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484-23-1,MFCD01250766
Catalog No.:AA00I8PG

484-23-1 | 1,4-Dihydrazinylphthalazine

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500mg
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1g
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00I8PG
Chemical Name:
1,4-Dihydrazinylphthalazine
CAS Number:
484-23-1
Molecular Formula:
C8H10N6
Molecular Weight:
190.2052
MDL Number:
MFCD01250766
SMILES:
NNc1n[nH]/c(=N\N)/c2c1cccc2
NSC Number:
526654
Properties
Computed Properties
 
Complexity:
167  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
0.2  

Literature

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Journal: International journal of cardiology 20150115

Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101

Title: The differential effects of recombinant brain natriuretic peptide, nitroglycerine and dihydralazine on systemic oxygen delivery and gastric mucosal microvascular oxygenation in dogs.

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Title: Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study.

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Title: Performance scores in general practice: a comparison between the clinical versus medication-based approach to identify target populations.

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Title: Long-term efficacy and tolerability of a fixed-dose combination of antihypertensive agents: an open-label surveillance study in China.

Journal: Clinical drug investigation 20111101

Title: High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy.

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Journal: International journal of nephrology 20110101

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Journal: Annales francaises d'anesthesie et de reanimation 20100401

Title: Flow-injection chemiluminescence determination of dihydralazine sulfate in serum using luminol and diperiodatocuprate (III) system.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100101

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Title: Emitting species in chemiluminescence reactions with acidic potassium permanganate: a re-evaluation based on new spectroscopic evidence.

Journal: Journal of fluorescence 20090901

Title: Effects of dihydralazine on renal water and aquaporin-2 excretion in humans.

Journal: Scandinavian journal of clinical and laboratory investigation 20090101

Title: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development.

Journal: Current medicinal chemistry 20090101

Title: Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination.

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Title: [Eclampsia at a teaching hospital in Ivory Coast: management, outcome and prognostic factors].

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20080701

Title: Chemiluminescence investigation of carbon dioxide-enhanced oxidation of dihydralazine sulfate by peroxynitrite and its application to pharmaceutical analysis.

Journal: Analytica chimica acta 20080602

Title: Nitric oxide-deficiency regulates hepatic heme oxygenase-1.

Journal: Nitric oxide : biology and chemistry 20080201

Title: Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end-diastolic flow in the umbilical artery.

Journal: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 20080101

Title: Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071201

Title: Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.

Journal: Critical reviews in toxicology 20070601

Title: Method development for dihydralazine with HPLC-MS/MS--an old but tricky substance in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20070117

Title: Antihypertensive therapy in patients with pre-eclampsia: A prospective randomised multicentre study comparing dihydralazine with urapidil.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20060801

Title: Positive effects of nitric oxide on left ventricular function in humans.

Journal: European heart journal 20060701

Title: Dihydralazine treatment limits liver injury after hemorrhagic shock in rats.

Journal: Critical care medicine 20060301

Title: [Hypertension in pregnancy].

Journal: Vnitrni lekarstvi 20060301

Title: Changes in metabolism and blood flow following catecholamine stimulation in the synovial membrane measured with microdialysis.

Journal: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20060201

Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Journal: Current drug metabolism 20051001

Title: Morbidity and development in childhood of infants born after temporising treatment of early onset pre-eclampsia.

Journal: BJOG : an international journal of obstetrics and gynaecology 20050701

Title: Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

Journal: Therapeutics and clinical risk management 20050301

Title: Isolated sarcoid granulomatous interstitial nephritis responding to infliximab therapy.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20050201

Title: Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

Journal: Clinical pharmacokinetics 20050101

Title: Hypertension in children with chronic renal failure.

Journal: The Turkish journal of pediatrics 20050101

Title: Evaluation of a strict protocol approach in managing women with severe disease due to hypertension in pregnancy: a before and after study.

Journal: Reproductive health 20050101

Title: Flow-injection chemiluminescence determination of dihydralazine sulfate based on hexacyanoferrate(III) oxidation sensitized by eosin Y.

Journal: Talanta 20041008

Title: Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4.

