483-18-1,MFCD00242944
Catalog No.:AA01E4H7

483-18-1 | Emetine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
2 weeks  
$252.00   $177.00
- +
5mg
>98%(HPLC)
2 weeks  
$952.00   $667.00
- +
20mg
2 weeks  
$1,205.00   $844.00
- +
  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01E4H7
Chemical Name:
Emetine
CAS Number:
483-18-1
Molecular Formula:
C29H40N2O4
Molecular Weight:
480.6389
MDL Number:
MFCD00242944
SMILES:
CC[C@H]1CN2CCc3c([C@@H]2C[C@@H]1C[C@H]1NCCc2c1cc(OC)c(c2)OC)cc(c(c3)OC)OC
Properties
Computed Properties
 
Complexity:
679  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.7  

Literature

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Journal: European journal of medicinal chemistry 20131101

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Journal: Bioorganic & medicinal chemistry 20130901

Title: Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids.

Journal: Bioorganic & medicinal chemistry 20130101

Title: Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines.

Journal: Bioorganic & medicinal chemistry letters 20130101

Title: Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer.

Journal: Journal of medicinal chemistry 20120913

Title: The cytotoxic effect of emetine and CGP-74514A studied with the hollow fiber model and ArrayScan assay in neuroendocrine tumors in vitro.

Journal: Anti-cancer agents in medicinal chemistry 20120901

Title: Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds.

Journal: European journal of medicinal chemistry 20120901

Title: Angustinine--a new benzopyridoquinolizine alkaloid from Alangium lamarckii.

Journal: Natural product communications 20120901

Title: Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.

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Journal: Bioorganic & medicinal chemistry 20120801

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Title: Evolution meets disease: penetrance and functional epistasis of mitochondrial tRNA mutations.

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Title: Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids.

Journal: Bioorganic & medicinal chemistry letters 20110315

Title: Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!

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Title: Apoptosis induces Bcl-XS and cleaved Bcl-XL in chronic lymphocytic leukaemia.

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Title: Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores.

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Title: Emetine regulates the alternative splicing of Bcl-x through a protein phosphatase 1-dependent mechanism.

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Title: T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs.

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Title: Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells.

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Title: Spontaneous recovery from extinction depends on the reconsolidation of the acquisition memory in an appetitive learning paradigm in the honeybee (Apis mellifera).

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Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20040607

Title: Emetine ditartrate: a possible lead for emergency contraception.

Journal: Contraception 20040501

Title: 5-fluorouracil-induced oligodendrocyte death and inhibitory effect of cycloheximide, Trolox, and Z-VAD-FMK in murine cortical culture.

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Journal: Cell biology international 20040101

Title: Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells.

Journal: Molecular cancer 20040101

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Journal: Journal of biochemistry 20031201

Title: Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells.

Journal: American journal of human genetics 20031101

Title: Transformation of ipecac (Cephaelis ipecacuanha) with Agrobacterium rhizogenes.

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Title: A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation.

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Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201

Title: Determination of chlorpheniramine maleate and tincture ipecac in dosage form by liquid chromatography with ultraviolet detection.

Journal: Journal of AOAC International 20030101

Title: Emetine inhibits glycolysis in isolated, perfused rat hearts.

Journal: Cardiovascular toxicology 20030101

Title: [Cytopathological effects of protein synthesis inhibitor emetine on HeLa cells and their nucleoli].

Journal: Tsitologiia 20030101

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Journal: Revista de gastroenterologia de Mexico 20030101

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Title: Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis.

Journal: Oncogene 20021121

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Journal: Veterinary and human toxicology 20021001

Title: Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase.

Journal: Archives of biochemistry and biophysics 20020915

Title: Memory consolidation for the discrimination of frequency-modulated tones in mongolian gerbils is sensitive to protein-synthesis inhibitors applied to the auditory cortex.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20020901

Title: Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis.

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Title: Effects of the inhibitors of dynamics of cytoskeletal structures on the development of apoptosis induced by the tumor necrosis factor.

Journal: Biochemistry. Biokhimiia 20020701

Title: Separation and determination of emetine dithiocarbamate metal complexes by capillary electrophoresis with chemiluminescence detection of the tris(2,2'-bipyridine)-ruthenium(II) complex.

Journal: Journal of chromatography. A 20020607

Title: Studies for the emetic mechanisms of ipecac syrup (TJN-119) and its active components in ferrets: involvement of 5-hydroxytryptamine receptors.

