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501684-93-1,MFCD11100189
Catalog No.:AA00DGQE

501684-93-1 | NS 1738

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $11.00
- +
5mg
98%
in stock  
$38.00   $27.00
- +
10mg
98%
in stock  
$53.00   $37.00
- +
25mg
98%
in stock  
$89.00   $62.00
- +
50mg
98%
in stock  
$123.00   $86.00
- +
100mg
98%
in stock  
$189.00   $132.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DGQE
Chemical Name:
NS 1738
CAS Number:
501684-93-1
Molecular Formula:
C14H9Cl2F3N2O2
Molecular Weight:
365.1347
MDL Number:
MFCD11100189
SMILES:
O=C(Nc1cc(Cl)ccc1O)Nc1cc(ccc1Cl)C(F)(F)F
NSC Number:
213859
Properties
Properties
 
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
425  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
4.3  

Downstream Synthesis Route

[1]Patent:WO2005/92843,2005,A1.Locationinpatent:Page/Pagecolumn18

501684-93-1   
N-(3,5-dichloro-6-hydroxy-phenyl)-N'-(2-chloro-5-trifluoromethyl-phenyl)urea 

[1]Patent:WO2005/92843,2005,A1.Locationinpatent:Page/Pagecolumn19

501684-93-1   
N-(3-bromo-5-chloro-2-hydroxy-phenyl)-N'-(2-chloro-5-trifluoromethyl-phenyl)urea 

[1]Patent:WO2005/92843,2005,A1.Locationinpatent:Page/Pagecolumn19-20

Literature

Title: Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.

Journal: Neuropharmacology 20111201

Title: Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.

Journal: Biochemical pharmacology 20091001

Title: In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.

Journal: The Journal of pharmacology and experimental therapeutics 20090701

Title: Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology.

Journal: Journal of neuroscience methods 20090215

Title: Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment.

Journal: Molecular pharmacology 20081101

Title: Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.

Journal: Journal of medicinal chemistry 20080227

Title: An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20071001

Title: Timmermann DB, et al. An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307.

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SDS
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