Home Other Building Blocks 515814-01-4
515814-01-4,MFCD30720011
Catalog No.:AA00E7Y9

515814-01-4 | Voclosporin [usan]

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
in stock  
$649.00   $454.00
- +
25mg
95%
in stock  
$2,109.00   $1,477.00
- +
100mg
95%
in stock  
$4,808.00   $3,365.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E7Y9
Chemical Name:
Voclosporin [usan]
CAS Number:
515814-01-4
Molecular Formula:
C63H111N11O12
Molecular Weight:
1214.6219
MDL Number:
MFCD30720011
SMILES:
C=C/C=C/C[C@H]([C@H]([C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)O)C
Properties
Computed Properties
 
Complexity:
2380  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
86  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
16  
XLogP3:
7.9  

Literature

Title: The PROMISE study: a phase 2b multicenter study of voclosporin (ISA247) versus tacrolimus in de novo kidney transplantation.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20111201

Title: Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).

Journal: Acta crystallographica. Section D, Biological crystallography 20110201

Title: Novel immunosuppressive agents in kidney transplantation.

Journal: Clinical nephrology 20100501

Title: Next-generation calcineurin inhibitors for ophthalmic indications.

Journal: Expert opinion on investigational drugs 20071001

Title: ISA 247: trans-ISA 247, trans-R 1524, ISA(TX)247, ISAtx 247, ISATx247, LX 211, LX211, R 1524, R-1524.

Journal: Drugs in R&D 20070101

Title: A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis.

Journal: Journal of the American Academy of Dermatology 20060301

Title: The novel calcineurin inhibitor ISA247: a more potent immunosuppressant than cyclosporine in vitro.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20050501

Title: Potential future therapies for psoriasis.

Journal: Seminars in cutaneous medicine and surgery 20050301

Title: Compared with cyclosporine, ISATX247 significantly prolongs renal-allograft survival in a nonhuman primate model.

Journal: Transplantation 20040915

Title: ISAtx-247 (Isotechnika/Roche).

Journal: Current opinion in investigational drugs (London, England : 2000) 20040501

Title: Abel MD, et al. ISATX247: a novel calcineurin inhibitor. J Heart Lung Transplant. 2001 Feb;20(2):161.

Title: Stalder M, et al. In vivo evaluation of the novel calcineurin inhibitor ISATX247 in non-human primates. J Heart Lung Transplant. 2003 Dec;22(12):1343-52.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:515814-01-4 Molecular Formula|515814-01-4 MDL|515814-01-4 SMILES|515814-01-4 Voclosporin [usan]