Title: Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo.
Journal: Journal of dermatological science 20160801
Title: Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity.
Journal: Gut 20141201
Title: Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.
Journal: Journal of medicinal chemistry 20140327
Title: Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.
Journal: British journal of pharmacology 20121001
Title: Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis.
Journal: Experimental dermatology 20120901
Title: The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice.
Journal: Allergy 20120801
Title: Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.
Journal: European journal of medicinal chemistry 20120801
Title: Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations.
Journal: Biochemical pharmacology 20120715
Title: A bioinformatics search for selective histamine h4 receptor antagonists through structure-based virtual screening strategies.
Journal: Chemical biology & drug design 20120501
Title: Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion.
Journal: Investigative ophthalmology & visual science 20120501
Title: Synthesis of novel histamine H4 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20120115
Title: Strain-dependent effects of the histamine H₄ receptor antagonist JNJ7777120 in a murine model of acute skin inflammation.
Journal: Experimental dermatology 20120101
Title: Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation.
Journal: PloS one 20120101
Title: Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
Journal: PloS one 20120101
Title: Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.
Journal: Pharmacology 20120101
Title: Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.
Journal: Journal of medicinal chemistry 20111208
Title: Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Journal: Bioorganic & medicinal chemistry letters 20111101
Title: Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R.
Journal: Bioorganic & medicinal chemistry letters 20111101
Title: Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
Journal: Bioorganic & medicinal chemistry letters 20111101
Title: Role of H4 receptor in histamine-mediated responses in human melanoma.
Journal: Melanoma research 20111001
Title: Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model.
Journal: European journal of pharmacology 20110930
Title: Histamine H1, H3 and H4 receptors are involved in pruritus.
Journal: Neuroscience 20110908
Title: Role of the second and third extracellular loops of the histamine H(4) receptor in receptor activation.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110901
Title: Lack of preventing effect of systemically and topically administered histamine H(1) or H(4) receptor antagonists in a dog model of acute atopic dermatitis.
Journal: Experimental dermatology 20110701
Title: Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation.
Journal: European journal of immunology 20110601
Title: Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.
Journal: Bioorganic & medicinal chemistry letters 20110515
Title: Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110501
Title: Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins.
Journal: Molecular pharmacology 20110401
Title: Paradoxical stimulatory effects of the 'standard' histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity.
Journal: Molecular pharmacology 20110401
Title: Histamine H(4) receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells.
Journal: European journal of pharmacology 20110125
Title: Histamine H(4) receptor activation on human slan-dendritic cells down-regulates their pro-inflammatory capacity.
Journal: Immunology 20110101
Title: [Effect of histamine H4 receptor and its antagonist on allergic rhinitis in rats].
Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20100601
Title: Molecular determinants of ligand binding to H4R species variants.
Journal: Molecular pharmacology 20100501
Title: Histamine stimulates human lung fibroblast migration.
Journal: Molecular and cellular biochemistry 20100401
Title: The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation.
Journal: The Journal of investigative dermatology 20100401
Title: Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma?
Journal: Pharmacology 20100101
Title: Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines.
Journal: Respiratory research 20100101
Title: Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor.
Journal: Molecular pharmacology 20091101
Title: Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists.
Journal: Journal of medicinal chemistry 20091022
Title: 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization.
Journal: Bioorganic & medicinal chemistry 20091015
Title: Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist.
Journal: The Journal of toxicological sciences 20091001
Title: The histamine H receptor as a new target for treatment of canine inflammatory skin diseases.
Journal: Veterinary dermatology 20091001
Title: A new generation of anti-histamines: Histamine H4 receptor antagonists on their way to the clinic.
Journal: Current opinion in drug discovery & development 20090901
Title: The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090601
Title: Effect of histamine H4 receptor antagonist on allergic rhinitis in mice.
Journal: International immunopharmacology 20090601
Title: Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation.
Journal: Experimental dermatology 20090101
Title: Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.
Journal: Journal of medicinal chemistry 20081225
Title: cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Journal: Journal of medicinal chemistry 20081127
Title: Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
Journal: Journal of medicinal chemistry 20081023
Title: Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
Journal: Journal of medicinal chemistry 20081023
Title: Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20081001
Title: Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine.
Journal: Allergy 20081001
Title: Cloning and pharmacological characterization of the dog histamine H4 receptor.
Journal: European journal of pharmacology 20080911
Title: Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
Journal: Journal of medicinal chemistry 20080612
Title: Histamine H(4) receptors regulate ACTH release in AtT-20 cells.
Journal: European journal of pharmacology 20080610
Title: Activation mechanism of the human histamine H4 receptor--an explicit membrane molecular dynamics simulation study.
Journal: Journal of chemical information and modeling 20080601
Title: Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor.
Journal: European journal of medicinal chemistry 20080501
Title: Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Journal: Journal of medicinal chemistry 20080424
Title: Histamine receptor H4R-selective ligands influence the STAT6 Transcription Activation Domain (TAD) and the DNA-binding.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080101
Title: Histamine downregulates monocyte CCL2 production through the histamine H4 receptor.
Journal: The Journal of allergy and clinical immunology 20070801
Title: Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.
Journal: European journal of pharmacology 20070601
Title: The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders.
Journal: Pharmacology & therapeutics 20070301
Title: Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.
Journal: The Journal of allergy and clinical immunology 20070101
Title: Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury.
Journal: Neuroimmunomodulation 20070101
Title: Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives.
Journal: Journal of medicinal chemistry 20060727
Title: The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060601
Title: Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
Journal: Journal of medicinal chemistry 20051229
Title: Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.
Journal: European journal of pharmacology 20051017
Title: Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
Journal: The Journal of pharmacology and experimental therapeutics 20050901
Title: Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20041101
Title: A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.
Journal: The Journal of pharmacology and experimental therapeutics 20040401
Title: The first potent and selective non-imidazole human histamine H4 receptor antagonists.
Journal: Journal of medicinal chemistry 20030911
Title: Jablonowski JA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-3960.
Title: Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ-7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-316.
Title: Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-413.
