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481-42-5,MFCD00001682
Catalog No.:AA003TQN

481-42-5 | 5-hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione

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1mg
97%
in stock  
$9.00   $7.00
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10mg
97%
in stock  
$32.00   $22.00
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100mg
≥98%
in stock  
$52.00   $36.00
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250mg
≥98%
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1g
>98.0%(T)(HPLC)
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003TQN
Chemical Name:
5-hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione
CAS Number:
481-42-5
Molecular Formula:
C11H8O3
Molecular Weight:
188.1794
MDL Number:
MFCD00001682
SMILES:
CC1=CC(=O)c2c(C1=O)cccc2O
Properties
Properties
 
BP:
383.9°C at 760 mmHg  
Form:
Solid  
MP:
76-78 °C(lit.);  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
317  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
2.3  

Downstream Synthesis Route

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[3]Takeya,Tetsuya;Kajiyama,Manabu;Nakamura,Chikara;Tobinaga,Seisho[ChemicalandPharmaceuticalBulletin,1999,vol.47,#2,p.209-219]

[4]Gunaherath,G.M.KamalB.;Gunatilaka,A.A.Leslie;Thompson,RonaldH.[JournaloftheChemicalSociety.PerkintransactionsI,1988,p.407-410]

[5]Fiorito,Serena;Genovese,Salvatore;Taddeo,VitoAlessandro;Mathieu,Véronique;Kiss,Robert;Epifano,Francesco[BioorganicandMedicinalChemistryLetters,2016,vol.26,#2,p.334-337]

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[8]Locationinpatent:experimentalpartPrasad,K.Rajendra;Babu,K.Suresh;Rao,R.Ranga;Suresh;Rekha;Murthy,J.Madhusudana;Rani,P.Usha;Rao,J.Madhusudana[MedicinalChemistryResearch,2012,vol.21,#5,p.578-583]

[9]Jardim,GuilhermeA.M.;Silva,ThaissaL.;Goulart,MariliaO.F.;deSimone,CarlosA.;Barbosa,JulianaM.C.;Salomão,Kelly;deCastro,SolangeL.;Bower,JohnF.;daSilvaJúnior,EufrânioN.[EuropeanJournalofMedicinalChemistry,2017,vol.136,p.406-419]

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[13]Locationinpatent:experimentalpartSreelatha,Thonthula;Hymavathi,Atmakur;Babu,KatragaddaSuresh;Murthy,JoishMadhusudana;Pathipati,UshaRani;Rao,JanaswamyMadhusudana[JournalofAgriculturalandFoodChemistry,2009,vol.57,#14,p.6090-6094]

[14]Sreelatha,Thonthula;Kandhasamy,Subramani;Dinesh,Raghu;Shruthy,Suresh;Shweta,Sinha;Mukesh,Doble;Karunagaran,Devarajan;Balaji,Ravichandran;Mathivanan,Narayanasamy;Perumal,ParamasivanThirumalai[BioorganicandMedicinalChemistryLetters,2014,vol.24,#15,p.3647-3651]

[15]CurrentPatentAssignee:PELLFICUREPHARMACEUTICALS-WO2016/40896,2016,A1Locationinpatent:Paragraph0272-0273

54497-00-6    481-42-5   
3-propoxymethylplumbagin 

[1]ChemicalandPharmaceuticalBulletin,1997,vol.45,p.437-445

2516-93-0    481-42-5   
3-butoxymethylplumbagin 

[1]Ogihara,Kazuhito;Yamashiro,Rieko;Higa,Matsutake;Yogi,Seiichi[ChemicalandPharmaceuticalBulletin,1997,vol.45,#3,p.437-445]

[1]Takeya,Tetsuya;Kajiyama,Manabu;Nakamura,Chikara;Tobinaga,Seisho[ChemicalandPharmaceuticalBulletin,1999,vol.47,#2,p.209-219]

[2]Tokunaga,Takashi;Dohmura,Atsushi;Takada,Noboru;Ueda,Minoru[BulletinoftheChemicalSocietyofJapan,2004,vol.77,#3,p.537-541]

[3]CurrentPatentAssignee:KOBEGAKUINUNIVERSITY-JP2015/54842,2015,ALocationinpatent:Paragraph0094-0096

[4]Fiorito,Serena;Genovese,Salvatore;Taddeo,VitoAlessandro;Mathieu,Véronique;Kiss,Robert;Epifano,Francesco[BioorganicandMedicinalChemistryLetters,2016,vol.26,#2,p.334-337]

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Title: Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells.

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Title: Room-temperature B(OAc)3-promoted Diels-Alder reaction of juglone with styrenes: total syntheses of tetrangulol and anhydrolandomycinone.

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Title: Possible mechanism of superoxide formation through redox cycling of plumbagin in pig heart.

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Journal: Cell biology and toxicology 20120201

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Title: Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling.

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Journal: International journal of oncology 20120101

Title: Modulation of plumbagin production in Plumbago zeylanica using a single-chain variable fragment antibody against plumbagin.

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Journal: Aging 20110301

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Journal: Journal of inorganic biochemistry 20110301

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Journal: Arteriosclerosis, thrombosis, and vascular biology 20110201

Title: Immune responses to novel allergens and modulation of inflammation by vitamin K3 analogue: a ROS dependent mechanism.

Journal: International immunopharmacology 20110201

Title: Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype.

Journal: International journal of antimicrobial agents 20110201

Title: DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine.

Journal: PLoS pathogens 20110201

Title: Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110101

Title: Negative feedback regulation of Raf/MEK/ERK cascade after sublethal cerebral ischemia in the rat hippocampus.

Journal: Neurochemical research 20110101

Title: Prolyl isomerase pin1 protects mice from endotoxin shock.

