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5080-50-2,MFCD00082230
Catalog No.:AA003TCO

5080-50-2 | O-Acetyl-L-carnitine HCl

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1g
98%
in stock  
$24.00   $17.00
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5g
97%
in stock  
$29.00   $20.00
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25g
97%
in stock  
$42.00   $29.00
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100g
97%
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$95.00   $67.00
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500g
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$261.00   $183.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003TCO
Chemical Name:
O-Acetyl-L-carnitine HCl
CAS Number:
5080-50-2
Molecular Formula:
C9H18ClNO4
Molecular Weight:
239.6965
MDL Number:
MFCD00082230
SMILES:
[O-]C(=O)C[C@@H](C[N+](C)(C)C)OC(=O)C.Cl
NSC Number:
747431
Properties
Properties
 
Form:
Solid  
MP:
194 °C  
Refractive Index:
-28 ° (C=1, H2O)  
Solubility:
H2O: 100 mg/mL  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
219  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  

Downstream Synthesis Route

[1]JournalofOrganicChemistry,1991,vol.56,p.3752-3755

[1]JournalofOrganicChemistry,1986,vol.51,p.2842-2844

[1]Patent:CN104177271,2016,B.Locationinpatent:Paragraph0059;0060;0061;0062

[2]HelveticaChimicaActa,1987,vol.70,p.2058-2064

[1]Krimberg;Wittandt[BiochemischeZeitschrift,1932,vol.251,p.229]Strack;Woerdehoff;Schwaneberg[Hoppe-Seyler'sZeitschriftfurPhysiologischeChemie,1936,vol.238,p.189]

Literature

Title: Acetyl L-carnitine targets adenosine triphosphate synthase in protecting zebrafish embryos from toxicities induced by verapamil and ketamine: An in vivo assessment.

Journal: Journal of applied toxicology : JAT 20170201

Title: Effect of Acetyl-L-Carnitine on Antioxidant Status, Lipid Peroxidation, and Oxidative Damage of Arsenic in Rat.

Journal: Biological trace element research 20160501

Title: Prophylactic and Therapeutic Potential of Acetyl-L-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice.

Journal: Journal of biochemical and molecular toxicology 20160101

Title: Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC-MS based metabolomics study.

Journal: Toxicology 20151002

Title: Acetyl-L-carnitineameliorates mitochondrial damage and apoptosis following spinal cord injury in rats.

Journal: Neuroscience letters 20150914

Title: ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain.

Journal: Neurotoxicology 20150101

Title: Skeletal muscle ¹H MRSI before and after prolonged exercise. II. visibility of free carnitine.

Journal: Magnetic resonance in medicine 20121101

Title: Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis.

Journal: Chemistry & biodiversity 20121001

Title: Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice.

Journal: Neurochemistry international 20120901

Title: Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans.

Journal: Therapeutic drug monitoring 20120801

Title: Identification of human plasma metabolites exhibiting time-of-day variation using an untargeted liquid chromatography-mass spectrometry metabolomic approach.

Journal: Chronobiology international 20120801

Title: Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.

Journal: Free radical biology & medicine 20120715

Title: Neurophysiological and morphological responses to treatment with acetyl-L-carnitine in a sciatic nerve injury model: preliminary data.

Journal: The Journal of hand surgery, European volume 20120701

Title: The acetylcholinesterase inhibitors competitively inhibited an acetyl L-carnitine transport through the blood-brain barrier.

Journal: Neurochemical research 20120701

Title: Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice.

Journal: Neurochemistry international 20120701

Title: Re: Karsidag S, Akcal A, Sahin S, et al. Neurophysiological and morphological responses to treatment with acetyl-L-carnitine in a sciatic nerve injury model: preliminary data. J Hand Surg Eur. 2012, 37: 529-536.

Journal: The Journal of hand surgery, European volume 20120701

Title: Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery.

Journal: Neuroscience 20120517

Title: Carnitine for fatigue in multiple sclerosis.

Journal: The Cochrane database of systematic reviews 20120516

Title: Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.

Journal: Cell metabolism 20120502

Title: Drug treatment for spinal muscular atrophy types II and III.

Journal: The Cochrane database of systematic reviews 20120418

Title: Acetyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2-regulated mitochondrial biosynthesis.

Journal: Hippocampus 20120401

Title: Inhibition of OCTN2-mediated transport of carnitine by etoposide.

Journal: Molecular cancer therapeutics 20120401

Title: Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor-γ coactivators PGC-1α/PGC-1β-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver.

Journal: Rejuvenation research 20120401

Title: Biochemical and genetic alterations of oxidant/antioxidant status of the brain in rats treated with dexamethasone: protective roles of melatonin and acetyl-L-carnitine.

Journal: Journal of physiology and biochemistry 20120301

Title: The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease.

Journal: Biochimica et biophysica acta 20120301

Title: The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.

Journal: Circulation. Cardiovascular imaging 20120301

Title: Carnitine derivatives: clinical usefulness.

Journal: Current opinion in gastroenterology 20120301

Title: In vivo clinical measures of intermediary metabolism are inadequate: can a new magnetic resonance spectroscopy technology do better?

Journal: Circulation. Cardiovascular imaging 20120301

Title: Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy.

Journal: Pharmacology, biochemistry, and behavior 20120101

Title: Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent.

Journal: Journal of andrology 20120101

Title: Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.

Journal: Molecular genetics and metabolism 20120101

Title: Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment.

Journal: Hearing research 20120101

Title: Protective effects of acetyl-L-carnitine on neurodegenarative changes in chronic cerebral ischemia models and learning-memory impairment in aged rats.

Journal: Archives of pharmacal research 20120101

Title: Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.

Journal: Mechanisms of ageing and development 20120101

Title: Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro.

Journal: International journal of molecular sciences 20120101

Title: Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats.

Journal: PloS one 20120101

Title: Deciphering the potential efficacy of acetyl-L-carnitine (ALCAR) in maintaining connexin-mediated lenticular homeostasis.

Journal: Molecular vision 20120101

Title: Stability of carboplatin, paclitaxel, and docetaxel with acetyl-l-carnitine during simulated Y-site administration.

Journal: International journal of pharmaceutical compounding 20120101

Title: Stability of acetyl-1-carnitine in 5% dextrose using a high-performance liquid chromatography-mass spectrometry times 2 method.

Journal: International journal of pharmaceutical compounding 20120101

Title: Drug treatment for spinal muscular atrophy types II and III.

Journal: The Cochrane database of systematic reviews 20111207

Title: Acetyl-L-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats.

Journal: Journal of physiology and biochemistry 20111201

Title: Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.

Journal: Metabolic brain disease 20111201

Title: Acetyl-L-carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities.

Journal: Rejuvenation research 20111201

Title: Quantitative tandem mass spectrometric imaging of endogenous acetyl-L-carnitine from piglet brain tissue using an internal standard.

Journal: Analytical chemistry 20111115

Title: Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression.

Journal: Psychopharmacology 20111101

Title: The nerve injury and the dying neurons: diagnosis and prevention.

Journal: The Journal of hand surgery, European volume 20111101

Title: Protective effect of acetyl-l-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes.

Journal: Toxicology 20111028

Title: Rat liver mitochondrial proteome: changes associated with aging and acetyl-L-carnitine treatment.

Journal: Journal of proteomics 20111019

Title: Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach.

Journal: Free radical biology & medicine 20111015

Title: Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C.

Journal: Journal of neurochemistry 20110901

Title: Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet.

Journal: Molecular nutrition & food research 20110901

Title: The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-α 2b plus ribavirin.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20110901

Title: Effect of in vivo L-acetylcarnitine administration on ATP-ases enzyme systems of synaptic plasma membranes from rat cerebral cortex.

Journal: Neurochemical research 20110801

Title: Modulation of myelin basic protein gene expression by acetyl-L-carnitine.

Journal: Molecular neurobiology 20110801

Title: Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): a systematic review of the evidence.

Journal: Complementary therapies in medicine 20110801

Title: [Roles of PYK2 and caveolin-1 in alcoholic cardiomyopathy and the effect of drug intervention].

Journal: Zhonghua yi xue za zhi 20110614

Title: Role of mitochondria in the maintenance of platelet function during in vitro storage.

Journal: Transfusion medicine (Oxford, England) 20110601

Title: Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20110601

Title: Acetyl-L-carnitine as an adjunctive therapy in the treatment of attention-deficit/hyperactivity disorder in children and adolescents: a placebo-controlled trial.

Journal: Child psychiatry and human development 20110601

Title: Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.

Journal: Scandinavian journal of gastroenterology 20110601

Title: Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes.

Journal: Investigative ophthalmology & visual science 20110501

Title: Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea.

Journal: Journal of endocrinological investigation 20110401

Title: Inhibitory effects of alcohol on glucose transport across the blood-brain barrier leads to neurodegeneration: preventive role of acetyl-L: -carnitine.

Journal: Psychopharmacology 20110401

Title: Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells.

Journal: Toxicology and industrial health 20110401

Title: Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function.

Journal: Neurotoxicity research 20110201

Title: Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain.

Journal: Developmental neuroscience 20110201

Title: Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies.

Journal: European journal of pharmacology 20110110

Title: Noninvasive assessment of exercise-related intramyocellular acetylcarnitine in euglycemia and hyperglycemia in patients with type 1 diabetes using ¹H magnetic resonance spectroscopy: a randomized single-blind crossover study.

Journal: Diabetes care 20110101

Title: Biochemical and pharmacological effects of mitoxantrone and acetyl-L-carnitine in mice with a solid form of Ehrlich tumour.

Journal: Chemotherapy 20110101

Title: Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.

Journal: Vascular health and risk management 20110101

Title: Evaluation of the effect of acetyl L-carnitine on experimental cisplatin ototoxicity and neurotoxicity.

Journal: Chemotherapy 20110101

Title: Methamphetamine inhibits the glucose uptake by human neurons and astrocytes: stabilization by acetyl-L-carnitine.

Journal: PloS one 20110101

Title: [Acetyl-L-carnitine (carnicetine) in the treatment of early stages of Alzheimer's disease and vascular dementia].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain.

Journal: Free radical biology & medicine 20101130

Title: Effects of acetyl-L-carnitine and oxfenicine on aorta stiffness in diabetic rats.

Journal: European journal of clinical investigation 20101101

Title: Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study.

Journal: AIDS research and human retroviruses 20101101

Title: Cisplatin-induced downregulation of OCTN2 affects carnitine wasting.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20101001

Title: Nerve regeneration in neuropathic pain.

Journal: Pain medicine (Malden, Mass.) 20101001

Title: [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia].

Journal: Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20100901

Title: Malonylcarnitine in newborns with non-syndromic cleft lip with or without cleft palate.

Journal: International journal of oral science 20100901

Title: Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrol.

Journal: Neuroscience letters 20100816

Title: AMPK attenuates bupivacaine-induced neurotoxicity.

Journal: Journal of dental research 20100801

Title: Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain.

Journal: Journal of neurochemistry 20100801

Title: Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission.

Journal: Aging cell 20100801

Title: Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100801

Title: Behavior of acetyl-L-carnitine injections (Nicetile fiale) with different drugs used for combined therapy.

Journal: Advances in therapy 20100801

Title: Acetyl-l-carnitine increases nerve regeneration and target organ reinnervation - a morphological study.

Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20100701

Title: Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury.

Journal: Journal of neurochemistry 20100701

Title: Carnitine palmitoyltransferase 2 deficiency: the time-course of blood and urinary acylcarnitine levels during initial L-carnitine supplementation.

Journal: The Tohoku journal of experimental medicine 20100701

Title: Acetyl-L-carnitine improves aged brain function.

Journal: Geriatrics & gerontology international 20100701

Title: Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy.

Journal: Neuroscience 20100602

Title: Oxidative stress and cognitive longevity.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20100601

Title: Oral acetyl-L-carnitine therapy and insulin resistance.

Journal: Hypertension (Dallas, Tex. : 1979) 20100601

Title: Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan.

Journal: Journal of the Chinese Medical Association : JCMA 20100601

Title: Acetyl-L-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats.

Journal: Annals of the New York Academy of Sciences 20100601

Title: Managing diabetic peripheral neuropathic pain in primary care.

Journal: The Journal of family practice 20100501

Title: Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain.

Journal: Trends in pharmacological sciences 20100401

Title: Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model.

Journal: Current HIV research 20100401

Title: Differential metabolomics for quantitative assessment of oxidative stress with strenuous exercise and nutritional intervention: thiol-specific regulation of cellular metabolism with N-acetyl-L-cysteine pretreatment.

Journal: Analytical chemistry 20100401

Title: Acetyl-L-carnitine. Monograph.

Journal: Alternative medicine review : a journal of clinical therapeutic 20100401

Title: Regulatory effect of acetyl-l-carnitine on expression of lenticular antioxidant and apoptotic genes in selenite-induced cataract.

Journal: Chemico-biological interactions 20100330

Title: Protective effects of acetyl-L-carnitine on cisplatin cytotoxicity and oxidative stress in neuroblastoma.

Journal: Neurochemical research 20100301

Title: A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia.

Journal: The journal of nutrition, health & aging 20100301

Title: [Effect of acetyl-L-carnitine on the insulin resistance of L6 cells induced by tumor necrosis factor-alpha].

Journal: Wei sheng yan jiu = Journal of hygiene research 20100301

Title: The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain.

Journal: Neuroscience 20100217

Title: Carnitine for fatigue in multiple sclerosis.

Journal: The Cochrane database of systematic reviews 20100217

Title: Involvement of OCTN2 in the transport of acetyl-L-carnitine across the inner blood-retinal barrier.

Journal: Investigative ophthalmology & visual science 20100101

Title: Acylcarnitines: role in brain.

Journal: Progress in lipid research 20100101

Title: Redox homeostasis and cellular stress response in aging and neurodegeneration.

Journal: Methods in molecular biology (Clifton, N.J.) 20100101

Title: Muscle unloading potentiates the effects of acetyl-L-carnitine on the slow oxidative muscle phenotype.

Journal: BioFactors (Oxford, England) 20100101

Title: Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis.

Journal: Rejuvenation research 20100101

Title: Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.

Journal: Journal of cellular and molecular medicine 20100101

Title: Optimal micronutrients delay mitochondrial decay and age-associated diseases.

Journal: Mechanisms of ageing and development 20100101

Title: Acetyl-L-carnitine for alcohol craving and relapse prevention in anhedonic alcoholics: a randomized, double-blind, placebo-controlled pilot trial.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20100101

Title: Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women.

Journal: PloS one 20100101

Title: Tissue-specific short chain fatty acid metabolism and slow metabolic recovery after ischemia from hyperpolarized NMR in vivo.

Journal: The Journal of biological chemistry 20091225

Title: Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.

Journal: Experimental gerontology 20091201

Title: Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?

Journal: Advanced drug delivery reviews 20091130

Title: A case of holocarboxylase synthetase deficiency with insufficient response to prenatal biotin therapy.

Journal: Brain & development 20091101

Title: Effect of L-acetylcarnitine on body composition in HIV-related lipodystrophy.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091101

Title: Effect of acetyl-L-carnitine on axonal sprouting following donor nerve injury distal to an end-to-side neurorrhaphy model.

Journal: Journal of reconstructive microsurgery 20091101

Title: Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy.

Journal: Hypertension (Dallas, Tex. : 1979) 20090901

Title: Hypertension and insulin resistance.

Journal: Hypertension (Dallas, Tex. : 1979) 20090901

Title: Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation.

Journal: Epigenetics 20090816

Title: The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.

Journal: Journal of the neurological sciences 20090815

Title: Defective inhibition and inter-regional phase synchronization in pianists with musician's dystonia: an EEG study.

Journal: Human brain mapping 20090801

Title: Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090801

Title: Oral acetate supplementation after prolonged moderate intensity exercise enhances early muscle glycogen resynthesis in horses.

Journal: Experimental physiology 20090801

Title: Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria.

Journal: Biochimica et biophysica acta 20090701

Title: Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: a randomized and controlled double blind study.

Journal: European journal of gastroenterology & hepatology 20090701

Title: Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats.

Journal: Basic & clinical pharmacology & toxicology 20090701

Title: 1H NMR to investigate metabolism and energy supply in rhesus macaque sperm.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20090701

Title: Acetyl-l-carnitine (ALCAR) prevents hypobaric hypoxia-induced spatial memory impairment through extracellular related kinase-mediated nuclear factor erythroid 2-related factor 2 phosphorylation.

Journal: Neuroscience 20090630

Title: Sodium azide induced neuronal damage in vitro: evidence for non-apoptotic cell death.

Journal: Neurochemical research 20090501

Title: The effect of acetyl-L-carnitine on lenticular calpain activity in prevention of selenite-induced cataractogenesis.

Journal: Experimental eye research 20090501

Title: Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20090501

Title: Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.

Journal: Neurochemical research 20090401

Title: Cytoprotective effect of acetyl-L-carnitine evidenced by analysis of gene expression in the rat brain.

Journal: Molecular neurobiology 20090401

Title: Cerebral metabolic effects of acetyl-l-carnitine in rats during aging.

Journal: Brain research 20090309

Title: The effect of 3-hydroxybutyrate methyl ester on learning and memory in mice.

Journal: Biomaterials 20090301

Title: Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin.

Journal: Gynecologic oncology 20090301

Title: Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.

Journal: Journal of cellular and molecular medicine 20090201

Title: Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers.

Journal: Clinical and investigative medicine. Medecine clinique et experimentale 20090201

Title: Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection.

Journal: HIV medicine 20090201

Title: Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain.

Journal: Neuroscience 20090123

Title: Acetyl-l-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells.

Journal: FEBS letters 20090122

Title: Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor.

Journal: Journal of neuroscience research 20090101

Title: Medical management of Peyronie's disease.

Journal: Journal of andrology 20090101

Title: Acetyl-L-carnitine in the management of pain during methadone withdrawal syndrome.

Journal: Clinical neuropharmacology 20090101

Title: Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance.

Journal: Nutrition research (New York, N.Y.) 20090101

Title: Effects of acetylo-L-carnitine in end-to-side neurorrhaphy: a pilot study.

Journal: Microsurgery 20090101

Title: Vitagenes, cellular stress response, and acetylcarnitine: relevance to hormesis.

Journal: BioFactors (Oxford, England) 20090101

Title: Evaluation of lenticular antioxidant and redox system components in the lenses of acetyl-L-carnitine treatment in BSO-induced glutathione deprivation.

Journal: Molecular vision 20090101

Title: Systematic review of pharmacological treatments in fragile X syndrome.

Journal: BMC neurology 20090101

Title: Evaluation of the effect of acetyl L-carnitine on experimental cisplatin nephrotoxicity.

Journal: Chemotherapy 20090101

Title: Treatments for fragile X syndrome: a closer look at the data.

Journal: Developmental disabilities research reviews 20090101

Title: Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease.

Journal: Neurochemistry international 20081201

Title: Modulatory effect of acetyl-L-carnitine on amyloid precursor protein metabolism in hippocampal neurons.

Journal: European journal of pharmacology 20081112

Title: Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.

Journal: Digestive diseases and sciences 20081101

Title: Determination of the reference range of endogenous plasma carnitines in healthy adults.

Journal: Annals of clinical biochemistry 20081101

Title: Role of acetyl-L-carnitine in the treatment of diabetic peripheral neuropathy.

Journal: The Annals of pharmacotherapy 20081101

Title: Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells.

Journal: Archives of biochemistry and biophysics 20081015

Title: In the rat brain acetyl-L-carnitine treatment modulates the expression of genes involved in neuronal ceroid lipofuscinosis.

Journal: Molecular neurobiology 20081001

Title: Hypoxia-induced deactivation of NGF-mediated ERK1/2 signaling in hippocampal cells: neuroprotection by acetyl-L-carnitine.

Journal: Journal of neuroscience research 20080901

Title: A DIGE approach for the assessment of rat soleus muscle changes during unloading: effect of acetyl-L-carnitine supplementation.

Journal: Proteomics 20080901

Title: Acetyl-L-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism.

Journal: Neuropharmacology 20080801

Title: Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20080801

Title: Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice.

Journal: European journal of pharmacology 20080707

Title: Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid.

Journal: Journal of cellular biochemistry 20080701

Title: Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies.

Journal: European journal of cancer (Oxford, England : 1990) 20080701

Title: Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders?

Journal: Expert opinion on investigational drugs 20080601

Title: [Physiological functions of carnitine and carnitine transporters in the central nervous system].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20080601

Title: Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-L-carnitine.

Journal: Pain 20080401

Title: A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys.

Journal: American journal of medical genetics. Part A 20080401

Title: Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation.

Journal: Rejuvenation research 20080401

Title: Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells.

Journal: Experimental neurology 20080301

Title: [Clinical efficacy of combined L-carnitine and acetyl-L-carnitine on idiopathic asthenospermia].

Journal: Zhonghua nan ke xue = National journal of andrology 20080201

Title: Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.

Journal: Archives of gerontology and geriatrics 20080101

Title: R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes.

Journal: Diabetologia 20080101

Title: Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts.

Journal: Redox report : communications in free radical research 20080101

Title: Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study.

Journal: Clinical drug investigation 20080101

Title: Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat.

Journal: Journal of negative results in biomedicine 20080101

Title: L-carnitine and its derivatives: exciting experimental and clinical data are accumulating in the treatment of ocular disorders.

Journal: Drugs in R&D 20080101

Title: The aging eye and the role of L-carnitine and its derivatives.

Journal: Drugs in R&D 20080101

Title: [Metabolic therapy for early treatment of age-related macular degeneration].

Journal: Orvosi hetilap 20071202

Title: Metabolomics identifies perturbations in human disorders of propionate metabolism.

Journal: Clinical chemistry 20071201

Title: Natural antioxidants in Alzheimer's disease.

Journal: Expert opinion on investigational drugs 20071201

Title: Putting evidence into practice: evidence-based interventions for chemotherapy-induced peripheral neuropathy.

Journal: Clinical journal of oncology nursing 20071201

Title: Valproate and acetyl-L-carnitine prevent methamphetamine-induced behavioral sensitization in mice.

Journal: Annals of the New York Academy of Sciences 20071201

Title: Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial.

Journal: Journal of child and adolescent psychopharmacology 20071201

Title: Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071101

Title: Protective effect of intravenous levocarnitine on subsequent-month hospitalization among prevalent hemodialysis patients, 1998 to 2003.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20071101

Title: Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.

Journal: Reproduction (Cambridge, England) 20071101

Title: Acetyl-L-carnitine prevents selenite-induced cataractogenesis in an experimental animal model.

Journal: Current eye research 20071101

Title: Elevated free fatty acids attenuate the insulin-induced suppression of PDK4 gene expression in human skeletal muscle: potential role of intramuscular long-chain acyl-coenzyme A.

Journal: The Journal of clinical endocrinology and metabolism 20071001

Title: Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles.

Journal: Analytical chemistry 20070915

Title: Acetyl-L-carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats.

Journal: European journal of pharmacology 20070910

Title: Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral neuropathy.

Journal: The European journal of neuroscience 20070801

Title: Urinary excretion of L-carnitine and its short-chain acetyl-L-carnitine in patients undergoing carboplatin treatment.

Journal: Cancer chemotherapy and pharmacology 20070601

Title: New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle.

Journal: The Journal of physiology 20070601

Title: [Molecular/neural mechanisms of fatigue].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070601

Title: Is the human masticatory system devoid of recurrent inhibition?

Journal: Experimental brain research 20070501

Title: A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection.

Journal: HIV medicine 20070501

Title: Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-L-carnitine.

Journal: Hearing research 20070401

Title: Recurrence quantification analysis of surface EMG detects changes in motor unit synchronization induced by recurrent inhibition.

Journal: Experimental brain research 20070401

Title: Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20070401

Title: More light please.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20070401

Title: Neuroprotective effects of acetyl-L-carnithine in experimental chronic compression neuropathy. A prospective, randomized and placebo-control trials.

Journal: Turkish neurosurgery 20070401

Title: Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.

Journal: Free radical biology & medicine 20070201

Title: [Molecular/neural mechanisms of fatigue and the way to overcome fatigue].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070201

Title: Delayed acetyl-L-carnitine administration and its effect on sensory neuronal rescue after peripheral nerve injury.

Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20070101

Title: Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review.

Journal: Asia Pacific journal of clinical nutrition 20070101

Title: Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients.

Journal: Clinical and experimental rheumatology 20070101

Title: Overview on pathophysiology and newer approaches to treatment of peripheral neuropathies.

Journal: CNS drugs 20070101

Title: Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data.

Journal: CNS drugs 20070101

Title: Acetyl-L-carnitine in HIV-associated antiretroviral toxic neuropathy.

Journal: CNS drugs 20070101

Title: Acetyl-L-carnitine in neuropathic pain: experimental data.

Journal: CNS drugs 20070101

Title: Acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy: a short review.

Journal: CNS drugs 20070101

Title: Effects of dietary supplementation with N-acetyl cysteine, acetyl-L-carnitine and S-adenosyl methionine on cognitive performance and aggression in normal mice and mice expressing human ApoE4.

Journal: Neuromolecular medicine 20070101

Title: Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs.

Journal: FEBS letters 20061211

Title: Prevention of selenite-induced cataractogenesis by acetyl-L-carnitine: an experimental study.

Journal: Experimental eye research 20061201

Title: Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial.

Journal: Digestive diseases and sciences 20061201

Title: Acetyl-L-carnitine affects nonassociative learning processes in the leech Hirudo medicinalis.

Journal: Neuroscience 20061103

Title: The association of acetyl-l-carnitine and nicotinamide remits the experimental diabetes in mice by multiple low-dose streptozotocin.

Journal: Pancreas 20061101

Title: Muscle metabolites: functional MR spectroscopy during exercise imposed by tetanic electrical nerve stimulation.

Journal: Radiology 20061001

Title: Susceptibility of human metabolic phenotypes to dietary modulation.

Journal: Journal of proteome research 20061001

Title: Systemic lupus erythematosus after mesotherapy with acetyl-L-carnitine.

Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20061001

Title: Protective role of carnitine ester against radiation-induced oxidative stress in rats.

Journal: Pharmacological research 20060901

Title: Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.

Journal: The Journal of biological chemistry 20060804

Title: Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.

Journal: Journal of neuroscience research 20060801

Title: Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid.

Journal: Pharmaceutical research 20060801

Title: Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2.

Journal: Archives of biochemistry and biophysics 20060801

Title: Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.

Journal: Clinical and experimental pharmacology & physiology 20060801

Title: SANDO: two novel mutations in POLG1 gene.

Journal: Neuromuscular disorders : NMD 20060801

Title: Motor unit synchronous firing as revealed by determinism of surface myoelectric signal.

Journal: Journal of neuroscience methods 20060715

Title: Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis.

Journal: Pediatric research 20060701

Title: Reversal of mitochondrial defects before ischemia protects the aged heart.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701

Title: Acetyl-L-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine.

Journal: Neuropharmacology 20060601

Title: Acetyl-L-carnitine up-regulates expression of voltage-dependent anion channel in the rat brain.

Journal: Neurochemistry international 20060601

Title: Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue.

Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20060601

Title: A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy.

Journal: Neuroscience letters 20060424

Title: Male idiopathic oligoasthenoteratozoospermia.

Journal: Asian journal of andrology 20060301

Title: Acetyl-l-carnitine in the treatment of painful antiretroviral toxic neuropathy in human immunodeficiency virus patients: an open label study.

Journal: Journal of the peripheral nervous system : JPNS 20060301

Title: Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat.

Journal: Pharmacology, biochemistry, and behavior 20060301

Title: Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes.

Journal: The Journal of nutritional biochemistry 20060201

Title: Behavioral and electrophysiological changes induced by acetyl-L-carnitine in aged freely-moving rats.

Journal: Archives italiennes de biologie 20060201

Title: Morphoquantitative aspects of NADH-diaphorase myenteric neurons in the ileum of diabetic rats treated with acetyl-L-carnitine.

Journal: Anatomia, histologia, embryologia 20060201

Title: Accumulation of acetyl groups following cycling: a 1H-MR spectroscopy study.

Journal: International journal of sports medicine 20060201

Title: Debate forum: levocarnitine therapy is rational and justified in selected dialysis patients.

Journal: Blood purification 20060101

Title: Effects of a single, short intravenous dose of acetyl-L-carnitine on pattern-reversal visual-evoked potentials in cirrhotic patients with hepatic encephalopathy.

Journal: Clinical and experimental pharmacology & physiology 20060101

Title: The effect of acetyl-L-carnitine administration on persons with Down syndrome.

Journal: Research in developmental disabilities 20060101

Title: Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress.

Journal: Antioxidants & redox signaling 20060101

Title: Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function.

Journal: Antioxidants & redox signaling 20060101

Title: Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine.

Journal: Molecular pain 20060101

Title: Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis.

Journal: Biochimica et biophysica acta 20060101

Title: Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells.

Journal: Reproduction (Cambridge, England) 20051201

Title: Folate, vitamin E, and acetyl-L-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta.

Journal: Brain research 20051109

Title: Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy.

Journal: Urology 20051101

Title: The European Association of Addiction Therapy - Inaugural Conference.

Journal: IDrugs : the investigational drugs journal 20051001

Title: [A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia].

Journal: Zhonghua nan ke xue = National journal of andrology 20051001

Title: Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia.

Journal: Fertility and sterility 20050901

Title: Enantiomeric purity determination of acetyl-L-carnitine by NMR with chiral lanthanide shift reagents.

Journal: Journal of pharmaceutical and biomedical analysis 20050810

Title: Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine.

Journal: European journal of cancer (Oxford, England : 1990) 20050801

Title: Mechanisms of ischemic neuroprotection by acetyl-L-carnitine.

Journal: Annals of the New York Academy of Sciences 20050801

Title: Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver.

Journal: The Biochemical journal 20050715

Title: Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination.

Journal: The Plant cell 20050701

Title: Morphometric and quantitative evaluation of the NADH-diaphorase positive myenteric neurons of the jejunum of streptozotocin-diabetic rats supplemented with acetyl-L-carnitine.

Journal: Anatomia, histologia, embryologia 20050601

Title: Reduction of apoptosis through the mitochondrial pathway by the administration of acetyl-L-carnitine to mouse fibroblasts in culture.

Journal: Experimental cell research 20050515

Title: Differential carnitine/acylcarnitine translocase expression defines distinct metabolic signatures in skeletal muscle cells.

Journal: Journal of cellular physiology 20050501

Title: Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments.

Journal: European journal of human genetics : EJHG 20050501

Title: Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs.

Journal: Neuroscience letters 20050418

Title: Morphoquantitative aspects of nitrergic myoenteric neurons from the stomach of diabetic rats supplemented with acetyl-L-carnitine.

Journal: Anatomia, histologia, embryologia 20050401

Title: Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate.

Journal: The Journal of biological chemistry 20050311

Title: Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats.

Journal: The international journal of neuropsychopharmacology 20050301

Title: Strategy for the isolation, derivatization, chromatographic separation, and detection of carnitine and acylcarnitines.

Journal: Analytical chemistry 20050301

Title: Prevention of impulse noise-induced hearing loss with antioxidants.

Journal: Acta oto-laryngologica 20050301

Title: Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2.

Journal: Journal of neuroscience research 20050215

Title: Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle.

Journal: American journal of physiology. Endocrinology and metabolism 20050201

Title: Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise.

Journal: American journal of physiology. Endocrinology and metabolism 20050101

Title: Nerve growth factor and acetyl-L-carnitine evoked shifts in acetyl-CoA and cholinergic SN56 cell vulnerability to neurotoxic inputs.

Journal: Journal of neuroscience research 20050101

Title: Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.

Journal: Diabetes care 20050101

Title: Correlation between seminal carnitine and functional spermatozoal characteristics in men with semen dysfunction of various origins.

Journal: Drugs in R&D 20050101

Title: Free and total carnitine concentrations in pig plasma after oral ingestion of various L-carnitine compounds.

Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20050101

Title: Chemotherapy-induced allodinia: neuroprotective effect of acetyl-L-carnitine.

Journal: In vivo (Athens, Greece) 20050101

Title: Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20050101

Title: A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy.

Journal: Tumori 20050101

Title: Evaluation of carnitine, acetylcarnitine and isovalerylcarnitine on immune function and apoptosis.

Journal: Drugs under experimental and clinical research 20050101

Title: Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties.

Journal: Anticancer research 20050101

Title: HIV-associated antiretroviral toxic neuropathy (ATN): a review of recent advances in pathophysiology and treatment.

Journal: Antiviral therapy 20050101

Title: Effects of acetyl-L-carnitine on cardiac dysautonomia in Rett syndrome: prevention of sudden death?

Journal: Pediatric cardiology 20050101

Title: A review of antioxidants and Alzheimer's disease.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20050101

Title: Long-term effect of acetyl-L-carnitine for antiretroviral toxic neuropathy.

Journal: HIV clinical trials 20050101

Title: [Vitamine-like substances L-carnitine and acetyl-L-carnitine: from biochemical studies to medicine].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101

Title: Identification of differentially expressed genes induced in the rat brain by acetyl-L-carnitine as evidenced by suppression subtractive hybridisation.

Journal: Brain research. Molecular brain research 20041206

Title: Effects of 7 wk of endurance training on human skeletal muscle metabolism during submaximal exercise.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20041201

Title: Acetyl-L-carnitine reduces impulsive behaviour in adolescent rats.

Journal: Psychopharmacology 20041101

Title: Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism.

Journal: Annals of the New York Academy of Sciences 20041101

Title: Delaying the mitochondrial decay of aging with acetylcarnitine.

Journal: Annals of the New York Academy of Sciences 20041101

Title: Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats.

Journal: Annals of the New York Academy of Sciences 20041101

Title: Acetyl-L-carnitine for the treatment of HIV lipoatrophy.

Journal: Annals of the New York Academy of Sciences 20041101

Title: Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease.

Journal: Kidney international 20041001

Title: Role of mitochondrial dysfunction in neurotoxicity of MPP+: partial protection of PC12 cells by acetyl-L-carnitine.

Journal: Annals of the New York Academy of Sciences 20041001

Title: Natural antioxidants and neurodegenerative diseases.

Journal: Frontiers in bioscience : a journal and virtual library 20040901

Title: Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception.

Journal: Neuropharmacology 20040801

Title: Effect of L-carnitine administration on the seminal characteristics of oligoasthenospermic stallions.

Journal: Theriogenology 20040801

Title: Acetyl-L-carnitine prevents total body hydroxyl free radical and uric acid production induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat.

Journal: Life sciences 20040723

Title: Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy.

Journal: AIDS (London, England) 20040723

Title: Propofol infusion in children: when does an anesthetic tool become an intensive care liability?

Journal: Paediatric anaesthesia 20040601

Title: A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia.

Journal: Fertility and sterility 20040601

Title: Delaying the mitochondrial decay of aging.

Journal: Annals of the New York Academy of Sciences 20040601

Title: Acetyl-L-carnitine dietary supplementation to old rats increases mitochondrial transcription factor A content in rat hindlimb skeletal muscles.

Journal: Annals of the New York Academy of Sciences 20040601

Title: HPLC determination and pharmacokinetics of endogenous acetyl-L-carnitine (ALC) in human volunteers orally administered a single dose of ALC.

Journal: Archives of pharmacal research 20040601

Title: Response to therapy in carnitine/acylcarnitine translocase (CACT) deficiency due to a novel missense mutation.

Journal: American journal of medical genetics. Part A 20040415

Title: Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats.

Journal: Journal of lipid research 20040401

Title: Effects of carnitines on rat sertoli cell protein metabolism.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040401

Title: Carnitines and male infertility.

Journal: Reproductive biomedicine online 20040401

Title: Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial.

Journal: Journal of the neurological sciences 20040315

Title: Repeated acetyl-l-carnitine administration increases phospho-Thr34 DARPP-32 levels and antagonizes cocaine-induced increase in Cdk5 and phospho-Thr75 DARPP-32 levels in rat striatum.

Journal: The European journal of neuroscience 20040301

Title: Complications & side effects. Supplements and CD4+ counts: study finds surprising results.

Journal: TreatmentUpdate 20040301

Title: Glutamate-induced over-expression of GAD is down-regulated by acetyl-L-carnitine in rat islet cells.

Journal: Endocrine research 20040201

Title: Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome.

Journal: Psychosomatic medicine 20040101

Title: Brain cholinesterases: III. Future perspectives of AD research and clinical practice.

Journal: Medical hypotheses 20040101

Title: Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia.

Journal: Journal of andrology 20040101

Title: Acetyl-L-carnitine induces a sustained potentiation of the afterhyperpolarization.

Journal: Neuroscience 20040101

Title: Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain.

Journal: Journal of endocrinological investigation 20040101

Title: Primary sensory neuronal rescue with systemic acetyl-L-carnitine following peripheral axotomy. A dose-response analysis.

Journal: British journal of plastic surgery 20031201

Title: Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts.

Journal: Molecular and cellular biochemistry 20031201

Title: Effect of acetyl-L-carnitine on VIP-ergic neurons in the jejunum submucous plexus of diabetic rats.

Journal: Arquivos de neuro-psiquiatria 20031201

Title: Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031115

Title: Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2.

Journal: Biopharmaceutics & drug disposition 20031101

Title: Protective role of carnitine esters against alcohol-induced gastric lesions in rats.

Journal: Pharmacological research 20030901

Title: Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine.

Journal: Neurochemical research 20030901

Title: Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain.

Journal: Neurochemistry international 20030801

Title: Biosensors for the determination of ortho-acetyl-L-carnitine. Their utilization as detectors in a sequential injection analysis system.

Journal: Preparative biochemistry & biotechnology 20030801

Title: Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells.

Journal: Biochemical pharmacology 20030715

Title: Role of acetyl-L-carnitine in the brain: revealed by Bioradiography.

Journal: Biochemical and biophysical research communications 20030711

Title: Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep.

Journal: Nature genetics 20030701

Title: Modulation of methylation in the FMR1 promoter region after long term treatment with L-carnitine and acetyl-L-carnitine.

Journal: Journal of medical genetics 20030601

Title: [Neural and molecular mechanisms of fatigue and recovery from fatigue].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20030601

Title: Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish: a 31P-NMR-spectroscopy study.

Journal: Neurochemical research 20030501

Title: Pharmacologically induced enhancement of recurrent inhibition in humans: effects on motoneurone discharge patterns.

Journal: The Journal of physiology 20030415

Title: Effects of long-term acetyl-L-carnitine administration in rats--II: Protection against the disrupting effect of stress on the acquisition of appetitive behavior.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030401

Title: The lowdown on Ginkgo biloba.

Journal: Scientific American 20030401

Title: Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease.

Journal: International clinical psychopharmacology 20030301

Title: Bioenergetic approaches for neuroprotection in Parkinson's disease.

Journal: Annals of neurology 20030101

Title: Acetyl-L-carnitine for dementia.

Journal: The Cochrane database of systematic reviews 20030101

Title: Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors.

Journal: Current medical research and opinion 20030101

Title: Mitotropic compounds for the treatment of age-related macular degeneration. The metabolic approach and a pilot study.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20030101

Title: 'Brain-specific' nutrients: a memory cure?

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20030101

Title: Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice.

Journal: Neuroscience letters 20021216

Title: Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment.

Journal: Neuroscience letters 20021216

Title: Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine.

Journal: Brain research 20021213

Title: Effect of active warm-up on metabolism prior to and during intense dynamic exercise.

Journal: Medicine and science in sports and exercise 20021201

Title: Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats.

Journal: Neuropharmacology 20021201

Title: The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle.

Journal: The Journal of physiology 20021115

Title: Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man.

Journal: The Journal of physiology 20021101

Title: Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain.

Journal: NeuroImage 20021101

Title: Effects of acetyl-L-carnitine on regional cerebral glucose metabolism in awake rats.

Journal: Brain research 20021004

Title: Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons.

Journal: Neuroscience letters 20020906

Title: Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020901

Title: Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss.

Journal: The Laryngoscope 20020901

Title: Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration.

Journal: Diabetes 20020801

Title: Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle.

Journal: Pediatric research 20020701

Title: Systemic acetyl-L-carnitine eliminates sensory neuronal loss after peripheral axotomy: a new clinical approach in the management of peripheral nerve trauma.

Journal: Experimental brain research 20020701

Title: Bicarbonate-induced alkalosis augments cellular acetyl group availability and isometric force during the rest-to-work transition in canine skeletal muscle.

Journal: Experimental physiology 20020701

Title: Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients.

Journal: British journal of cancer 20020617

Title: Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man.

Journal: The Journal of physiology 20020615

Title: Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl-L-carnitine.

Journal: Diabetes research and clinical practice 20020601

Title: Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels.

Journal: Neurochemical research 20020601

Title: L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors.

Journal: Molecular pharmacology 20020501

Title: Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites.

Journal: Annals of the New York Academy of Sciences 20020401

Title: Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.

Journal: Annals of the New York Academy of Sciences 20020401

Title: [Assay of carnitine in plasma and urine of healthy adults].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020401

Title: Tandem mass spectrometric assay for the determination of carnitine palmitoyltransferase II activity in muscle tissue.

Journal: Analytical biochemistry 20020315

Title: 31P-MRS study of acetyl-L-carnitine treatment in geriatric depression: preliminary results.

Journal: Bipolar disorders 20020201

Title: Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin.

Journal: American journal of physiology. Endocrinology and metabolism 20020101

Title: Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate.

Journal: The Journal of physiology 20020101

Title: Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study.

Journal: Drugs in R&D 20020101

Title: Long-term ethanol administration enhances age-dependent modulation of redox state in brain and peripheral organs of rat: protection by acetyl carnitine.

Journal: International journal of tissue reactions 20020101

Title: Long-term ethanol administration enhances age-dependent modulation of redox state in different brain regions in the rat: protection by acetyl carnitine.

Journal: International journal of tissue reactions 20020101

Title: Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation after onset of moderate exercise.

Journal: American journal of physiology. Endocrinology and metabolism 20011201

Title: Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier.

Journal: Journal of neurochemistry 20011201

Title: Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency.

Journal: Neuromuscular disorders : NMD 20011101

Title: Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis.

Journal: Human reproduction (Oxford, England) 20011101

Title: Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats.

Journal: Journal of neuroscience research 20011015

Title: The effects of increasing exercise intensity on muscle fuel utilisation in humans.

Journal: The Journal of physiology 20011001

Title: Lethal neonatal presentation of carnitine palmitoyltransferase I deficiency.

Journal: Journal of inherited metabolic disease 20011001

Title: [L-acetylcarnitine treatment on fragile X patients hyperactive behaviour].

Journal: Revista de neurologia 20011001

Title: Carnitine protects the molecular chaperone activity of lens alpha-crystallin and decreases the post-translational protein modifications induced by oxidative stress.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010701

Title: Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease: a preliminary report.

Journal: BJU international 20010701

Title: The action of acetyl-L-carnitine on the neurotoxicity evoked by amyloid fragments and peroxide on primary rat cortical neurones.

Journal: Annals of the New York Academy of Sciences 20010601

Title: A polymeric microfluidic chip for CE/MS determination of small molecules.

Journal: Analytical chemistry 20010501

Title: A new technique to elevate night time growth hormone release and a potential growth hormone feedback control loop.

Journal: Medical hypotheses 20010501

Title: Chip-based quantitative capillary electrophoresis/mass spectrometry determination of drugs in human plasma.

Journal: Analytical chemistry 20010401

Title: Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions.

Journal: Neuroscience letters 20010323

Title: Enzymatic determination of acetylcarnitine for diagnostic applications.

Journal: Journal of pharmaceutical and biomedical analysis 20010301

Title: Acetyl-L-carnitine treatment stimulates oxygen consumption and biosynthetic function in perfused liver of young and old rats.

Journal: Cellular and molecular life sciences : CMLS 20010301

Title: Hepatic mitochondrial proteins in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine.

Journal: Bioscience, biotechnology, and biochemistry 20010301

Title: A 1-year controlled trial of acetyl-L-carnitine in early-onset AD.

Journal: Neurology 20010213

Title: Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat.

Journal: Neurochemical research 20010201

Title: Acetyl-L-carnitine infusion increases glucose disposal in type 2 diabetic patients.

Journal: Metabolism: clinical and experimental 20000601

Title: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter.

Journal: The Journal of biological chemistry 20000121

Title: Acetyl-carnitine deficiency in AIDS patients with neurotoxicity on treatment with antiretroviral nucleoside analogues.

Journal: AIDS (London, England) 19970201

Title: L-acetylcarnitine treatment of mental decline in the elderly.

Journal: Drugs under experimental and clinical research 19940101

Title: [Effect of DL-carnitine and gamma-butyrobetaine hydroxylase inhibitor 3-(2,2,2-trimethylhydrazinium) propionate on isoproterenol-induced changes in the metabolism of the rat myocardium].

Journal: Voprosy meditsinskoi khimii 19880101

Title: Effect of clofibrate treatment on acylcarnitine oxidation in isolated rat liver mitochondria.

Journal: Medical biology 19790201

Title: Marcon M, et al. Acetyl-L-carnitine as a putative candidate for the treatment of stress-related psychiatric disorders: Novel evidence from a zebrafish model. Neuropharmacology. 2019 May 15;150:145-152.

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Tags:5080-50-2 Molecular Formula|5080-50-2 MDL|5080-50-2 SMILES|5080-50-2 O-Acetyl-L-carnitine HCl