Home Other Building Blocks 479543-46-9
479543-46-9,MFCD11616590
Catalog No.:AA00DBFF

479543-46-9 | VX-702

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Purity
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5mg
99% (HPLC)
in stock  
$148.00   $104.00
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10mg
99% (HPLC)
in stock  
$206.00   $144.00
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25mg
99% (HPLC)
in stock  
$364.00   $255.00
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50mg
99% (HPLC)
in stock  
$575.00   $403.00
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100mg
99% (HPLC)
in stock  
$949.00   $664.00
- +
500mg
99% (HPLC)
in stock  
$2,920.00   $2,044.00
- +
1000mg
99% (HPLC)
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DBFF
Chemical Name:
VX-702
CAS Number:
479543-46-9
Molecular Formula:
C19H12F4N4O2
Molecular Weight:
404.3178
MDL Number:
MFCD11616590
SMILES:
C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F
Properties
Computed Properties
 
Complexity:
603  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.5  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.

Journal: Journal of medicinal chemistry 20100325

Title: Comparative renal excretion of VX-702, a novel p38 MAPK inhibitor, and methotrexate in the perfused rat kidney model.

Journal: Drug development and industrial pharmacy 20100301

Title: The as-yet unfulfilled promise of p38 MAPK inhibitors.

Journal: Nature reviews. Rheumatology 20090901

Title: Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies.

Journal: Arthritis and rheumatism 20090501

Title: Inhibition of p38: has the fat lady sung?

Journal: Arthritis and rheumatism 20090201

Title: Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome.

Journal: Current opinion in investigational drugs (London, England : 2000) 20061101

Title: p38 MAP kinase inhibitors: many are made, but few are chosen.

Journal: Current opinion in drug discovery & development 20050701

Title: MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alpha protein.

Journal: Current medicinal chemistry 20050101

Title: Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation.

Journal: Thrombosis and haemostasis 20041201

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