Home Amines 509088-69-1
509088-69-1,MFCD09952233
Catalog No.:AA006VA9

509088-69-1 | 2-amino-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]propane-1,3-diol hydrochloride

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1mg
≥98%
in stock  
$72.00   $50.00
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5mg
≥98%
in stock  
$269.00   $188.00
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10mg
≥98%
in stock  
$500.00   $350.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006VA9
Chemical Name:
2-amino-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]propane-1,3-diol hydrochloride
CAS Number:
509088-69-1
Molecular Formula:
C24H27Cl2NO3S
Molecular Weight:
480.4471
MDL Number:
MFCD09952233
SMILES:
OCC(CCc1ccc(cc1Cl)Sc1cccc(c1)OCc1ccccc1)(CO)N.Cl
Properties
Properties
 
BP:
657.1°C at 760 mmHg  
Form:
Solid  
MP:
199-200 °C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
487  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  

Literature

Title: Synthesis of a key intermediate for the preparation of FTY720 analogs.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist.

Journal: Kidney international 20081101

Title: 'Inside-out' signaling of sphingosine-1-phosphate: therapeutic targets.

Journal: Pharmacological reviews 20080601

Title: New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.

Journal: Biochemical pharmacology 20080515

Title: A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice.

Journal: The Journal of pharmacology and experimental therapeutics 20080101

Title: A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditis.

Journal: Biochemical and biophysical research communications 20070928

Title: Use of sphingosine-1-phosphate 1 receptor agonist, KRP-203, in combination with a subtherapeutic dose of cyclosporine A for rat renal transplantation.

Journal: Transplantation 20060927

Title: Change from cyclosporine to combination therapy of mycophenolic acid with the new sphingosine-1-phosphate receptor agonist, KRP-203, prevents host nephrotoxicity and transplant vasculopathy in rats.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060701

Title: Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice.

Journal: Biochemical and biophysical research communications 20060623

Title: Efficacy of mycophenolic acid combined with KRP-203, a novel immunomodulator, in a rat heart transplantation model.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060301

Title: KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.

Journal: Circulation 20050118

Title: A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts.

Journal: Transplantation proceedings 20050101

Title: Potì F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12.

Title: Shimizu H, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronicrejection in rat skin and heart allografts. Circulation. 2005 Jan 18;111(2):222-9. Epub 2005 Jan 10.

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Tags:509088-69-1 Molecular Formula|509088-69-1 MDL|509088-69-1 SMILES|509088-69-1 2-amino-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]propane-1,3-diol hydrochloride