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Home Other Building Blocks 47491-38-3
47491-38-3,MFCD00871911
Catalog No.:AA00DFBM

47491-38-3 | desmethylazelastine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$205.00   $143.00
- +
10mg
≥98%
in stock  
$283.00   $198.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DFBM
Chemical Name:
desmethylazelastine
CAS Number:
47491-38-3
Molecular Formula:
C21H22ClN3O
Molecular Weight:
367.8719
MDL Number:
MFCD00871911
SMILES:
Clc1ccc(cc1)Cc1nn(C2CCNCCC2)c(=O)c2c1cccc2
Properties
Computed Properties
 
Complexity:
529  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.9  

Downstream Synthesis Route

[1]Patent:WO2007/122156,2007,A1.Locationinpatent:Page/Pagecolumn68-69

[1]Patent:WO2007/122156,2007,A1

[1]Patent:WO2007/122156,2007,A1

Literature

Title: Simultaneous determination of azelastine and its major metabolite desmethylazelastine in human plasma using high performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121001

Title: Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression system and the differences in the marker activities.

Journal: Journal of pharmaceutical sciences 20020401

Title: Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201

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SDS
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