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497-18-7,MFCD00007591
Catalog No.:AA003OMJ

497-18-7 | Carbohydrazide

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Technical Information
Catalog Number:
AA003OMJ
Chemical Name:
Carbohydrazide
CAS Number:
497-18-7
Molecular Formula:
CH6N4O
Molecular Weight:
90.0845
MDL Number:
MFCD00007591
SMILES:
NNC(=O)NN
NSC Number:
1934
Properties
Properties
 
BP:
167.26°C (rough estimate)  
Form:
Solid  
MP:
150-153 °C(lit.)  
Refractive Index:
1.4164 (estimate)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
45.5  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
6  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
4  
XLogP3:
-1.6  

Literature

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Title: Synthesis of new 1,3,4-thiadiazole and 1,2,3,4-oxathiadiazole derivatives from carbohydrate precursors and study of their effect on tyrosinase enzyme.

Journal: Molecules (Basel, Switzerland) 20120711

Title: N'-[(E)-4-Benz-yloxy-2-hy-droxy-benzyl-idene]-4-nitro-benzohydrazide monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20120501

Title: 4-Methyl-benzoic acid-N'-[(E)-4-methyl-benzyl-idene]pyridine-4-carbohydrazide-water (1/1/1).

Journal: Acta crystallographica. Section E, Structure reports online 20120501

Title: Synthesis and herbicidal activity evaluation of novel β-carboline derivatives.

Journal: Molecules (Basel, Switzerland) 20120402

Title: 3-Methyl-1-benzofuran-2-carbohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: Synthesis and antimicrobial activity of N'-heteroarylidene-1-adamantylcarbohydrazides and (±)-2-(1-adamantyl)-4-acetyl-5-[5-(4-substituted phenyl-3-isoxazolyl)]-1,3,4-oxadiazolines.

Journal: Molecules (Basel, Switzerland) 20120316

Title: A hydrazine- and phosgene-free synthesis of tetrazinanones, precursors to 1,5-dialkyl-6-oxoverdazyl radicals.

Journal: The Journal of organic chemistry 20120302

Title: (Z)-4-(3-Fluoro-phen-yl)-1-(5-nitro-2-oxo-indolin-3-yl-idene)thio-semicarbazide.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: N'-[(E)-2-Hy-droxy-5-iodo-benzyl-idene]furan-2-carbohydrazide monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: Production of high amounts of 3-hydroxypropionaldehyde from glycerol by Lactobacillus reuteri with strongly increased biocatalyst lifetime and productivity.

Journal: New biotechnology 20120115

Title: Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates.

Journal: ChemMedChem 20120102

Title: 2-[((E)-2-{2-[(E)-2-Hy-droxy-benzyl-idene]hydrazinecarbon-yl}hydrazinyl-idene)meth-yl]phenol.

Journal: Acta crystallographica. Section E, Structure reports online 20120101

Title: Recent advances in potential clinical application of ghrelin in obesity.

Journal: Journal of obesity 20120101

Title: Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives.

Journal: European journal of medicinal chemistry 20111201

Title: N'-[(E)-Furan-2-yl-methyl-idene]pyridine-3-carbohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Azabicyclo[3.1.0]hexane-1-carbohydrazides as potent and selective GHSR1a ligands presenting a specific in vivo behavior.

Journal: ChemMedChem 20111104

Title: Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents.

Journal: European journal of medicinal chemistry 20111101

Title: Rapid synthesis and in vitro and in vivo evaluation of folic acid derivatives labeled with fluorine-18 for PET imaging of folate receptor-positive tumors.

Journal: Nuclear medicine and biology 20111001

Title: Synthesis, antitubercular activity, and SAR study of N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides.

Journal: Bioorganic & medicinal chemistry 20110915

Title: [Study on inhibition of NO(x) and dioxin emissions by carbohydrazide under moderate to high temperatures].

Journal: Huan jing ke xue= Huanjing kexue 20110901

Title: Synthesis and antimycobacterial evaluation of N'-(E)-heteroaromaticpyrazine-2-carbohydrazide derivatives.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20110501

Title: Mechanisms of combustion synthesis and magnetic response of high-surface-area hexaboride compounds.

Journal: ACS applied materials & interfaces 20110401

Title: Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents.

Journal: Bioorganic & medicinal chemistry 20110315

Title: Design & synthesis of N'-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents.

Journal: European journal of medicinal chemistry 20110201

Title: (E)-N'-(2-Fluoro-benzyl-idene)furan-2-carbohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20110201

Title: Synthesis, crystal structures, insecticidal activities, and structure--activity relationships of novel N'-tert-Butyl-N'-substituted-benzoyl-N-[di(octa)hydro]benzofuran{(2,3-dihydro)benzo[1,3]([1,4])dioxine}carbohydrazide derivatives.

Journal: Journal of agricultural and food chemistry 20110126

Title: Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.

Journal: European journal of medicinal chemistry 20110101

Title: Cellular vacuoles induced by Mycoplasma pneumoniae CARDS toxin originate from Rab9-associated compartments.

Journal: PloS one 20110101

Title: 1,5-Bis(1-phenyl-ethyl-idene)carbonohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: 1,5-Bis[1-(2,4-dihy-droxy-phen-yl)ethyl-idene]carbonohydrazide dimethyl-formamide disolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building.

Journal: European journal of medicinal chemistry 20101001

Title: Novel indoline-1- or 3,4-dihydroquinoline-1(2H)-substituted carbothiohydrazides as TPO receptor agonists.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Synthesis and evaluation of novel chloropyrrole molecules designed by molecular hybridization of common pharmacophores as potential antimicrobial agents.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: 1,5-Bis-[1-(2-hy-droxy-phen-yl)ethyl-idene]carbonohydrazide dimethyl-formamide monosolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: 1-(1-Phenyl-ethyl-idene)carbonohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists.

Journal: ChemMedChem 20100903

Title: Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20100901

Title: Antiplatelet activity and structure-activity relationship study of Pyrazolopyridine Derivatives as potential series for treating thrombotic diseases.

Journal: Journal of atherosclerosis and thrombosis 20100730

Title: A screened hybrid density functional study on energetic complexes: cobalt, nickel and copper carbohydrazide perchlorates.

Journal: Journal of hazardous materials 20100715

Title: Directed derivatization of organotin sulfide compounds: synthesis and self-assembly of an SnS backpack-like cage and a CuSnS ternary cluster.

Journal: Chemical communications (Cambridge, England) 20100714

Title: Self-assembly of cerium-based metal-organic tetrahedrons for size-selectively luminescent sensing natural saccharides.

Journal: Chemical communications (Cambridge, England) 20091228

Title: Synthesis and antimycobacterial activity of N'-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives.

Journal: European journal of medicinal chemistry 20091201

Title: N'-[(E)-Benzyl-idene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Synthesis and antiviral activity of beta-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1).

Journal: European journal of medicinal chemistry 20091101

Title: (E)-1-Ethyl-4-oxo-N'-(4-pyridylmethyl-ene)-1,4-dihydroquinoline-3-carbo-hydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20091001

Title: Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools.

Journal: Biological chemistry 20090901

Title: 1-[1-(4-Chloro-phen-yl)ethyl-idene]carbono-hydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20090901

Title: 1,5-Bis(2-chloro-benzyl-idene)carbonohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: Effect of oral treatment with pyrazole carbohydrazide derivatives against murine infection by Leishmania amazonensis.

Journal: The American journal of tropical medicine and hygiene 20090401

Title: 1-Ethyl-N'-[(E)-4-hydroxy-benzyl-idene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20090401

Title: Selective P2X(7) receptor antagonists for chronic inflammation and pain.

Journal: Purinergic signalling 20090301

Title: A facile synthesis of novel biologically active 4-hydroxy-N'-(benzylidene)-2H-benzo[e][1,2]thiazine-3-carbohydrazide 1,1-dioxides.

Journal: European journal of medicinal chemistry 20090301

Title: Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells.

Journal: Bioorganic & medicinal chemistry 20090301

Title: Synthesis, characterization and properties of nitrogen-rich salts of trinitrophloroglucinol.

Journal: Journal of hazardous materials 20090130

Title: EPR, mass, electronic, IR spectroscopic and thermal studies of bimetallic copper(II) complexes with tetradentate ligand, 1,4-diformyl piperazine bis(carbohydrazone).

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090101

Title: Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series.

Journal: Bioorganic & medicinal chemistry 20090101

Title: P2X(7) Receptors in Neurological and Cardiovascular Disorders.

Journal: Cardiovascular psychiatry and neurology 20090101

Title: N-[1-(2-Hydroxy-phen-yl)ethyl-idene]-N-(1H-indol-3-ylmethyl-ene)carbonic dihydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20081201

Title: Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives.

