51146-56-6,MFCD00069289
Catalog No.:AA003CF1

51146-56-6 | (S)-(+)-Ibuprofen

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  • Properties
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Technical Information
Catalog Number:
AA003CF1
Chemical Name:
(S)-(+)-Ibuprofen
CAS Number:
51146-56-6
Molecular Formula:
C13H18O2
Molecular Weight:
206.2808
MDL Number:
MFCD00069289
SMILES:
CC(Cc1ccc(cc1)[C@@H](C(=O)O)C)C
NSC Number:
759814
Properties
Properties
 
BP:
319.6±11.0°C at 760 mmHg  
Form:
Solid  
MP:
49-53 °C(lit.)  
Refractive Index:
59 ° (C=2, EtOH)  
Solubility:
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
203  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.5  

Literature

Title: Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews 20131023

Title: Chiral-substrate-assisted stereoselective epoxidation catalyzed by H2O2-dependent cytochrome P450SPα.

Journal: Chemistry, an Asian journal 20121001

Title: 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3.

Journal: Journal of medicinal chemistry 20120913

Title: A validated enantioselective HPLC assay of dexibuprofen in dexibuprofen tablet formulations.

Journal: Biomedical chromatography : BMC 20120401

Title: An examination of the thermodynamics of fusion, vaporization, and sublimation of ibuprofen and naproxen by correlation gas chromatography.

Journal: Journal of pharmaceutical sciences 20120201

Title: In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery.

Journal: Acta pharmacologica Sinica 20120201

Title: Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.

Journal: PLoS computational biology 20120201

Title: [UV spectroscopy coupled with partial least squares to determine the enantiomeric composition in chiral drugs].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20120201

Title: Case series of 64 slice computed tomography-computed tomographic angiography with 3D reconstruction to diagnose symptomatic cerebral aneurysms: new standard of care?

Journal: Neurology international 20120109

Title: Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease.

Journal: Neurobiology of aging 20120101

Title: A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting.

Journal: International journal of nanomedicine 20120101

Title: Specificity quantification of biomolecular recognition and its implication for drug discovery.

Journal: Scientific reports 20120101

Title: Pharmacokinetics of ibuprofen enantiomers in rats after intravenous and oral administration of ibuprofen arginate.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120101

Title: Improvement of the bioavailability and glycaemic metabolism of cinnamon oil in rats by liquid loadable tablets.

Journal: TheScientificWorldJournal 20120101

Title: Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison.

Journal: The open rheumatology journal 20120101

Title: Pharmacokinetic-pharmacodynamic model of newly developed dexibuprofen sustained release formulations.

Journal: ISRN pharmaceutics 20120101

Title: In vitro evaluation of (S)-ibuprofen toxicity on joint cells and explants of cartilage and synovial membrane.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111201

Title: Production of ibuprofen acyl glucosides by human UGT2B7.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20111201

Title: Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid.

Journal: Journal of pharmaceutical sciences 20111201

Title: Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3.

Journal: Biopharmaceutics & drug disposition 20111201

Title: Enantiospecific fate of ibuprofen, ketoprofen and naproxen in a laboratory-scale membrane bioreactor.

Journal: Water research 20111115

Title: Synthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids.

Journal: Journal of enzyme inhibition and medicinal chemistry 20111001

Title: Novel imaging agents for β-amyloid plaque based on the N-benzoylindole core.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.

Journal: Pharmacological research 20110901

Title: Pharmacokinetic comparison of controlled- and immediate-release formulations of dexibuprofen after single and multiple oral doses in fasting healthy male Korean volunteers.

Journal: Clinical therapeutics 20110901

Title: Lack of enantiomeric influence on the brain cytoprotective effect of ibuprofen and flurbiprofen.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110801

Title: Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo.

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: Understanding the terahertz spectra of crystalline pharmaceuticals: terahertz spectroscopy and solid-state density functional theory study of (S)-(+)-ibuprofen and (RS)-ibuprofen.

Journal: Journal of pharmaceutical sciences 20110301

Title: Pharmacokinetics and bioequivalence of single dose and multiple doses of immediate- and extended-release formulations of dexibuprofen in healthy Chinese subjects.

Journal: International journal of clinical pharmacology and therapeutics 20110301

Title: Dry elixir formulations of dexibuprofen for controlled release and enhanced oral bioavailability.

Journal: International journal of pharmaceutics 20110214

Title: Interaction between dexibuprofen and dexketoprofen in the orofacial formalin test in mice.

Journal: Pharmacology, biochemistry, and behavior 20110101

Title: Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}.

Journal: Cancer prevention research (Philadelphia, Pa.) 20110101

Title: Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility.

Journal: International journal of nanomedicine 20110101

Title: Single dose oral analgesics for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews 20110101

Title: Molecularly imprinted polymers: present and future prospective.

Journal: International journal of molecular sciences 20110101

Title: Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells.

Journal: BMC neuroscience 20110101

Title: Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex.

Journal: International journal of nanomedicine 20110101

Title: Development and Validation of a HPLC and an UV Spectrophotometric Methods for Determination of Dexibuprofen in Pharmaceutical Preparations.

Journal: ISRN pharmaceutics 20110101

Title: Differences in the in vitro antiplatelet effect of dexibuprofen, ibuprofen, and flurbiprofen in human blood.

Journal: Anesthesia and analgesia 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.

Journal: Journal of medicinal chemistry 20100923

Title: Identifying early prescribers of cycloxygenase-2 inhibitors (COX-2s) in Nova Scotia, Canada: Considerations for targeted academic detailing.

