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500-92-5,MFCD00866201
Catalog No.:AA00DBDN

500-92-5 | Proguanil

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Purity
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5mg
≥98%
in stock  
$69.00   $48.00
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250mg
95%
in stock  
$112.00   $78.00
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1g
95%
in stock  
$261.00   $183.00
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5g
97%
in stock  
$1,000.00   $700.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DBDN
Chemical Name:
Proguanil
CAS Number:
500-92-5
Molecular Formula:
C11H16ClN5
Molecular Weight:
253.7312
MDL Number:
MFCD00866201
SMILES:
CC(NC(=N)NC(=N)Nc1ccc(cc1)Cl)C
Properties
Computed Properties
 
Complexity:
292  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
1.5  

Downstream Synthesis Route

[1]JournaloftheIndianInstituteofScience,SectionA,1947,vol.29,p.12    CurrentScience,1947,vol.16,p.254

[2]Currentscience,1949,vol.18,p.77-77

1482-62-8   
CASUnavailable 
  500-92-5 

[1]Curd;Rose[JournaloftheChemicalSociety,1946,p.729,736]Fernandes;Ganapathi[Proceedings-IndianAcademyofSciences,SectionA,1948,vol.28,p.567][Chem.Abstr.,1949,p.5746]

[2]Bechli;Ufimzew;Toptschiew[ZhurnalPrikladnoiKhimii,1947,vol.20,p.591,595][Chem.Abstr.,1949,p.3793]

[3]CurrentPatentAssignee:AKZONOBELNV-DE815487,1951,C[DRP/DRBPOrg.Chem.][DRP/DRBPOrg.Chem.]

[4]CurrentPatentAssignee:USVLTD.-WO2009/113092,2009,A2Locationinpatent:Page/Pagecolumn16-17

[5]CurrentPatentAssignee:USVLTD.-WO2009/113092,2009,A2Locationinpatent:Page/Pagecolumn17

CASUnavailable 
  500-92-5 

[1]Birtwelletal.[JournaloftheChemicalSociety,1948,p.1650]

500-92-5   
CASUnavailable 

[1]Spacu,P.;Gheorghiu,C.[RevueRoumainedeChimie,1967,vol.12,p.1459-1468][GmelinHandbuchderAnorganischenChemie,GmelinHandbook:Ru:SVol.,172,page467-469]

500-92-5   
CASUnavailable 

[1]Spacu,P.;Gheorghiu,C.[RevueRoumainedeChimie,1967,vol.12,p.1459-1468][GmelinHandbuchderAnorganischenChemie,GmelinHandbook:Ru:SVol.,172,page467-469]

Literature

Title: Quinolone-3-diarylethers: a new class of antimalarial drug.

Journal: Science translational medicine 20130320

Title: Efficacy and safety of atovaquone-proguanil in treating imported malaria in Japan: the second report from the research group.

Journal: Parasitology international 20120901

Title: A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. vivax.

Journal: The Journal of infection 20120901

Title: Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene.

Journal: Parasitology international 20120601

Title: Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.

Journal: The Journal of pharmacology and experimental therapeutics 20120601

Title: Standby emergency treatment of malaria in travelers: experience to date and new developments.

Journal: Expert review of anti-infective therapy 20120501

Title: Dosing rationale for fixed-dose combinations in children: shooting from the hip?

Journal: Clinical pharmacology and therapeutics 20120401

Title: Bridging strategies for drug combinations in pediatric indications.

Journal: Clinical pharmacology and therapeutics 20120401

Title: Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.

Journal: The Journal of biological chemistry 20120323

Title: Mosquito infection studies with Aotus monkeys and humans infected with the Chesson strain of Plasmodiun vivax.

Journal: The American journal of tropical medicine and hygiene 20120301

Title: Anti-malarial chemoprophylaxis following evacuation from Afghanistan.

Journal: Journal of the Royal Army Medical Corps 20120301

Title: Prolonged protection provided by a single dose of atovaquone-proguanil for the chemoprophylaxis of Plasmodium falciparum malaria in a human challenge model.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120115

Title: Randomized, prospective, three-arm study to confirm the auditory safety and efficacy of artemether-lumefantrine in Colombian patients with uncomplicated Plasmodium falciparum malaria.

Journal: The American journal of tropical medicine and hygiene 20120101

Title: Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria.

Journal: Malaria journal 20120101

Title: Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study.

Journal: Malaria journal 20120101

Title: A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria.

Journal: PloS one 20120101

Title: Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia.

