p.6651]

[5]Rice;Grogan[JournalofOrganicChemistry,1955,vol.20,p.1687,1693]

[6]Pirisino;Alamanni;Savelli;Sparatore;Manca;Satta[Farmaco,EdizioneScientifica,1983,vol.38,#5,p.330-339]

[7]Kumar,VershaVinay;Singh,SudhirK.;Sharma;Bhaduri;Gupta,Suman;Zaidi,Alima;Tiwari,Suman;Katiyar[BioorganicandMedicinalChemistryLetters,1997,vol.7,#6,p.675-680]

[1]CollectionofCzechoslovakChemicalCommunications,1990,vol.55,p.797-808

[1]Tazarki,Helmi;Zeinyeh,Wael;Esvan,YannickJ.;Knapp,Stefan;Chatterjee,Deep;Schröder,Martin;Joerger,AndreasC.;Khiari,Jameleddine;Josselin,Béatrice;Baratte,Blandine;Bach,Stéphane;Ruchaud,Sandrine;Anizon,Fabrice;Giraud,Francis;Moreau,Pascale[EuropeanJournalofMedicinalChemistry,2019,vol.166,p.304-317]

[2]Locationinpatent:experimentalpartQian,Jin;Cuerrier,Dominic;Davies,PeterL.;Li,Zhaozhao;Powers,JamesC.;Campbell,RobertL.[JournalofMedicinalChemistry,2008,vol.51,#17,p.5264-5270]

[3]Ovat,Asli;Li,ZhaoZhao;Hampton,ChristinaY.;Asress,SeneshawA.;Fernández,FacundoM.;Glass,JonathanD.;Powers,JamesC.[JournalofMedicinalChemistry,2010,vol.53,#17,p.6326-6336]

[4]Turner,SeanC.;Esbenshade,TimothyA.;Bennani,YoussefL.;Hancock,ArthurA.[BioorganicandMedicinalChemistryLetters,2003,vol.13,#13,p.2131-2135]

[5]CurrentPatentAssignee:ASTELLASPHARMAINC.-US4331665,1982,A

[6]CurrentPatentAssignee:ASTELLASPHARMAINC.-US4390534,1983,A

[7]CurrentPatentAssignee:ASTELLASPHARMAINC.-US4425340,1984,A

[8]CurrentPatentAssignee:ASTELLASPHARMAINC.-US4332798,1982,A

[9]CurrentPatentAssignee:ASTELLASPHARMAINC.-US4381299,1983,A

[10]Zhang,Jun;Shen,Weiyi;Li,Xiaoning;Chai,Yun;Li,Senjun;Lv,Kai;Guo,Huiyuan;Liu,Mingliang[Molecules,2016,vol.21,#12]

[11]Li,Xun;Li,Zhi-Ying;Song,Yu-Liang;Xu,Guang-Sen[BioorganicChemistry,2022,vol.119]

[12]Li,Xun;Li,Zhi-Ying;Song,Yu-Liang;Xu,Guang-Sen[BioorganicChemistry,2022,vol.119]

4572-03-6    2471-70-7   
6-methoxy-naphthalene-2-carboxylicacid3-(4-methyl-piperazin-1-yl)-propyl-amide 

[1]BioorganicandMedicinalChemistry,2006,vol.14,p.6022-6026

3-((1R,3R)-3-Bromo-cyclopentyl)-benzonitrile 
  4572-03-6   
cis-3-{3-3-(4-methylpiperazin-1-yl)propylaminocyclopentyl}benzonitrile 

[1]McBriar,MarkD.;Guzik,Henry;Shapiro,Sherry;Paruchova,Jaroslava;Xu,Ruo;Palani,Anandan;Clader,JohnW.;Cox,Kathleen;Greenlee,WilliamJ.;Hawes,BrianE.;Kowalski,TimothyJ.;O'Neill,Kim;Spar,BrianD.;Weig,Blair;Weston,DanielJ.;Farley,Constance;Cook,John[JournalofMedicinalChemistry,2006,vol.49,#7,p.2294-2310]

Literature

Title: Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cells.

Journal: International journal of nanomedicine 20110101

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