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Title: Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.
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Title: Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.
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Title: Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry.
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Title: Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.
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Title: Assessment of drug-drug interactions caused by metabolism-dependent cytochrome P450 inhibition.
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Title: N-[3-(4-Fluoro-benz-yl)-2,4-dioxo-1,3-diaza-spiro-[4.5]dec-8-yl]-2-methyl-benzene-sulfonamide.
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Title: N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-meth-oxy-benzene-sulfonamide.
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Title: Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.
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Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
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Title: Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: focusing on CYP2A6.
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Title: Dravet syndrome as epileptic encephalopathy: evidence from long-term course and neuropathology.
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Title: Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.
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Title: Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4'-hydroxylation and omeprazole 5'-hydroxylation.
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Title: A UPLC-MS/MS assay of the 'Pittsburgh cocktail': six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution.
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Title: Traditional Medicine to Modern Pharmacogenomics: Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability.
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Title: CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population.
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Title: Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey.
Journal: PloS one20110101
Title: Effect of proton pump inhibitors on platelet inhibition activity of clopidogrel in Chinese patients with percutaneous coronary intervention.
Journal: Vascular health and risk management20110101
Title: Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment.
Journal: Addiction science & clinical practice20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
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Title: Can the genotype or phenotype of two polymorphic drug metabolising cytochrome P450-enzymes identify oral lichenoid drug eruptions?
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Title: Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. carnitine and glucose/thiamine.
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Title: Antiepileptic drug use, falls, fractures, and BMD in postmenopausal women: findings from the women's health initiative (WHI).
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research20100401
Title: Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis).
Journal: The Journal of veterinary medical science20100201
Title: Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
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Title: Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole.
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Title: Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.
Journal: Chemical research in toxicology20090901
Title: Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam.
Journal: European journal of clinical pharmacology20090401
Title: In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: diiminoquinone formation and conjugation.
Journal: Chemical research in toxicology20090101
Title: Interactions between herbal medicines and prescribed drugs: an updated systematic review.
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Title: Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population.
Journal: BMC medical genetics20090101
Title: Kinetics of omeprazole and escitalopram in relation to the CYP2C19*17 allele in healthy subjects.
Journal: European journal of clinical pharmacology20081201
Title: Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.
Journal: Drug metabolism and disposition: the biological fate of chemicals20081201
Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Journal: Journal of medicinal chemistry20081113
Title: CYP2C19 pharmacogenetics in advanced cancer: compromised function independent of genotype.
Journal: British journal of cancer20081021
Title: Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20080801
Title: Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.
Journal: Drug metabolism and disposition: the biological fate of chemicals20080701
Title: Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical.
Journal: The AAPS journal20080601
Title: Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expression.
Journal: Drug metabolism and disposition: the biological fate of chemicals20080501
Title: Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity.
Journal: European journal of clinical pharmacology20080401
Title: A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens.
Journal: Journal of pharmacokinetics and pharmacodynamics20080401
Title: CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles.
Journal: Drug metabolism and disposition: the biological fate of chemicals20080301
Title: Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
Journal: European journal of clinical pharmacology20080201
Title: Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.
Journal: Journal of pharmacological and toxicological methods20080101
Title: Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model.
Journal: Acta veterinaria Scandinavica20080101
Title: High-throughput radiometric CYP2C19 inhibition assay using tritiated (S)-mephenytoin.
Journal: Drug metabolism and disposition: the biological fate of chemicals20071001
Title: Identification of a novel laser dye substrate of mammalian cytochromes P450: application in rapid kinetic analysis, inhibitor screening, and directed evolution.
Journal: Journal of biomolecular screening20070801
Title: Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070601
Title: Evaluation of 3-O-methylfluorescein as a selective fluorometric substrate for CYP2C19 in human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals20070601
Title: Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
Journal: Fundamental & clinical pharmacology20070601
Title: Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.
Journal: Journal of pharmaceutical and biomedical analysis20070509
Title: Effect of sinomenine on human cytochrome P450 activity.
Journal: Clinica chimica acta; international journal of clinical chemistry20070401
Title: Functional characterization of two novel CYP2C19 variants (CYP2C19*18 and CYP2C19*19) found in a Japanese population.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20070401
Title: Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the 'cocktail' approach.
Journal: Clinical pharmacology and therapeutics20070201
Title: CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20070101
Title: The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications.
Journal: Clinical pharmacokinetics20070101
Title: Evolution and medicine: the long reach of 'Dr. Darwin'.
Journal: Philosophy, ethics, and humanities in medicine : PEHM20070101
Title: In vitro metabolism of tributyltin and triphenyltin by human cytochrome P-450 isoforms.
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Title: The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes.
Journal: Life sciences20061125
Title: Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women.
Journal: Journal of clinical pharmacology20061101
Title: Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes.
