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50335-03-0,MFCD31380758
Catalog No.:AA00D7WH

50335-03-0 | CHAETOGLOBOSIN A

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1mg
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5mg
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  • Technical Information
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Technical Information
Catalog Number:
AA00D7WH
Chemical Name:
CHAETOGLOBOSIN A
CAS Number:
50335-03-0
Molecular Formula:
C32H36N2O5
Molecular Weight:
528.6386
MDL Number:
MFCD31380758
SMILES:
C[C@H]1C/C=C/[C@H]2[C@@H]3O[C@]3(C)[C@H]([C@@H]3[C@]2(C(=O)N[C@H]3Cc2c[nH]c3c2cccc3)C(=O)/C=C/C(=O)[C@@H](/C(=C/1)/C)O)C C32H36N2O5
Properties
Computed Properties
 
Complexity:
1140  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
3.7  

Literature

Title: Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.

Journal: Journal of the American Chemical Society 20130515

Title: Electrospray ionization tandem mass spectrometry of chaetoglobosins.

Journal: Rapid communications in mass spectrometry : RCM 20120930

Title: Chaetoglobosin Vb from endophytic Chaetomium globosum: absolute configuration of chaetoglobosins.

Journal: Chirality 20120801

Title: Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215

Title: Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action.

Journal: Chemical communications (Cambridge, England) 20110227

Title: The possible role of fungal contamination in sick building syndrome.

Journal: Frontiers in bioscience (Elite edition) 20110101

Title: Chaetoglobosin Fex from the marine-derived endophytic fungus inhibits induction of inflammatory mediators via Toll-like receptor 4 signaling in macrophages.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum.

Journal: Planta medica 20101101

Title: Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01.

Journal: Archives of pharmacal research 20100801

Title: Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14.

Journal: Journal of natural products 20100423

Title: Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: Protective effect of the natural product, chaetoglobosin K, on lindane- and dieldrin-induced changes in astroglia: identification of activated signaling pathways.

Journal: Pharmaceutical research 20080601

Title: Heat stability of chaetoglobosins A and C.

Journal: Canadian journal of microbiology 20080501

Title: Growth and mycotoxin production by Chaetomium globosum.

Journal: Mycopathologia 20070701

Title: Inhibition of cytokinesis and akt phosphorylation by chaetoglobosin K in ras-transformed epithelial cells.

Journal: Cancer chemotherapy and pharmacology 20060601

Title: Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019.

Journal: Journal of natural products 20060201

Title: Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.

Journal: Journal of natural products 20051101

Title: Chaetoglobosins Q, R, and T, three further new metabolites from Chaetomium globosum.

Journal: Journal of natural products 20041001

Title: Penicillium expansum: consistent production of patulin, chaetoglobosins, and other secondary metabolites in culture and their natural occurrence in fruit products.

Journal: Journal of agricultural and food chemistry 20040421

Title: Mycotoxin production by indoor molds.

Journal: Fungal genetics and biology : FG & B 20030701

Title: Prevention of organochlorine-induced inhibition of gap junctional communication by chaetoglobosin K in astrocytes.

Journal: Cell biology and toxicology 20010101

Title: Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28(6):1289-98.

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Tags:50335-03-0 Molecular Formula|50335-03-0 MDL|50335-03-0 SMILES|50335-03-0 CHAETOGLOBOSIN A