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51781-21-6,MFCD00941499
Catalog No.:AA00I96B

51781-21-6 | Carteolol hydrochloride

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25mg
≥98%
in stock  
$98.00   $68.00
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50mg
≥98%
in stock  
$173.00   $121.00
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100mg
99%
in stock  
$304.00   $213.00
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250mg
≥98%
in stock  
$718.00   $502.00
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500mg
99%
in stock  
$1,168.00   $818.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I96B
Chemical Name:
Carteolol hydrochloride
CAS Number:
51781-21-6
Molecular Formula:
C16H25ClN2O3
Molecular Weight:
328.8343
MDL Number:
MFCD00941499
SMILES:
OC(COc1cccc2c1CCC(=O)N2)CNC(C)(C)C.Cl
Properties
Computed Properties
 
Complexity:
354  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Effects of topical carteolol on retinal arterial blood flow in primary open-angle glaucoma patients.

Journal: Japanese journal of ophthalmology 20120901

Title: Effects of a long-acting ophthalmic formulation of carteolol containing alginic acid on the corneal epithelial barrier function and water retentive effect.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20120401

Title: Time course of changes in ocular aberrations after instillation of carteolol long-acting solution and timolol gel-forming solution.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110401

Title: [Effects of carteolol hydrochloride on experimental choroidal neovascularization].

Journal: Nippon Ganka Gakkai zasshi 20110401

Title: Allergic contact dermatitis due to carteolol, with good tolerance to betaxolol.

Journal: Dermatitis : contact, atopic, occupational, drug 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Long-acting carteolol hydrochloride 2% ophthalmic solution phase IV study--investigation of the effectiveness, safety and plasma concentration].

Journal: Nippon Ganka Gakkai zasshi 20101101

Title: Extraction and preconcentration of beta-blockers in human urine for analysis with high performance liquid chromatography by means of carrier-mediated liquid phase microextraction.

Journal: Talanta 20100815

Title: [Effect of anti-glaucoma drugs on inflammatory cytokine production by human and murine peripheral blood mononuclear cells].

Journal: Nippon Ganka Gakkai zasshi 20100801

Title: Simultaneous quantification of carteolol and dorzolamide in rabbit aqueous humor and ciliary body by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100315

Title: Effect of carteolol hydrochloride on 24-hour variation of intraocular pressure in normal-tension glaucoma.

Journal: Japanese journal of ophthalmology 20100301

Title: [The influence of carteolol and pentoxyphylin on the visual field in glaucoma patients--case reports of selected patients].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20100201

Title: Designing dendrimers for ocular drug delivery.

Journal: European journal of medicinal chemistry 20100101

Title: Mechanism of carteolol-induced cytosolic Ca2+ mobilization in cultured vascular smooth muscle cells.

Journal: Vascular pharmacology 20100101

Title: Changes in optic nerve head blood flow induced by the combined therapy of latanoprost and beta blockers.

Journal: Acta ophthalmologica 20091101

Title: Carteolol, a non-conventional partial agonist of beta(1)-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at alpha(1)-adrenoceptors.

Journal: European journal of pharmacology 20080820

Title: Effects of switching from topical beta-blockers to latanoprost on intraocular pressure in patients with normal-tension glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080401

Title: [Ocular hypotensive effect of 1% carteolol long-acting eye drops--a double-masked, randomized phase III study in ocular hypertension or primary open-angle glaucoma patients comparing long-acting carteolol eye drops vs. current product].

Journal: Nippon Ganka Gakkai zasshi 20070601

Title: Cellular cytotoxicity of antiglaucoma drugs in cultured corneal endothelial cells.

Journal: The Kaohsiung journal of medical sciences 20070301

Title: Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs.

Journal: The British journal of ophthalmology 20070101

Title: Ocular carteolol: a review of its use in the management of glaucoma and ocular hypertension.

Journal: Drugs & aging 20070101

Title: [The deleterious effect of certain surface active agents on the ocular surface].

Journal: Bulletin de la Societe belge d'ophtalmologie 20070101

Title: Improvement of the ocular bioavailability of carteolol by ion pair.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20061001

Title: Additive effect of dorzolamide or carteolol to latanoprost in primary open-angle glaucoma: a prospective randomized crossover trial.

Journal: Journal of glaucoma 20060801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Beta-blocker eye drops.

Journal: Nursing times 20060501

Title: [A case of severe glaucoma with pseudopemphigoid successfully treated by filtration surgery using amniotic membrane].

Journal: Nippon Ganka Gakkai zasshi 20060401

Title: Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride.

Journal: Drug delivery 20060101

Title: Comparison of the additive effects of nipradilol and carteolol to latanoprost in open-angle glaucoma.

Journal: Japanese journal of ophthalmology 20060101

Title: Comparison of carteolol plasmatic levels after repeated instillations of long-acting and regular formulations of carteolol 2% in glaucoma patients.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20051201

Title: In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol.

Journal: The Journal of pharmacology and experimental therapeutics 20051201

Title: Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro.

Journal: Cornea 20050301

Title: Ventricular tachycardia in a neonate with prenatally diagnosed cardiac tumors: a case with tuberous sclerosis.

Journal: Pediatric cardiology 20050101

Title: Beta 2-adrenoceptor-mediated intrinsic sympathomimetic activity of carteolol: an in vivo study.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041101

Title: Effects of carteolol hydrochloride on the in vitro production of LPS-induced proinflammatory cytokines by murine macrophage.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601

Title: Characterization of intrinsic sympathomimetic activity of carteolol in rat cardiovascular preparations.