Journal: PloS one 20120101

Title: Review: Malaria chemoprophylaxis for travelers to Latin America.

Journal: The American journal of tropical medicine and hygiene 20111201

Title: Malaria therapy in HIV: drug interactions between nevirapine and quinine.

Journal: International journal of STD & AIDS 20111201

Title: [Atovaquone-proguanil treatment failure in Plasmodium falciparum].

Journal: Presse medicale (Paris, France : 1983) 20111101

Title: Pharmacokinetics of antimalarials in pregnancy: a systematic review.

Journal: Clinical pharmacokinetics 20111101

Title: Prophylactic use of antimalarials during pregnancy.

Journal: Canadian family physician Medecin de famille canadien 20111101

Title: Prolonged administration of proguanil induces reproductive toxicity in male rats.

Journal: The Journal of toxicological sciences 20111001

Title: Community management of anti-malarials in Africa and iatrogenic risk.

Journal: Journal of tropical pediatrics 20110601

Title: Severe hypersensitivity reaction as acute eosinophilic pneumonia and skin eruption induced by proguanil.

Journal: The European respiratory journal 20110601

Title: Improvements in compliance with medical force protection measures by simplification of the anti-malarial chemoprophylaxis regime.

Journal: Journal of the Royal Army Medical Corps 20110601

Title: Exploring QSAR, pharmacophore mapping and docking studies and virtual library generation for cycloguanil derivatives as PfDHFR-TS inhibitors.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20110501

Title: Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets.

Journal: Journal of pharmaceutical and biomedical analysis 20110220

Title: Azithromycin for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20110216

Title: Atovaquone-proguanil use in early pregnancy and the risk of birth defects.

Journal: Archives of internal medicine 20110214

Title: [Post-malaria neurological syndrome complicating a relapse of Plasmodium falciparum malaria after atovaquone-proguanil treatment].

Journal: Medecine et maladies infectieuses 20110101

Title: Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.

Journal: Malaria journal 20110101

Title: Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum.

Journal: PloS one 20110101

Title: Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia.

Journal: PloS one 20110101

Title: Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.

Journal: Malaria journal 20110101

Title: Antimalarial chemoprophylaxis in a deployed Naval Unit.

Journal: Journal of the Royal Naval Medical Service 20110101

Title: [Duodenal ulcers caused by chloroquine-proguanil association].

Journal: Medecine tropicale : revue du Corps de sante colonial 20101201

Title: Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.

Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20101001

Title: The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics.

Journal: Lancet (London, England) 20100828

Title: Pancytopenia due to proguanil toxicity in a returning traveller with fever.

Journal: European journal of clinical pharmacology 20100801

Title: Do 5-fluorouracil therapies alter CYP2C19 metaboliser status?

Journal: Cancer chemotherapy and pharmacology 20100701

Title: Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.

Journal: AIDS (London, England) 20100515

Title: Letter to the editor of travel medicine and infectious disease.

Journal: Travel medicine and infectious disease 20100501

Title: Quantitative structure-activity relationships for cycloguanil analogs as PfDHFR inhibitors using mathematical molecular descriptors.

Journal: SAR and QSAR in environmental research 20100401

Title: Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population.

Journal: Journal of evolutionary biology 20100301

Title: Alteration of pharmacokinetics of proguanil in healthy volunteers following concurrent administration of efavirenz.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100219

Title: Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: identification of potential leads for P. falciparum DHFR enzyme inhibition.

Journal: Chemical biology & drug design 20100101

Title: Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants.

Journal: PloS one 20100101

Title: Intermittent preventive treatment in infants for the prevention of malaria in rural Western kenya: a randomized, double-blind placebo-controlled trial.

Journal: PloS one 20100101

Title: Alternatives for malaria prophylaxis during the first trimester of pregnancy: our personal view.

Journal: Journal of travel medicine 20100101

Title: Assessment of adherence to atovaquone-proguanil prophylaxis in travelers.

Journal: Journal of travel medicine 20100101

Title: Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.

Journal: Malaria journal 20100101

Title: Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface.

Journal: Analytical chemistry 20091215

Title: Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria.

Journal: The American journal of tropical medicine and hygiene 20091201

Title: 3D-QSAR analysis of cycloguanil derivatives as inhibitors of A16V + S108T mutant Plasmodium falciparum dihydrofolate reductase enzyme.

Journal: Journal of molecular graphics & modelling 20091101

Title: Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: retrospective observational data.

Journal: Travel medicine and infectious disease 20091101

Title: Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.

Journal: Lancet (London, England) 20091031

Title: Mefloquine has more adverse effects than other drugs for malaria prophylaxis.

