496-30-0,MFCD00129941
Catalog No.:AA00DA51

496-30-0 | Indoline-2-thione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$200.00   $140.00
- +
1g
95%
in stock  
$333.00   $233.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DA51
Chemical Name:
Indoline-2-thione
CAS Number:
496-30-0
Molecular Formula:
C8H7NS
Molecular Weight:
149.2129
MDL Number:
MFCD00129941
SMILES:
S=C1Cc2c(N1)cccc2
Properties
Properties
 
BP:
243.4°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
155  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.8  

Downstream Synthesis Route

[1]Pedras,M.SoledadeC.;Jha,Mukund[JournalofOrganicChemistry,2005,vol.70,#5,p.1828-1834]

[2]Locationinpatent:experimentalpartBergman,Jan;Pettersson,Birgitta;Hasimbegovic,Vedran;Svensson,PerH.[JournalofOrganicChemistry,2011,vol.76,#6,p.1546-1553]

[3]CurrentPatentAssignee:VIRONOVATHIONATION-WO2012/104415,2012,A1Locationinpatent:Page/Pagecolumn10

[4]Wenkert,Ernest;Hanna,JamesM.;Leftin,MichaelH.;Michelotti,EnriqueL.;Potts,KevinT.;Usifer,Douglas[JournalofOrganicChemistry,1985,vol.50,#7,p.1125-1126]

[5]Olgen,Sureyya;Akaho,Eiichi;Nebioglu,Dogu[IlFarmaco,2005,vol.60,#6-7,p.497-506]

[6]Oelgen,Suereyya;Goetz,Claudia;Jose,Joachim[BiologicalandPharmaceuticalBulletin,2007,vol.30,#4,p.715-718]

[7]Locationinpatent:experimentalpartThanigaimalai,Pillaiyar;Lee,Ki-Cheul;Sharma,VinayKumar;Sharma,Niti;Roh,Eunmiri;Kim,Youngsoo;Jung,Sang-Hun[ChemicalandPharmaceuticalBulletin,2011,vol.59,#10,p.1285-1288]

[8]Kamila,Sukanta;Biehl,Ed[Heterocycles,2004,vol.63,#12,p.2785-2795]

[9]Takada;Ishizuka;Sasatani;Makisumi;Jyoyama;Hatakeyama;Asanuma;Hirose[ChemicalandPharmaceuticalBulletin,1984,vol.32,#3,p.877-886]

[10]Saputra,Adi;Fan,Rong;Yao,Tuanli;Chen,Jian;Tan,Jiajing[AdvancedSynthesisandCatalysis,2020,vol.362,#13,p.2683-2688]

[11]Demchenko,AlexeiV.;Shrestha,Ganesh;Panza,Matteo;Singh,Yashapal;Rath,NigamP.[JournalofOrganicChemistry,2020,vol.85,#24,p.15885-15894]

[12]Banerjee,Satarupa;Sarkar,Sandipan;Basak,Ramkrishna;Chakrabarty,Manas[JournaloftheIndianChemicalSociety,2004,vol.81,#2,p.169-170]

[13]Lopes,AlexandraBasilio;Choury,Mickael;Wagner,Patrick;Gulea,Mihaela[OrganicLetters,2019,vol.21,#15,p.5943-5947]

[14]Jackson,AnthonyN.;Johnston,DavidK.;Shannon,PatrickV.R.[JournalofChemicalResearch,Miniprint,1988,#9,p.2017-2063]

[15]Sugasawaetal.[YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1938,vol.58,p.139;engl.Ref.S.29][Chem.Abstr.,1938,p.4161]

[16]Bordwell,FrederickG.;Fried,HerbertE.[JournalofOrganicChemistry,1991,vol.56,#13,p.4218-4223]

[17]Hartke,Klaus;Teuber,Dorothee;Gerber,Hans-Dieter[Tetrahedron,1988,vol.44,#11,p.3261-3270]

[18]Takada;Makisumi[ChemicalandPharmaceuticalBulletin,1984,vol.32,#3,p.872-876]

[19]Pedras,M.SoledadeC.;Khan,AbdulQ.[JournalofAgriculturalandFoodChemistry,1996,vol.44,#10,p.3403-3407]

[20]Locationinpatent:experimentalpartBoeini,HassanZali[HelveticaChimicaActa,2009,vol.92,#7,p.1268-1272]

[21]Berg,Robert;Bergman,Jan[Tetrahedron,2017,vol.73,#38,p.5654-5658]

[22]Rhodes,Steven;Short,Spencer;Sharma,Sidhika;Kaur,Ramneet;Jha,Mukund[OrganicandBiomolecularChemistry,2019,vol.17,#16,p.3914-3920]

