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471-95-4,MFCD00210248
Catalog No.:AA019FSC

471-95-4 | Bufotalin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$188.00   $131.00
- +
10mg
≥98%
in stock  
$348.00   $243.00
- +
25mg
≥98%
in stock  
$762.00   $533.00
- +
500mg
98% by HPLC
in stock  
$11,485.00   $8,040.00
- +
1000mg
98% by HPLC
in stock  
$18,340.00   $12,838.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA019FSC
Chemical Name:
Bufotalin
CAS Number:
471-95-4
Molecular Formula:
C26H36O6
Molecular Weight:
444.5604
MDL Number:
MFCD00210248
SMILES:
O[C@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@]1(O)C[C@@H]([C@@H]2c1ccc(=O)oc1)OC(=O)C)C)C
Properties
Computed Properties
 
Complexity:
878  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.5  

Literature

Title: Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis.

Journal: European journal of pharmacology 20121005

Title: Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways.

Journal: International journal of oncology 20120101

Title: Plasma pharmacokinetics and tissue distribution of bufotalin in mice following single-bolus injection and constant-rate infusion of bufotalin solution.

Journal: European journal of drug metabolism and pharmacokinetics 20110101

Title: Studies on cytotoxic constituents from the skin of the toad Bufo bufo gargarizans.

Journal: Journal of Asian natural products research 20100901

Title: Involvement of caspases and apoptosis-inducing factor in bufotalin-induced apoptosis of Hep 3B cells.

Journal: Journal of agricultural and food chemistry 20090114

Title: Microbial transformation of bufotalin by Alternaria alternata AS 3.4578.

Journal: Journal of Asian natural products research 20090101

Title: Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.

Journal: Journal of natural products 20041201

Title: Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.

Journal: Journal of natural products 20010901

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SDS
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