Journal: PloS one 20110101

Title: Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside?

Journal: Fibrogenesis & tissue repair 20110101

Title: Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2.

Journal: PloS one 20110101

Title: Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.

Journal: PloS one 20110101

Title: Formulation of plumbagin loaded long circulating pegylated liposomes: in vivo evaluation in C57BL/6J mice bearing B16F1 melanoma.

Journal: Drug delivery 20110101

Title: Synergistic use of plant-prokaryote comparative genomics for functional annotations.

Journal: BMC genomics 20110101

Title: The emphysematous lung is abnormally sensitive to TRAIL-mediated apoptosis.

Journal: Respiratory research 20110101

Title: Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.

Journal: Molecular cancer 20110101

Title: One carbon metabolism in SAR11 pelagic marine bacteria.

Journal: PloS one 20110101

Title: Is nitric oxide decrease observed with naphthoquinones in LPS stimulated RAW 264.7 macrophages a beneficial property?

Journal: PloS one 20110101

Title: A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress.

Journal: PloS one 20110101

Title: Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis.

Journal: PloS one 20110101

Title: Acaricidal effect of an isolate from Hoslundia opposita vahl against Amblyomma variegatum (Acari: Ixodidae).

Journal: Pharmacognosy research 20110101

Title: Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy.

Journal: Mutation research 20110101

Title: Antioxidant Activities of Plumbagin and Its Cu (II) Complex.

Journal: Bioinorganic chemistry and applications 20110101

Title: Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-κB signaling pathways.

Journal: PloS one 20110101

Title: Modulation of T cell proliferation and cytokine response by Plumbagin, extracted from Plumbago zeylanica in collagen induced arthritis.

Journal: BMC complementary and alternative medicine 20110101

Title: Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles.

Journal: International journal of nanomedicine 20110101

Title: Tasco(®), a product of Ascophyllum nodosum, imparts thermal stress tolerance in Caenorhabditis elegans.

Journal: Marine drugs 20110101

Title: Expression patterns of glutathione transferase gene (GstI) in maize seedlings under juglone-induced oxidative stress.

Journal: International journal of molecular sciences 20110101

Title: Modeling natural anti-inflammatory compounds by molecular topology.

Journal: International journal of molecular sciences 20110101

Title: Potential of herbs in skin protection from ultraviolet radiation.

Journal: Pharmacognosy reviews 20110101

Title: The prospective role of plant products in radiotherapy of cancer: a current overview.

Journal: Frontiers in pharmacology 20110101

Title: Enhancing hepatoprotective bioactives of phyllanthus amarus through immobilization by growth promoters and media changes.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils.

Journal: Blood 20101223

Title: Plumbagin promotes the generation of astrocytes from rat spinal cord neural progenitors via activation of the transcription factor Stat3.

Journal: Journal of neurochemistry 20101201

Title: Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-κB activation.

Journal: The Journal of pharmacology and experimental therapeutics 20101201

Title: Expression, purification, and characterization of anti-plumbagin single-chain variable fragment antibody in Sf9 insect cell.

Journal: Hybridoma (2005) 20101201

Title: Determination of cytotoxic compounds of Thai traditional medicine called Benjakul using HPLC.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20101201

Title: Effect of different strains of Agrobacterium rhizogenes and nature of explants on Plumbago indica hairy root culture with special emphasis on root biomass and plumbagin production.

Journal: Natural product communications 20101201

Title: Role of quinones in the ascorbate reduction rates of S-nitrosoglutathione.

Journal: Free radical biology & medicine 20101115

Title: Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway.

Journal: European journal of pharmacology 20101025

Title: In vitro antiamyloidogenic properties of 1,4-naphthoquinones.

Journal: Biochemical and biophysical research communications 20100910

Title: Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100901

Title: Antimicrobial activities of neo- and 1-epineo-isoshinanolones from Plumbago zeylanica roots.

Journal: Pharmaceutical biology 20100901

Title: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.

Journal: Cancer metastasis reviews 20100901

Title: Plumbagin-induced apoptosis in lymphocytes is mediated through increased reactive oxygen species production, upregulation of Fas, and activation of the caspase cascade.

Journal: Toxicology and applied pharmacology 20100815

Title: Uncoating of human immunodeficiency virus type 1 requires prolyl isomerase Pin1.

Journal: The Journal of biological chemistry 20100813

Title: Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols.

Journal: Journal of cellular biochemistry 20100801

Title: NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Plumbagin enhances TRAIL-mediated apoptosis through up-regulation of death receptor in human melanoma A375 cells.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100801

Title: The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer.

Journal: The Journal of biological chemistry 20100730

Title: Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 cells.

Journal: European journal of pharmacology 20100725

Title: Inhibition of mycobacterial growth by plumbagin derivatives.

Journal: Chemical biology & drug design 20100701

Title: Glucose 6-phosphate accumulation in mycobacteria: implications for a novel F420-dependent anti-oxidant defense system.

Journal: The Journal of biological chemistry 20100618

Title: Role of Pin1 in neointima formation: down-regulation of Nrf2-dependent heme oxygenase-1 expression by Pin1.

Journal: Free radical biology & medicine 20100615

Title: 5-Hydroxy-1,4-naphthoquinone (juglone) and 2-hydroxy-1,4-naphthoquinone (lawsone) influence on jack bean urease activity: Elucidation of the difference in inhibition activity.

Journal: Bioorganic chemistry 20100601

Title: Roles for Nox4 in the contractile response of bovine pulmonary arteries to hypoxia.

Journal: American journal of physiology. Heart and circulatory physiology 20100601

Title: Progresses in TCM metal-based antitumour agents.

Journal: Anti-cancer agents in medicinal chemistry 20100601

Title: Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo.