[23]Bhave,VishakhaS.;Hojo,Ryoga;Jha,Mukund;Rhodes,Steven;Short,Spencer[Synthesis,2019,vol.51,#22,p.4263-4270]

[24]Yang,Wei;Lin,Xiaobin;Zhang,Yongyan;Cao,Weidi;Liu,Xiaohua;Feng,Xiaoming[ChemicalCommunications,2020,vol.56,#69,p.10002-10005]

[1]TetrahedronLetters,1970,p.2895-2898

[1]Ishizuka,Natsuki[JournaloftheChemicalSociety.PerkintransactionsI,1990,#4,p.813-826]

[1]Nishio,Takehiko;Oka,Mitsuru[HelveticaChimicaActa,1997,vol.80,#2,p.388-397]

[1]LettersinOrganicChemistry,2009,vol.6,p.526-528

Literature

Title: Identification of indoline-2-thione analogs as novel potent inhibitors of α-melanocyte stimulating hormone induced melanogenesis.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: Synthesis, antimicrobial and antioxidant activity of some oxindoles.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Scavenging of reactive oxygen species by novel indolin-2-one and indoline-2-thione derivatives.

Journal: Biopolymers 20050701

Title: Design, synthesis, and antiviral evaluation of some polyhalogenated indole C-nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: Dirhodium(II) tetraacetate catalysed reactions of diazo thioamides: isolation and cycloaddition of anhydro-4-hydroxy-1,3-thiazolium hydroxides (thioisomünchnones), an approach to analogues of dehydrogliotoxin.

Journal: Organic & biomolecular chemistry 20030807

Title: Unprecedented Vilsmeier formylation: expedient syntheses of the cruciferous phytoalexins sinalexin and brassilexin and discovery of a new heteroaromatic ring system.

Journal: Organic letters 20010419

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SDS
Tags:496-30-0 Molecular Formula|496-30-0 MDL|496-30-0 SMILES|496-30-0 Indoline-2-thione
Catalog No.: AA00DA51
496-30-0,MFCD00129941
496-30-0 | Indoline-2-thione
Pack Size: 250mg
Purity: 95%
in stock
$200.00 $140.00
Pack Size: 1g
Purity: 95%
in stock
$333.00 $233.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00DA51
Chemical Name: Indoline-2-thione
CAS Number: 496-30-0
Molecular Formula: C8H7NS
Molecular Weight: 149.2129
MDL Number: MFCD00129941
SMILES: S=C1Cc2c(N1)cccc2
Properties
BP: 243.4°C at 760 mmHg  
Form: Solid  
Storage: Keep in dry area;2-8℃;  
Complexity: 155  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 10  
Hydrogen Bond Acceptor Count: 1  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.8  
Downstream Synthesis Route
59-48-3    496-30-0 

[1]Pedras,M.SoledadeC.;Jha,Mukund[JournalofOrganicChemistry,2005,vol.70,#5,p.1828-1834]

[2]Locationinpatent:experimentalpartBergman,Jan;Pettersson,Birgitta;Hasimbegovic,Vedran;Svensson,PerH.[JournalofOrganicChemistry,2011,vol.76,#6,p.1546-1553]

[3]CurrentPatentAssignee:VIRONOVATHIONATION-WO2012/104415,2012,A1Locationinpatent:Page/Pagecolumn10

[4]Wenkert,Ernest;Hanna,JamesM.;Leftin,MichaelH.;Michelotti,EnriqueL.;Potts,KevinT.;Usifer,Douglas[JournalofOrganicChemistry,1985,vol.50,#7,p.1125-1126]

[5]Olgen,Sureyya;Akaho,Eiichi;Nebioglu,Dogu[IlFarmaco,2005,vol.60,#6-7,p.497-506]

[6]Oelgen,Suereyya;Goetz,Claudia;Jose,Joachim[BiologicalandPharmaceuticalBulletin,2007,vol.30,#4,p.715-718]

[7]Locationinpatent:experimentalpartThanigaimalai,Pillaiyar;Lee,Ki-Cheul;Sharma,VinayKumar;Sharma,Niti;Roh,Eunmiri;Kim,Youngsoo;Jung,Sang-Hun[ChemicalandPharmaceuticalBulletin,2011,vol.59,#10,p.1285-1288]

[8]Kamila,Sukanta;Biehl,Ed[Heterocycles,2004,vol.63,#12,p.2785-2795]

