Title: Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism.
Journal: Alimentary pharmacology & therapeutics 20120901
Title: High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment.
Journal: Alimentary pharmacology & therapeutics 20120501
Title: Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment.
Journal: Journal of Crohn's & colitis 20120201
Title: Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.
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Title: A validated HPLC method for the monitoring of thiopurine metabolites in whole blood in paediatric patients with inflammatory bowel disease.
Journal: International journal of immunopathology and pharmacology 20120101
Title: Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: a worldwide survey of experts.
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Title: Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series.
Journal: Nucleosides, nucleotides & nucleic acids 20111201
Title: Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine.
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Title: Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS).
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Title: Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease.
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Title: Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.
Journal: Journal of Crohn's & colitis 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine.
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Title: Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence.
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Title: Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis.
Journal: Therapeutic drug monitoring 20100801
Title: Limited stability of thiopurine metabolites in blood samples: relevant in research and clinical practise.
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Title: How should thiopurine treatment be monitored?--methodological aspects.
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Title: Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20100201
Title: Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.
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Title: Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease.
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Title: Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.
Journal: British journal of clinical pharmacology 20081201
Title: Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides.
Journal: European journal of gastroenterology & hepatology 20081201
Title: Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines.
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Title: Stability of thiopurine metabolites: a potential analytical bias.
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Title: Optimizing drug therapy in inflammatory bowel disease.
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Title: 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.
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Title: Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.
Journal: Journal of hepatology 20061001
Title: Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs.
Journal: British journal of clinical pharmacology 20061001
Title: Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.
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Title: Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.
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Title: Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.
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Title: Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
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Title: Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.
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Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.
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Title: Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.
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Title: Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.
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Title: Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy.
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Title: The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease.
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Title: Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.
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Title: Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.
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Title: Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression.
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Title: Mercaptopurine metabolite results in clinical gastroenterology practice.
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Title: Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children.
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Title: 6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment.
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Title: Utility of measuring 6-methylmercaptopurine and 6-thioguanine nucleotide levels in managing inflammatory bowel disease patients treated with 6-mercaptopurine in a clinical practice setting.
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Title: Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning.
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Title: Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.
Journal: Leukemia 20011101
Title: Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.
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Title: Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
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Title: Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.
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Title: Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.
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Title: Thiopurine methyltransferase activity in the erythrocytes of adults and children: and HPLC-linked assay.
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