Journal: Leukemia research 20100501

Title: Enhanced plumbagin production from in vitro cultures of Drosera burmanii using elicitation.

Journal: Biotechnology letters 20100501

Title: Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: 1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes.

Journal: Archives of biochemistry and biophysics 20100415

Title: Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1.

Journal: Biogerontology 20100401

Title: Effect of hydroxy substituent on the prooxidant action of naphthoquinone compounds.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100401

Title: Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma.

Journal: Drug delivery 20100401

Title: Development of sensitivity-improved fluorescence-linked immunosorbent assay using a fluorescent single-domain antibody against the bioactive naphthoquinone, plumbagin.

Journal: Analytical and bioanalytical chemistry 20100401

Title: Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.

Journal: Bioorganic & medicinal chemistry 20100401

Title: Conjugates of plumbagin and phenyl-2-amino-1-thioglucoside inhibit MshB, a deacetylase involved in the biosynthesis of mycothiol.

Journal: Bioorganic & medicinal chemistry 20100401

Title: Polar and antioxidant fraction of Plumbago europaea L., a spontaneous plant of Sardinia.

Journal: Natural product research 20100401

Title: Bioassay-guided isolation of anti-inflammatory and antinociceptive compound from Plumbago zeylanica leaf.

Journal: Pharmaceutical biology 20100401

Title: Cytotoxic activity of naphthoquinones with special emphasis on juglone and its 5-O-methyl derivative.

Journal: Chemico-biological interactions 20100330

Title: Induced production of antifungal naphthoquinones in the pitchers of the carnivorous plant Nepenthes khasiana.

Journal: Journal of experimental botany 20100301

Title: Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia.

Journal: Journal of neurochemistry 20100301

Title: The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.

Journal: Molecular cancer therapeutics 20100301

Title: A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways.

Journal: Aging 20100301

Title: Simultaneous detection of pro- and antioxidative effects in the variants of the deoxyribose degradation assay.

Journal: Journal of agricultural and food chemistry 20100224

Title: Origins of regioselectivity of Diels-Alder reactions for the synthesis of bisanthraquinone antibiotic BE-43472B.

Journal: The Journal of organic chemistry 20100205

Title: Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung cancer cells.

Journal: Molecular and cellular biochemistry 20100201

Title: Antifungal constituents isolated from the seeds of Aegle marmelos.

Journal: Phytochemistry 20100201

Title: Design of a new electrogenerated polyquinone film substituted with glutathione. Towards direct electrochemical biosensors.

Journal: Talanta 20100115

Title: The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model.

Journal: Fibrogenesis & tissue repair 20100101

Title: 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.

Journal: Molecular cancer research : MCR 20100101

Title: Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor.

Journal: PloS one 20100101

Title: Quality control standards for the roots of three plumbago species.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Iron and its complexation by phenolic cellular metabolites: from oxidative stress to chemical weapons.

Journal: Plant signaling & behavior 20100101

Title: A systematic investigation of Escherichia coli central carbon metabolism in response to superoxide stress.

Journal: BMC systems biology 20100101

Title: An update on the therapeutic role of alkylglycerols.

Journal: Marine drugs 20100101

Title: Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery.

Journal: International journal of cell biology 20100101

Title: A role of ygfZ in the Escherichia coli response to plumbagin challenge.

Journal: Journal of biomedical science 20100101

Title: Pinning down viral proteins: a new prototype for virus-host cell interaction.

Journal: Frontiers in microbiology 20100101

Title: Cameroonian medicinal plants: pharmacology and derived natural products.

Journal: Frontiers in pharmacology 20100101

Title: Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry.

Journal: Dalton transactions (Cambridge, England : 2003) 20091228

Title: High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy.

Journal: Free radical biology & medicine 20091201

Title: Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats.

Journal: Indian journal of pharmacology 20091201

Title: Histopathology and cholinergic assessment of Pterocarya fraxinifolia on chicken embryo.

Journal: Interdisciplinary toxicology 20091201

Title: Novel role of Pin1 induction in type II collagen-mediated rheumatoid arthritis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20091115

Title: 4-(8-Hydr-oxy-3-methyl-1,4-dioxo-1,4-dihydro-2-naphth-yl)butanoic acid.

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: The rotamase Pin1 is up-regulated, hypophosphorylated and required for cell cycle progression in head and neck squamous cell carcinomas.

Journal: Oral oncology 20091001

Title: Diospyrone, crassiflorone and plumbagin: three antimycobacterial and antigonorrhoeal naphthoquinones from two Diospyros spp.

Journal: International journal of antimicrobial agents 20091001

Title: Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells.

Journal: Cell biology international 20091001

Title: In vitro antifilarial activity of glutathione S-transferase inhibitors.

Journal: Parasitology research 20091001

Title: Plumbagin inhibits invasion and migration of liver cancer HepG2 cells by decreasing productions of matrix metalloproteinase-2 and urokinase- plasminogen activator.

Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20091001

Title: Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans.

Journal: Mechanisms of ageing and development 20091001

Title: The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism.

Journal: The Journal of clinical investigation 20091001

Title: Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin.

Journal: The Journal of biological chemistry 20090904

Title: Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells.

Journal: Mutagenesis 20090901

Title: Pin1 affects Tau phosphorylation in response to Abeta oligomers.

Journal: Molecular and cellular neurosciences 20090901

Title: Superoxide protects Escherichia coli from bleomycin mediated lethality.

Journal: Journal of inorganic biochemistry 20090901

Title: Pin1 as an anticancer drug target.

Journal: Drug news & perspectives 20090901

Title: Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation.

Journal: Nature cell biology 20090801

Title: Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression.

Journal: Molecular cancer therapeutics 20090801

Title: (+/-)-catechin: chemical weapon, antioxidant, or stress regulator?

