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4736-71-4,MFCD00509172
Catalog No.:AA00DID8

4736-71-4 | Pyrrolidine-1-carboxylic acid amide

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250mg
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500mg
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1g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DID8
Chemical Name:
Pyrrolidine-1-carboxylic acid amide
CAS Number:
4736-71-4
Molecular Formula:
C5H10N2O
Molecular Weight:
114.1457
MDL Number:
MFCD00509172
SMILES:
NC(=O)N1CCCC1
NSC Number:
117254
Properties
Computed Properties
 
Complexity:
96.6  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
-0.2  

Downstream Synthesis Route

[1]Malik,Abdul;Afza,Nighat;Siddiqui,Salimuzzaman[ZeitschriftfurNaturforschung,TeilB:AnorganischeChemie,OrganischeChemie,1982,vol.37,#4,p.512-518]

[2]Álvarez,Daniel;Cadierno,Victorio;Crochet,Pascale;González-Fernández,Rebeca;López,Ramón;Menéndez,M.Isabel[Catalysisscienceandtechnology,2020,vol.10,#12,p.4084-4098]

[3]Overman,L.E.;Tsuboi,S.;Ross,J.P.[JournaloftheAmericanChemicalSociety,1980,vol.102,p.747]

[4]Overman,L.E.;Tsuboi,S.;Ross,J.P.[JournaloftheAmericanChemicalSociety,1980,vol.102,p.747]

[1]Schroth,Werner;Kluge,Helmut;Matthias,Michael;Krieg,Reimar;Schaedler,Hans-Dieter[ZeitschriftfurChemie,1981,vol.21,#1,p.25-27]

[2]Schroth,W.;Kluge,H.;Frach,R.;Hodek,W.;Schaedler,H.D.[JournalfurpraktischeChemie(Leipzig1954),1983,vol.325,#5,p.787-802]

[1]Patent:US2014/275016,2014,A1.Locationinpatent:Paragraph0360

Literature

Title: Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20111216

Title: A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types.

Journal: The Biochemical journal 20110815

Title: Neighboring pyrrolidine amide participation in thioether oxidation. Methionine as a 'hopping' site.

Journal: Organic letters 20110603

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

Journal: Journal of molecular biology 20101119

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening.

Journal: European journal of medicinal chemistry 20090901

Title: Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

Journal: PLoS computational biology 20090701

Title: CoMFA based de novo design of pyrrolidine carboxamides as inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis.

Journal: Journal of molecular modeling 20081001

Title: Cyclobutane-containing alkaloids: origin, synthesis, and biological activities.

Journal: The open medicinal chemistry journal 20080101

Title: Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM).

Journal: Chemical communications (Cambridge, England) 20060407

Title: Synthesis of the 1,6,8-trioxadispiro[4.1.5.2]tetradec-11-ene ring system present in the spirolide family of shellfish toxins and its conversion into a 1,6,8-trioxadispiro[4.1.5.2]-tetradec-9-en-12-ol via base-induced rearrangement of an epoxide.

Journal: Organic & biomolecular chemistry 20041221

Title: Synthesis and antibacterial evaluation of 1beta-methyl-2-(5-substituted heterocyclic carbamoyl)pyrrolidin-3-ylthio)carbapenem derivatives.

Journal: Archiv der Pharmazie 20040701

Title: Synthesis and absolute configuration of MQ-A3 [1-(14'-methylhexadecanoyl) pyrrolidine], a novel aliphatic pyrrolidine amide from the tropical convolvulaceous species.

Journal: Bioscience, biotechnology, and biochemistry 20010201

Title: Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine-amide oligonucleotide mimic (POM).

Journal: Nucleosides, nucleotides & nucleic acids 20010101

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