Journal: Clinical and experimental pharmacology & physiology20060901
Title: Liver disease selectively modulates cytochrome P450--mediated metabolism.
Journal: Clinical pharmacology and therapeutics20060901
Title: Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
Journal: Clinical pharmacology and therapeutics20060901
Title: CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.
Journal: Molecular pharmacology20060801
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501
Title: Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purification and characterization.
Journal: Journal of biochemistry20060501
Title: Investigation of sarizotan's impact on the pharmacokinetics of probe drugs for major cytochrome P450 isoenzymes: a combined cocktail trial.
Journal: European journal of clinical pharmacology20060401
Title: Enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma and urine by liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM20060101
Title: A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.
Journal: Clinical pharmacology and therapeutics20060101
Title: CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation assayed by high-performance liquid chromatography with radiometric detection.
Journal: Methods in molecular biology (Clifton, N.J.)20060101
Title: Evaluation of the activity of CYP2C19 in Gujrati and Marwadi subjects living in Mumbai (Bombay).
Journal: BMC clinical pharmacology20060101
Title: Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers.
Journal: Drug metabolism and disposition: the biological fate of chemicals20051201
Title: Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis.
Journal: Drug metabolism and disposition: the biological fate of chemicals20051101
Title: Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals20050801
Title: Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population.
Journal: European journal of clinical pharmacology20050801
Title: Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation.
Journal: Journal of clinical pharmacology20050601
Title: Cytochrome P-450 activity is differentially altered in severely injured patients.
Journal: Critical care medicine20050301
Title: Lack of interaction of milnacipran with the cytochrome p450 isoenzymes frequently involved in the metabolism of antidepressants.
Journal: Clinical pharmacokinetics20050101
Title: High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM20050101
Title: Bioequivalence revisited: influence of age and sex on CYP enzymes.
Journal: Clinical pharmacology and therapeutics20041201
Title: Studies of binding modes of (S)-mephenytoin to wild types and mutants of cytochrome P450 2C19 and 2C9 using homology modeling and computational docking.
Journal: Pharmaceutical research20041201
Title: Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors.
Journal: Archives of biochemistry and biophysics20040901
Title: CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals20040901
Title: Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20040901
Title: Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities.
Journal: Drug metabolism and disposition: the biological fate of chemicals20040801
Title: The influence of St John's Wort on CYP2C19 activity with respect to genotype.
Journal: Journal of clinical pharmacology20040601
Title: Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability.
Journal: Journal of clinical pharmacology20040601
Title: Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro.
Journal: Drug metabolism and disposition: the biological fate of chemicals20040601
Title: Validated assays for human cytochrome P450 activities.
Journal: Drug metabolism and disposition: the biological fate of chemicals20040601
Title: Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients.
Journal: Clinical pharmacology and therapeutics20040601
Title: Identification and relative contributions of human cytochrome P450 isoforms involved in the metabolism of glibenclamide and lansoprazole: evaluation of an approach based on the in vitro substrate disappearance rate.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20040501
Title: Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20040501
Title: Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes.
Journal: Life sciences20040416
Title: Key structural features of ligands for activation of human pregnane X receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals20040401
Title: Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1.
Journal: Drug metabolism and pharmacokinetics20040401
Title: Developmental expression of human hepatic CYP2C9 and CYP2C19.
Journal: The Journal of pharmacology and experimental therapeutics20040301
Title: Sex-dependent modulation of treatment response.
Journal: Dialogues in clinical neuroscience20040301
Title: Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6.
Journal: Cellular and molecular neurobiology20040201
Title: Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method.
Journal: Rapid communications in mass spectrometry : RCM20040101
Title: Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.
Journal: The Journal of pharmacology and experimental therapeutics20031201
Title: Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20031201
Title: Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes.
Journal: British journal of clinical pharmacology20031001
Title: Interferon-beta treatment in patients with multiple sclerosis does not alter CYP2C19 or CYP2D6 activity.
Journal: British journal of clinical pharmacology20030901
Title: Capillary electrophoresis to assess drug metabolism induced in vitro using single CYP450 enzymes (Supersomes): application to the chiral metabolism of mephenytoin and methadone.
Journal: Electrophoresis20030801
Title: Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma by liquid chromatography.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20030705
Title: Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.
Journal: Drug metabolism and disposition: the biological fate of chemicals20030701
Title: Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.
Journal: Clinical pharmacology and therapeutics20030701
Title: Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?
Journal: Archives of toxicology20030601
Title: Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19.
Journal: Drug metabolism and disposition: the biological fate of chemicals20030501
Title: Interaction of serum proteins with CYP isoforms in human liver microsomes: inhibitory effects of human and bovine albumin, alpha-globulins, alpha-1-acid glycoproteins and gamma-globulins on CYP2C19 and CYP2D6.
Journal: Life sciences20030314
Title: Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.
