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51166-71-3,MFCD00011616
Catalog No.:AA00I92Y

51166-71-3 | 2,6-Di-O-methyl-β-cyclodextrin

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250mg
98%
in stock  
$42.00   $29.00
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1g
98%
in stock  
$106.00   $74.00
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25g
98%
in stock  
$116.00   $82.00
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100g
98%
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$306.00   $214.00
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250g
99%
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$500.00   $350.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I92Y
Chemical Name:
2,6-Di-O-methyl-β-cyclodextrin
CAS Number:
51166-71-3
Molecular Formula:
C56H98O35
Molecular Weight:
1331.3563
MDL Number:
MFCD00011616
SMILES:
COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COC)O[C@@H]([C@@H]([C@H]3O)OC)O[C@@H]3[C@@H](COC)O[C@@H]([C@@H]([C@H]3O)OC)O[C@@H]3[C@@H](COC)O[C@@H]([C@@H]([C@H]3O)OC)O[C@@H]3[C@H](O[C@H](O[C@@H]4[C@H](O[C@H](O[C@@H]5[C@H](O[C@H](O[C@H]1[C@@H]([C@H]2OC)O)[C@H](OC)[C@H]5O)COC)[C@H](OC)[C@H]4O)COC)[C@H](OC)[C@H]3O)COC
Properties
Computed Properties
 
Complexity:
1690  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
35  
Heavy Atom Count:
91  
Hydrogen Bond Acceptor Count:
35  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
21  
XLogP3:
-7.5  

Literature

Title: Analysis of repaglinide enantiomers in pharmaceutical formulations by capillary electrophoresis using 2,6-di-o-methyl-β-cyclodextrin as a chiral selector.

Journal: Journal of chromatographic science 20120901

Title: DSC, X-ray and FTIR studies of a gemfibrozil/dimethyl-β-cyclodextrin inclusion complex produced by co-grinding.

Journal: Journal of pharmaceutical and biomedical analysis 20120105

Title: Enantiomeric separation of some common controlled stimulants by capillary electrophoresis with contactless conductivity detection.

Journal: Electrophoresis 20120101

Title: Evaluation of the separation mechanism of electrokinetic chromatography with a microemulsion and cyclodextrins using NMR and molecular modeling.

Journal: Electrophoresis 20111101

Title: Methods for determination of all binding parameters in systems with simultaneous borate and cyclodextrin complexation.

Journal: Journal of chromatography. A 20111007

Title: Morphological modification of nanostructured ultrathin-layer chromatography stationary phases.

Journal: Journal of chromatography. A 20111007

Title: Selective interaction of 2,6-di-O-methyl-β-cyclodextrin and Pluronic F127 micelles leading to micellar rupture: a nuclear magnetic resonance study.

Journal: The journal of physical chemistry. B 20110728

Title: New perspective for the treatment of Alzheimer diseases: liposomal rivastigmine formulations.

Journal: Drug development and industrial pharmacy 20110701

Title: Physico-chemical characterization and in vitro/in vivo evaluation of loratadine:dimethyl-β-cyclodextrin inclusion complexes.

Journal: Journal of pharmaceutical and biomedical analysis 20110515

Title: Dual CD system-modified MEEKC method for the determination of clemastine and its impurities.

Journal: Electrophoresis 20101001

Title: Low-frequency vibrational spectrum of water around cyclodextrin and its methyl-substituted derivatives.

Journal: Langmuir : the ACS journal of surfaces and colloids 20100907

Title: Evaluation of the cytotoxicity of beta-cyclodextrin derivatives: evidence for the role of cholesterol extraction.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100711

Title: Enantiomeric separation of cis-bifenthrin by CD-MEKC: quantitative analysis in a commercial insecticide formulation.

Journal: Electrophoresis 20100501

Title: Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20100401

Title: Investigation of liposome formulation effects on rivastigmine transport through human colonic adenocarcinoma cell line (CACO-2).

Journal: Die Pharmazie 20100101

Title: Spectroscopic studies and molecular modeling for understanding the interactions between cholesterol and cyclodextrins.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101

Title: Permeation of losartan across human respiratory epithelium: an in vitro study with Calu-3 cells.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20091201

Title: Separation of stereoisomers of sertraline and its related enantiomeric impurities on a dimethylated beta-cyclodextrin stationary phase by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20091015

Title: Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-beta-cyclodextrin, not 2,6-di-O-methyl-alpha-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091008

Title: Molecular encapsulation of 5-nitroindazole derivatives in 2,6-dimethyl-beta-cyclodextrin: electrochemical and spectroscopic studies.

Journal: Bioorganic & medicinal chemistry 20090701

Title: Enhancement of oral bioavailability of cilostazol by forming its inclusion complexes.

Journal: AAPS PharmSciTech 20090601

Title: Transport evaluation of alendronate across Caco-2 cell monolayers.

Journal: Die Pharmazie 20090201

Title: Grapevine cell early activation of specific responses to DIMEB, a resveratrol elicitor.

Journal: BMC genomics 20090101

Title: Effect of dimethyl-beta-cyclodextrin concentrations on the pulmonary delivery of recombinant human growth hormone dry powder in rats.

Journal: Journal of pharmaceutical sciences 20081201

Title: Inclusion complexes of tadalafil with natural and chemically modified beta-cyclodextrins. I: preparation and in-vitro evaluation.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101

Title: Interaction between nitroheterocyclic compounds with beta-cyclodextrins: phase solubility and HPLC studies.

Journal: Journal of pharmaceutical and biomedical analysis 20080805

Title: In vitro assessment of acyclovir permeation across cell monolayers in the presence of absorption enhancers.

