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552292-08-7,MFCD23105917
Catalog No.:AA00DBK3

552292-08-7 | Rolapitant

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
- +
10mg
≥98%
in stock  
$306.00   $214.00
- +
25mg
98%
in stock  
$524.00   $367.00
- +
50mg
98%
in stock  
$834.00   $584.00
- +
100mg
98%
in stock  
$1,224.00   $857.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DBK3
Chemical Name:
Rolapitant
CAS Number:
552292-08-7
Molecular Formula:
C25H26F6N2O2
Molecular Weight:
500.4766
MDL Number:
MFCD23105917
SMILES:
O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1
Properties
Computed Properties
 
Complexity:
731  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4.4  

Literature

Title: Rolapitant: first global approval.

Journal: Drugs 20151101

Title: Rolapitant (SCH 619734): a potent, selective and orally active neurokinin NK1 receptor antagonist with centrally-mediated antiemetic effects in ferrets.

Journal: Pharmacology, biochemistry, and behavior 20120701

Title: Rolapitant for the prevention of postoperative nausea and vomiting: a prospective, double-blinded, placebo-controlled randomized trial.

Journal: Anesthesia and analgesia 20110401

Title: Management of postoperative nausea and vomiting: focus on palonosetron.

Journal: Therapeutics and clinical risk management 20090101

Title: The ATPase activity of cardiac myosin from failing and hypertropied hearts.

Journal: Journal of molecular and cellular cardiology 19751101

Title: Duffy RA, et al. Rolapitant (SCH 619734): a potent, selective and orally active neurokininNK1 receptor antagonist with centrally-mediated antiemetic effects inferrets. Pharmacol Biochem Behav. 2012 Jul;102(1):95-100.

Title: Rapoport B, et al. Study of rolapitant, a novel, long-acting, NK-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting (CINV) due to highly emetogenic chemotherapy (HEC). Support Care Cancer. 2015 Nov;23(11):3281-8.

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SDS
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