Home Other Building Blocks 466-06-8
466-06-8,MFCD00214065
Catalog No.:AA01CC8G

466-06-8 | Bufa-4,20,22-trienolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-14-hydroxy-, (3b)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
≥80%
in stock  
$738.00   $517.00
- +
100mg
≥80%
in stock  
$2,838.00   $1,987.00
- +
1g
≥80%
in stock  
$27,202.00   $19,042.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CC8G
Chemical Name:
Bufa-4,20,22-trienolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-14-hydroxy-, (3b)-
CAS Number:
466-06-8
Molecular Formula:
C30H42O8
Molecular Weight:
530.6497
MDL Number:
MFCD00214065
SMILES:
O[C@H]1[C@H](O[C@H]2CC[C@]3(C(=C2)CC[C@@H]2[C@@H]3CC[C@]3([C@]2(O)CC[C@@H]3c2ccc(=O)oc2)C)C)O[C@H]([C@@H]([C@H]1O)O)C
Properties
Properties
 
BP:
530.03°C (rough estimate)  
Form:
Solid  
MP:
>211ºC (dec.)  
Storage:
Keep in dry area;-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
1070  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
1.9  

Literature

Title: Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo.

Journal: Oncotarget 20141101

Title: Interaction of digitalis-like compounds with p-glycoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130201

Title: On the biophysics of cathodal galvanotaxis in rat prostate cancer cells: Poisson-Nernst-Planck equation approach.

Journal: European biophysics journal : EBJ 20120601

Title: 'The Lower Threshold' phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis?

Journal: Journal of carcinogenesis 20120101

Title: The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20111101

Title: Ex vivo activity of cardiac glycosides in acute leukaemia.

Journal: PloS one 20110101

Title: Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.

Journal: Leukemia research 20100701

Title: Dual effects of ouabain, digoxin and proscillaridin A on the regulation of apoptosis in human fibroblasts.

Journal: Natural product research 20100201

Title: Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells.

Journal: Pharmacological reports : PR 20100101

Title: Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.

Journal: PloS one 20100101

Title: Inhibition of DNA topoisomerases I and II by G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in a cell free system.

Journal: Acta poloniae pharmaceutica 20100101

Title: Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.

Journal: Journal of natural products 20091101

Title: Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

Journal: Bioorganic & medicinal chemistry 20091001

Title: Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis.

Journal: PloS one 20090101

Title: Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells.

Journal: Biological & pharmaceutical bulletin 20080601

Title: Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells.

Journal: Archives of pharmacal research 20071001

Title: Combinatorial computational approaches to identify tetracycline derivatives as flavivirus inhibitors.

Journal: PloS one 20070101

Title: Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.

Journal: Biological & pharmaceutical bulletin 20060701

Title: A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.

Journal: Clinical biochemistry 20050101

Title: Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.

Journal: Journal of medicinal chemistry 20020718

Title: [Separation and purification of an endogenous inhibitor of sodium pump from chansu by thin-layer chromatography and reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20011101

Title: [An elderly case of idiopathic dilatation of the right atrium in which right-sided heart failure was exacerbated by drug-induced bradyarrhythmia].

Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20010701

Title: Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells.

Journal: Anti-cancer drugs 20010601

Title: Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010201

Title: Exquisitely small amounts of nonglucocorticoid natural steroids suppress the human allogeneic T-cell response.

Journal: Transplantation proceedings 20010101

Title: The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity.

Journal: International immunopharmacology 20010101

Title: Bielawski K, et al. Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.Biol Pharm Bull. 2006 Jul;29(7):1493-7.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:466-06-8 Molecular Formula|466-06-8 MDL|466-06-8 SMILES|466-06-8 Bufa-4,20,22-trienolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-14-hydroxy-, (3b)-