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51022-77-6,MFCD00600136
Catalog No.:AA01CB30

51022-77-6 | Etazolate

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Purity
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Price(USD)
Quantity
  
5mg
3 weeks  
$359.00   $251.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CB30
Chemical Name:
Etazolate
CAS Number:
51022-77-6
Molecular Formula:
C14H19N5O2
Molecular Weight:
289.3330
MDL Number:
MFCD00600136
SMILES:
CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC
Properties
Properties
 
Form:
Solid  
MP:
92-93°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
397  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
2.1  

Literature

Title: Antidepressant-like effect of etazolate, a cyclic nucleotide phosphodiesterase 4 inhibitor--an approach using rodent behavioral antidepressant tests battery.

Journal: European journal of pharmacology 20120815

Title: EHT0202 in Alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study.

Journal: Current Alzheimer research 20110301

Title: Etazolate improves performance in a foraging and homing task in aged rats.

Journal: European journal of pharmacology 20100525

Title: A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20100223

Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing.

Journal: Journal of neurochemistry 20080701

Title: TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi.

Journal: Molecular and biochemical parasitology 20060101

Title: Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation.

Journal: Respiratory research 20050101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D.

Journal: Biochemical and biophysical research communications 19970519

Title: Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits.

Journal: European journal of pharmacology 19960422

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