Journal: Japanese journal of pharmacology 20020601

Title: Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus.

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Title: Counter-antigen presentation: fibroblasts produce cytokines by signalling through HLA class II molecules without inducing T-cell proliferation.

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Journal: Blood 20010915

Title: Fertilization blocks apoptosis of starfish eggs by inactivation of the MAP kinase pathway.

Journal: Developmental biology 20010901

Title: High-performance liquid chromatographic assay with fluorescence detection for the determination of cephaeline and emetine in human plasma and urine.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010615

Title: Sensitive determination of metal ions by liquid chromatography with tris(2,2'-bipyridine) ruthenium (II) complex electrogenerated chemiluminescence detection.

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Title: Treatment of amebic liver abscess with emetine hydrochloride, niridazole, and metronidazole. A controlled clinical trial.

Journal: The American journal of tropical medicine and hygiene 19740701

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SDS
Tags:483-18-1 Molecular Formula|483-18-1 MDL|483-18-1 SMILES|483-18-1 Emetine
Catalog No.: AA01E4H7
483-18-1,MFCD00242944
483-18-1 | Emetine
Pack Size: 1mg
Purity:
2 weeks
$252.00 $177.00
Pack Size: 5mg
Purity: >98%(HPLC)
2 weeks
$952.00 $667.00
Pack Size: 20mg
Purity:
2 weeks
$1,205.00 $844.00
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Technical Information
Catalog Number: AA01E4H7
Chemical Name: Emetine
CAS Number: 483-18-1
Molecular Formula: C29H40N2O4
Molecular Weight: 480.6389
MDL Number: MFCD00242944
SMILES: CC[C@H]1CN2CCc3c([C@@H]2C[C@@H]1C[C@H]1NCCc2c1cc(OC)c(c2)OC)cc(c(c3)OC)OC
Properties
Complexity: 679  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 4  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 35  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.7  
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Journal: The Journal of biological chemistry20100305

Title: eIF4E-binding proteins are differentially modified after ammonia versus intracellular calcium activation of sea urchin unfertilized eggs.

Journal: Molecular reproduction and development20100101

Title: Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.

Journal: The Journal of biological chemistry20100101

Title: Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.

Journal: PLoS biology20100101

Title: Regulation of gene expression in protozoa parasites.

Journal: Journal of biomedicine & biotechnology20100101

Title: Endangered species hold clues to human evolution.

Journal: The Journal of heredity20100101

Title: Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.

Journal: PloS one20100101

Title: TTFields alone and in combination with chemotherapeutic agents effectively reduce the viability of MDR cell sub-lines that over-express ABC transporters.

Journal: BMC cancer20100101

Title: Dependency on de novo protein synthesis and proteomic changes during metamorphosis of the marine bryozoan Bugula neritina.

Journal: Proteome science20100101

Title: Transcripts expressed using a bicistronic vector pIREShyg2 are sensitized to nonsense-mediated mRNA decay.

Journal: BMC molecular biology20100101

Title: A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization.

Journal: BMC bioinformatics20100101

Title: Neural Protein Synthesis during Aging: Effects on Plasticity and Memory.

Journal: Frontiers in aging neuroscience20100101

Title: Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.

Journal: PloS one20100101

Title: Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.

Journal: BMC genomics20100101

Title: Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue.

Journal: PloS one20100101

Title: Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess.

Journal: PloS one20100101

Title: Memory formation in reversal learning of the honeybee.

Journal: Frontiers in behavioral neuroscience20100101

Title: Biochemistry and occurrence of o-demethylation in plant metabolism.

Journal: Frontiers in physiology20100101

Title: Clonal diversity and conservation genetics of the medicinal plant Carapichea ipecacuanha (Rubiaceae).

Journal: Genetics and molecular biology20100101

Title: Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines.

Journal: Cancer chemotherapy and pharmacology20091201

Title: Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

Journal: Cell cycle (Georgetown, Tex.)20091201

Title: [Research on endemic diseases and Japanese colonial rule: focusing on the emetine poisoning accident in Yeongheung and Haenam counties in 1927].

Journal: Ui sahak20091201

Title: Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells.

Journal: Blood20091105

Title: Limited uptake of the cyanobacterial toxin cylindrospermopsin by Vero cells.

Journal: Toxicon : official journal of the International Society on Toxinology20091101

Title: TDP-43 is recruited to stress granules in conditions of oxidative insult.

Journal: Journal of neurochemistry20091101

Title: Tnni3k modifies disease progression in murine models of cardiomyopathy.

Journal: PLoS genetics20090901

Title: Nonsense-mediated mRNA decay and ubiquitin-proteasome system regulate cardiac myosin-binding protein C mutant levels in cardiomyopathic mice.

Journal: Circulation research20090731

Title: Consolidation of an extinction memory depends on the unconditioned stimulus magnitude previously experienced during training.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20090729

Title: Antiplasmodial isoflavanones from the roots of Sophora mollis.

Journal: Journal of natural products20090701

Title: Popularizing controversial science: a popular treatise on poisons by Mateu Orfila (1818).

Journal: Medical history20090701

Title: Infusion of protein synthesis inhibitors in the entorhinal cortex blocks consolidation but not reconsolidation of object recognition memory.

Journal: Neurobiology of learning and memory20090501

Title: Conjugate addition-dipolar cycloaddition cascade for the synthesis of benzo[a]quinolizine and indolo[a]quinolizine scaffolds: application to the total synthesis of (+/-)-yohimbenone.

Journal: The Journal of organic chemistry20090501

Title: Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors.

Journal: Parasitology20090501

Title: Translocon closure to Ca2+ leak in proliferating vascular smooth muscle cells.

Journal: American journal of physiology. Heart and circulatory physiology20090401

Title: An extreme strategy for the production of hybridoma.

Journal: Hybridoma (2005)20090401

Title: Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.

Journal: Nature biotechnology20090401

Title: Expression levels of Protocadherin-alpha transcripts are decreased by nonsense-mediated mRNA decay with frameshift mutations and by high DNA methylation in their promoter regions.

Journal: Gene20090201

Title: Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules.

Journal: Experimental cell research20090201

Title: Persistent LTP without triggered protein synthesis.

Journal: Neuroscience research20090101

Title: Nonsense-mediated decay of human LDL receptor mRNA.

Journal: Scandinavian journal of clinical and laboratory investigation20090101

Title: Naming a phantom - the quest to find the identity of Ulluchu, an unidentified ceremonial plant of the Moche culture in Northern Peru.

Journal: Journal of ethnobiology and ethnomedicine20090101

Title: Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion.

Journal: PloS one20090101

Title: Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line.

Journal: BMC medical genomics20090101

Title: NMD inhibition fails to identify tumour suppressor genes in microsatellite stable gastric cancer cell lines.

Journal: BMC medical genomics20090101

Title: Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells.

Journal: BMC cancer20090101

Title: Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down.

Journal: BMC genomics20090101

Title: VHL frameshift mutation as target of nonsense-mediated mRNA decay in Drosophila melanogaster and human HEK293 cell line.

Journal: Journal of biomedicine & biotechnology20090101

Title: Pharmacologic and nonpharmacologic options for the management of HIV infection during pregnancy.

Journal: HIV/AIDS (Auckland, N.Z.)20090101

Title: The new beta-D-glucosidase in terpenoid-isoquinoline alkaloid biosynthesis in Psychotria ipecacuanha.

Journal: The Journal of biological chemistry20081212

Title: Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay.

Journal: Genes, chromosomes & cancer20081201

Title: Ipecacuanha: the South American vomiting root.

Journal: The journal of the Royal College of Physicians of Edinburgh20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Long-term depression in the superior cervical ganglion of the rat.

Journal: Brain research20081009

Title: Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei).

Journal: Molecules (Basel, Switzerland)20081003

Title: Rhythmic discharge induced by temperature variation and drugs in isolated sympathetic ganglia.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993)20081001

Title: Sustained CPEB-dependent local protein synthesis is required to stabilize synaptic growth for persistence of long-term facilitation in Aplysia.

Journal: Neuron20080925

Title: Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20080601

Title: One retrieval trial induces reconsolidation in an appetitive learning paradigm in honeybees (Apis mellifera).

Journal: Neurobiology of learning and memory20080501

Title: Two silent substitutions in the PDHA1 gene cause exon 5 skipping by disruption of a putative exonic splicing enhancer.

Journal: Molecular genetics and metabolism20080301

Title: Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.