Journal: Journal of chemical ecology 20090801

Title: Plant antimicrobial agents and their effects on plant and human pathogens.

Journal: International journal of molecular sciences 20090801

Title: Synthesis and insect antifeedant activity of plumbagin derivatives with the amino acid moiety.

Journal: Journal of agricultural and food chemistry 20090722

Title: No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.

Journal: Biochemistry 20090707

Title: Juglone derivatives as antitubercular agents: a rationale for the activity profile.

Journal: European journal of medicinal chemistry 20090701

Title: Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes.

Journal: International immunopharmacology 20090701

Title: The comparative toxicity to soil invertebrates of natural chemicals and their synthetic analogues.

Journal: Chemosphere 20090701

Title: Spatial distribution, kinetics, signaling and cytokine production during homeostasis driven proliferation of CD4+ T cells.

Journal: Molecular immunology 20090701

Title: The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.

Journal: Aging 20090701

Title: In vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand.

Journal: Journal of ethnopharmacology 20090625

Title: Combined directed remote metalation-transition metal catalyzed cross coupling strategies: the total synthesis of the aglycones of the gilvocarcins V, M, and E and arnottin I.

Journal: The Journal of organic chemistry 20090605

Title: Inhibition of insulin-stimulated hydrogen peroxide production prevents stimulation of sodium transport in A6 cell monolayers.

Journal: American journal of physiology. Renal physiology 20090601

Title: Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone.

Journal: Mechanisms of ageing and development 20090601

Title: Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family.

Journal: Cancer research 20090601

Title: [Effect of juglone on the ultrastructure of human liver cancer BEL-7402 cells].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090601

Title: Towards a molecular-level understanding of the reactivity differences for radical anions of juglone and plumbagin: an electrochemical and spectroelectrochemical approach.

Journal: Organic & biomolecular chemistry 20090507

Title: The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation.

Journal: Carcinogenesis 20090401

Title: Two novel phospholipid hydroperoxide glutathione peroxidase genes of Paragonimus westermani induced by oxidative stress.

Journal: Parasitology 20090401

Title: Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia.

Journal: Immunology letters 20090324

Title: Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090301

Title: Construction and expression of specificity-improved single-chain variable fragments against the bioactive naphthoquinone, plumbagin.

Journal: Biological & pharmaceutical bulletin 20090301

Title: Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis.

Journal: Genes & nutrition 20090301

Title: Milieu-dependent pro- and antioxidant activity of juglone may explain linear and nonlinear effects on seedling development.

Journal: Journal of chemical ecology 20090301

Title: [Recent advance in the study of novel anti-tumor targets and drugs--aurora kinase and Pin1].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090301

Title: Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1.

Journal: The Journal of biological chemistry 20090206

Title: Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.

Journal: PLoS genetics 20090201

Title: Quinone-enhanced sonochemical production of nitric oxide from s-nitrosoglutathione.

Journal: Ultrasonics sonochemistry 20090101

Title: Characterization of an NADH oxidase of the flavin-dependent disulfide reductase family from Methanocaldococcus jannaschii.

Journal: Microbiology (Reading, England) 20090101

Title: Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Journal: BMC medical genomics 20090101

Title: Use of folding modulators to improve heterologous protein production in Escherichia coli.

Journal: Microbial cell factories 20090101

Title: Antimicrobial activity of Drosophyllum lusitanicum, an endemic Mediterranean insectivorous plant.

Journal: Natural product research 20090101

Title: Taking ecological function seriously: soil microbial communities can obviate allelopathic effects of released metabolites.

Journal: PloS one 20090101

Title: Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals.

Journal: BMC evolutionary biology 20090101

Title: Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization.

Journal: BMC microbiology 20090101

Title: Co-ordinated stage-dependent enhancement of Plasmodium falciparum antioxidant enzymes and heat shock protein expression in parasites growing in oxidatively stressed or G6PD-deficient red blood cells.

Journal: Malaria journal 20090101

Title: Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.

Journal: BMC neuroscience 20090101

Title: Determination of psoralen and plumbagin from its polyherbal oil formulations by an HPTLC densitometric method.

Journal: Journal of AOAC International 20090101

Title: Plumbagin, isolated from Plumbago zeylanica, induces cell death through apoptosis in human pancreatic cancer cells.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20090101

Title: Plumbagin-induced apoptosis of human breast cancer cells is mediated by inactivation of NF-kappaB and Bcl-2.

Journal: Journal of cellular biochemistry 20081215

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer.

Journal: Cancer research 20081101

Title: Effects of electron transfer mediators on the bioreduction of lepidocrocite (gamma-FeOOH) by Shewanella putrefaciens CN32.

Journal: Environmental science & technology 20080915

Title: Plumbagin-induced apoptosis in human prostate cancer cells is associated with modulation of cellular redox status and generation of reactive oxygen species.

Journal: Pharmaceutical research 20080901

Title: Cancer is a preventable disease that requires major lifestyle changes.

Journal: Pharmaceutical research 20080901

Title: [Study on qualitative and quantitatire methods for Ceratostigma willmottianum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

Title: Juglone inactivates cysteine-rich proteins required for progression through mitosis.

Journal: The Journal of biological chemistry 20080801

Title: 5-Hydr-oxy-8-nitro-1,4-naphthoquinone.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: The natural naphthoquinone plumbagin exhibits antiproliferative activity and disrupts the microtubule network through tubulin binding.

Journal: Biochemistry 20080729

Title: Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization.

Journal: Acta pharmacologica Sinica 20080701

Title: Investigation of Indian diospyros species for antiplasmodial properties.