Journal: BMJ (Clinical research ed.) 20091013

Title: Drugs for preventing malaria in travellers.

Journal: The Cochrane database of systematic reviews 20091007

Title: Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.

Journal: European journal of clinical pharmacology 20091001

Title: Plasmodium relictum (lineage P-SGS1): Further observation of effects on experimentally infected passeriform birds, with remarks on treatment with Malarone.

Journal: Experimental parasitology 20091001

Title: Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090915

Title: Drug impurity profiling by capillary electrophoresis/mass spectrometry using various ionization techniques.

Journal: Rapid communications in mass spectrometry : RCM 20090901

Title: Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.

Journal: Pharmacogenomics 20090901

Title: Structure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors.

Journal: Journal of chemical information and modeling 20090701

Title: Atovaquone + proguanil: new indication. For children weighing as little as 5 kg; an inconvenient form. A flavoured syrup would be better suited to infants and young children.

Journal: Prescrire international 20090601

Title: Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases.

Journal: Journal of computer-aided molecular design 20090401

Title: A novel in silico approach to drug discovery via computational intelligence.

Journal: Journal of chemical information and modeling 20090401

Title: [Fever in returning travellers].

Journal: Praxis 20090318

Title: Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria.

Journal: The American journal of tropical medicine and hygiene 20090201

Title: Evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study.

Journal: Journal of travel medicine 20090101

Title: Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.

Journal: PloS one 20090101

Title: Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.

Journal: PloS one 20090101

Title: Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.

Journal: Malaria journal 20090101

Title: Influence of the genetic polymorphisms in the 5' flanking and exonic regions of CYP2C19 on proguanil oxidation.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents.

Journal: Bioorganic & medicinal chemistry letters 20081215

Title: Bone marrow aplasia following acute poisoning with chloroquine-proguanil.

Journal: Clinical toxicology (Philadelphia, Pa.) 20081201

Title: Well-tolerated chemoprophylaxis uniformly prevented Swedish soldiers from Plasmodium falciparum malaria in Liberia, 2004-2006.

Journal: Military medicine 20081201

Title: Bullous erythema multiforme after treatment with Malarone, a combination antimalarial composed of atovaquone and proguanil hydrochloride.

Journal: Tropical doctor 20080701

Title: Atovaquone-proguanil resistance in imported falciparum malaria in a young child.

Journal: The Pediatric infectious disease journal 20080601

Title: Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.

Journal: Parasitology research 20080501

Title: A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20080501

Title: Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon.

Journal: Travel medicine and infectious disease 20080501

Title: Artemether + lumefantrine: new drug. An alternative to atovaquone + proguanil.

Journal: Prescrire international 20080401

Title: A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda.

Journal: Journal of infection in developing countries 20080401

Title: [Tolerance and efficacy of atovaquone-proguanil for the treatment of paediatric imported Plasmodium falciparum malaria in France: clinical practice in a university hospital in Paris].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080301

Title: Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201

Title: Plasmodium falciparum malaria and atovaquone-proguanil treatment failure.

Journal: Emerging infectious diseases 20080201

Title: An investigation into the native-like properties of de novo designed cavitand-based four-helix bundle proteins.

Journal: Biopolymers 20080101

Title: In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.

Journal: Malaria journal 20080101

Title: Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria.

Journal: PloS one 20080101

Title: Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia.

Journal: Malaria journal 20080101

Title: An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.

Journal: PloS one 20080101

Title: Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial.

Journal: Malaria journal 20080101

Title: Trends in antimalarial prescriptions in Australia 2002 to 2005.

Journal: Journal of travel medicine 20080101

Title: Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil.

Journal: Malaria journal 20080101

Title: Pharmacodynamic interaction between monodesbutyl-benflumetol and artemisinin as well as proguanil in Plasmodium falciparum in vitro.

Journal: Wiener klinische Wochenschrift 20080101

Title: High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.

Journal: PloS one 20080101

Title: Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071215

Title: The risk of antimalarials in patients with renal failure.

Journal: Postgraduate medical journal 20071201

Title: Inadequate chemoprophylaxis and the risk of malaria.

Journal: Australian family physician 20071201

Title: Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.

Journal: The American journal of tropical medicine and hygiene 20071201

Title: Selective ambulatory management of Plasmodium falciparum malaria in paediatric refugees.

Journal: Archives of disease in childhood 20071101

Title: A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria.

Journal: The Journal of antimicrobial chemotherapy 20071101

Title: Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.

