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Home Fluorides 487051-12-7
487051-12-7,MFCD18969149
Catalog No.:AA00DGQD

487051-12-7 | N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$173.00   $121.00
- +
10mg
≥98%
in stock  
$312.00   $218.00
- +
25mg
≥98%
in stock  
$688.00   $481.00
- +
50mg
≥98%
in stock  
$1,202.00   $841.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00DGQD
Chemical Name:
N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride
CAS Number:
487051-12-7
Molecular Formula:
C29H33ClF2N2O2
Molecular Weight:
515.0343
MDL Number:
MFCD18969149
SMILES:
O=C(C(C)C)Nc1ccc(c(c1)C1CCN(CC1)Cc1ccc(cc1)Oc1ccc(c(c1)F)F)C.Cl
Properties
Computed Properties
 
Complexity:
661  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  

Literature

Title: David DJ, et al. Efficacy of the MCHR1 antagonist N--(1-{-(3,4-difluorophenoxy)phenylmethyl}(4-piperidyl))-4-methylphenyl-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48. Epub 2007 Jan 19.

Title: Nair SG, et al. Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats.Psychopharmacology (Berl). 2009 Jul;205(1):129-40.

Title: Chen CA, et al. Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.J Med Chem. 2007 Aug 9;50(16):3883-90.

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Tags:487051-12-7 Molecular Formula|487051-12-7 MDL|487051-12-7 SMILES|487051-12-7 N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride