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508-75-8,MFCD00069477
Catalog No.:AA00D8NV

508-75-8 | CONVALLATOXIN

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5mg
98%
1 week  
$685.00   $480.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00D8NV
Chemical Name:
CONVALLATOXIN
CAS Number:
508-75-8
Molecular Formula:
C29H42O10
Molecular Weight:
550.6378
MDL Number:
MFCD00069477
SMILES:
O=C[C@@]12CC[C@@H](C[C@@]2(O)CC[C@@H]2[C@@H]1CC[C@]1([C@]2(O)CC[C@@H]1C1=CC(=O)OC1)C)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
1050  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
13  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
4  
XLogP3:
-0.7  

Literature

Title: Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle.

Journal: Antiviral research 20150101

Title: 'The Lower Threshold' phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis?

Journal: Journal of carcinogenesis 20120101

Title: Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.

Journal: Journal of natural products 20091101

Title: Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.

Journal: Journal of natural products 20090522

Title: [Effects of digoxin and corglycon on ion currents in neuronal membrane of snail (Lymnaea stagnalis)].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20080101

Title: Cardenolides from Saussurea stella with cytotoxicity toward cancer cells.

Journal: Journal of natural products 20070901

Title: The positive inotropic effect of the aqueous extract of Convallaria keiskei in beating rabbit atria.

Journal: Life sciences 20060815

Title: Li MY, et al. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ. Pharmacol Res. 2019 Sep;147:104355.

Title: Gozalpour E, et al. Convallatoxin: a new P-glycoprotein substrate. Eur J Pharmacol. 2014 Dec 5;744:18-27.

Title: Chao PK, et al. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice. Sci Rep. 2019 Feb 20;9(1):2405.

Title: Jiang BW, et al. Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. Biomed Pharmacother. 2020 Jan;121:109615.

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Tags:508-75-8 Molecular Formula|508-75-8 MDL|508-75-8 SMILES|508-75-8 CONVALLATOXIN