Journal: Clinical pharmacology and therapeutics 20071101

Title: Clinical efficacy of antiparasite treatments against intestinal helminths and haematic protozoa in Gallotia caesaris (lizards).

Journal: Experimental parasitology 20070801

Title: Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.

Journal: Molecular biology and evolution 20070801

Title: The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.

Journal: International journal for parasitology 20070601

Title: Chloroquine-resistant Plasmodium falciparum infections among UK travellers returning with malaria after chloroquine prophylaxis.

Journal: The Journal of antimicrobial chemotherapy 20070601

Title: Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial.

Journal: JAMA 20070523

Title: Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers.

Journal: Basic & clinical pharmacology & toxicology 20070401

Title: Quality evaluation of chloroquine, quinine, sulfadoxine-pyrimethamine and proguanil formulations sold on the market in East Congo DR.

Journal: Journal of clinical pharmacy and therapeutics 20070401

Title: Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand.

Journal: The American journal of tropical medicine and hygiene 20070401

Title: Cerebral malaria in spite of peripheral parasite clearance in a patient treated with atovaquone/proguanil.

Journal: Parasitology research 20070301

Title: Analyses of cytochrome b mutations in Plasmodium falciparum isolates in Thai-Myanmar border.

Journal: Travel medicine and infectious disease 20070301

Title: Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Journal: Nature 20070301

Title: Simultaneous determination of monodesethylchloroquine, chloroquine, cycloguanil and proguanil on dried blood spots by reverse-phase liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20070219

Title: Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II).

Journal: The American journal of tropical medicine and hygiene 20070201

Title: The safety and tolerance of atovaquone/proguanil for the long-term prophylaxis of plasmodium falciparum malaria in non-immune travelers and expatriates [corrected].

Journal: Journal of travel medicine 20070101

Title: Hodgkin lymphoma in a child with sickle cell anemia.

Journal: Pediatric hematology and oncology 20070101

Title: A man with tropical travel history, fever, and pulmonary infiltrates.

Journal: Comprehensive therapy 20070101

Title: Relapsing vivax malaria after 6 months of daily atovaquone/proguanil in Afghanistan: the case for expanded use of primaquine as a causal prophylactic.

Journal: Journal of travel medicine 20070101

Title: Outpatient treatment of malaria in recently arrived African migrants.

Journal: The Medical journal of Australia 20061201

Title: A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children.

Journal: Tropical medicine & international health : TM & IH 20061101

Title: Plasmodium falciparum malaria associated with mefloquine failure in Gambia.

Journal: Pharmacotherapy 20061001

Title: Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs.

Journal: The American journal of tropical medicine and hygiene 20061001

Title: Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061001

Title: Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.

Journal: Microbes and infection 20060901

Title: Randomized, double-blind, placebo-controlled study of Malarone for malaria prophylaxis in non-immune Colombian soldiers.

Journal: The American journal of tropical medicine and hygiene 20060901

Title: Evaluation of the bio-efficacy of three brands of repellents against wild populations of anthropophilic mosquitoes.

Journal: Tanzania health research bulletin 20060901

Title: Resisting resistance: dealing with the irrepressible problem of malaria.

Journal: British journal of clinical pharmacology 20060601

Title: Folic acid treatment of Zambian children with moderate to severe malaria anemia.

Journal: The American journal of tropical medicine and hygiene 20060601

Title: Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.

Journal: European journal of clinical pharmacology 20060501

Title: Efficacy of chloroquine-proguanil malaria prophylaxis in a non-immune population in Bangui, Central African Republic: a case-control study.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20060401

Title: [Malaria: a medical and economic problem].

Journal: Presse medicale (Paris, France : 1983) 20060401

Title: [Retrospective analysis of 107 imported adult cases of malaria. Experience report of uncomplicated falciparum malaria treatment in adults with oral atovaquone-proguanil].

Journal: Presse medicale (Paris, France : 1983) 20060401

Title: Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy.

Journal: Acta tropica 20060301

Title: Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.

Journal: British journal of clinical pharmacology 20060301

Title: Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

Title: Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.

Journal: The Journal of antimicrobial chemotherapy 20060101

Title: [Cytochrome P-450 and the response to antimalarial drugs].

Journal: Revista panamericana de salud publica = Pan American journal of public health 20060101

Title: Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola.

Journal: Malaria journal 20060101

Title: Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.

Journal: Malaria journal 20060101

Title: [Severe imported malaria. The experience of the military hospital of Marrakech].

Journal: Annales de biologie clinique 20060101

Title: Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis.

