Home Quinolines 5154-02-9
5154-02-9,MFCD00006900
Catalog No.:AA00DE6M

5154-02-9 | 1,5-Isoquinolinediol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$52.00   $36.00
- +
25mg
≥98%
in stock  
$112.00   $78.00
- +
100mg
95%
in stock  
$145.00   $102.00
- +
250mg
95%
in stock  
$211.00   $148.00
- +
1g
95%
in stock  
$527.00   $369.00
- +
5g
95%
in stock  
$1,540.00   $1,078.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DE6M
Chemical Name:
1,5-Isoquinolinediol
CAS Number:
5154-02-9
Molecular Formula:
C9H7NO2
Molecular Weight:
161.1574
MDL Number:
MFCD00006900
SMILES:
Oc1cccc2c1ccnc2O
NSC Number:
65585
Properties
Computed Properties
 
Complexity:
225  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
1  

Literature

Title: Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120101

Title: Small fragment homologous replacement: evaluation of factors influencing modification efficiency in an eukaryotic assay system.

Journal: PloS one 20120101

Title: Potential role of poly(ADP-ribose) polymerase (PARP) activation in methotrexate-induced nephrotoxicity and tubular apoptosis.

Journal: International journal of toxicology 20120101

Title: PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: correlation with peripheral nerve function.

Journal: Free radical biology & medicine 20110515

Title: A 3-D microfluidic combinatorial cell array.

Journal: Biomedical microdevices 20110201

Title: Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2.

Journal: Vascular cell 20110101

Title: Butyrate-induced cell death and differentiation are associated with distinct patterns of ROS in HT29-derived human colon cancer cells.

Journal: Digestive diseases and sciences 20100401

Title: Role of the poly(ADP-ribose)polymerase activity in vancomycin-induced renal injury.

Journal: Toxicology letters 20100201

Title: A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: an immunohistochemical and behavioral study.

Journal: International journal of molecular sciences 20100101

Title: Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy.

Journal: Endocrinology 20091201

Title: Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.

Journal: Molecular pharmacology 20091001

Title: Aldosterone-induced endothelial dysfunction of rat aorta: role of poly(ADP-ribose) activation.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20090901

Title: Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats.

Journal: Investigative ophthalmology & visual science 20090401

Title: Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining.

Journal: Acta biochimica Polonica 20090101

Title: PARP inhibition reduces acute colonic inflammation in rats.

Journal: European journal of pharmacology 20070601

Title: Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.

Journal: Biochemical and biophysical research communications 20061201

Title: Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy.

Journal: Diabetes 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060301

Title: Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression.

Journal: BMC molecular biology 20060101

Title: Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation.

Journal: Journal of neurochemistry 20051001

Title: Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy.

Journal: Diabetes 20050501

Title: Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.

Journal: Shock (Augusta, Ga.) 20050301

Title: Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria.

Journal: Cancer research 20041215

Title: Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity.

Journal: The European journal of neuroscience 20041001

Title: Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose) polymerase inhibitor alone and in combination in rats with focal cerebral ischemia.

Journal: Journal of neurosurgery 20041001

Title: Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.

Journal: International journal of molecular medicine 20040701

Title: Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy.

Journal: Diabetes 20040301

Title: Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex.

Journal: Neuroscience letters 20040206

Title: Activation of poly(adenosine diphosphate-ribose) polymerase in mouse tumors treated by photodynamic therapy.

Journal: Photochemistry and photobiology 20031001

Title: Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801

Title: Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation.

Journal: The Journal of biological chemistry 20030523

Title: Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.

Journal: European journal of pharmacology 20030523

Title: The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

Journal: The Journal of urology 20030501

Title: 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20030201

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor.

Journal: Leukemia research 20000401

Title: Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:5154-02-9 Molecular Formula|5154-02-9 MDL|5154-02-9 SMILES|5154-02-9 1,5-Isoquinolinediol