Journal: Research in social & administrative pharmacy : RSAP 20100901

Title: Rationale and conditions for the requirement of chiral bioanalytical methods in bioequivalence studies.

Journal: European journal of clinical pharmacology 20100601

Title: Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors.

Journal: Journal of medicinal chemistry 20100311

Title: Effect of drug chirality on the skin permeability of ibuprofen.

Journal: International journal of pharmaceutics 20100215

Title: Macroscopic small bowel mucosal injury caused by chronic nonsteroidal anti-inflammatory drugs (NSAID) use as assessed by capsule endoscopy.

Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20100201

Title: Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100101

Title: Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

Journal: PloS one 20100101

Title: Microencapsulation: an acclaimed novel drug-delivery system for NSAIDs in arthritis.

Journal: Critical reviews in therapeutic drug carrier systems 20100101

Title: A prospective study of aspirin use and the risk of gastrointestinal bleeding in men.

Journal: PloS one 20100101

Title: Determination of actarit from human plasma for bioequivalence studies.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin.

Journal: Organic & biomolecular chemistry 20091021

Title: Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care.

Journal: Methods and findings in experimental and clinical pharmacology 20091001

Title: Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs.

Journal: British journal of clinical pharmacology 20090901

Title: Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS).

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090801

Title: Commercially viable resolution of ibuprofen.

Journal: Biotechnology journal 20090801

Title: Influence of benzylamine on the resolution of ibuprofen with (+)-(R)-phenylethylamine via supercritical fluid extraction.

Journal: Chirality 20090601

Title: Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity.

Journal: Experimental neurology 20090501

Title: Assessment of the pharmaceutical active compounds removal in wastewater treatment systems at enantiomeric level. Ibuprofen and naproxen.

Journal: Chemosphere 20090401

Title: Nicotinamide-2,2,2-trifluoro-ethanol (2/1).

Journal: Acta crystallographica. Section E, Structure reports online 20090401

Title: Cyclic resolution of racemic ibuprofen via coupled efficient lipase and acid-base catalysis.

Journal: Chirality 20090301

Title: A revised conformational code for the exhaustive analysis of conformers with one-to-one correspondence between conformation and code: application to the VCD analysis of (S)-ibuprofen.

Journal: The Journal of organic chemistry 20090206

Title: ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial.

Journal: Gynecologic and obstetric investigation 20090101

Title: Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews 20090101

Title: Painful red nodules in female patient with recent travel history: a case report.

Journal: Cases journal 20090101

Title: Solid Dispersion Matrix Tablet Comprising Indomethacin-PEG-HPMC Fabricated with Fusion and Mold Technique.

Journal: Indian journal of pharmaceutical sciences 20090101

Title: Population pharmacokinetic analysis of Ibuprofen enantiomers in preterm newborn infants.

Journal: Journal of clinical pharmacology 20081201

Title: The effects and safety of dexibuprofen compared with ibuprofen in febrile children caused by upper respiratory tract infection.

Journal: British journal of clinical pharmacology 20081201

Title: Formulation of a extended release tablet containing dexibuprofen.

Journal: Archives of pharmacal research 20081201

Title: Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20081101

Title: Necrotizing vasculitis as a complication of propylthiouracil.

Journal: The western journal of emergency medicine 20081101

Title: Characterization of drug-protein binding process by employing equilibrium sampling through hollow-fiber supported liquid membrane and Bjerrum and Scatchard plots.

Journal: Journal of pharmaceutical and biomedical analysis 20080910

Title: Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.

Journal: Chemical research in toxicology 20080901

Title: Chiral non-steroidal anti-inflammatory drugs--a review.

Journal: Journal of the Indian Medical Association 20080901

Title: Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia.

Journal: Neuroscience 20080826

Title: Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteers.

Journal: Pharmacological research 20080701

Title: Dexibuprofen (S(+)-isomer ibuprofen) reduces microglial activation and impairments of spatial working memory induced by chronic lipopolysaccharide infusion.

Journal: Pharmacology, biochemistry, and behavior 20080501

Title: Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis.

Journal: Spine 20080501

Title: NMR evaluation of adipocyte fatty acid binding protein (aP2) with R- and S-ibuprofen.

Journal: Bioorganic & medicinal chemistry 20080415

Title: Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: the effect of rofecoxib withdrawal.

Journal: Arthritis and rheumatism 20080415

Title: Development of an affinity silica monolith containing human serum albumin for chiral separations.

Journal: Journal of pharmaceutical and biomedical analysis 20080414

Title: Emergency department patient knowledge concerning acetaminophen (paracetamol) in over-the-counter and prescription analgesics.

Journal: Emergency medicine journal : EMJ 20080401

Title: Analgesic synergy between topical opioids and topical non-steroidal anti-inflammatory drugs in the mouse model of thermal pain.

Journal: European journal of pharmacology 20080128

Title: S-ibuprofen effectively inhibits thromboxane B2 levels and platelet function in an experimental model of lipopolysaccharide-stimulated and non-stimulated whole blood.

Journal: Pharmacology 20080101

Title: A randomized, crossover study to determine bioequivalence of two brands of dexibuprofen 400 mg tablets in healthy Asian adult male subjects of Indian origin.

Journal: International journal of clinical pharmacology and therapeutics 20080101

Title: The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos.

Journal: PPAR research 20080101

Title: Free drug metabolic clearance in elderly people.

