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484-12-8,MFCD00076049
Catalog No.:AA00I8PF

484-12-8 | Osthole

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250mg
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1g
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10g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I8PF
Chemical Name:
Osthole
CAS Number:
484-12-8
Molecular Formula:
C15H16O3
Molecular Weight:
244.2857
MDL Number:
MFCD00076049
SMILES:
COc1ccc2c(c1CC=C(C)C)oc(=O)cc2
NSC Number:
31868
Properties
Computed Properties
 
Complexity:
366  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
3.8  

Downstream Synthesis Route

[1]Molecules,2000,vol.5,p.880-885

[2]ChemischeBerichte,1942,vol.75,p.1623,1629

[1]BioorganicandMedicinalChemistryLetters,2010,vol.20,p.7426-7428

[2]JustusLiebigsAnnalenderChemie,1932,vol.495,p.187,202

[3]ChemischeBerichte,1934,vol.67,p.262

[4]BioorganicandMedicinalChemistryLetters,1996,vol.6,p.1791-1794

[5]EuropeanJournalofMedicinalChemistry,2011,vol.46,p.4042-4049

[1]ChemMedChem,2010,vol.5,p.598-607

[2]EuropeanJournalofMedicinalChemistry,2011,vol.46,p.4042-4049

[3]ChemischeBerichte,1933,vol.66,p.754,759

484-12-8   
8-(2,3-dibromo-3-methyl-butyl)-7-methoxy-coumarin 

[1]BioorganicandMedicinalChemistryLetters,1996,vol.6,p.1791-1794

[2]JournaloftheAmericanPharmaceuticalAssociation.(Practicalpharmacyedition),1950,vol.39,p.107-107

[1]ChemischeBerichte,1938,vol.71,p.1662,1664

Literature

Title: Osthole induces human nasopharyngeal cancer cells apoptosis through Fas-Fas ligand and mitochondrial pathway.

Journal: Environmental toxicology 20180401

Title: Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway.

Journal: PloS one 20130101

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Isolation and identification of metabolites of osthole in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20121101

Title: Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro.

Journal: Molecular medicine reports 20121101

Title: Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers.

Journal: Phytochemistry 20121001

Title: Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.

Journal: Lipids 20121001

Title: Synthesis and anthelmintic activity of osthol analogs against Dactylogyrus intermedius in goldfish.

Journal: European journal of medicinal chemistry 20120801

Title: Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti.

Journal: Pest management science 20120701

Title: Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression.

Journal: Toxicology and applied pharmacology 20120515

Title: Acute and subchronic toxicological evaluation of Echinophora platyloba DC (Apiaceae) total extract in Wistar rats.

Journal: Clinics (Sao Paulo, Brazil) 20120501

Title: Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants.

Journal: Journal of pharmaceutical and biomedical analysis 20120407

Title: Mechanism of osthole inhibition of vascular Ca(v)1.2 current.

Journal: European journal of pharmacology 20120405

Title: Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings.

Journal: Synapse (New York, N.Y.) 20120301

Title: [Effect of osthol on apoptosis and bone resorption of osteoclasts cultured in vitro].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120201

Title: Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats.

Journal: Brain research 20120118

Title: Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

Journal: Bioorganic & medicinal chemistry 20120115

Title: Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity.

Journal: Natural product research 20120101

Title: [Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20120101

Title: Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Modified huo-luo-xiao-ling dan suppresses adjuvant arthritis by inhibiting chemokines and matrix-degrading enzymes.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.

Journal: PloS one 20120101

Title: Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Osthole attenuates focal inflammatory reaction following permanent middle cerebral artery occlusion in rats.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Pharmacokinetics and tissue distribution study of Praeruptorin D from Radix peucedani in rats by high-performance liquid chromatography (HPLC).

Journal: International journal of molecular sciences 20120101

Title: Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells.

Journal: Journal of agricultural and food chemistry 20111228

Title: Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20111101

Title: Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice.

Journal: Toxicology and applied pharmacology 20111015

Title: Insights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarins.

Journal: European journal of pharmacology 20111001

Title: [Inhibitory effects of osthole, psoralen and aconitine on invasive activities of breast cancer MDA-MB-231BO cell line and the mechanisms].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111001

Title: Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met/Akt/mTOR pathway in human breast cancer cells.

Journal: Journal of agricultural and food chemistry 20110914

Title: Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.