[9]Takada;Ishizuka;Sasatani;Makisumi;Jyoyama;Hatakeyama;Asanuma;Hirose[ChemicalandPharmaceuticalBulletin,1984,vol.32,#3,p.877-886]

[10]Saputra,Adi;Fan,Rong;Yao,Tuanli;Chen,Jian;Tan,Jiajing[AdvancedSynthesisandCatalysis,2020,vol.362,#13,p.2683-2688]

[11]Demchenko,AlexeiV.;Shrestha,Ganesh;Panza,Matteo;Singh,Yashapal;Rath,NigamP.[JournalofOrganicChemistry,2020,vol.85,#24,p.15885-15894]

[12]Banerjee,Satarupa;Sarkar,Sandipan;Basak,Ramkrishna;Chakrabarty,Manas[JournaloftheIndianChemicalSociety,2004,vol.81,#2,p.169-170]

[13]Lopes,AlexandraBasilio;Choury,Mickael;Wagner,Patrick;Gulea,Mihaela[OrganicLetters,2019,vol.21,#15,p.5943-5947]

[14]Jackson,AnthonyN.;Johnston,DavidK.;Shannon,PatrickV.R.[JournalofChemicalResearch,Miniprint,1988,#9,p.2017-2063]

[15]Sugasawaetal.[YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1938,vol.58,p.139;engl.Ref.S.29][Chem.Abstr.,1938,p.4161]

[16]Bordwell,FrederickG.;Fried,HerbertE.[JournalofOrganicChemistry,1991,vol.56,#13,p.4218-4223]

[17]Hartke,Klaus;Teuber,Dorothee;Gerber,Hans-Dieter[Tetrahedron,1988,vol.44,#11,p.3261-3270]

[18]Takada;Makisumi[ChemicalandPharmaceuticalBulletin,1984,vol.32,#3,p.872-876]

[19]Pedras,M.SoledadeC.;Khan,AbdulQ.[JournalofAgriculturalandFoodChemistry,1996,vol.44,#10,p.3403-3407]

[20]Locationinpatent:experimentalpartBoeini,HassanZali[HelveticaChimicaActa,2009,vol.92,#7,p.1268-1272]

[21]Berg,Robert;Bergman,Jan[Tetrahedron,2017,vol.73,#38,p.5654-5658]

[22]Rhodes,Steven;Short,Spencer;Sharma,Sidhika;Kaur,Ramneet;Jha,Mukund[OrganicandBiomolecularChemistry,2019,vol.17,#16,p.3914-3920]

[23]Bhave,VishakhaS.;Hojo,Ryoga;Jha,Mukund;Rhodes,Steven;Short,Spencer[Synthesis,2019,vol.51,#22,p.4263-4270]

[24]Yang,Wei;Lin,Xiaobin;Zhang,Yongyan;Cao,Weidi;Liu,Xiaohua;Feng,Xiaoming[ChemicalCommunications,2020,vol.56,#69,p.10002-10005]

6668-24-2    496-30-0    28871-03-6 

[1]TetrahedronLetters,1970,p.2895-2898

6089-17-4    496-30-0    129627-18-5 

[1]Ishizuka,Natsuki[JournaloftheChemicalSociety.PerkintransactionsI,1990,#4,p.813-826]

496-30-0    120-72-9    1484-19-1 

[1]Nishio,Takehiko;Oka,Mitsuru[HelveticaChimicaActa,1997,vol.80,#2,p.388-397]

496-30-0    33097-11-9    1217361-23-3 

[1]LettersinOrganicChemistry,2009,vol.6,p.526-528

Literature fold

Title: Identification of indoline-2-thione analogs as novel potent inhibitors of α-melanocyte stimulating hormone induced melanogenesis.

Journal: Chemical & pharmaceutical bulletin20110101

Title: Synthesis, antimicrobial and antioxidant activity of some oxindoles.

Journal: Indian journal of pharmaceutical sciences20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Scavenging of reactive oxygen species by novel indolin-2-one and indoline-2-thione derivatives.

Journal: Biopolymers20050701

Title: Design, synthesis, and antiviral evaluation of some polyhalogenated indole C-nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids20050101

Title: Dirhodium(II) tetraacetate catalysed reactions of diazo thioamides: isolation and cycloaddition of anhydro-4-hydroxy-1,3-thiazolium hydroxides (thioisomünchnones), an approach to analogues of dehydrogliotoxin.

Journal: Organic & biomolecular chemistry20030807

Title: Unprecedented Vilsmeier formylation: expedient syntheses of the cruciferous phytoalexins sinalexin and brassilexin and discovery of a new heteroaromatic ring system.

Journal: Organic letters20010419

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