Journal: Clinical pharmacokinetics 20080101

Title: Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study.

Journal: Breast cancer research : BCR 20080101

Title: Chiral separation of ibuprofen and chiral pharmacokinetics in healthy Chinese volunteers.

Journal: European journal of drug metabolism and pharmacokinetics 20080101

Title: Bioequivalence study of two formulations containing 400 mg dexibuprofen in healthy Indian subjects.

Journal: Arzneimittel-Forschung 20080101

Title: A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms.

Journal: Clinical therapeutics 20071201

Title: NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues.

Journal: Analytical chemistry 20071115

Title: Effect of absorption rate on pharmacokinetics of ibuprofen in relation to chiral inversion in humans.

Journal: The Journal of pharmacy and pharmacology 20071101

Title: Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling.

Journal: Chirality 20070901

Title: Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats.

Journal: Bioorganic & medicinal chemistry letters 20070701

Title: Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen.

Journal: European journal of clinical pharmacology 20070501

Title: A novel method for assessing inhibition of ibuprofen chiral inversion and its application in drug discovery.

Journal: International journal of pharmaceutics 20070420

Title: Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs.

Journal: Neuroscience 20070223

Title: [Pharmacokinetic interaction between phenitoin and dexibuprofen resulting in acute neurologic toxicity].

Journal: Medicina clinica 20070217

Title: Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates.

Journal: Bioorganic & medicinal chemistry letters 20070201

Title: Effects of dexibuprofen on platelet function in humans: comparison with low-dose aspirin.

Journal: Anesthesiology 20070201

Title: Effects of St. John's wort supplementation on ibuprofen pharmacokinetics.

Journal: The Annals of pharmacotherapy 20070201

Title: Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.

Journal: Bioorganic & medicinal chemistry 20070115

Title: An internet survey of 2,596 people with fibromyalgia.

Journal: BMC musculoskeletal disorders 20070101

Title: The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.

Journal: BMC medicine 20070101

Title: (S)-Ibuprofen-imprinted polymers incorporating gamma-methacryloxypropyl-trimethoxysilane for CEC separation of ibuprofen enantiomers.

Journal: Electrophoresis 20061101

Title: A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers.

Journal: European journal of clinical pharmacology 20061001

Title: Binding studies of taxanes to human serum albumin by bioaffinity chromatography and circular dichroism.

Journal: Journal of pharmaceutical and biomedical analysis 20060911

Title: Use of triplet excited States for the study of drug binding to human and bovine serum albumins.

Journal: ChemMedChem 20060901

Title: Optimization of enantioselective resolution of racemic ibuprofen by native lipase from Aspergillus niger.

Journal: Journal of industrial microbiology & biotechnology 20060801

Title: Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.

Journal: European journal of pharmacology 20060701

Title: Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.

Journal: Journal of natural products 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Modification of pepsinogen I levels and their correlation with gastrointestinal injury after administration of dexibuprofen, ibuprofen or diclofenac: a randomized, open-label, controlled clinical trial.

Journal: International journal of clinical pharmacology and therapeutics 20060401

Title: [Study on ion beam mutagenizing of the Trichosporon lactis T for enantioselective separation of ibuprofen].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20060401

Title: Dynamic kinetic resolution: alternative approach in optimizing S-ibuprofen production.

Journal: Bioprocess and biosystems engineering 20060301

Title: Beyond the white coat ceremony.

Journal: The Yale journal of biology and medicine 20060301

Title: Increased expression of cyclooxygenase and nitric oxide isoforms, and exaggerated sensitivity to prostaglandin E2, in the rat lumbar spinal cord 3 days after L5-L6 spinal nerve ligation.

Journal: Anesthesiology 20060201

Title: Chromatographic analysis of allosteric effects between ibuprofen and benzodiazepines on human serum albumin.

Journal: Chirality 20060101

Title: An eutomer/distomer ratio near unity does not justify non-enantiospecific assay methods in bioequivalence studies.

Journal: Chirality 20051001

Title: Similarity in structures of racemic and enantiomeric ibuprofen sodium dihydrates.

Journal: Acta crystallographica. Section C, Crystal structure communications 20050901

Title: Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration.

Journal: Paediatric anaesthesia 20050701

Title: 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.

Journal: Journal of medicinal chemistry 20050630

Title: The effect of a dexibuprofen mouth rinse on experimental gingivitis in humans.

Journal: Journal of clinical periodontology 20050601

Title: The interaction of lipophilic drugs with intestinal fatty acid-binding protein.

Journal: The Journal of biological chemistry 20050506

Title: Solid-phase microextraction and chiral HPLC analysis of ibuprofen in urine.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425

Title: A supported liquid membrane encapsulating a surfactant-lipase complex for the selective separation of organic acids.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20050204

Title: Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study.

Journal: BMC geriatrics 20050101

Title: Enantioselective pharmacokinetics of ibuprofen and involved mechanisms.

Journal: Drug metabolism reviews 20050101

Title: Solubility of (+/-)-ibuprofen and S (+)-ibuprofen in the presence of cosolvents and cyclodextrins.

Journal: Pharmaceutical development and technology 20050101

Title: Application of thin-layer chromatography to investigate oscillatory instability of the selected profen enantiomers in dichloromethane.

Journal: Journal of chromatographic science 20050101

Title: Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography.

Journal: Nature biotechnology 20041101

Title: Population pharmacokinetics of ibuprofen enantiomers in very premature neonates.

Journal: Journal of clinical pharmacology 20041001

Title: Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms.

Journal: Clinical pharmacology and therapeutics 20040801

Title: Optical purity determination of (S)-ibuprofen in tablets by achiral gas chromatography.

Journal: Archives of pharmacal research 20040801

Title: Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex.

Journal: Journal of the American Chemical Society 20040721

Title: Enantioselective immunorecognition of protein modification with optically active ibuprofen using polyclonal antibody.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040625

Title: Synthesis and evaluation of S-4-(3-thienyl)phenyl-alpha-methylacetic acid.

Journal: Bioorganic & medicinal chemistry letters 20040223

Title: Bioequivalence study of two Ibuprofen formulations administered intravenously in healthy male volunteers.

Journal: Clinical drug investigation 20040101

Title: Enzyme-facilitated enantioselective transport of (S)-ibuprofen through a supported liquid membrane based on ionic liquids.

Journal: Chemical communications (Cambridge, England) 20031207

Title: Aspirin use and lung cancer in men.

Journal: British journal of cancer 20031103

Title: Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat.

Journal: Anesthesiology 20031101

Title: Dexibuprofen (S+-isomer ibuprofen) reduces gastric damage and improves analgesic and antiinflammatory effects in rodents.

Journal: Anesthesia and analgesia 20030801

Title: Regio- and enantiospecific rhodium-catalyzed arylation of unsymmetrical fluorinated acyclic allylic carbonates: inversion of absolute configuration.

Journal: Journal of the American Chemical Society 20030618

Title: Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers.

Journal: British journal of clinical pharmacology 20030601

Title: Comparison of the efficacy and tolerability of dexibuprofen and celecoxib in the treatment of osteoarthritis of the hip.

Journal: International journal of clinical pharmacology and therapeutics 20030401

Title: Ask the doctors. I have arthritis and take Motrin. Is there a problem with also taking aspirin, since my doctor has told me to do this ever since my heart attack?

Journal: Heart advisor 20030401

Title: Spinal nerve injury activates prostaglandin synthesis in the spinal cord that contributes to early maintenance of tactile allodynia.

Journal: Pain 20030101

Title: In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile.

Journal: Neuroscience 20030101

Title: Bioavailability of two dermal formulations of S(+)ibuprofen in rabbit.

Journal: Arzneimittel-Forschung 20030101

Title: Dexibuprofen: pharmacology, therapeutic uses and safety.

Journal: Inflammopharmacology 20030101

Title: The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK.

Journal: Journal of cancer research and clinical oncology 20021001

Title: Enantioselective analysis of ibuprofen in human plasma by anionic cyclodextrin-modified electrokinetic chromatography.

Journal: Electrophoresis 20020901

Title: Stereoselectivity of ibuprofen metabolism and pharmacokinetics following the administration of the racemate to healthy volunteers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020801

Title: Aspirin and lung cancer in women.

Journal: British journal of cancer 20020701

Title: Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2.

Journal: Clinical pharmacology and therapeutics 20020701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Enantioselective release of controlled delivery granules based on molecularly imprinted polymers.

Journal: Drug delivery 20020101

Title: Aseptic meningo-encephalitis related to dexibuprofen use in a patient with systemic lupus erythematosus: a case report with MR findings.

Journal: Lupus 20020101

Title: Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin.

Journal: Biochemical pharmacology 20011215

Title: Ibuprofen interference in the determination of 3-phenoxybenzoic acid in urine.

Journal: Fresenius' journal of analytical chemistry 20011101

Title: Overview on clinical data of dexibuprofen.

Journal: Clinical rheumatology 20011101

Title: Treatment of non-malignant pain in the Dutch GP population: an analysis of treatment standards, prescription habits and basic attitudes.

Journal: Clinical rheumatology 20011101

Title: Efficacy and long-term safety of dexibuprofen [S(+)-ibuprofen]: a short-term efficacy study in patients with osteoarthritis of the hip and a 1-year tolerability study in patients with rheumatic disorders.

Journal: Clinical rheumatology 20011101

Title: Pain treatment with NSAIDs, primary focus on ibuprofen.

Journal: Clinical rheumatology 20011101

Title: Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen.

Journal: Clinical rheumatology 20011101

Title: Simultaneous fitting of R- and S-ibuprofen plasma concentrations after oral administration of the racemate.

Journal: British journal of clinical pharmacology 20011001

Title: The enantioselective immunoaffinity extraction of an optically active ibuprofen-modified peptide fragment.

Journal: Analytical biochemistry 20010901

Title: The oral bioavailability of ibuprofen enantiomers in broiler chickens.

Journal: Journal of veterinary pharmacology and therapeutics 20010401

Title: Radical degradation of high molecular weight hyaluronan: inhibition of the reaction by ibuprofen enantiomers.

Journal: Methods and findings in experimental and clinical pharmacology 20010301

Title: Synthesis of (S)-ibuprofen via enantioselective degradation of racemic ibuprofen with an isolated yeast, Trichosporon cutaneum KPY 30802, in an interface bioreactor.

Journal: Journal of bioscience and bioengineering 20010101

Title: Effectiveness evaluation of available without prescription medicines for postoperative pain treatment after 'one day surgery'.

Journal: Ortopedia, traumatologia, rehabilitacja 20010101

Title: Comparison of the bioavailability of dexibuprofen administered alone or as part of racemic ibuprofen.

Journal: European journal of clinical pharmacology 19950101

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Tags:51146-56-6 Molecular Formula|51146-56-6 MDL|51146-56-6 SMILES|51146-56-6 (S)-(+)-Ibuprofen
Catalog No.: AA003CF1
51146-56-6,MFCD00069289
51146-56-6 | (S)-(+)-Ibuprofen
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Technical Information
Catalog Number: AA003CF1
Chemical Name: (S)-(+)-Ibuprofen
CAS Number: 51146-56-6
Molecular Formula: C13H18O2
Molecular Weight: 206.2808
MDL Number: MFCD00069289
SMILES: CC(Cc1ccc(cc1)[C@@H](C(=O)O)C)C
NSC Number: 759814
Properties
BP: 319.6±11.0°C at 760 mmHg  
Form: Solid  
MP: 49-53 °C(lit.)  
Refractive Index: 59 ° (C=2, EtOH)  
Solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL  
Storage: Keep in dry area;Room Temperature;  
Complexity: 203  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 15  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.5  
Literature fold

Title: Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews20131023

Title: Chiral-substrate-assisted stereoselective epoxidation catalyzed by H2O2-dependent cytochrome P450SPα.

Journal: Chemistry, an Asian journal20121001

Title: 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3.

Journal: Journal of medicinal chemistry20120913

Title: A validated enantioselective HPLC assay of dexibuprofen in dexibuprofen tablet formulations.

Journal: Biomedical chromatography : BMC20120401

Title: An examination of the thermodynamics of fusion, vaporization, and sublimation of ibuprofen and naproxen by correlation gas chromatography.

Journal: Journal of pharmaceutical sciences20120201

Title: In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery.

Journal: Acta pharmacologica Sinica20120201

Title: Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.

Journal: PLoS computational biology20120201

Title: [UV spectroscopy coupled with partial least squares to determine the enantiomeric composition in chiral drugs].

Journal: Guang pu xue yu guang pu fen xi = Guang pu20120201

Title: Case series of 64 slice computed tomography-computed tomographic angiography with 3D reconstruction to diagnose symptomatic cerebral aneurysms: new standard of care?

Journal: Neurology international20120109

Title: Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease.

Journal: Neurobiology of aging20120101

Title: A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting.

Journal: International journal of nanomedicine20120101

Title: Specificity quantification of biomolecular recognition and its implication for drug discovery.

Journal: Scientific reports20120101

Title: Pharmacokinetics of ibuprofen enantiomers in rats after intravenous and oral administration of ibuprofen arginate.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20120101

Title: Improvement of the bioavailability and glycaemic metabolism of cinnamon oil in rats by liquid loadable tablets.

Journal: TheScientificWorldJournal20120101

Title: Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison.

Journal: The open rheumatology journal20120101

Title: Pharmacokinetic-pharmacodynamic model of newly developed dexibuprofen sustained release formulations.

Journal: ISRN pharmaceutics20120101

Title: In vitro evaluation of (S)-ibuprofen toxicity on joint cells and explants of cartilage and synovial membrane.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20111201

Title: Production of ibuprofen acyl glucosides by human UGT2B7.

Journal: Drug metabolism and disposition: the biological fate of chemicals20111201

Title: Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid.

Journal: Journal of pharmaceutical sciences20111201

Title: Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3.

Journal: Biopharmaceutics & drug disposition20111201

Title: Enantiospecific fate of ibuprofen, ketoprofen and naproxen in a laboratory-scale membrane bioreactor.

Journal: Water research20111115

Title: Synthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids.

Journal: Journal of enzyme inhibition and medicinal chemistry20111001

Title: Novel imaging agents for β-amyloid plaque based on the N-benzoylindole core.

Journal: Bioorganic & medicinal chemistry letters20110915

Title: A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.

Journal: Pharmacological research20110901

Title: Pharmacokinetic comparison of controlled- and immediate-release formulations of dexibuprofen after single and multiple oral doses in fasting healthy male Korean volunteers.

Journal: Clinical therapeutics20110901

Title: Lack of enantiomeric influence on the brain cytoprotective effect of ibuprofen and flurbiprofen.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20110801

Title: Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo.

Journal: Bioorganic & medicinal chemistry letters20110615

Title: Understanding the terahertz spectra of crystalline pharmaceuticals: terahertz spectroscopy and solid-state density functional theory study of (S)-(+)-ibuprofen and (RS)-ibuprofen.

Journal: Journal of pharmaceutical sciences20110301

Title: Pharmacokinetics and bioequivalence of single dose and multiple doses of immediate- and extended-release formulations of dexibuprofen in healthy Chinese subjects.

Journal: International journal of clinical pharmacology and therapeutics20110301

Title: Dry elixir formulations of dexibuprofen for controlled release and enhanced oral bioavailability.

Journal: International journal of pharmaceutics20110214

Title: Interaction between dexibuprofen and dexketoprofen in the orofacial formalin test in mice.

Journal: Pharmacology, biochemistry, and behavior20110101

Title: Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}.

Journal: Cancer prevention research (Philadelphia, Pa.)20110101

Title: Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility.

Journal: International journal of nanomedicine20110101

Title: Single dose oral analgesics for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews20110101

Title: Molecularly imprinted polymers: present and future prospective.

Journal: International journal of molecular sciences20110101

Title: Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells.

Journal: BMC neuroscience20110101

Title: Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex.

Journal: International journal of nanomedicine20110101

Title: Development and Validation of a HPLC and an UV Spectrophotometric Methods for Determination of Dexibuprofen in Pharmaceutical Preparations.