Journal: Matrix biology : journal of the International Society for Matrix Biology20080301

Title: Nonsense-mediated messenger RNA decay of survival motor neuron 1 causes spinal muscular atrophy.

Journal: Human genetics20080301

Title: Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20080201

Title: Separation and SAR study of HIF-1alpha inhibitory tubulosines from Alangium cf. longiflorum.

Journal: Planta medica20080201

Title: Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis.

Journal: BMC cancer20080101

Title: A map of human protein interactions derived from co-expression of human mRNAs and their orthologs.

Journal: Molecular systems biology20080101

Title: A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials.

Journal: PloS one20080101

Title: Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: a model for identifying candidate breast-tumor suppressors.

Journal: Molecular cancer20080101

Title: Oh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection.

Journal: Parasites & vectors20080101

Title: A distinct translation initiation mechanism generates cryptic peptides for immune surveillance.

Journal: PloS one20080101

Title: Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.

Journal: The EMBO journal20071212

Title: Emetine and the alternative splicing of Bcl-X: where to next?

Journal: Chemistry & biology20071201

Title: Emetine regulates the alternative splicing of Bcl-x through a protein phosphatase 1-dependent mechanism.

Journal: Chemistry & biology20071201

Title: T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs.

Journal: The Journal of biological chemistry20071012

Title: Emetine and/or its metabolites are genotoxic in somatic cells of Drosophila melanogaster.

Journal: Journal of toxicology and environmental health. Part A20071001

Title: Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines.

Journal: Planta medica20071001

Title: mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG.

Journal: Molecular cell20070907

Title: The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells.

Journal: Oncology reports20070901

Title: Ribotoxic stress sensitizes glioblastoma cells to death receptor induced apoptosis: requirements for c-Jun NH2-terminal kinase and Bim.

Journal: Molecular cancer research : MCR20070801

Title: Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.

Journal: Journal of medicinal chemistry20070726

Title: Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells.

Journal: Oncogene20070503

Title: Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons.

Journal: The Journal of biological chemistry20070427

Title: Protein synthesis inhibitors, in synergy with 5-azacytidine, restore sodium/iodide symporter gene expression in human thyroid adenoma cell line, KAK-1, suggesting trans-active transcriptional repressor.

Journal: The Journal of clinical endocrinology and metabolism20070301

Title: Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry.

Journal: Pflugers Archiv : European journal of physiology20070301

Title: Apoptosis in early development of the sea urchin, Strongylocentrotus purpuratus.

Journal: Developmental biology20070301

Title: In vivo antigiardial activity of three flavonoids isolated of some medicinal plants used in Mexican traditional medicine for the treatment of diarrhea.

Journal: Journal of ethnopharmacology20070212

Title: Relating protein pharmacology by ligand chemistry.

Journal: Nature biotechnology20070201

Title: Persistent (>24h) long-term depression in the dentate gyrus of freely moving rats is not dependent on activation of NMDA receptors, L-type voltage-gated calcium channels or protein synthesis.

Journal: Neuropharmacology20070101

Title: Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum.

Journal: Phytotherapy research : PTR20070101

Title: Structural and functional analysis of the Entamoeba histolytica EhrabB gene promoter.

Journal: BMC molecular biology20070101

Title: Amoebic dysentery.

Journal: BMJ clinical evidence20070101

Title: Antigiardial activity of methanolic extracts from Helianthemum glomeratum Lag. and Rubus coriifolius Focke in suckling mice CD-1.

Journal: Journal of ethnopharmacology20061206

Title: In vitro susceptibility of Entamoeba histolytica and Giardia lamblia to plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders.

Journal: Journal of ethnopharmacology20061206

Title: Contribution of calcium influx in mediating glucose-stimulated oxygen consumption in pancreatic islets.

Journal: Diabetes20061201

Title: Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines.

Journal: Planta medica20061001

Title: Cell size checkpoint control by the retinoblastoma tumor suppressor pathway.

Journal: PLoS genetics20061001

Title: Bivalent probes of the human multidrug transporter P-glycoprotein.

Journal: Biochemistry20060926

Title: Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD).

Journal: Neurobiology of disease20060801

Title: p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes.

Journal: Toxicology and applied pharmacology20060615

Title: State of nucleolar proteins B23/nucleophosmin and UBF in HeLa cells during apoptosis induced by tumor necrosis factor.

Journal: Biochemistry. Biokhimiia20060601

Title: Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex.