Journal: Journal of travel medicine 20060101

Title: Molecular surveillance of mutations in the cytochrome b gene of Plasmodium falciparum in Gabon and Ethiopia.

Journal: Malaria journal 20060101

Title: Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro.

Journal: Wiener klinische Wochenschrift 20060101

Title: [Severe imported malaria: the experience of the Avicenna military hospital of Marrakech].

Journal: Sante (Montrouge, France) 20060101

Title: Atovaquone/proguanil for the prophylaxis and treatment of malaria.

Journal: Expert review of anti-infective therapy 20051201

Title: Malaria: prevention in travellers.

Journal: Clinical evidence 20051201

Title: Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.

Journal: Experimental parasitology 20051101

Title: [Ineffective change of antimalaria prophylaxis to Artemisia vulgaris in a group travelling to West Africa].

Journal: Ugeskrift for laeger 20051024

Title: Atovaquone-proguanil for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20051019

Title: [Malaria chemoprophylaxis].

Journal: Ugeskrift for laeger 20051017

Title: [Malaria prophylaxis for long-term travellers and expatriates].

Journal: Ugeskrift for laeger 20051017

Title: A simple dual selection for functionally active mutants of Plasmodium falciparum dihydrofolate reductase with improved solubility.

Journal: Protein engineering, design & selection : PEDS 20051001

Title: Susceptibility studies of Malaysian Plasmodium falciparum clones to type II antifolate drugs after 3 years of continuous in vitro culture.

Journal: Chemotherapy 20051001

Title: The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.

Journal: European journal of clinical pharmacology 20050901

Title: A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy.

Journal: The Journal of infectious diseases 20050901

Title: Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo.

Journal: Basic & clinical pharmacology & toxicology 20050901

Title: Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil.

Journal: International journal of antimicrobial agents 20050801

Title: Short report: no evidence of cardiotoxicity of atovaquone-proguanil alone or in combination with artesunate.

Journal: The American journal of tropical medicine and hygiene 20050801

Title: Effectiveness of antimalarial drugs.

Journal: The New England journal of medicine 20050728

Title: Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni.

Journal: Molecular and biochemical parasitology 20050701

Title: The chemotherapy of rodent malaria. LXIII. Drug combinations to impede the selection of drug resistance, part 6: the potential value of chlorproguanil and dapsone in combination, and with the addition of artesunate.

Journal: Annals of tropical medicine and parasitology 20050701

Title: Occult Plasmodium vivax infection diagnosed by a polymerase chain reaction-based detection system: a case report.

Journal: The American journal of tropical medicine and hygiene 20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Malaria: uncomplicated, caused by Plasmodium falciparum.

Journal: Clinical evidence 20050601

Title: In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.

Journal: Journal of medicinal chemistry 20050421

Title: Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa.

Journal: The American journal of tropical medicine and hygiene 20050401

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Title: Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents.

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Title: A malaria outbreak following a British military deployment to Sierra Leone.

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Title: Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil.

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Journal: Journal of chromatographic science 20050101

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Journal: Journal of travel medicine 20050101

Title: Acute hepatitis and atovaquone/proguanil.

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Title: Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe.

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Journal: Lancet (London, England) 20041101

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Title: Chlorproguanil-dapsone for malaria in Africa.

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Title: Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial.

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Title: Malaria: prevention in travellers.

Journal: Clinical evidence 20040601

Title: Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.

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Title: A malaria outbreak following a British military deployment to Sierra Leone.

Journal: The Journal of infection 20040201

Title: CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.

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Title: Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.

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Title: Susceptibility of Plasmodium falciparum to the drugs used to treat severe malaria (quinine) and to prevent malaria (mefloquine, cycloguanil) in Comoros Union and Madagascar.

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Title: Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark.

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Title: Long-term malaria prophylaxis for travelers.

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Title: Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children.

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Title: Military aviators, special operations forces, and causal malaria prophylaxis.

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Title: Malaria: prevention in travellers.

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Title: Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia.

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Title: Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil.

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Title: DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy.

Journal: The Journal of antimicrobial chemotherapy 20030701

Title: Stevens-Johnson syndrome associated with Malarone antimalarial prophylaxis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030701

Title: The impact of Malarone and primaquine on psychomotor performance.

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Title: The development of Lapdap, an affordable new treatment for malaria.

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Title: Atovaquone/proguanil: a review of its use for the prophylaxis of Plasmodium falciparum malaria.

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Journal: Scandinavian journal of infectious diseases 20030101

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Tags:500-92-5 Molecular Formula|500-92-5 MDL|500-92-5 SMILES|500-92-5 Proguanil