Journal: Clinical pharmacology and therapeutics20030301
Title: Verification of the selectivity of (+)N-3-benzylnirvanol as a CYP2C19 inhibitor.
Journal: Drug metabolism and disposition: the biological fate of chemicals20030301
Title: mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20030301
Title: Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Journal: Neuroscience and behavioral physiology20030301
Title: Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review.
Journal: Progress in neuro-psychopharmacology & biological psychiatry20030201
Title: Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20030105
Title: Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
Journal: Archives of biochemistry and biophysics20030101
Title: High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis20030101
Title: Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.
Journal: Rapid communications in mass spectrometry : RCM20030101
Title: In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.
Journal: Drug metabolism and pharmacokinetics20030101
Title: Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.
Journal: Drug metabolism and disposition: the biological fate of chemicals20021201
Title: Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19.
Journal: Epilepsy research20021201
Title: Identification and functional characterization of new potentially defective alleles of human CYP2C19.
Journal: Pharmacogenetics20021201
Title: Japanese pharmaceutical and regulatory environment.
Journal: Dialogues in clinical neuroscience20021201
Title: Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20021125
Title: Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.
Journal: Journal of cardiac failure20021001
Title: An effective anticonvulsant prepared following a host-guest strategy that uses hydroxypropyl-beta-cyclodextrin and benzaldehyde semicarbazone.
Journal: Biochemical and biophysical research communications20020816
Title: Amino acid residues affecting the activities of human cytochrome P450 2C9 and 2C19.
Journal: Drug metabolism and disposition: the biological fate of chemicals20020801
Title: Evidence for environmental influence on CYP2D6-catalysed debrisoquine hydroxylation as demonstrated by phenotyping and genotyping of Ethiopians living in Ethiopia or in Sweden.
Journal: Pharmacogenetics20020701
Title: Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans.
Journal: Clinical pharmacology and therapeutics20020401
Title: CYP2C19 genotype and S-mephenytoin 4'-hydroxylation phenotype in a Chinese Dai population.
Journal: European journal of clinical pharmacology20020401
Title: (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.
Journal: Drug metabolism and disposition: the biological fate of chemicals20020301
Title: Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men.
Journal: Clinical pharmacology and therapeutics20020301
Title: Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
Journal: Biochemical pharmacology20020301
Title: Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes.
Journal: Journal of toxicology and environmental health. Part A20020301
Title: Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Journal: Pharmacology & toxicology20020301
Title: Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
Journal: British journal of clinical pharmacology20020201
Title: Pharmacokinetics and non-analgesic effects of S- and R-ketamines in healthy volunteers with normal and reduced metabolic capacity.
Journal: European journal of clinical pharmacology20020201
Title: The pharmacokinetics of ketobemidone are not affected by CYP2D6 or CYP2C19 phenotype.
Journal: European journal of clinical pharmacology20020201
Title: Cytochrome p450 assays.
Journal: Current protocols in pharmacology20020201
Title: The prevalence of CYP2D6 and CYP2C19 genotypes in a population of healthy Dutch volunteers.
Journal: European journal of clinical pharmacology20011201
Title: Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19.
Journal: Drug metabolism and disposition: the biological fate of chemicals20011101
Title: Assessment of cytochrome P450 activity by a five-drug cocktail approach.
Journal: Clinical pharmacology and therapeutics20011101
Title: An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
Journal: British journal of clinical pharmacology20011101
Title: Clinical relevance of genetic polymorphisms in the human CYP2C subfamily.
Journal: British journal of clinical pharmacology20011001
Title: Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes.
Journal: Drug metabolism and disposition: the biological fate of chemicals20010901
Title: Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram.
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20010801
Title: Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test.
Journal: Therapeutic drug monitoring20010601
Title: CYP2C19 polymorphism is not important for the in vivo metabolism of selegiline.
Journal: European journal of clinical pharmacology20010501
Title: Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra-individual reproducibility and occurrence of adverse events.
Journal: British journal of clinical pharmacology20010501
Title: Moving toward genetic profiling in patient care: the scope and rationale of pharmacogenetic/ecogenetic investigation.
Journal: Drug metabolism and disposition: the biological fate of chemicals20010401
Title: Fluoxetine pharmacokinetics and effect on CYP2C19 in young and elderly volunteers.
Journal: Journal of clinical psychopharmacology20010401
Title: P-hydroxylation of phenobarbital: relationship to (S)-mephenytoin hydroxylation (CYP2C19) polymorphism.
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Title: Metabolic characterization of the major human small intestinal cytochrome p450s.
Journal: Drug metabolism and disposition: the biological fate of chemicals20010301
Title: Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin.
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Title: Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9.
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Title: Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers.
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Title: In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
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Title: Examination of purported probes of human CYP2B6.
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Title: Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations.
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Title: Mechanism of iron potentiation of hepatic uroporphyria: studies in cultured chick embryo liver cells.
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Title: P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
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