Journal: Brain research20060426

Title: Formal total synthesis of (-)-emetine using catalytic asymmetric allylation of cyclic imines as a key step.

Journal: Organic letters20060330

Title: Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.

Journal: Cancer research20060201

Title: Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.

Journal: Molecular neurodegeneration20060101

Title: [Hepatic fasciolasis diagnosed in state phase].

Journal: Revista de gastroenterologia de Mexico20060101

Title: Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines.

Journal: Anticancer research20060101

Title: An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm.

Journal: PloS one20060101

Title: Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun.

Journal: PLoS biology20051201

Title: Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion.

Journal: Cell death and differentiation20051101

Title: Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis.

Journal: Cancer genetics and cytogenetics20050901

Title: Ipecac syrup abuse, morbidity, and mortality: isn't it time to repeal its over-the-counter status?

Journal: The Journal of adolescent health : official publication of the Society for Adolescent Medicine20050901

Title: Entamoeba histolytica EhPgp5 transcriptional activation depends on putative emetine response elements.

Journal: Experimental parasitology20050701

Title: Entamoeba histolytica: cloning and expression of the poly(A) polymerase EhPAP.

Journal: Experimental parasitology20050701

Title: Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20050601

Title: Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells.

Journal: Journal of natural products20050601

Title: Spontaneous recovery from extinction depends on the reconsolidation of the acquisition memory in an appetitive learning paradigm in the honeybee (Apis mellifera).

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050504

Title: A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.

Journal: Journal of medicinal chemistry20050421

Title: Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050223

Title: Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050216

Title: GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos.

Journal: Development (Cambridge, England)20050201

Title: Myxobacterial epothilones and tubulysins as promising anticancer agents.

Journal: Molecular diversity20050101

Title: Inactivation of MAP kinase signalling in Myc transformed cells and rescue by LiCl inhibition of GSK3.

Journal: Molecular cancer20050101

Title: Investigations of the protein synthesis dependency of mGluR-induced long-term depression in the dentate gyrus of freely moving rats.

Journal: Neuropharmacology20050101

Title: NMD microarray analysis for rapid genome-wide screen of mutated genes in cancer.

Journal: Cellular oncology : the official journal of the International Society for Cellular Oncology20050101

Title: Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer.

Journal: Nature genetics20040901

Title: From mRNA to tumor suppressor.

Journal: Nature genetics20040901

Title: The type IV-specific phosphodiesterase inhibitor rolipram and its effect on hippocampal long-term potentiation and synaptic tagging.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20040901

Title: Histopathology of cutaneous amebiasis.

Journal: The American Journal of dermatopathology20040801

Title: Cyclosporin A inhibits calcineurin (phosphatase 2B) and P-glycoprotein activity in Entamoeba histolytica.

Journal: International journal for parasitology20040801

Title: Enantioselective total syntheses of the Ipecacuanha alkaloid emetine, the Alangium alkaloid tubulosine and a novel benzoquinolizidine alkaloid by using a domino process.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)20040607

Title: Emetine ditartrate: a possible lead for emergency contraception.

Journal: Contraception20040501

Title: 5-fluorouracil-induced oligodendrocyte death and inhibitory effect of cycloheximide, Trolox, and Z-VAD-FMK in murine cortical culture.

Journal: Cancer20040401

Title: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.

Journal: Biochemical and biophysical research communications20040319

Title: The nonclassical MHC class I molecule Qa-1 forms unstable peptide complexes.

Journal: Journal of immunology (Baltimore, Md. : 1950)20040201

Title: Transcriptional regulation of TNF family receptors and Bcl-2 family by chemotherapeutic agents in murine CT26 cells.

Journal: Journal of cellular biochemistry20040201

Title: Increased calbindin-D28K immunoreactivity in rat cerebellar Purkinje cell with excitatory amino acids agonists is not dependent on protein synthesis.

Journal: Archives italiennes de biologie20040201

Title: Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability.

Journal: Oncogene20040122

Title: Inhibition of puromycin-induced apoptosis in breast cancer cells by IGF-I occurs simultaneously with increased protein synthesis.

Journal: Neoplasma20040101

Title: Marginal blebbing during the early stages of TNF-induced apoptosis indicates alteration in actomyosin contractility.

Journal: Cell biology international20040101

Title: Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells.

