494-52-0,MFCD00871391
Catalog No.:AA0032E8

494-52-0 | (S)-3-(Piperidin-2-yl)pyridine

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Purity
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10mg
95%
in stock  
$78.00   $54.00
- +
25mg
95%
in stock  
$116.00   $81.00
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50mg
95%
in stock  
$206.00   $144.00
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100mg
97%
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$216.00   $151.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0032E8
Chemical Name:
(S)-3-(Piperidin-2-yl)pyridine
CAS Number:
494-52-0
Molecular Formula:
C10H14N2
Molecular Weight:
162.2316
MDL Number:
MFCD00871391
SMILES:
C1CC[C@H](NC1)c1cccnc1
NSC Number:
87504
Properties
Properties
 
BP:
271°C at 760 mmHg  
Form:
Liquid  
MP:
9°C  
Refractive Index:
1.543  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
136  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1  

Upstream Synthesis Route

[1]Chemistry-AEuropeanJournal,2006,vol.12,#30,p.7872-7881

[2]ChemicalCommunications,2002,#5,p.526-527

[3]EuropeanJournalofOrganicChemistry,2000,#9,p.1719-1726

[1]Synlett,2000,#11,p.1646-1648

[2]JournalofOrganicChemistry,2001,vol.66,#19,p.6305-6312

[1]Tetrahedron,1993,vol.49,#9,p.1749-1760

[2]JournalofOrganicChemistry,1992,vol.57,#12,p.3264-3265

[1]EuropeanJournalofOrganicChemistry,2001,p.975-986

[2]EuropeanJournalofOrganicChemistry,2000,#9,p.1719-1726

[3]Tetrahedron,1993,vol.49,#9,p.1749-1760

[4]Tetrahedron,1993,vol.49,#9,p.1749-1760

[5]JournalofOrganicChemistry,1989,vol.54,#18,p.4261-4263

[6]TetrahedronLetters,2011,vol.52,#14,p.1549-1552

[7]TetrahedronLetters,2011,vol.52,#14,p.1549-1552

[1]Synthesis,2009,#22,p.3797-3802

Downstream Synthesis Route

[1]Tetrahedron,1993,vol.49,p.1749-1760

[2]JournalofOrganicChemistry,1992,vol.57,p.3264-3265

494-52-0    72036-33-0   
4-(S)-2-(3-pyridyl)piperidin-1-yl-1-oxaspiro4.5dec-3-en-2-one 

[1]MendeleevCommunications,2011,vol.21,p.94-96

[2]RussianChemicalBulletin,2005,vol.54,p.2857-2866

494-52-0   
3,4,5,6-tetrahydro2,3'bipyridinyl1'-oxide 

[1]RussianChemicalBulletin,2006,vol.55,p.331-337

[1]Phytochemistry,2005,vol.66,p.1890-1897

[1]JournalofMolecularStructure,2007,vol.840,p.44-52

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Title: Simultaneous quantification of nicotine and metabolites in rat brain by liquid chromatography-tandem mass spectrometry.

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Journal: Journal of agricultural and food chemistry 20110413

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Journal: Journal of agricultural and food chemistry 20110413

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Journal: Ecotoxicology and environmental safety 20110101

Title: Determination of neonicotinoid insecticides residues in bovine tissues by pressurized solvent extraction and liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110101

Title: Advanced research on cis-Neonicotinoids.

Journal: Chimia 20110101

Title: Determination of nicotine, anabasine, and cotinine in urine and saliva samples using single-drop microextraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015

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Journal: Toxicology 20100930

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Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100903

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Journal: Journal of agricultural and food chemistry 20100526

Title: Trifluoroacetyl neonicotinoid insecticides with enhanced hydrophobicity and effectiveness.

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Journal: Molecular pharmacology 20090701

Title: Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site.

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Title: Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

Title: Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors.

Journal: British journal of pharmacology 20090501

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Journal: The AAPS journal 20050901

Title: Neonicotinoids show selective and diverse actions on their nicotinic receptor targets: electrophysiology, molecular biology, and receptor modeling studies.

Journal: Bioscience, biotechnology, and biochemistry 20050801

Title: Stereoselectivity of the demethylation of nicotine piperidine homologues by Nicotiana plumbaginifolia cell suspension cultures.

Journal: Phytochemistry 20050801

Title: Identification of aldehyde oxidase as the neonicotinoid nitroreductase.

Journal: Chemical research in toxicology 20050201

Title: Inhibition of cholinesterases of various origin by anabasine derivatives.

Journal: Doklady. Biochemistry and biophysics 20050101

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Journal: Journal of medicinal chemistry 20041230

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Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225

Title: Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry.

Journal: Clinical chemistry 20041201

Title: Quantitative structure-activity relationship study using refractotopological state atom index on some neonicotinoid insecticides.

Journal: Bioorganic & medicinal chemistry 20041201

Title: Comparative analysis of neonicotinoid binding to insect membranes: I. A structure-activity study of the mode of [3H]imidacloprid displacement in Myzus persicae and Aphis craccivora.

Journal: Pest management science 20041001

Title: Comparative analysis of neonicotinoid binding to insect membranes: II. An unusual high affinity site for [3H]thiamethoxam in Myzus persicae and Aphis craccivora.

Journal: Pest management science 20041001

Title: Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia.

Journal: Behavioural brain research 20040831

Title: The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors.

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Title: Structural diversity and defensive properties of norditerpenoid alkaloids.

Journal: Journal of chemical ecology 20040701

Title: Super agonist actions of clothianidin and related compounds on the SAD beta 2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes.

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Journal: The Journal of organic chemistry 20030530

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Journal: Journal of agricultural and food chemistry 20030507

Title: Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors.

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Journal: Pest management science 20030201

Title: Bisalkaloid derivatives of dicarboxylic acids on the basis of lupinine, anabasine, and cytisine as reversible cholinesterase inhibitors.

Journal: Doklady. Biochemistry and biophysics 20030101

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Journal: Physiological research 20030101

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Journal: Bioorganicheskaia khimiia 20030101

Title: Quantitative structure-activity relationship study on some azidopyridinyl neonicotinoid insecticides for their selective affinity towards the drosophila nicotinic receptor over mammalian alpha4beta2 receptor using electrotopological state atom index.

Journal: Drug design and discovery 20030101

Title: Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20021201

Title: Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors.

Journal: Brain research 20020906

Title: Structure-activity relationships of benzylidene anabaseines in nicotinic acetylcholine receptors of cockroach nerve cords.

Journal: Bioorganic & medicinal chemistry 20020901

Title: Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis.

Journal: British journal of pharmacology 20020901

Title: Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles.

Journal: Clinical chemistry 20020901

Title: Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry.

Journal: Forensic science international 20020717

Title: Enantioselective synthesis of 2-arylpiperidines from chiral lactams. A concise synthesis of (-)-anabasine.

Journal: Chemical communications (Cambridge, England) 20020307

Title: Translocation and translaminar bioavailability of two neonicotinoid insecticides after foliar application to cabbage and cotton.

Journal: Pest management science 20020101

Title: Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20011201

Title: Insecticidal and neural activities of candidate photoaffinity probes for neonicotinoid binding sites.

Journal: Bioscience, biotechnology, and biochemistry 20010701

Title: Absolute configuration of anabasine from Messor and Aphaenogaster ants.

Journal: Journal of chemical ecology 20010501

Title: The discovery of thiamethoxam: a second-generation neonicotinoid.

Journal: Pest management science 20010201

Title: GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue.

Journal: Pharmacology, biochemistry, and behavior 19991001

Title: Levin ED, et al. Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. J Psychopharmacol. 2014 Oct;28(10):915-22.

Title: Benedict T Green, et al. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicol Teratol. May-Jun 2010;32(3):383-90.

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Tags:494-52-0 Molecular Formula|494-52-0 MDL|494-52-0 SMILES|494-52-0 (S)-3-(Piperidin-2-yl)pyridine
Catalog No.: AA0032E8
494-52-0,MFCD00871391
494-52-0 | (S)-3-(Piperidin-2-yl)pyridine
Pack Size: 10mg
Purity: 95%
in stock
$78.00 $54.00
Pack Size: 25mg
Purity: 95%
in stock
$116.00 $81.00
Pack Size: 50mg
Purity: 95%
in stock
$206.00 $144.00
Pack Size: 100mg
Purity: 97%
in stock
$216.00 $151.00
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Technical Information
Catalog Number: AA0032E8
Chemical Name: (S)-3-(Piperidin-2-yl)pyridine
CAS Number: 494-52-0
Molecular Formula: C10H14N2
Molecular Weight: 162.2316
MDL Number: MFCD00871391
SMILES: C1CC[C@H](NC1)c1cccnc1
NSC Number: 87504
Properties
BP: 271°C at 760 mmHg  
Form: Liquid  
MP: 9°C  
Refractive Index: 1.543  
Storage: Inert atmosphere;2-8℃;  
Complexity: 136  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 12  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1  
Upstream Synthesis Route
283610-12-8    494-52-0 

[1]Chemistry-AEuropeanJournal,2006,vol.12,#30,p.7872-7881

[2]ChemicalCommunications,2002,#5,p.526-527

[3]EuropeanJournalofOrganicChemistry,2000,#9,p.1719-1726

314280-34-7    494-52-0 

[1]Synlett,2000,#11,p.1646-1648

[2]JournalofOrganicChemistry,2001,vol.66,#19,p.6305-6312

31944-77-1    494-52-0 

[1]Tetrahedron,1993,vol.49,#9,p.1749-1760

[2]JournalofOrganicChemistry,1992,vol.57,#12,p.3264-3265

500-22-1    494-52-0 

[1]EuropeanJournalofOrganicChemistry,2001,p.975-986

[2]EuropeanJournalofOrganicChemistry,2000,#9,p.1719-1726

[3]Tetrahedron,1993,vol.49,#9,p.1749-1760

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1207459-99-1    494-52-0 

[1]Synthesis,2009,#22,p.3797-3802

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494-52-0    72036-33-0   
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494-52-0   
3,4,5,6-tetrahydro2,3'bipyridinyl1'-oxide 

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1966-44-5    24380-92-5    494-52-0    34366-21-7 

[1]Phytochemistry,2005,vol.66,p.1890-1897

494-52-0    53912-89-3 

[1]JournalofMolecularStructure,2007,vol.840,p.44-52

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