Journal: Archiv der Pharmazie 20081101

Title: Efficacy of nano-hydroxyapatite prepared by an aqueous solution combustion technique in healing bone defects of goat.

Journal: Journal of veterinary science 20080601

Title: Synthesis, structure elucidation and identification of antitumoural properties of novel fused 1,2,4-triazine aryl derivatives.

Journal: European journal of medicinal chemistry 20080501

Title: Bis[2-hydroxy-N'-(3-phenylprop-2-enylidene)benzohydrazidato-kappa2N',O]bis(methanol-kappaO)nickel(II) and bis[2-hydroxy-N'-(3-phenylprop-2-enylidene)benzohydrazidato-kappa2N',O]bis(pyridine-kappaN)nickel(II).

Journal: Acta crystallographica. Section C, Crystal structure communications 20080501

Title: 1H-Indole-3-carbaldehyde azine.

Journal: Acta crystallographica. Section E, Structure reports online 20080301

Title: 2'-(3-Hydroxy-benzyl-idene)pyrazine-2-carbohydrazide monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells.

Journal: Bioorganic & medicinal chemistry 20071115

Title: Water transfer via ectomycorrhizal fungal hyphae to conifer seedlings.

Journal: Mycorrhiza 20070701

Title: Comparative transport efficiencies of urea analogues through urea transporter UT-B.

Journal: Biochimica et biophysica acta 20070701

Title: Carbohydrazones of substituted salicylaldehydes as potential lead compounds for the development of narrow-spectrum antimicrobials.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

Title: Pharmacological attenuation of Paramecium fluid-phase endocytosis.

Journal: Folia biologica 20070101

Title: N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II.

Journal: Bioorganic & medicinal chemistry letters 20061115

Title: N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20061115

Title: Multinuclear magnetic resonance, electrospray ionization-mass spectroscopy, and parametric method 5 studies of a new derivative of gossypol with 2-thiophenecarbohydrazide as well as its complexes with LI+, Na+, K+, RB+, and Cs+ cations.

Journal: Biopolymers 20061015

Title: Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols.

Journal: Journal of enzyme inhibition and medicinal chemistry 20060801

Title: Effect of organic additives on the mitigation of volatility of 1-nitro-3,3'-dinitroazetidine (TNAZ): next generation powerful melt cast able high energy material.

Journal: Journal of hazardous materials 20060630

Title: Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N'-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides.

Journal: European journal of medicinal chemistry 20060101

Title: Low temperature reduction of hexavalent chromium by a microbial enrichment consortium and a novel strain of Arthrobacter aurescens.

Journal: BMC microbiology 20060101

Title: Synthesis and preliminary screening of carbohydrazides and hydrazones of pyrrole derivatives as potential tuberculostatics.

Journal: Arzneimittel-Forschung 20060101

Title: Inhibition of monoamine oxidase-A activity in rat brain by synthetic hydrazines: structure-activity relationship (SAR).

Journal: Journal of enzyme inhibition and medicinal chemistry 20050601

Title: Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives.

Journal: Journal of medicinal chemistry 20050113

Title: Studies on lead-free initiators: synthesis, characterization and performance evaluation of transition metal complexes of carbohydrazide.

Journal: Journal of hazardous materials 20040910

Title: About the mechanism of interference of silver staining with peptide mass spectrometry.

Journal: Proteomics 20040401

Title: Temperature dependence of fluid phase endocytosis coincides with membrane properties of pig platelets.

Journal: Biochimica et biophysica acta 20030610

Title: Synthesis and anticancer evaluation of some new hydrazone derivatives of 2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazole-5-carbohydrazide.

Journal: European journal of medicinal chemistry 20030101

Title: Live-cell imaging of endocytosis during conidial germination in the rice blast fungus, Magnaporthe grisea.

Journal: Fungal genetics and biology : FG & B 20021201

Title: A new synthesis of oxadiazole, thiazolidinone, N-phthalimidoamino carbonyl and arylidene derivatives with potential antimicrobial activity.

Journal: Archiv der Pharmazie 20020601

Title: Fluorimetric determination of copper(II) in aqueous solution using lucifer yellow CH as selective metal reagent.

Journal: Fresenius' journal of analytical chemistry 20010901

Title: Loading process of sugars into cabbage petiole and asparagus shoot apex cells by incubation with hypertonic sugar solutions.

Journal: Protoplasma 20010101

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