Journal: ISRN pharmaceutics20110101

Title: Differences in the in vitro antiplatelet effect of dexibuprofen, ibuprofen, and flurbiprofen in human blood.

Journal: Anesthesia and analgesia20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.

Journal: Journal of medicinal chemistry20100923

Title: Identifying early prescribers of cycloxygenase-2 inhibitors (COX-2s) in Nova Scotia, Canada: Considerations for targeted academic detailing.

Journal: Research in social & administrative pharmacy : RSAP20100901

Title: Rationale and conditions for the requirement of chiral bioanalytical methods in bioequivalence studies.

Journal: European journal of clinical pharmacology20100601

Title: Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors.

Journal: Journal of medicinal chemistry20100311

Title: Effect of drug chirality on the skin permeability of ibuprofen.

Journal: International journal of pharmaceutics20100215

Title: Macroscopic small bowel mucosal injury caused by chronic nonsteroidal anti-inflammatory drugs (NSAID) use as assessed by capsule endoscopy.

Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva20100201

Title: Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20100101

Title: Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

Journal: PloS one20100101

Title: Microencapsulation: an acclaimed novel drug-delivery system for NSAIDs in arthritis.

Journal: Critical reviews in therapeutic drug carrier systems20100101

Title: A prospective study of aspirin use and the risk of gastrointestinal bleeding in men.

Journal: PloS one20100101

Title: Determination of actarit from human plasma for bioequivalence studies.

Journal: Indian journal of pharmaceutical sciences20100101

Title: Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin.

Journal: Organic & biomolecular chemistry20091021

Title: Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care.

Journal: Methods and findings in experimental and clinical pharmacology20091001

Title: Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs.

Journal: British journal of clinical pharmacology20090901

Title: Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS).

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20090801

Title: Commercially viable resolution of ibuprofen.

Journal: Biotechnology journal20090801

Title: Influence of benzylamine on the resolution of ibuprofen with (+)-(R)-phenylethylamine via supercritical fluid extraction.

Journal: Chirality20090601

Title: Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity.

Journal: Experimental neurology20090501

Title: Assessment of the pharmaceutical active compounds removal in wastewater treatment systems at enantiomeric level. Ibuprofen and naproxen.

Journal: Chemosphere20090401

Title: Nicotinamide-2,2,2-trifluoro-ethanol (2/1).

Journal: Acta crystallographica. Section E, Structure reports online20090401

Title: Cyclic resolution of racemic ibuprofen via coupled efficient lipase and acid-base catalysis.

Journal: Chirality20090301

Title: A revised conformational code for the exhaustive analysis of conformers with one-to-one correspondence between conformation and code: application to the VCD analysis of (S)-ibuprofen.

Journal: The Journal of organic chemistry20090206

Title: ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial.

Journal: Gynecologic and obstetric investigation20090101

Title: Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews20090101

Title: Painful red nodules in female patient with recent travel history: a case report.

Journal: Cases journal20090101

Title: Solid Dispersion Matrix Tablet Comprising Indomethacin-PEG-HPMC Fabricated with Fusion and Mold Technique.

Journal: Indian journal of pharmaceutical sciences20090101

Title: Population pharmacokinetic analysis of Ibuprofen enantiomers in preterm newborn infants.

Journal: Journal of clinical pharmacology20081201

Title: The effects and safety of dexibuprofen compared with ibuprofen in febrile children caused by upper respiratory tract infection.

Journal: British journal of clinical pharmacology20081201

Title: Formulation of a extended release tablet containing dexibuprofen.

Journal: Archives of pharmacal research20081201

Title: Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20081101

Title: Necrotizing vasculitis as a complication of propylthiouracil.

Journal: The western journal of emergency medicine20081101

Title: Characterization of drug-protein binding process by employing equilibrium sampling through hollow-fiber supported liquid membrane and Bjerrum and Scatchard plots.

Journal: Journal of pharmaceutical and biomedical analysis20080910

Title: Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.

Journal: Chemical research in toxicology20080901

Title: Chiral non-steroidal anti-inflammatory drugs--a review.

Journal: Journal of the Indian Medical Association20080901

Title: Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia.

Journal: Neuroscience20080826

Title: Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteers.

Journal: Pharmacological research20080701

Title: Dexibuprofen (S(+)-isomer ibuprofen) reduces microglial activation and impairments of spatial working memory induced by chronic lipopolysaccharide infusion.

Journal: Pharmacology, biochemistry, and behavior20080501

Title: Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis.

Journal: Spine20080501

Title: NMR evaluation of adipocyte fatty acid binding protein (aP2) with R- and S-ibuprofen.

Journal: Bioorganic & medicinal chemistry20080415

Title: Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: the effect of rofecoxib withdrawal.

Journal: Arthritis and rheumatism20080415

Title: Development of an affinity silica monolith containing human serum albumin for chiral separations.

Journal: Journal of pharmaceutical and biomedical analysis20080414

Title: Emergency department patient knowledge concerning acetaminophen (paracetamol) in over-the-counter and prescription analgesics.

Journal: Emergency medicine journal : EMJ20080401

Title: Analgesic synergy between topical opioids and topical non-steroidal anti-inflammatory drugs in the mouse model of thermal pain.

Journal: European journal of pharmacology20080128

Title: S-ibuprofen effectively inhibits thromboxane B2 levels and platelet function in an experimental model of lipopolysaccharide-stimulated and non-stimulated whole blood.

Journal: Pharmacology20080101

Title: A randomized, crossover study to determine bioequivalence of two brands of dexibuprofen 400 mg tablets in healthy Asian adult male subjects of Indian origin.

Journal: International journal of clinical pharmacology and therapeutics20080101

Title: The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos.

Journal: PPAR research20080101

Title: Free drug metabolic clearance in elderly people.

Journal: Clinical pharmacokinetics20080101

Title: Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study.

Journal: Breast cancer research : BCR20080101

Title: Chiral separation of ibuprofen and chiral pharmacokinetics in healthy Chinese volunteers.

Journal: European journal of drug metabolism and pharmacokinetics20080101

Title: Bioequivalence study of two formulations containing 400 mg dexibuprofen in healthy Indian subjects.

Journal: Arzneimittel-Forschung20080101

Title: A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms.

Journal: Clinical therapeutics20071201

Title: NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues.

Journal: Analytical chemistry20071115

Title: Effect of absorption rate on pharmacokinetics of ibuprofen in relation to chiral inversion in humans.

Journal: The Journal of pharmacy and pharmacology20071101

Title: Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling.

Journal: Chirality20070901

Title: Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats.

Journal: Bioorganic & medicinal chemistry letters20070701

Title: Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen.

Journal: European journal of clinical pharmacology20070501

Title: A novel method for assessing inhibition of ibuprofen chiral inversion and its application in drug discovery.

Journal: International journal of pharmaceutics20070420

Title: Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs.

Journal: Neuroscience20070223

Title: [Pharmacokinetic interaction between phenitoin and dexibuprofen resulting in acute neurologic toxicity].

Journal: Medicina clinica20070217

Title: Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates.

Journal: Bioorganic & medicinal chemistry letters20070201

Title: Effects of dexibuprofen on platelet function in humans: comparison with low-dose aspirin.

Journal: Anesthesiology20070201

Title: Effects of St. John's wort supplementation on ibuprofen pharmacokinetics.

Journal: The Annals of pharmacotherapy20070201

Title: Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.

Journal: Bioorganic & medicinal chemistry20070115

Title: An internet survey of 2,596 people with fibromyalgia.

Journal: BMC musculoskeletal disorders20070101

Title: The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.

Journal: BMC medicine20070101

Title: (S)-Ibuprofen-imprinted polymers incorporating gamma-methacryloxypropyl-trimethoxysilane for CEC separation of ibuprofen enantiomers.

Journal: Electrophoresis20061101

Title: A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers.

Journal: European journal of clinical pharmacology20061001

Title: Binding studies of taxanes to human serum albumin by bioaffinity chromatography and circular dichroism.

Journal: Journal of pharmaceutical and biomedical analysis20060911

Title: Use of triplet excited States for the study of drug binding to human and bovine serum albumins.

Journal: ChemMedChem20060901

Title: Optimization of enantioselective resolution of racemic ibuprofen by native lipase from Aspergillus niger.

Journal: Journal of industrial microbiology & biotechnology20060801

Title: Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.

Journal: European journal of pharmacology20060701

Title: Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.

Journal: Journal of natural products20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Modification of pepsinogen I levels and their correlation with gastrointestinal injury after administration of dexibuprofen, ibuprofen or diclofenac: a randomized, open-label, controlled clinical trial.

Journal: International journal of clinical pharmacology and therapeutics20060401

Title: [Study on ion beam mutagenizing of the Trichosporon lactis T for enantioselective separation of ibuprofen].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica20060401

Title: Dynamic kinetic resolution: alternative approach in optimizing S-ibuprofen production.

Journal: Bioprocess and biosystems engineering20060301

Title: Beyond the white coat ceremony.

Journal: The Yale journal of biology and medicine20060301

Title: Increased expression of cyclooxygenase and nitric oxide isoforms, and exaggerated sensitivity to prostaglandin E2, in the rat lumbar spinal cord 3 days after L5-L6 spinal nerve ligation.

Journal: Anesthesiology20060201

Title: Chromatographic analysis of allosteric effects between ibuprofen and benzodiazepines on human serum albumin.

Journal: Chirality20060101

Title: An eutomer/distomer ratio near unity does not justify non-enantiospecific assay methods in bioequivalence studies.

Journal: Chirality20051001

Title: Similarity in structures of racemic and enantiomeric ibuprofen sodium dihydrates.

Journal: Acta crystallographica. Section C, Crystal structure communications20050901

Title: Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration.

Journal: Paediatric anaesthesia20050701

Title: 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.

Journal: Journal of medicinal chemistry20050630

Title: The effect of a dexibuprofen mouth rinse on experimental gingivitis in humans.

Journal: Journal of clinical periodontology20050601

Title: The interaction of lipophilic drugs with intestinal fatty acid-binding protein.

Journal: The Journal of biological chemistry20050506

Title: Solid-phase microextraction and chiral HPLC analysis of ibuprofen in urine.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20050425

Title: A supported liquid membrane encapsulating a surfactant-lipase complex for the selective separation of organic acids.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)20050204

Title: Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study.

Journal: BMC geriatrics20050101

Title: Enantioselective pharmacokinetics of ibuprofen and involved mechanisms.

Journal: Drug metabolism reviews20050101

Title: Solubility of (+/-)-ibuprofen and S (+)-ibuprofen in the presence of cosolvents and cyclodextrins.

Journal: Pharmaceutical development and technology20050101

Title: Application of thin-layer chromatography to investigate oscillatory instability of the selected profen enantiomers in dichloromethane.

Journal: Journal of chromatographic science20050101

Title: Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography.

Journal: Nature biotechnology20041101

Title: Population pharmacokinetics of ibuprofen enantiomers in very premature neonates.

Journal: Journal of clinical pharmacology20041001

Title: Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms.

Journal: Clinical pharmacology and therapeutics20040801

Title: Optical purity determination of (S)-ibuprofen in tablets by achiral gas chromatography.

Journal: Archives of pharmacal research20040801

Title: Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex.

Journal: Journal of the American Chemical Society20040721

Title: Enantioselective immunorecognition of protein modification with optically active ibuprofen using polyclonal antibody.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20040625

Title: Synthesis and evaluation of S-4-(3-thienyl)phenyl-alpha-methylacetic acid.

Journal: Bioorganic & medicinal chemistry letters20040223

Title: Bioequivalence study of two Ibuprofen formulations administered intravenously in healthy male volunteers.

Journal: Clinical drug investigation20040101

Title: Enzyme-facilitated enantioselective transport of (S)-ibuprofen through a supported liquid membrane based on ionic liquids.

Journal: Chemical communications (Cambridge, England)20031207

Title: Aspirin use and lung cancer in men.

Journal: British journal of cancer20031103

Title: Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat.

Journal: Anesthesiology20031101

Title: Dexibuprofen (S+-isomer ibuprofen) reduces gastric damage and improves analgesic and antiinflammatory effects in rodents.

Journal: Anesthesia and analgesia20030801

Title: Regio- and enantiospecific rhodium-catalyzed arylation of unsymmetrical fluorinated acyclic allylic carbonates: inversion of absolute configuration.

Journal: Journal of the American Chemical Society20030618

Title: Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers.

Journal: British journal of clinical pharmacology20030601

Title: Comparison of the efficacy and tolerability of dexibuprofen and celecoxib in the treatment of osteoarthritis of the hip.

Journal: International journal of clinical pharmacology and therapeutics20030401

Title: Ask the doctors. I have arthritis and take Motrin. Is there a problem with also taking aspirin, since my doctor has told me to do this ever since my heart attack?

Journal: Heart advisor20030401

Title: Spinal nerve injury activates prostaglandin synthesis in the spinal cord that contributes to early maintenance of tactile allodynia.

Journal: Pain20030101

Title: In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile.

Journal: Neuroscience20030101

Title: Bioavailability of two dermal formulations of S(+)ibuprofen in rabbit.

Journal: Arzneimittel-Forschung20030101

Title: Dexibuprofen: pharmacology, therapeutic uses and safety.

Journal: Inflammopharmacology20030101

Title: The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK.

Journal: Journal of cancer research and clinical oncology20021001

Title: Enantioselective analysis of ibuprofen in human plasma by anionic cyclodextrin-modified electrokinetic chromatography.

Journal: Electrophoresis20020901

Title: Stereoselectivity of ibuprofen metabolism and pharmacokinetics following the administration of the racemate to healthy volunteers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20020801

Title: Aspirin and lung cancer in women.

Journal: British journal of cancer20020701

Title: Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2.

Journal: Clinical pharmacology and therapeutics20020701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Enantioselective release of controlled delivery granules based on molecularly imprinted polymers.

Journal: Drug delivery20020101

Title: Aseptic meningo-encephalitis related to dexibuprofen use in a patient with systemic lupus erythematosus: a case report with MR findings.

Journal: Lupus20020101

Title: Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin.

Journal: Biochemical pharmacology20011215

Title: Ibuprofen interference in the determination of 3-phenoxybenzoic acid in urine.

Journal: Fresenius' journal of analytical chemistry20011101

Title: Overview on clinical data of dexibuprofen.

Journal: Clinical rheumatology20011101

Title: Treatment of non-malignant pain in the Dutch GP population: an analysis of treatment standards, prescription habits and basic attitudes.

Journal: Clinical rheumatology20011101

Title: Efficacy and long-term safety of dexibuprofen [S(+)-ibuprofen]: a short-term efficacy study in patients with osteoarthritis of the hip and a 1-year tolerability study in patients with rheumatic disorders.

Journal: Clinical rheumatology20011101

Title: Pain treatment with NSAIDs, primary focus on ibuprofen.

Journal: Clinical rheumatology20011101

Title: Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen.

Journal: Clinical rheumatology20011101

Title: Simultaneous fitting of R- and S-ibuprofen plasma concentrations after oral administration of the racemate.

Journal: British journal of clinical pharmacology20011001

Title: The enantioselective immunoaffinity extraction of an optically active ibuprofen-modified peptide fragment.

Journal: Analytical biochemistry20010901

Title: The oral bioavailability of ibuprofen enantiomers in broiler chickens.

Journal: Journal of veterinary pharmacology and therapeutics20010401

Title: Radical degradation of high molecular weight hyaluronan: inhibition of the reaction by ibuprofen enantiomers.

Journal: Methods and findings in experimental and clinical pharmacology20010301

Title: Synthesis of (S)-ibuprofen via enantioselective degradation of racemic ibuprofen with an isolated yeast, Trichosporon cutaneum KPY 30802, in an interface bioreactor.

Journal: Journal of bioscience and bioengineering20010101

Title: Effectiveness evaluation of available without prescription medicines for postoperative pain treatment after 'one day surgery'.

Journal: Ortopedia, traumatologia, rehabilitacja20010101

Title: Comparison of the bioavailability of dexibuprofen administered alone or as part of racemic ibuprofen.

Journal: European journal of clinical pharmacology19950101

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