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Home Amines 457657-34-0
457657-34-0,MFCD28133393
Catalog No.:AA01ENK4

457657-34-0 | 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylicacid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%(HPLC)
in stock  
$200.00   $140.00
- +
5mg
≥98%(HPLC)
in stock  
$504.00   $353.00
- +
10mg
≥98%(HPLC)
in stock  
$772.00   $540.00
- +
25mg
≥98%(HPLC)
in stock  
$1,232.00   $863.00
- +
50mg
≥98%(HPLC)
in stock  
$1,731.00   $1,212.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01ENK4
Chemical Name:
2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylicacid
CAS Number:
457657-34-0
Molecular Formula:
C26H37N3O3
Molecular Weight:
439.5903
MDL Number:
MFCD28133393
SMILES:
CCCCCCOc1cc2c(cc1N(c1ncc(cn1)C(=O)O)C)C(C)(C)CCC2(C)C
Properties
Computed Properties
 
Complexity:
615  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
7.2  

Literature

Title: Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB.

Journal: ACS medicinal chemistry letters 20111208

Title: Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.

Journal: Journal of medicinal chemistry 20020801

Title: Iwata M, et al. Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int Immunol. 2003 Aug;15(8):1017-25.

Title: Varley CL, et al. Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. Am J Pathol. 2004 May;164(5):1789-98.

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Tags:457657-34-0 Molecular Formula|457657-34-0 MDL|457657-34-0 SMILES|457657-34-0 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylicacid