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497871-47-3,MFCD22665743
Catalog No.:AA00DJWD

497871-47-3 | LURBINECTEDIN

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
1 week  
$1,733.00   $1,213.00
- +
2mg
95%
1 week  
$2,332.00   $1,632.00
- +
5mg
95%
1 week  
$3,440.00   $2,408.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DJWD
Chemical Name:
LURBINECTEDIN
CAS Number:
497871-47-3
Molecular Formula:
C41H44N4O10S
Molecular Weight:
784.8739
MDL Number:
MFCD22665743
SMILES:
COc1ccc2c(c1)c1CCN[C@@]3(c1[nH]2)CS[C@@H]1c2c(OC(=O)C)c(C)c4c(c2[C@H](COC3=O)N2[C@@H]1[C@@H]1N([C@H]([C@@H]2O)Cc2c1c(O)c(c(c2)C)OC)C)OCO4
Properties
Computed Properties
 
Complexity:
1530  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
56  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
3.9  

Literature

Title: Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells.

Journal: Molecular cancer therapeutics 20110801

Title: Takahashi R, et al. Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary. PLoS One. 2016 Mar 17;11(3):e0151050.

Title: Leal JF, et al. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Br J Pharmacol. 2010 Nov;161(5):1099-110.

Title: Vidal A, et al. Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of NSC 119875-resistant epithelial ovarian cancer. Clin Cancer Res. 2012 Oct 1;18(19):5399-411.

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SDS
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