Journal: Journal of pharmacological sciences 20040501

Title: Latanoprost therapy in patients with glaucoma and ocular hypertension inadequately controlled with carteolol.

Journal: Japanese journal of ophthalmology 20040101

Title: [Neuroprotection and vasoprotection in glaucoma].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20040101

Title: Ocular factors relevant to anti-glaucomatous eyedrop-related keratoepitheliopathy.

Journal: Journal of glaucoma 20031201

Title: In vitro effects of preserved or preservative-free antiglaucoma medications on human complement system.

Journal: Current eye research 20031001

Title: A new method using pulmonary gas-exchange kinetics to evaluate efficacy of beta-blocking agents in patients with dilated cardiomyopathy.

Journal: Chest 20030901

Title: Cytoprotective effects of rebamipide and carteolol hydrochloride against ultraviolet B-induced corneal damage in mice.

Journal: Investigative ophthalmology & visual science 20030701

Title: Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030601

Title: [Efficacy and safety of long-acting carteolol 1% once daily. A double-masked, randomized study].

Journal: Journal francais d'ophtalmologie 20030201

Title: Comparison of the intraocular pressure lowering effect of latanoprost and carteolol-pilocarpine combination in newly diagnosed glaucoma.

Journal: Japanese journal of ophthalmology 20030101

Title: Corneal neovascularization possibly associated with latanoprost therapy.

Journal: European journal of ophthalmology 20030101

Title: Pharmacokinetic and pharmacodynamic differences between ocular and nasal instillation of carteolol on intraocular pressure and heart rate in Japanese men with high CYP2D6 activity.

Journal: Journal of clinical pharmacology 20020901

Title: Ocular drug delivery using 20-kHz ultrasound.

Journal: Ultrasound in medicine & biology 20020601

Title: The beta-blocker carteolol inhibits contractions induced by KCl in pig ciliary arteries: an effect modulated by extracellular Ca++.

Journal: Klinische Monatsblatter fur Augenheilkunde 20020401

Title: Alginic acid effect on carteolol ocular pharmacokinetics in the pigmented rabbit.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020201

Title: Topical beta blockers and atrioventricular block in the elderly.

Journal: Journal of postgraduate medicine 20020101

Title: Ocular and retrobulbar blood flow in ocular hypertensives treated with topical timolol, betaxolol and carteolol.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20011201

Title: Spontaneous hyphema secondary to iris vascular tufts.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20011101

Title: Heart function challenged with beta-receptor agonism or antagonism in a heart failure model.

Journal: Cardiovascular drugs and therapy 20011101

Title: Mitochondrial activity and glutathione injury in apoptosis induced by unpreserved and preserved beta-blockers on Chang conjunctival cells.

Journal: Investigative ophthalmology & visual science 20011001

Title: Color Doppler imaging of retrobulbar hemodynamics after topical carteolol in normal tension glaucoma.

Journal: Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 20011001

Title: Short-term effect of beta-adrenoreceptor blocking agents on ocular blood flow.

Journal: Current eye research 20011001

Title: Ocular hypotensive efficacy and safety of once daily carteolol alginate.

Journal: The British journal of ophthalmology 20010801

Title: A 7 year prospective comparative study of three topical beta blockers in the management of primary open angle glaucoma.

Journal: The British journal of ophthalmology 20010801

Title: Allergic contact dermatitis due to the beta-blocker befunolol in eyedrops, with cross-sensitivity to carteolol.

Journal: Contact dermatitis 20010601

Title: Assessment of systemic adverse reactions induced by ophthalmic beta-adrenergic receptor antagonists.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010601

Title: Functional properties of atypical beta-adrenoceptors on the guinea pig duodenum.

Journal: European journal of pharmacology 20010323

Title: The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study.

Journal: European journal of ophthalmology 20010101

Title: Color Doppler imaging study in patients with primary open-angle glaucoma treated with timolol 0.5% and carteolol 2%.

Journal: European journal of ophthalmology 20010101

Title: Cardiovascular considerations in using topical, oral, and intravenous drugs for the treatment of glaucoma and ocular hypertension: focus on beta-adrenergic blockade.

Journal: Heart disease (Hagerstown, Md.) 20010101

Title: Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970501

Title: The attenuating effect of carteolol hydrochloride, a beta-adrenoceptor antagonist, on neuroleptic-induced catalepsy in rats.

Journal: Psychopharmacology 19970501

Title: Cardiovascular effects of topical carteolol hydrochloride and timolol maleate in patients with ocular hypertension and primary open-angle glaucoma. Night Study Group.

Journal: American journal of ophthalmology 19970401

Title: A comparison of the ocular hypotensive efficacy and systemic safety of 0.5% levobunolol and 2% carteolol.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 19940101

Title: Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism.

Journal: Journal of clinical pharmacology 19900501

Title: [Clinical significance of intrinsic sympathomimetic activity of the beta blocker carteolol. II: Comparative studies of carteolol and pindolol in patients with bradycardia].

Journal: Medizinische Klinik (Munich, Germany : 1983) 19890215

Title: Remission of mild to moderate hypertension after treatment with carteolol, a beta-adrenoceptor blocker with intrinsic sympathomimetic activity.

Journal: Archives of internal medicine 19880801

Title: Kuwahara, K., et al., Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro. Cornea, 2005. 24(2): p. 213-20.

Title: Trinquand, C., et al., [Efficacy and safety of long-acting carteolol 1% once daily. A double-masked, randomized study J Fr Ophtalmol, 2003. 26(2): p. 131-6.

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Tags:51781-21-6 Molecular Formula|51781-21-6 MDL|51781-21-6 SMILES|51781-21-6 Carteolol hydrochloride