Journal: Evidence-based complementary and alternative medicine : eCAM 20080601

Title: Thymic stromal lymphopoietin expression in allergic pulmonary inflammation is Pin1-dependent.

Journal: The Journal of allergy and clinical immunology 20080501

Title: Crystallization and preliminary characterization of a novel haem-binding protein of Streptomyces reticuli.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20080501

Title: Impact of lactic acid bacteria on oxidative DNA damage in human derived colon cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080401

Title: Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20080401

Title: Solubilization of hydrophobic drugs by methoxy poly(ethylene glycol)-block-polycaprolactone diblock copolymer micelles: theoretical and experimental data and correlations.

Journal: Journal of pharmaceutical sciences 20080301

Title: Topoisomerase inhibitors as anti-arthritic agents.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080301

Title: Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1).

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080201

Title: Acaricidal activity and function of mite indicator using plumbagin and its derivatives isolated from Diospyros kaki Thunb. roots (Ebenaceae).

Journal: Journal of microbiology and biotechnology 20080201

Title: Development of an enzyme-linked immunosorbent assay (ELISA) using highly-specific monoclonal antibodies against plumbagin.

Journal: Analytica chimica acta 20080121

Title: Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells.

Journal: Cancer letters 20080118

Title: Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway.

Journal: Molecular carcinogenesis 20080101

Title: Plumbagin recovery from field specimens of Drosophyllum lusitanicum (L.) link.

Journal: Phytochemical analysis : PCA 20080101

Title: Synthesis, structure, electrochemistry, and spectral characterization of bis-isatin thiocarbohydrazone metal complexes and their antitumor activity against ehrlich ascites carcinoma in swiss albino mice.

Journal: Metal-based drugs 20080101

Title: Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology.

Journal: Journal of translational medicine 20080101

Title: Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells.

Journal: PloS one 20080101

Title: Anticancer mechanism of plumbagin, a natural compound, on non-small cell lung cancer cells.

Journal: Anticancer research 20080101

Title: A multicopy suppressor screening approach as a means to identify antibiotic resistance determinant candidates in Yersinia pestis.

Journal: BMC microbiology 20080101

Title: A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores.

Journal: BMC pharmacology 20080101

Title: Genome-wide transcriptional response of an avian pathogenic Escherichia coli (APEC) pst mutant.

Journal: BMC genomics 20080101

Title: Identification and characterization of sigma, a novel component of the Staphylococcus aureus stress and virulence responses.

Journal: PloS one 20080101

Title: Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability.

Journal: Molecular cancer 20080101

Title: Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae.

Journal: PloS one 20080101

Title: Fingerprinting of Plumbagin in lic>Drosera burmannii Vahl using High Performance Thin Layer Chromatography.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: A Reverse Phase HPLC-UV and HPTLC Methods for Determination of Plumbagin in Plumbago indica and Plumbago zeylanica.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans.

Journal: Archives of toxicology 20071201

Title: Induction of multiple antibiotic resistance in Bacteroides fragilis by benzene and benzene-derived active compounds of commonly used analgesics, antiseptics and cleaning agents.

Journal: The Journal of antimicrobial chemotherapy 20071201

Title: The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2.

Journal: Molecular cancer therapeutics 20071201

Title: [Insecticidal activity and active components of alcohol extract from Juglans mandshurica Maxim leaves].

Journal: Ying yong sheng tai xue bao = The journal of applied ecology 20071201

Title: A critical role for Pin1 in allergic pulmonary eosinophilia in rats.

Journal: The Journal of allergy and clinical immunology 20071101

Title: Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071001

Title: The influence of water quality on the toxicity and degradation of juglone (5-hydroxy 1,4-naphthoquinone).

Journal: Environmental technology 20071001

Title: Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II.

Journal: Toxicology and applied pharmacology 20070915

Title: Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts.

Journal: The Biochemical journal 20070815

Title: Mycobacterium smegmatis mc2 155 fbiC and MSMEG_2392 are involved in triphenylmethane dye decolorization and coenzyme F420 biosynthesis.

Journal: Microbiology (Reading, England) 20070801

Title: In vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae).

Journal: Phytotherapy research : PTR 20070701

Title: Phytotoxic effects of 21 plant secondary metabolites on Arabidopsis thaliana germination and root growth.

Journal: Journal of chemical ecology 20070701

Title: Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.

Journal: PLoS medicine 20070601

Title: [Naphthoquinones and their pharmacological properties].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20070601

Title: [Chemical constituents from aerial parts of Plumbago zeylanica Linn].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070501

Title: Naphthoquinones as broad spectrum biocides for treatment of ship's ballast water: toxicity to phytoplankton and bacteria.

Journal: Water research 20070301

Title: Screening of natural product biocides for control of non-indigenous species.

Journal: Environmental technology 20070301

Title: A polyketide synthase of Plumbago indica that catalyzes the formation of hexaketide pyrones.

Journal: The FEBS journal 20070101

Title: Pin1 modulates the type 1 immune response.

Journal: PloS one 20070101

Title: Occurrence and fate of the phytotoxin juglone in alley soils under black walnut trees.

Journal: Journal of environmental quality 20070101

Title: Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress.

Journal: Journal of biology 20070101

Title: Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.

Journal: Drug target insights 20070101

Title: Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells.

Journal: Molecular cancer therapeutics 20061201

Title: DNA microarrays in herbal drug research.

Journal: Evidence-based complementary and alternative medicine : eCAM 20061201

Title: Therapeutic Strategies in Huntington's Disease.

Journal: Journal of clinical neurology (Seoul, Korea) 20061201

Title: Measurement and pharmacokinetic study of plumbagin in a conscious freely moving rat using liquid chromatography/tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061121

Title: [Determination of plumbagin in different parts of Plumbago zeylanica by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

Title: Using of liquid chromatography coupled with diode array detector for determination of naphthoquinones in plants and for investigation of influence of pH of cultivation medium on content of plumbagin in Dionaea muscipula.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060914

Title: Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis.

Journal: Phytochemistry 20060901

Title: Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: Mono and dimeric naphthalene derivatives from the roots of Diospyros assimilis.

Journal: Natural product research 20060720

Title: The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease.

Journal: The Journal of biological chemistry 20060714

Title: Electrocoagulation of quinone pigments.

Journal: Molecules (Basel, Switzerland) 20060714

Title: Effects of quinones and flavonoids on the reduction of all-trans retinal to all-trans retinol in pig heart.

Journal: European journal of pharmacology 20060701

Title: UV/Vis spectra and solubility of some naphthoquinones, and the extraction behavior of plumbagin from Plumbago scandens roots in supercritical CO2.

Journal: Analytical and bioanalytical chemistry 20060701

Title: Acute irritant contact dermatitis due to Juglans regia.

Journal: Contact dermatitis 20060701

Title: Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.

Journal: The Journal of biological chemistry 20060623

Title: The development of a reagentless lactate biosensor based on a novel conducting polymer.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20060501

Title: Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori.

Journal: Journal of ethnopharmacology 20060421

Title: Transformation of carbon tetrachloride by bisulfide treated goethite, hematite, magnetite, and kaolinite.

Journal: Chemosphere 20060401

Title: [Effects of plumbagin on the human acute promyelocytic leukemia cells in vitro].

Journal: Zhongguo shi yan xue ye xue za zhi 20060401

Title: Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells.

Journal: The Journal of biological chemistry 20060303

Title: Immunology and homeopathy. 2. Cells of the immune system and inflammation.

Journal: Evidence-based complementary and alternative medicine : eCAM 20060301

Title: Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm.

Journal: BMC biology 20060101

Title: Use of natural dye-casein complexes: effect of proteolytic treatment.

Journal: Preparative biochemistry & biotechnology 20060101

Title: Dyeing of wool fibres with natural dyes: effect of proteolytic enzymes.

Journal: Preparative biochemistry & biotechnology 20060101

Title: [Tolerance of the yeast Yarrowia lipolytica to oxidative stress].

Journal: Mikrobiologiia 20060101

Title: Ethnopharmacological evaluation of radal (leaves of Lomatia hirsuta) and isolation of 2-methoxyjuglone.

Journal: BMC complementary and alternative medicine 20060101

Title: An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm.

Journal: PloS one 20060101

Title: The whcE gene of Corynebacterium glutamicum is important for survival following heat and oxidative stress.

Journal: Biochemical and biophysical research communications 20051125

Title: Investigation into the resistance of lactoperoxidase tolerant Escherichia coli mutants to different forms of oxidative stress.

Journal: FEMS microbiology letters 20051115

Title: The natural toxin juglone causes degradation of p53 and induces rapid H2AX phosphorylation and cell death in human fibroblasts.

Journal: Toxicology and applied pharmacology 20051115

Title: High-performance liquid chromatography for quantification of plumbagin, an anti-Helicobacter pylori compound of Plumbago zeylanica L.

Journal: Journal of chromatography. A 20051111

Title: Identification of a novel two-component system SenS/SenR modulating the production of the catalase-peroxidase CpeB and the haem-binding protein HbpS in Streptomyces reticuli.

Journal: Microbiology (Reading, England) 20051101

Title: Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance.

Journal: Eukaryotic cell 20051001

Title: Transformation of carbon tetrachloride by thiol reductants in the presence of quinone compounds.

Journal: Environmental science & technology 20051001

Title: Determination and identification of plumbagin from the roots of Plumbago zeylanica L. by liquid chromatography with tandem mass spectrometry.

Journal: Journal of chromatography. A 20050812

Title: Phenolic acids, syringaldehyde, and juglone in fruits of different cultivars of Juglans regia L.

Journal: Journal of agricultural and food chemistry 20050810

Title: Induction of phenotypes resembling CuZn-superoxide dismutase deletion in wild-type yeast cells: an in vivo assay for the role of superoxide in the toxicity of redox-cycling compounds.

Journal: Chemical research in toxicology 20050801

Title: Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations in Alzheimer's disease.

Journal: Biochimica et biophysica acta 20050610

Title: Bacillus subtilis paraquat resistance is directed by sigmaM, an extracytoplasmic function sigma factor, and is conferred by YqjL and BcrC.

Journal: Journal of bacteriology 20050501

Title: Feeding response to host and nonhost compounds by males and females of the spruce bark beetle Ips typographus in a tunneling microassay.

Journal: Journal of chemical ecology 20050401

Title: Unique stress response to the lactoperoxidase-thiocyanate enzyme system in Escherichia coli.

Journal: Research in microbiology 20050301

Title: Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria.

Journal: Journal of agricultural and food chemistry 20050223

Title: Phosphorylation modulates the alpha-helical structure and polymerization of a peptide from the third tau microtubule-binding repeat.

Journal: Biochimica et biophysica acta 20050118

Title: Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii.

Journal: The Journal of biological chemistry 20050107

Title: Photoreactions of 1,4-Naphthoquinones: effects of substituents and water on the intermediates and reactivity.

Journal: Photochemistry and photobiology 20050101

Title: Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.

Journal: The Journal of pharmacy and pharmacology 20050101

Title: Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation.

Journal: BMC neuroscience 20050101

Title: An extract from teak (Tectona grandis) bark inhibited Listeria monocytogenes and methicillin resistant Staphylococcus aureus.

Journal: Letters in applied microbiology 20050101

Title: Secondary metabolites in in vitro cultured plants of the genus Drosera.

