Home Other Building Blocks 497259-23-1
497259-23-1,MFCD09037558
Catalog No.:AA00DIJD

497259-23-1 | TPPB

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥99%
in stock  
$411.00   $288.00
- +
5mg
≥99%
in stock  
$1,472.00   $1,030.00
- +
10mg
≥99%
in stock  
$2,443.00   $1,710.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DIJD
Chemical Name:
TPPB
CAS Number:
497259-23-1
Molecular Formula:
C27H30F3N3O3
Molecular Weight:
501.5406
MDL Number:
MFCD09037558
SMILES:
OC[C@H]1NC(=O)[C@H](C(C)C)N(c2c(C1)cc(cc2)NC(=O)/C=C/C=C/c1ccc(cc1)C(F)(F)F)C
Properties
Computed Properties
 
Complexity:
806  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
5  

Literature

Title: New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha.

Journal: Journal of medicinal chemistry 20030130

Title: Kozikowski AP, et al. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha. J Med Chem. 2003 Jan 30;46(3):364-73.

Title: Yang HQ, et al. Neuroprotective effects of new protein kinase C activator TPPB against Aβ25-35 induced neurotoxicity in PC12 cells. Neurochem Res. 2012 Oct;37(10):2213-21.

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SDS
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