Journal: Current drug metabolism 20041001

Title: Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde.

Journal: Organic & biomolecular chemistry 20040921

Title: 3,6-Bis(2-pyridyl)di-1,2,4-triazolo[3,4-a:4',3'-c]phthalazine.

Journal: Acta crystallographica. Section C, Crystal structure communications 20040901

Title: Site-specific 99mTc-labeling of antibody using dihydrazinophthalazine (DHZ) conjugation to Fc region of heavy chain.

Journal: Archives of pharmacal research 20040901

Title: [Determination of five components in compound hypotensive tablet by HPLC].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801

Title: Plasma volume and blood pressure regulation in hypertensive pregnancy.

Journal: Journal of hypertension 20040701

Title: The impact of maternal plasma volume expansion and antihypertensive treatment with intravenous dihydralazine on fetal and maternal hemodynamics during pre-eclampsia: a clinical, echo-Doppler and viscometric study.

Journal: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 20040401

Title: Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity.

Journal: Molecular pharmacology 20040301

Title: Flow injection chemiluminescence determination of dihydralazine sulphate based on permanganate oxidation sensitized by rhodamine B.

Journal: Luminescence : the journal of biological and chemical luminescence 20040101

Title: [When hypertension becomes an emergency case: lower the blood pressure, but slowly!].

Journal: MMW Fortschritte der Medizin 20030529

Title: Myocyte loss in early left ventricular hypertrophy of experimental renovascular hypertension.

Journal: Virchows Archiv : an international journal of pathology 20030401

Title: [Reversible loss of vision in severe preeclampsia: case report and review of the literature].

Journal: Zeitschrift fur Geburtshilfe und Neonatologie 20030101

Title: Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products.

Journal: Toxicology 20021227

Title: Drug-induced lupus as a cause of relapsing inflammatory disease after renal transplantation.

Journal: Pediatric transplantation 20020801

Title: Immune-mediated drug-induced liver disease.

Journal: Clinics in liver disease 20020801

Title: [Effect of Urapidil in antihypertensive therapy of preeclampsia on newborns].

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Title: [Hypertensive disorders in pregnancy].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20010215

Title: Influence of metabolic activation on the induction of micronuclei by antihypertensive drugs in L929 cells.

Journal: Archives of toxicology 20010201

Title: Ketanserin for the treatment of preeclampsia.

Journal: Journal of perinatal medicine 20010101

Title: Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.

Journal: Chemical research in toxicology 19960101

Title: Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 19880501

Title: Comparative study on the short-term effects of angiotensin converting enzyme inhibitors (Lopirin, SQUIBB and Tensiomin), and dihydralazine in chronic cardiac failure.

Journal: Acta physiologica Hungarica 19880101

Title: [Liver lesions induced by dihydralazine and propranolol].

Journal: Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie 19850101

Title: Vagally mediated bradycardiac effect of prazosin in anaesthetized rats.

Journal: European journal of pharmacology 19841015

Title: Mode of antihypertensive action of nitrendipine.

Journal: Journal of cardiovascular pharmacology 19840101

Title: Action of vasodilating drugs on small and large arteries of hypertensive patients.

Journal: Journal of cardiovascular pharmacology 19830101

Title: Side-effects with long-term labetalol: an open study of 251 patients in a single centre.

Journal: Pharmatherapeutica 19830101

Title: [Hypotensive anaesthesia in the oto-rhino-laryngological surgery using nitroglycerine (author's transl)].

Journal: Der Anaesthesist 19800501

Title: [Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].

Journal: Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete 19800401

Title: Effects of acute hypotension and hypertension on serum TSH concentrations in male rats.

Journal: Acta physiologica Scandinavica 19791001

Title: [Treatment of essential hypertension with a combination of propranolol, spironolactone-thiabutazide and dihydralazine (author's transl)].

Journal: Deutsche medizinische Wochenschrift (1946) 19781020

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Tags:484-23-1 Molecular Formula|484-23-1 MDL|484-23-1 SMILES|484-23-1 1,4-Dihydrazinylphthalazine