Journal: Molecular cancer20040101

Title: Natural products for dental caries prevention.

Journal: Journal of medicinal food20040101

Title: In vitro activity of antiamoebic drugs against clinical isolates of Entamoeba histolytica and Entamoeba dispar.

Journal: Annals of clinical microbiology and antimicrobials20040101

Title: A role for dendritic protein synthesis in hippocampal late LTP.

Journal: The European journal of neuroscience20031201

Title: Cross-talk between the pathways leading to the induction of apoptosis and the secretion of tumor necrosis factor-alpha in ricin-treated RAW 264.7 cells.

Journal: Journal of biochemistry20031201

Title: Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells.

Journal: American journal of human genetics20031101

Title: Transformation of ipecac (Cephaelis ipecacuanha) with Agrobacterium rhizogenes.

Journal: Planta medica20031101

Title: M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.

Journal: Cell death and differentiation20031001

Title: Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20030801

Title: Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes.

Journal: Environmental toxicology20030801

Title: p38 mitogen-activated protein kinase activation by ultraviolet A radiation in human dermal fibroblasts.

Journal: Photochemistry and photobiology20030801

Title: Calyculin A causes the activation of histone H1 kinase and condensation of chromosomes in unfertilized sea urchin eggs independently of the maturation-promoting factor.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP20030801

Title: Antiparasitic alkaloids from Psychotria klugii.

Journal: Journal of natural products20030701

Title: MAPK is involved in metaphase I arrest in oyster and mussel oocytes.

Journal: Biology of the cell20030701

Title: Early maintenance of hippocampal mossy fiber--long-term potentiation depends on protein and RNA synthesis and presynaptic granule cell integrity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20030615

Title: Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase.

Journal: The Journal of biological chemistry20030606

Title: Antiprotozoal activity of the constituents of Rubus coriifolius.

Journal: Phytotherapy research : PTR20030601

Title: Targeted degradation of ENaC in response to PKC activation of the ERK1/2 cascade.

Journal: American journal of physiology. Renal physiology20030501

Title: Entamoeba moshkovskii infections in children, Bangladesh.

Journal: Emerging infectious diseases20030501

Title: Mechanism of action of some acrylophenones, quinolines and dithiocarbamate as potent, non-detergent spermicidal agents.

Journal: Contraception20030501

Title: Cycloheximide increases glucocorticoid-stimulated alpha -ENaC mRNA in collecting duct cells by p38 MAPK-dependent pathway.

Journal: American journal of physiology. Renal physiology20030401

Title: Transcription and translation inhibitors permit metamorphosis up to radiole formation in the serpulid polychaete Hydroides elegans haswell.

Journal: The Biological bulletin20030401

Title: EhPgp5 mRNA stability is a regulatory event in the Entamoeba histolytica multidrug resistance phenotype.

Journal: The Journal of biological chemistry20030328

Title: A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation.

Journal: The Journal of biological chemistry20030314

Title: [Antiprotozoal drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine20030201

Title: Determination of chlorpheniramine maleate and tincture ipecac in dosage form by liquid chromatography with ultraviolet detection.

Journal: Journal of AOAC International20030101

Title: Emetine inhibits glycolysis in isolated, perfused rat hearts.

Journal: Cardiovascular toxicology20030101

Title: [Cytopathological effects of protein synthesis inhibitor emetine on HeLa cells and their nucleoli].

Journal: Tsitologiia20030101

Title: [Fascioliasis: diagnosis, epidemiology and treatment].

Journal: Revista de gastroenterologia de Mexico20030101

Title: Inhibitory effect of isoquinoline alkaloids on movement of second-stage larvae of Toxocara canis.

Journal: Biological & pharmaceutical bulletin20021201

Title: Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis.

Journal: Oncogene20021121

Title: Urinary excretion of ipecac alkaloids in human volunteers.

Journal: Veterinary and human toxicology20021001

Title: Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase.

Journal: Archives of biochemistry and biophysics20020915

Title: Memory consolidation for the discrimination of frequency-modulated tones in mongolian gerbils is sensitive to protein-synthesis inhibitors applied to the auditory cortex.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20020901

Title: Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20020715

Title: Effects of the inhibitors of dynamics of cytoskeletal structures on the development of apoptosis induced by the tumor necrosis factor.

