459868-92-9,MFCD17010269
Catalog No.:AA00DA7J

459868-92-9 | Ag-014699

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$199.00   $139.00
- +
100mg
95%
in stock  
$236.00   $165.00
- +
250mg
95%
in stock  
$366.00   $257.00
- +
1g
95%
in stock  
$1,287.00   $901.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DA7J
Chemical Name:
Ag-014699
CAS Number:
459868-92-9
Molecular Formula:
C19H21FN3O5P
Molecular Weight:
421.3593
MDL Number:
MFCD17010269
SMILES:
OP(=O)(O)O.CNCc1ccc(cc1)c1[nH]c2c3c1CCNC(=O)c3cc(c2)F
Properties
Computed Properties
 
Complexity:
515  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.

Journal: Lancet (London, England) 20171028

Title: Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

Journal: The Lancet. Oncology 20170101

Title: Evaluation of rucaparib and companion diagnostics in the PARP inhibitor landscape for recurrent ovarian cancer therapy.

Journal: Future oncology (London, England) 20160601

Title: Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.

Journal: British journal of cancer 20160329

Title: An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma.

Journal: BMC cancer 20160101

Title: Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Journal: Cancer discovery 20120901

Title: Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

Journal: Nature medicine 20110701

Title: Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.

Journal: British journal of cancer 20101109

Title: Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100415

Title: Poly(adp-ribose) polymerase inhibitors: a novel drug class with a promising future.

Journal: Cancer journal (Sudbury, Mass.) 20100101

Title: Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.

Journal: Breast cancer research : BCR 20100101

Title: Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20091001

Title: Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215

Title: Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081201

Title: Thomas HD, et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther, 2007, 6(3), 945-956.

Title: J Murray, et al. Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules. Br J Cancer. 2014 Apr 15;110(8):1977-84.

Title: Matt Shirley, et al. Rucaparib: A Review in Ovarian Cancer. Target Oncol. 2019 Apr;14(2):237-246.

Title: Jianneng Li, et al. Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation. Sci Transl Med. 2021 May 26;13(595):eabe8226.

Title: Hunter JE, et al. NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699. Oncogene, 2012, 31(2), 251-264.

Title: Daniel RA, et al. Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. Clin Cancer Res, 2009, 15(4), 1241-1249.

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SDS
Tags:459868-92-9 Molecular Formula|459868-92-9 MDL|459868-92-9 SMILES|459868-92-9 Ag-014699
Catalog No.: AA00DA7J
459868-92-9,MFCD17010269
459868-92-9 | Ag-014699
Pack Size: 1mg
Purity: ≥98%
in stock
$46.00 $32.00
Pack Size: 5mg
Purity: ≥98%
in stock
$199.00 $139.00
Pack Size: 100mg
Purity: 95%
in stock
$236.00 $165.00
Pack Size: 250mg
Purity: 95%
in stock
$366.00 $257.00
Pack Size: 1g
Purity: 95%
in stock
$1,287.00 $901.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00DA7J
Chemical Name: Ag-014699
CAS Number: 459868-92-9
Molecular Formula: C19H21FN3O5P
Molecular Weight: 421.3593
MDL Number: MFCD17010269
SMILES: OP(=O)(O)O.CNCc1ccc(cc1)c1[nH]c2c3c1CCNC(=O)c3cc(c2)F
Properties
Complexity: 515  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 6  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.

Journal: Lancet (London, England)20171028

Title: Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

Journal: The Lancet. Oncology20170101

Title: Evaluation of rucaparib and companion diagnostics in the PARP inhibitor landscape for recurrent ovarian cancer therapy.

Journal: Future oncology (London, England)20160601

Title: Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.

Journal: British journal of cancer20160329

Title: An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma.

Journal: BMC cancer20160101

Title: Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Journal: Cancer discovery20120901

Title: Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

Journal: Nature medicine20110701

Title: Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.

Journal: British journal of cancer20101109

Title: Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20100415

Title: Poly(adp-ribose) polymerase inhibitors: a novel drug class with a promising future.

Journal: Cancer journal (Sudbury, Mass.)20100101

Title: Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.

Journal: Breast cancer research : BCR20100101

Title: Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20091001

Title: Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20090215

Title: Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20081201

Title: Thomas HD, et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther, 2007, 6(3), 945-956.

Title: J Murray, et al. Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules. Br J Cancer. 2014 Apr 15;110(8):1977-84.

Title: Matt Shirley, et al. Rucaparib: A Review in Ovarian Cancer. Target Oncol. 2019 Apr;14(2):237-246.

Title: Jianneng Li, et al. Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation. Sci Transl Med. 2021 May 26;13(595):eabe8226.

Title: Hunter JE, et al. NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699. Oncogene, 2012, 31(2), 251-264.

Title: Daniel RA, et al. Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. Clin Cancer Res, 2009, 15(4), 1241-1249.

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