Journal: Drug development and industrial pharmacy 20080301

Title: Modulation of ganciclovir intestinal absorption in presence of absorption enhancers.

Journal: Journal of pharmaceutical sciences 20071001

Title: Enantioselective determination of anteiso fatty acids in food samples.

Journal: Analytical chemistry 20070615

Title: Studies of inclusion complexes of natural and modified cyclodextrin with (+)catechin by NMR and molecular modeling.

Journal: Bioorganic & medicinal chemistry 20070501

Title: Investigation of heptakis(2,6-di-O-methyl)-beta-cyclodextrin inclusion complexes with flavonoid glycosides by electrospray ionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Nasal absorption of metoclopramide from different Carbopol 981 based formulations: In vitro, ex vivo and in vivo evaluation.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001

Title: Capillary electrophoresis combining field-amplified sample stacking and electroosmotic flow suppressant for analysis of sulindac and its two metabolites in plasma.

Journal: Journal of chromatography. A 20060630

Title: Pharmacokinetic advantage of an intranasal preparation of a novel anti-osteoporosis drug, L-Asp-hexapeptide-conjugated estradiol.

Journal: Biological & pharmaceutical bulletin 20060601

Title: Influence of modified cyclodextrins on solubility and percutaneous absorption of celecoxib through human skin.

Journal: International journal of pharmaceutics 20060511

Title: Modified cyclodextrins are chemically defined glucan inducers of defense responses in grapevine cell cultures.

Journal: Journal of agricultural and food chemistry 20060111

Title: Chiral separations on multichannel microfluidic chips.

Journal: Electrophoresis 20051201

Title: Characterization of a new methylated beta-cyclodextrin with a low degree of substitution by matrix-assisted laser desorption/ionization mass spectrometry and liquid chromatography using evaporative light scattering detection.

Journal: Journal of chromatography. A 20050812

Title: Preparation of celecoxib-dimethyl-beta-cyclodextrin inclusion complex: characterization and in vitro permeation study.

Journal: European journal of medicinal chemistry 20050701

Title: Application of dimethyl-beta-cyclodextrin as a chiral selector in capillary electrophoresis for enantiomer separation of ephedrine and related compounds in some drugs.

Journal: Biomedical chromatography : BMC 20050701

Title: Pulmonary delivery of low molecular weight heparins.

Journal: Pharmaceutical research 20041101

Title: [Enantiomeric determination of ephedrine derivatives in unregulated drugs using capillary electrophoresis].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040601

Title: Contribution of cholesterol and phospholipids to inhibitory effect of dimethyl-beta-cyclodextrin on efflux function of P-glycoprotein and multidrug resistance-associated protein 2 in vinblastine-resistant Caco-2 cell monolayers.

Journal: Pharmaceutical research 20040401

Title: Multicomponent complexes of piroxicam with cyclodextrins and hydroxypropyl methylcellulose.

Journal: Drug development and industrial pharmacy 20040101

Title: The effect of ruthenium(III) chloride on the formation of protonated parent ions in electrospray mass spectrometry.

Journal: Chemical communications (Cambridge, England) 20031107

Title: Pulmonary absorption of insulin mediated by tetradecyl-beta-maltoside and dimethyl-beta-cyclodextrin.

Journal: Pharmaceutical research 20031001

Title: Effects of the permeability enhancers, tetradecylmaltoside and dimethyl-beta-cyclodextrin, on insulin movement across human bronchial epithelial cells (16HBE14o-).

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030901

Title: Development and validation of a capillary zone electrophoresis method for the determination of ephedrine and related compounds in urine without extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030705

Title: Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-beta-cyclodextrins.

Journal: International journal of pharmaceutics 20030512

Title: Synthesis, characterization and in vitro evaluation of dimethyl-beta-cyclodextrin-4-biphenylylacetic acid conjugate.

Journal: Journal of drug targeting 20030501

Title: Involvement of cholesterol in the inhibitory effect of dimethyl-beta-cyclodextrin on P-glycoprotein and MRP2 function in Caco-2 cells.

Journal: FEBS letters 20030211

Title: Effect of inclusion complexation with cyclodextrins on photostability of nifedipine in solid state.

Journal: International journal of pharmaceutics 20020828

Title: Structure of the complex of heptakis(2,6-di-O-methyl)-beta-cyclodextrin with (2,4-dichlorophenoxy)acetic acid.

Journal: Carbohydrate research 20020716

Title: Separation of reboxetine enantiomers by means of capillary electrophoresis.

Journal: Electrophoresis 20020601

Title: pH-dependence of complexion constants and complex mobility in capillary electrophoresis separations of dipeptide enantiomers.

Journal: Electrophoresis 20010901

Title: Separation of ritalin racemate and its by-product racemates by capillary electrophoresis.

Journal: Electrophoresis 20010901

Title: Enantioseparation of chiral thiobarbiturates using cyclodextrin-modified capillary electrophoresis.

Journal: Electrophoresis 20010901

Title: Contribution of P-glycoprotein to the enhancing effects of dimethyl-beta-cyclodextrin on oral bioavailability of tacrolimus.

Journal: The Journal of pharmacology and experimental therapeutics 20010501

Title: Mutual inhibition of the insulin absorption-enhancing properties of dodecylmaltoside and dimethyl-beta-cyclodextrin following nasal administration.

Journal: Pharmaceutical research 20010501

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Tags:51166-71-3 Molecular Formula|51166-71-3 MDL|51166-71-3 SMILES|51166-71-3 2,6-Di-O-methyl-β-cyclodextrin