Journal: European journal of pharmacology 20110901

Title: Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.

Journal: European journal of medicinal chemistry 20110901

Title: N-[4-(7-Meth-oxy-2-oxo-2H-chromen-8-yl)-2-methyl-butan-2-yl]propionamide.

Journal: Acta crystallographica. Section E, Structure reports online 20110901

Title: Application of hollow fiber liquid phase microextraction coupled with high-performance liquid chromatography for the study of the osthole pharmacokinetics in cerebral ischemia hypoperfusion rat plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110801

Title: Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.

Journal: Journal of natural products 20110624

Title: Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.

Journal: European journal of pharmacology 20110611

Title: Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: involvement of mitogen-activated protein kinase pathway.

Journal: Neuroscience 20110602

Title: Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS.

Journal: Journal of agricultural and food chemistry 20110511

Title: Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress.

Journal: Phytotherapy research : PTR 20110501

Title: [Inhibitory acting mechanism of psoralen-osthole on bone metastasis of breast cancer--an expatiation viewing from OPG/RANKL/RANK system].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110501

Title: [Effects and mechanisms of osthole on sciatica induced by lumber disc herniation].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

Title: Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats.

Journal: Brain research 20110418

Title: Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells.

Journal: Journal of natural medicines 20110401

Title: HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes.

Journal: Fitoterapia 20110401

Title: Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats.

Journal: Planta medica 20110201

Title: Anthelmintic activity of the crude extracts, fractions, and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo.

Journal: Parasitology research 20110101

Title: Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway.

Journal: Journal of experimental & clinical cancer research : CR 20110101

Title: Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

Journal: PloS one 20110101

Title: Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro.

Journal: Pharmacology 20110101

Title: Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction.

Journal: Journal of osteoporosis 20110101

Title: Stimulation of Airway and Intestinal Mucosal Secretion by Natural Coumarin CFTR Activators.

Journal: Frontiers in pharmacology 20110101

Title: Discovery of novel osthole derivatives as potential anti-breast cancer treatment.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats.

Journal: Brain research 20101202

Title: [Effect of water-soluble polymers on the inhibition of osthole crystallization].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20101201

Title: Osthole regulates inflammatory mediator expression through modulating NF-κB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species.

Journal: Journal of agricultural and food chemistry 20101013

Title: Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production.

Journal: Neurochemistry international 20101001

Title: [Effect of Osthol on the proliferation and differentiate of osteoblasts in vitro].

Journal: Zhongguo gu shang = China journal of orthopaedics and traumatology 20100901

Title: Antifungal activity of the osthol derivative JS-B against Phytophthora capsici.

Journal: Journal of Asian natural products research 20100801

Title: Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100701

Title: Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus.

Journal: European journal of pharmacology 20100625

Title: Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.

Journal: Bioorganic & medicinal chemistry letters 20100615

Title: On-line concentration by field-enhanced sample injection with reverse migrating micelles in micellar electrokinetic capillary chromatography for the analysis of coumarins from traditional Chinese medicine and human serum.

Journal: Biomedical chromatography : BMC 20100601

Title: Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100601

Title: Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.

Journal: Synapse (New York, N.Y.) 20100501

Title: [Optimization of extraction process for compund kaliziran gel with orthogonal design].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100501

Title: Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.

Journal: Journal of agricultural and food chemistry 20100428

Title: Synthesis of N-hydroxycinnamides capped with a naturally occurring moiety as inhibitors of histone deacetylase.

Journal: ChemMedChem 20100406

Title: Fast separation and determination of coumarins in Fructus cnidii extracts by CEC using poly(butyl methacrylate-co-ethylene dimethacrylate-co-[2-(methacryloyloxy)ethyl] trimethylammonium chloride) monolithic columns.

Journal: Journal of separation science 20100401

Title: Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin.

Journal: European journal of pharmacology 20100310

Title: The effect of the major components of Fructus Cnidii on osteoblasts in vitro.

Journal: Journal of acupuncture and meridian studies 20100301

Title: Dammarane-type glycosides from Gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells.

Journal: Journal of natural products 20100226

Title: Osthol is a use-dependent blocker of voltage-gated Na+ channels in mouse neuroblastoma N2A cells.

Journal: Planta medica 20100101

Title: Effects of osthole on migration and invasion in breast cancer cells.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives.

Journal: BMC neuroscience 20100101

Title: Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit.

Journal: Journal of pharmaceutical and biomedical analysis 20091205

Title: Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice.

Journal: Chemico-biological interactions 20091030

Title: A vascular smooth muscle/cell membrane chromatography-offline-gas chromatography/mass spectrometry method for recognition, separation and identification of active components from traditional Chinese medicines.

Journal: Journal of chromatography. A 20091016

Title: [Metabolism of osthol in isolated hepatocytes of rat].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20091001

Title: Efficacy of osthol, a potent coumarin compound, in controlling powdery mildew caused by Sphaerotheca fuliginea.

Journal: Journal of Asian natural products research 20090901

Title: Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study.

Journal: Epilepsy research 20090801

Title: Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20090712

Title: Effects of osthole on apoptosis and TGF-beta1 of hypertrophic scar fibroblasts.

Journal: Journal of Asian natural products research 20090701

Title: Osthole suppresses seizures in the mouse maximal electroshock seizure model.

Journal: European journal of pharmacology 20090401

Title: Inhibitory effect of osthole on alcohol-induced fatty liver in mice.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090201

Title: Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM).

Journal: Natural product communications 20090201

Title: Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7.

Journal: Journal of natural medicines 20090101

Title: Identification and quantification of the volatile constituents in Cnidium monnieri using supercritical fluid extraction followed by GC-MS.

Journal: Journal of separation science 20090101

Title: Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae).

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.

Journal: BMC complementary and alternative medicine 20090101

Title: Immunomodulatory and anti-inflammatory activity of selected osthole derivatives.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals.

Journal: Neurochemistry international 20081201

Title: Osthol and isopimpinellin from Fructus cnidii for the control of Dactylogyrus intermedius in Carassius auratus.

Journal: Veterinary parasitology 20081125

Title: [Purification technology of Rhizoma et Radix Notopterygii and Radix Angelicae Pubescentis in Fufang Xuelian dropping pills by macroporous resin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: Identification of natural coumarin compounds that rescue defective DeltaF508-CFTR chloride channel gating.

Journal: Clinical and experimental pharmacology & physiology 20080801

Title: Attempts to bridge the gap between scientific mechanism-based medicine and Chinese herbal extract treatment for asthma.

Journal: Pediatrics and neonatology 20080801

Title: Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells.

Journal: Pediatrics and neonatology 20080801

Title: Micelle-mediated extraction and cloud-point preconcentration of osthole and imperatorin from Cnidium monnieri with analysis by high performance liquid chromatography.

Journal: Journal of chromatography. A 20080725

Title: Isolation and identification of insecticidal components from Citrus aurantium fruit peel extract.

Journal: Journal of agricultural and food chemistry 20080723

Title: Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats.

Journal: Journal of ethnopharmacology 20080522

Title: Determination and pharmacokinetic study of indirubin in rat plasma by high-performance liquid chromatography.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20080401

Title: [Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080401

Title: Fusarium graminearum growth inhibition due to glucose starvation caused by osthol.

Journal: International journal of molecular sciences 20080301

Title: Determination of osthole in rat plasma by high-performance liquid chromatograph using cloud-point extraction.

Journal: Analytica chimica acta 20080211

Title: Chemical and antibacterial constituents of Skimmia anquetelia.

Journal: Planta medica 20080201

Title: [In situ rats single pass perfusion intestinal absorption of the effectivein components in Radix Angelicae Pubescentis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080101

Title: Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats.

Journal: Journal of Asian natural products research 20080101

Title: Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

Title: Fluorimetric and mass spectrometric study of the interaction of beta-cyclodextrin and osthole.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071101

Title: [Simultaneous determination of 5 active components in Fructus Cnidii by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

Title: Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida.

Journal: Journal of ethnopharmacology 20070815

Title: Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.

Journal: Planta medica 20070701

Title: Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats.

Journal: Journal of ethnopharmacology 20070530

Title: Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study.

Journal: Phytotherapy research : PTR 20070301

Title: Therapeutic effect of osthole on hyperlipidemic fatty liver in rats.

Journal: Acta pharmacologica Sinica 20070301

Title: Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa.

Journal: Planta medica 20070201

Title: Synthetic derivatives of osthole for the prevention of hepatitis.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20070101

Title: Coumarins from Cnidium monnieri and their antiosteoporotic activity.

Journal: Planta medica 20070101

Title: A survey of Chinese herbal ingredients with liver protection activities.

Journal: Chinese medicine 20070101

Title: Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker.

Journal: Natural product research 20060801

Title: Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals.

Journal: World journal of gastroenterology 20060721

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Studies on chemical constituents in roots of Heracleum rapula].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

Title: Chemical constituents of Selinum cryptotaenium.

Journal: Journal of Asian natural products research 20060101

Title: Anti-inflammatory effect and mechanism of osthole in rats.

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20051101

Title: Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells.

Journal: The Journal of pharmacology and experimental therapeutics 20050901

Title: HPLC determination and pharmacokinetics of osthole in rat plasma after oral administration of Fructus Cnidii extract.

Journal: Journal of chromatographic science 20050901

Title: [Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901

Title: [Study on extraction of coumarins in Cnidium monieri by supercritical CO2 and separation of compositions analysis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050701

Title: [Coumarins from root of Zanthoxylum dimorphophyllum var. spinifolium].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050601

Title: [Determination of osthol in Shefengshi liqueur by HPLC].

Journal: Se pu = Chinese journal of chromatography 20050501

Title: Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas.

Journal: Current medicinal chemistry. Anti-cancer agents 20050101

Title: Toxic epidermal necrolysis associated with high intake of sildenafil and its response to infliximab.

Journal: Acta dermato-venereologica 20050101

Title: Genetic variation in primary metabolites of Pastinaca sativa; can herbivores act as selective agents?

Journal: Journal of chemical ecology 20041001

Title: [Determination of isoimperatorin and osthol in ganmao yixiaoshi capsule by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041001

Title: Coumarins from Cnidium monnieri (L.) and their proliferation stimulating activity on osteoblast-like UMR106 cells.

Journal: Die Pharmazie 20040801

Title: [Effects of osthol on androgen level and nitric oxide synthase activity in castrate rats].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040701

Title: Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase.

Journal: Bioorganic & medicinal chemistry letters 20040503

Title: [Advances in study on the pharmacological effects of active components of Chinese herbs on Alzheimer's disease].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040501

Title: Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb) using stepwise elution by high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20040416

Title: Osthole improves aspects of spatial performance in ovariectomized rats.

Journal: The American journal of Chinese medicine 20040101

Title: Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines.

Journal: Planta medica 20031201

Title: Effect of enhancers on percutaneous absorption of osthol across the excised full thickness rat skin.

Journal: Die Pharmazie 20030901

Title: Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.

Journal: Archives of pharmacal research 20030901

Title: [Pharmacokinetics of osthole in rabbits].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030801

Title: Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway.

Journal: Biochemical pharmacology 20030215

Title: [Advances in the study of chemical constituents and pharmacological actions of Cnidium monnieri (L.) Cusson].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030201

Title: 8-(2-bromo-3-methoxy-3-methylbutyl)-7-methoxycoumarin.

Journal: Acta crystallographica. Section C, Crystal structure communications 20030101

Title: Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol.

Journal: Biological & pharmaceutical bulletin 20020601

Title: Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.

Journal: Biological & pharmaceutical bulletin 20020601

Title: [Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020301

Title: Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON).

Journal: Biological & pharmaceutical bulletin 20020201

Title: Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells.

Journal: Biochemical pharmacology 20020115

Title: Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice.

Journal: Biological & pharmaceutical bulletin 20010901

Title: Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity.

Journal: Journal of natural products 20010901

Title: The coumarin osthol attenuates the binding of thyrotropin-releasing hormone in rat pituitary GH4C1 cells.

Journal: Planta medica 20010401

Title: Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.

Journal: Planta medica 20010401

Title: Inhibition of concanavalin A-induced mice hepatitis by coumarin derivatives.

Journal: Japanese journal of pharmacology 20010101

Title: Antiproliferative effect of isopentenylated coumarins on several cancer cell lines.

Journal: Anticancer research 20010101

Title: Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.

Journal: Phytochemistry 20000301

Title: Kordulewska NK, et al. Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients. Immunobiology.

Title: Tang DZ, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun;25(6):1234-45.

Title: Sun W, et al. Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. Acta Pharmacol Sin. 2017 Aug;38(8):1120-1128.

Title: Zhang ZR, et al. Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine. Evid Based Complement Alternat Med. 2015;2015:919616.

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Tags:484-12-8 Molecular Formula|484-12-8 MDL|484-12-8 SMILES|484-12-8 Osthole