Journal: Biochemistry. Biokhimiia20020701

Title: Separation and determination of emetine dithiocarbamate metal complexes by capillary electrophoresis with chemiluminescence detection of the tris(2,2'-bipyridine)-ruthenium(II) complex.

Journal: Journal of chromatography. A20020607

Title: Studies for the emetic mechanisms of ipecac syrup (TJN-119) and its active components in ferrets: involvement of 5-hydroxytryptamine receptors.

Journal: Japanese journal of pharmacology20020601

Title: Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus.

Journal: Neurobiology of learning and memory20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Characterization of the Fas ligand/Fas-dependent apoptosis of antiretroviral, class I MHC tetramer-defined, CD8+ CTL by in vivo retrovirus-infected cells.

Journal: Journal of immunology (Baltimore, Md. : 1950)20020315

Title: Counter-antigen presentation: fibroblasts produce cytokines by signalling through HLA class II molecules without inducing T-cell proliferation.

Journal: Cytokine20020221

Title: Absorption, distribution and excretion of 3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats.

Journal: European journal of drug metabolism and pharmacokinetics20020101

Title: Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats.

Journal: European journal of drug metabolism and pharmacokinetics20020101

Title: [Multiple drug resistance in Entamoeba histolytica].

Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion20020101

Title: [Emétine and quinine, a therapy to rescue Bellini in 1835].

Journal: Revue d'histoire de la pharmacie20020101

Title: Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis.

Journal: Biochemical and biophysical research communications20011221

Title: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.

Journal: Chemical research in toxicology20011201

Title: In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense.

Journal: Planta medica20011001

Title: Induction of heme oxygenase-1 by phenylarsine oxide. Studies in cultured primary liver cells.

Journal: Molecular and cellular biochemistry20011001

Title: Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT(388)-granulocyte-macrophage colony-stimulating factor (GM-CSF), a truncated diphtheria toxin fused to human GM-CSF.

Journal: Blood20010915

Title: Fertilization blocks apoptosis of starfish eggs by inactivation of the MAP kinase pathway.

Journal: Developmental biology20010901

Title: High-performance liquid chromatographic assay with fluorescence detection for the determination of cephaeline and emetine in human plasma and urine.

Journal: Journal of chromatography. B, Biomedical sciences and applications20010615

Title: Sensitive determination of metal ions by liquid chromatography with tris(2,2'-bipyridine) ruthenium (II) complex electrogenerated chemiluminescence detection.

Journal: Journal of chromatography. A20010615

Title: Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities.

Journal: Biological & pharmaceutical bulletin20010601

Title: Post-transcriptional inactivation of p53 in immortalized murine embryo fibroblast cells.

Journal: Oncogene20010531

Title: Antiprotozoal activity of the constituents of Conyza filaginoides.

Journal: Journal of natural products20010501

Title: [Effect of intralesional treatment with emetine hydrochloride on Leishmania (Viannia) braziliensis in hamsters].

Journal: Investigacion clinica20010301

Title: Maintenance of homeostasis of endogenous ethanol as a method for the therapy of alcoholism.

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Title: Monocytes are differentially activated through HLA-DR, -DQ, and -DP molecules via mitogen-activated protein kinases.

Journal: Journal of immunology (Baltimore, Md. : 1950)20010215

Title: De novo activation of the beta-phaseolin promoter by phosphatase or protein synthesis inhibitors.

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Title: Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.

Journal: Journal of natural products20010101

Title: Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets.

Journal: Thrombosis and haemostasis20010101

Title: [Myopathy caused by inhibition of muscle protein synthesis].

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Title: Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis.

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Title: Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes.

Journal: Toxicology and applied pharmacology19990401

Title: Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity.

Journal: Biochemical pharmacology19931117

Title: HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products.

Journal: Biochemical and biophysical research communications19920529

Title: Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase.

Journal: The Journal of biological chemistry19911215

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products19910101

Title: Ventricular tachycardia in a patient on dehydroemetine and chloroquine for amoebic liver abscess.

Journal: The Medical journal of Australia19790505

Title: [Hepatic amebiasis in the Kilimanjaro region. Serodiagnosis on micro-specimens of dried blood and attempts at treatment with tinidazole (fasigyn)].

Journal: Acta tropica19750101

Title: Treatment of amebic liver abscess with emetine hydrochloride, niridazole, and metronidazole. A controlled clinical trial.

Journal: The American journal of tropical medicine and hygiene19740701

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