Home Amines 483367-10-8
483367-10-8,MFCD09037557
Catalog No.:AA006WUZ

483367-10-8 | Purmorphamine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$23.00   $16.00
- +
5mg
98%
in stock  
$54.00   $38.00
- +
10mg
98%
in stock  
$85.00   $59.00
- +
50mg
95%
in stock  
$350.00   $245.00
- +
100mg
98%
in stock  
$395.00   $277.00
- +
250mg
98%
in stock  
$676.00   $473.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006WUZ
Chemical Name:
Purmorphamine
CAS Number:
483367-10-8
Molecular Formula:
C31H32N6O2
Molecular Weight:
520.6248
MDL Number:
MFCD09037557
SMILES:
C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2
NSC Number:
747596
Properties
Properties
 
BP:
790.3±70.0°C at 760 mmHg  
Form:
Solid  
MP:
>191°C (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
768  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
6.5  

Literature

Title: Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells.

Journal: Biochemical and biophysical research communications 20121019

Title: Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120701

Title: Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development.

Journal: Stem cells and development 20120501

Title: Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells.

Journal: Angewandte Chemie (International ed. in English) 20111118

Title: Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway.

Journal: Stem cells and development 20111101

Title: Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.

Journal: Nature protocols 20110728

Title: Modulators of the hedgehog signaling pathway.

Journal: Bioorganic & medicinal chemistry 20100915

Title: Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs.

Journal: Methods in molecular biology (Clifton, N.J.) 20100101

Title: Differentiation of embryonic stem cells into oligodendrocyte precursors.

Journal: Journal of visualized experiments : JoVE 20100101

Title: Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Journal: BMC cancer 20100101

Title: Evidence for allosteric interactions of antagonist binding to the smoothened receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20090601

Title: Identification of osteogenic purmorphamine derivatives.

Journal: Molecules and cells 20081031

Title: Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cells.

Journal: Stem cells (Dayton, Ohio) 20080401

Title: Agonizing hedgehog.

Journal: Nature chemical biology 20060101

Title: Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Journal: Nature chemical biology 20060101

Title: Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.

Journal: Chemistry & biology 20040901

Title: F. Faghihia, et al. The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Biomedicine & Pharmacotherapy. 2013, 67(1): 31-38.

Title: Gu D, et al. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012 Nov 2;287(45):38356-66.

Title: Beloti MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005 Jul;29(7):537-41.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 483367-10-8
Tags:483367-10-8 Molecular Formula|483367-10-8 MDL|483367-10-8 SMILES|483367-10-8 Purmorphamine