Home Indole and Oxindoles 496-12-8
496-12-8,MFCD00605324
Catalog No.:AA003R13

496-12-8 | Isoindoline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
≥97%
in stock  
$73.00   $51.00
- +
1g
95%
in stock  
$112.00   $78.00
- +
5g
95%
in stock  
$261.00   $183.00
- +
25g
95%
in stock  
$1,009.00   $706.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003R13
Chemical Name:
Isoindoline
CAS Number:
496-12-8
Molecular Formula:
C8H9N
Molecular Weight:
119.1638
MDL Number:
MFCD00605324
SMILES:
N1Cc2c(C1)cccc2
Properties
Properties
 
BP:
199.6°C at 760 mmHg  
Form:
Solid  
MP:
17 °C(lit.);  
Refractive Index:
n20/D 1.57(lit.)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
88.7  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.9  

Literature

Title: Sulfonate pseudohalides of boron subphthalocyanine.

Journal: Acta crystallographica. Section C, Crystal structure communications 20121101

Title: N-(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)-4,4''-difluoro-5'-hy-droxy-1,1':3',1''-terphenyl-4'-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online 20120901

Title: Computational design of cyclic nitroxides as efficient redox mediators for dye-sensitized solar cells.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120611

Title: 2-Benzyl-3-hy-droxy-3-methyl-2,3-dihydro-1H-isoindol-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20120601

Title: Rhodium-catalyzed synthesis of branched amines by direct addition of benzamides to imines.

Journal: Organic letters 20120504

Title: Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis strategy.

Journal: The Journal of organic chemistry 20120420

Title: Dynamic kinetic resolution of 1,3-dihydro-2H-isoindole-1-carboxylic acid methyl ester: asymmetric transformations toward isoindoline carbamates.

Journal: Organic letters 20120406

Title: Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy.

Journal: ACS combinatorial science 20120312

Title: 1,1,3,3-Tetra-ethyl-isoindolin-2-ium chloride.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: 2-[(E)-(2-Hy-droxy-naphthalen-1-yl)methyl-idene-amino]-isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: (E)-2-[(2-Chloro-benzyl-idene)amino]-isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?

Journal: Journal of medicinal chemistry 20110825

Title: 1,3-Bis[3-(1,3-dioxoisoindolin-2-yl)prop-yl]-1H-anthra[1,2-d]imidazole-2,6,11(3H)-trione.

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: 2-[(E)-(2,4-Dichloro-benzyl-idene)amino]-isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20110701

Title: Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: Structural determination of three different series of compounds as Hsp90 inhibitors using 3D-QSAR modeling, molecular docking and molecular dynamics methods.

Journal: International journal of molecular sciences 20110101

Title: Synthesis and pharmacological characterization of potent, selective, and orally bioavailable isoindoline class dipeptidyl peptidase IV inhibitors.

Journal: Organic and medicinal chemistry letters 20110101

Title: 2-{[(E)-2-Hy-droxy-benzyl-idene]amino}-1H-isoindole-1,3(2H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: Side reactions of nitroxide-mediated polymerization: N-O versus O-C cleavage of alkoxyamines.

Journal: The journal of physical chemistry. A 20100930

Title: 4,5,6,7-Tetra-chloro-2-(2,2,2-trifluoro-eth-yl)isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: Rearrangements and intramolecular Diels-Alder reactions of normal and vinylogous aza-Morita-Baylis-Hillman products leading to isoindoline derivatives.

Journal: The Journal of organic chemistry 20100604

Title: 2-{[(4-Methoxy-phen-yl)dimethyl-silyl]meth-yl}isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100101

Title: Does the sedative agent, JM-1232(-) cause QT prolongation with subsequent torsades de pointes?

Journal: Life sciences 20091118

Title: 2-(1,3-Dioxoisoindolin-2-yl)propanoic acid.

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: 1,2-Bis(bromo-meth-yl)-4,5-dimethoxy-benzene.

Journal: Acta crystallographica. Section E, Structure reports online 20090901

Title: 2-[2-(2-Pyrid-yl)eth-yl]isoindolinium perchlorate.

Journal: Acta crystallographica. Section E, Structure reports online 20090901

Title: 2-[2-(Methyl-sulfon-yl)eth-yl]isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: The shivering threshold in rabbits with JM-1232(-), a new benzodiazepine receptor agonist.

Journal: Anesthesia and analgesia 20090701

Title: 3',6'-Bis(diethyl-amino)-2-phenyl-spiro[isoindoline-1,9'-xanthen]-3-one.

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: The antinociceptive effects and pharmacological properties of JM-1232(-): a novel isoindoline derivative.

Journal: Anesthesia and analgesia 20090301

Title: Bishydrazide derivatives of isoindoline as simple anion receptors.

Journal: The Journal of organic chemistry 20090220

Title: N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1).

Journal: Bioorganic & medicinal chemistry letters 20090215

Title: 1,3-Di-1-adamantylimidazolium (phthalocyaninato)lithium(I) acetone hemisolvate monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20090101

Title: Experimental and theoretical studies of the redox potentials of cyclic nitroxides.

Journal: The Journal of organic chemistry 20080905

Title: Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: Interplay of hydrogenation and dehydrogenation in isoindoline and indoline isomers: a density functional theory study.

Journal: The journal of physical chemistry. A 20080612

Title: Synthesis of 5,15-diaryltetrabenzoporphyrins.

Journal: The Journal of organic chemistry 20080606

Title: 5,6-Dichloro-2-(3-methoxy-phen-yl)isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20080501

Title: 5,6-Dichloro-2-(2-fluoro-phen-yl)iso-indoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20080501

Title: Raman identification of yellow synthetic organic pigments in modern and contemporary paintings: reference spectra and case studies.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201

Title: 2-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-ylmeth-yl)isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20080201

Title: Microwave-mediated nickel-catalyzed cyclotrimerization reactions: total synthesis of illudinine.

Journal: The Journal of organic chemistry 20080104

Title: Asymmetric Brønsted acid catalyzed isoindoline synthesis: enhancement of enantiomeric ratio by stereoablative kinetic resolution.

Journal: Angewandte Chemie (International ed. in English) 20080101

Title: Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation.

Journal: PloS one 20080101

Title: Bis[1,3-bis-(diphenyl-phosphinoylimino)isoindolinato-κO,N,O']calcium(II).

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: One-electron oxidation and reduction potentials of nitroxide antioxidants: a theoretical study.

Journal: The journal of physical chemistry. A 20071227

Title: Formation of 4,5,6,7-tetrahydroisoindoles by palladium-catalyzed hydride reduction.

Journal: The Journal of organic chemistry 20071123

Title: Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.

Journal: Journal of medicinal chemistry 20070125

Title: Patented small molecule inhibitors in the ubiquitin proteasome system.

Journal: BMC biochemistry 20070101

Title: Size discrimination in the coordination chemistry of an isoindoline pincer ligand with CdII and ZnII.

Journal: Inorganic chemistry 20060724

Title: Solid-supported [2+2+2] cyclotrimerizations.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060717

Title: Synthesis, structure and DNA interaction of cobalt(III) bis-complexes of 1,3-bis(2-pyridylimino)isoindoline and 1,4,7-triazacyclononane.

Journal: Journal of inorganic biochemistry 20051101

Title: Cd(II), Zn(II), and Pd(II) complexes of an isoindoline pincer ligand: consequences of steric crowding.

Journal: Inorganic chemistry 20050905

Title: Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.

Journal: Bioorganic & medicinal chemistry letters 20050201

Title: Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.

Journal: Bioorganic & medicinal chemistry letters 20040223

Title: Intermolecular, markovnikov hydroamination of vinylarenes with alkylamines.

Journal: Journal of the American Chemical Society 20031126

Title: Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist.

Journal: Journal of medicinal chemistry 20031106

Title: Fluxional behavior of a cadmium zwitterion complex: proton transport and tautomerism in methylene chloride solution.

Journal: Inorganic chemistry 20030728

Title: A novel isoindoline, porritoxin sulfonic acid, from Alternaria porri and the structure-phytotoxicity correlation of its related compounds.

Journal: Bioscience, biotechnology, and biochemistry 20030701

Title: Syntheses and structures of isoindoline complexes of Zn(II) and Cu(II): an unexpected trinuclear Zn(II) complex.

Journal: Inorganic chemistry 20030113

Title: Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists.

Journal: Chembiochem : a European journal of chemical biology 20021004

Title: Synthesis and SAR studies for the inhibition of TNF-alpha production. Part 2. 2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-substituted-1-isoindolinone derivatives.

Journal: Archives of pharmacal research 20020401

Title: [Nickel-catalyzed [2 + 2 + 2] cocyclization and its application to the synthetic organic chemistry].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20011201

Title: cis-6-Phenyl-4bH,6H,11H,13H-isoindolo[1,2-c]benz[2,4]oxazepin-13-one.

Journal: Acta crystallographica. Section C, Crystal structure communications 20010601

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:496-12-8 Molecular Formula|496-12-8 MDL|496-12-8 SMILES|496-12-8 Isoindoline