Journal: Phytochemical analysis : PCA 20050101

Title: Isolation of secondary metabolites from roots of Plumbago auriculata Lam. by countercurrent chromatography.

Journal: Phytochemical analysis : PCA 20050101

Title: Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans.

Journal: BMC neuroscience 20050101

Title: In vivo micronucleus assay and GST activity in assessing genotoxicity of plumbagin in Swiss albino mice.

Journal: Drug and chemical toxicology 20050101

Title: Metabolism and disposition of juglone in male F344 rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050101

Title: A fluorescence-based rapid screening assay for cytotoxic compounds.

Journal: Biochemical and biophysical research communications 20041224

Title: Separation methods of quinonoid constituents of plants used in Oriental traditional medicines.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041205

Title: Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide.

Journal: Phytotherapy research : PTR 20041101

Title: Antimicrobial activity and chemical investigation of Brazilian Drosera.

Journal: Memorias do Instituto Oswaldo Cruz 20041101

Title: NO reductase from Bacillus azotoformans is a bifunctional enzyme accepting electrons from menaquinol and a specific endogenous membrane-bound cytochrome c551.

Journal: Biochemistry 20041026

Title: Co-induction of methyltransferase Rv0560c by naphthoquinones and fibric acids suggests attenuation of isoprenoid quinone action in Mycobacterium tuberculosis.

Journal: Canadian journal of microbiology 20041001

Title: Quinones as antimycobacterial agents.

Journal: Bioorganic & medicinal chemistry 20040915

Title: Plumbagin quantification in roots of Plumbago scandens L. obtained by different extraction techniques.

Journal: Anais da Academia Brasileira de Ciencias 20040901

Title: Proteome-level differences between auxinic-herbicide-susceptible and -resistant wild mustard (Sinapis arvensis L.).

Journal: Journal of agricultural and food chemistry 20040811

Title: Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells.

Journal: Molecular carcinogenesis 20040801

Title: Degradation of juglone by Pleurotus sajor-caju.

Journal: Mycological research 20040801

Title: Oxy2 as a transcriptional activator gene for copper uptake in Cryptococcus neoformans.

Journal: Medical mycology 20040801

Title: Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone.

Journal: Free radical biology & medicine 20040715

Title: Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans.

Journal: Free radical biology & medicine 20040715

Title: Cytotoxic constituents from Plumbago zeylanica.

Journal: Fitoterapia 20040701

Title: Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

Journal: Journal of natural products 20040701

Title: Antitermitic quinones from Diospyros sylvatica.

Journal: Phytochemistry 20040501

Title: Role of NAD(P)H:quinone oxidoreductase encoded by drgA gene in reduction of exogenous quinones in cyanobacterium Synechocystis sp. PCC 6803 cells.

Journal: Biochemistry. Biokhimiia 20040201

Title: Juglone disrupts root plasma membrane H+-ATPase activity and impairs water uptake, root respiration, and growth in soybean (Glycine max) and corn (Zea mays).

Journal: Journal of chemical ecology 20040201

Title: Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

Journal: The Journal of biological chemistry 20040109

Title: Antisense blocking of BRCA1 enhances sensitivity to plumbagin but not tamoxifen in BG-1 ovarian cancer cells.

Journal: Molecular carcinogenesis 20040101

Title: Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes.

Journal: Chemical research in toxicology 20040101

Title: N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA.

Journal: Molecular cancer 20040101

Title: Direct oxidation of 2',7'-dichlorodihydrofluorescein by pyocyanin and other redox-active compounds independent of reactive oxygen species production.

Journal: Free radical biology & medicine 20040101

Title: Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in mcf-7 cells.

Journal: Journal of biomedical science 20040101

Title: Multisite phosphorylation of Pin1-associated mitotic phosphoproteins revealed by monoclonal antibodies MPM-2 and CC-3.

Journal: BMC cell biology 20040101

Title: Source of tryptone in growth medium affects oxidative stress resistance in Escherichia coli.

Journal: Journal of applied microbiology 20040101

Title: Antioxidant properties of Plumbago zeylanica, an Indian medicinal plant and its active ingredient, plumbagin.

Journal: Redox report : communications in free radical research 20040101

Title: Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201

Title: Ultrasound-mediated release of iron from ferritin.

Journal: Ultrasound in medicine & biology 20031201

Title: Antimicrobial activity in vitro of plumbagin isolated from Plumbago species.

Journal: Memorias do Instituto Oswaldo Cruz 20031001

Title: Auxin action in a cell-free system.

Journal: Current biology : CB 20030819

Title: Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions.

Journal: Planta medica 20030701

Title: Regional and habitat differences in 7-methyljuglone content of Finnish Drosera rotundifolia.

Journal: Phytochemistry 20030601

Title: A photochemical study of cells loaded with 2',7'-dichlorofluorescin: implications for the detection of reactive oxygen species generated during UVA irradiation.

Journal: Free radical biology & medicine 20030415

Title: Enhanced production of plumbagin in immobilized cells of Plumbago rosea by elicitation and in situ adsorption.

Journal: Journal of biotechnology 20030306

Title: Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.

Journal: Phytochemistry 20030201

Title: Functional analysis of the glutathione S-transferase 3 from Onchocerca volvulus (Ov-GST-3): a parasite GST confers increased resistance to oxidative stress in Caenorhabditis elegans.

Journal: Journal of molecular biology 20030103

Title: In vitro mass multiplication and production of roots in Plumbago rosea.

Journal: Planta medica 20030101

Title: The prolyl isomerase Pin1 in breast development and cancer.

Journal: Breast cancer research : BCR 20030101

Title: Comparison of the antioxidant activities of extra virgin olive oils.

Journal: Journal of agricultural and food chemistry 20021218

Title: Antimicrobial activities of naphthazarins from Arnebia euchroma.

Journal: Journal of natural products 20021201

Title: Pin1: a therapeutic target in Alzheimer neurodegeneration.

Journal: Journal of molecular neuroscience : MN 20021201

Title: Temperature sensitive liposomes of plumbagin: characterization and in vivo evaluation in mice bearing melanoma B16F1.

Journal: Journal of drug targeting 20021201

Title: Purification and characterization of NAD(P)H quinone reductase from the latex of Hevea brasiliensis Müll.-Arg. (Euphorbiaceae).

Journal: Phytochemistry 20020901

Title: Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1.

Journal: Oncogene 20020829

Title: Increasing plasmalogen levels protects human endothelial cells during hypoxia.

Journal: American journal of physiology. Heart and circulatory physiology 20020801

Title: Addition of hydrogen sulfide to juglone.

Journal: Environmental science & technology 20020615

Title: Nepenthes insignis uses a C2-portion of the carbon skeleton of L-alanine acquired via its carnivorous organs, to build up the allelochemical plumbagin.

Journal: Phytochemistry 20020301

Title: Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20020301

Title: Synthesis of plumbagin derivatives and their inhibitory activities against Ehrlich ascites carcinoma in vivo and Leishmania donovani Promastigotes in vitro.

Journal: Phytotherapy research : PTR 20020301

Title: Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase.

Journal: Phytotherapy research : PTR 20020301

Title: Main constituents of a commercial Drosera fluid extract and their antagonist activity at muscarinic M3 receptors in guinea-pig ileum.

Journal: Die Pharmazie 20020301

Title: DNA synthesis in the imaginal wing discs of the American bollworm Helicoverpa armigera (Hübner).

Journal: Journal of biosciences 20020301

Title: Electrochemical properties of natural organic matter (NOM), fractions of NOM, and model biogeochemical electron shuttles.

Journal: Environmental science & technology 20020215

Title: Mitochondrial NADH dehydrogenase from Plasmodium falciparum and Plasmodium berghei.

Journal: Experimental parasitology 20020101

Title: [Respiratory activity and naphthoquinone synthesis in the fungus Fusarium decemcellulare exposed to oxidative stress].

Journal: Mikrobiologiia 20020101

Title: Thiol metabolism of the trypanosomatids as potential drug targets.

Journal: IUBMB life 20020101

Title: Effects of various environmental conditions on the transformation of chlorinated solvents by Methanosarcina thermophila cell exudates.

Journal: Biotechnology and bioengineering 20011220

Title: Effects of natural organic matter, anthropogenic surfactants, and model quinones on the reduction of contaminants by zero-valent iron.

Journal: Water research 20011201

Title: Interaction of camel lens zeta-crystallin with quinones: portrait of a substrate by fluorescence spectroscopy.

Journal: Archives of biochemistry and biophysics 20011115

Title: Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase.

Journal: The Journal of biological chemistry 20011109

Title: Mutagenicity of nitric oxide-releasing compounds in Escherichia coli: effect of superoxide generation and evidence for two mutagenic mechanisms.

Journal: Mutation research 20011018

Title: Plasmid-mediated dimethoate degradation in Pseudomonas aeruginosa MCMB-427.

Journal: Letters in applied microbiology 20011001

Title: Stress-related polyketide metabolism of Dioncophyllaceae and Ancistrocladaceae.

Journal: Journal of experimental botany 20011001

Title: Production of pyridoxal phosphate by a mutant strain of Schizosaccharomyces pombe.

Journal: Bioscience, biotechnology, and biochemistry 20010801

Title: Alkaloids, diarylheptanoid and naphthalene carboxylic acid ester from Rhoiptelea chiliantha.

Journal: Chemical & pharmaceutical bulletin 20010601

Title: Functional replacement of the essential ESS1 in yeast by the plant parvulin DlPar13.

Journal: The Journal of biological chemistry 20010427

Title: Functional conservation of phosphorylation-specific prolyl isomerases in plants.

Journal: The Journal of biological chemistry 20010427

Title: Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation.

Journal: Biochemistry 20010320

Title: 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

Journal: Journal of medicinal chemistry 20010215

Title: A stress-responsive glyoxalase I from the parasitic nematode Onchocerca volvulus.

Journal: The Biochemical journal 20010201

Title: Hyperpigmentation and contact dermatitis due to Juglans regia.

Journal: Contact dermatitis 20010201

Title: [Adaptation of the phytopathogenic fungus Fusarium decemcellulare to oxidative stress].

Journal: Mikrobiologiia 20010101

Title: Effects of plant-derived naphthoquinones on the growth of Pleurotus sajor-caju and degradation of the compounds by fungal cultures.

Journal: Journal of basic microbiology 20010101

Title: Ascorbate-independent electron transfer between cytochrome b561 and a 27 kDa ascorbate peroxidase of bean hypocotyls.

Journal: Protoplasma 20010101

Title: [Collection of Arabidopsis thaliana mutants with altered sensitivity to oxidative stress inductors].

Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20010101

Title: VARIABILITY AND CHARACTER ASSOCIATION IN ROSE COLOURED LEADWORT (PLUMBAGO ROSEA Linn.).

Journal: Ancient science of life 20010101

Title: Identification of a stress-responsive Onchocerca volvulus glutathione S-transferase (Ov-GST-3) by RT-PCR differential display.

Journal: Molecular and biochemical parasitology 20000701

Title: Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.

Journal: Chemico-biological interactions 20000103

Title: Screening of compounds for antimicrosporidial activity in vitro.

Journal: Folia parasitologica 19980101

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Tags:481-42-5 Molecular Formula|481-42-5 MDL|481-42-5 SMILES|481-42-5 5-hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione