520-26-3,MFCD00075663
Catalog No.:AA003959

520-26-3 | (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one

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1mg
in stock  
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100mg
97%
in stock  
$6.00   $4.00
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1g
97%
in stock  
$7.00   $5.00
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5g
in stock  
$9.00   $6.00
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10g
97%
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$16.00   $12.00
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25g
97%
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100g
97%
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250g
≥ 91% (HPLC)
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  • Technical Information
  • Properties
  • Literature
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Technical Information
Catalog Number:
AA003959
Chemical Name:
(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one
CAS Number:
520-26-3
Molecular Formula:
C28H34O15
Molecular Weight:
610.5606
MDL Number:
MFCD00075663
SMILES:
COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O1)cc(cc2O)O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@@H]([C@H]([C@H]2O)O)O)[C@H]([C@@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
940  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
8  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-1.1  

Literature

Title: Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats.

Journal: Chemico-biological interactions 20180801

Title: Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice.

Journal: Chemico-biological interactions 20180401

Title: Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson's disease.

Journal: Chemico-biological interactions 20180105

Title: Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation.

Journal: Chemico-biological interactions 20171101

Title: Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl(4)-induced acute liver injury and LPS-treated RAW264.7 cells.

Journal: Toxicology letters 20170515

Title: Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway.

Journal: Toxicology 20170415

Title: Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.

Journal: Chemico-biological interactions 20151205

Title: Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis.

Journal: Journal of biochemical and molecular toxicology 20150301

Title: Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB.

Journal: Chemico-biological interactions 20150225

Title: Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes.

Journal: Journal of biochemical and molecular toxicology 20141101

Title: Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity.

Journal: Pharmacology, biochemistry, and behavior 20140901

Title: Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor.

Journal: Chemico-biological interactions 20140805

Title: Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro.

Journal: Chemico-biological interactions 20140425

Title: Mangiferin has an additive effect on the apoptotic properties of hesperidin in Cyclopia sp. tea extracts.

Journal: PloS one 20140101

Title: Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.

Journal: Mediators of inflammation 20140101

Title: Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

Journal: Journal of pharmaceutical sciences 20130901

Title: Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori.

Journal: Food chemistry 20121215

Title: Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells.

Journal: Food chemistry 20121201

Title: Effect of natural cross-linkers incorporation in a self-etching primer on dentine bond strength.

Journal: Journal of dentistry 20121201

Title: Synthesis and anti-hyperglycemic activity of hesperidin derivatives.

Journal: Bioorganic & medicinal chemistry letters 20121201

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: The flavonoids hesperidin and rutin promote neural crest cell survival.

Journal: Cell and tissue research 20121101

Title: Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability.

Journal: Journal of molecular recognition : JMR 20121101

Title: Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats.

Journal: Molecules (Basel, Switzerland) 20121101

Title: The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.

Journal: The Journal of nutritional biochemistry 20121001

Title: The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent.

Journal: Journal of vascular surgery 20121001

Title: Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells.

Journal: Food & function 20121001

Title: Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats.

Journal: Neurotoxicology 20121001

Title: Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart.

Journal: The Journal of pharmacy and pharmacology 20121001

Title: Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells.

Journal: Journal of agricultural and food chemistry 20120926

Title: Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats.

Journal: Phytotherapy research : PTR 20120901

Title: Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

Journal: Chinese journal of integrative medicine 20120901

Title: Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques.

Journal: Journal of food science 20120901

Title: Hesperidin attenuates brain biochemical changes of irradiated rats.

Journal: International journal of radiation biology 20120801

Title: Bioevaluation of human serum albumin-hesperidin bioconjugate: insight into protein vector function and conformation.

Journal: Journal of agricultural and food chemistry 20120725

Title: Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701

Title: Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701

Title: Simultaneous determination of six active components in traditional herbal medicine 'Oyaksungisan' by HPLC-DAD.

Journal: Journal of natural medicines 20120701

Title: Simultaneous UPLC analysis of three major flavonoids in granule decoctions of Fructus aurantii-type formulae.

Journal: Die Pharmazie 20120701

Title: Effects of the flavonoid hesperidin in cerebral cortical progenitors in vitro: indirect action through astrocytes.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20120601

Title: Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

Journal: Toxicology mechanisms and methods 20120601

Title: An investigation on the interaction of DNA with hesperetin/apigenin in the presence of CTAB by resonance Rayleigh light scattering technique and its analytical application.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120501

Title: Protective effect of hesperidin, a citrus flavanoglycone, against γ-radiation-induced tissue damage in Sprague-Dawley rats.

Journal: Journal of medicinal food 20120501

Title: Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin.

Journal: Experimental dermatology 20120501

Title: Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.

Journal: Journal of natural products 20120427

Title: Interaction of antioxidant flavonoids with calf thymus DNA analyzed by spectroscopic and electrochemical methods.

Journal: Journal of pharmaceutical and biomedical analysis 20120407

Title: Intravitreal kinetics of hesperidin, hesperetin, and hesperidin G: effect of dose and physicochemical properties.

Journal: Journal of pharmaceutical sciences 20120401

Title: Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites.

Journal: Food & function 20120401

Title: Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy.

Journal: Molecular nutrition & food research 20120401

Title: Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.

Journal: Inflammation 20120201

Title: The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism.

Journal: European journal of nutrition 20120201

Title: Alleviation of allergic rhinitis symptoms with Pyeongwee-San extract (KMP6).

Journal: Immunopharmacology and immunotoxicology 20120201

Title: Neuroprotective effects of citrus flavonoids.

Journal: Journal of agricultural and food chemistry 20120201

Title: Phytonutrient intake by adults in the United States in relation to fruit and vegetable consumption.

Journal: Journal of the Academy of Nutrition and Dietetics 20120201

Title: Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20120125

Title: Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation.

Journal: Toxicology letters 20120125

Title: Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach.

Journal: Journal of agricultural and food chemistry 20120111

Title: UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices.

Journal: Journal of pharmaceutical and biomedical analysis 20120105

Title: Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study.

Journal: International journal of biological macromolecules 20120101

Title: Separation and purification of neohesperidin from the albedo of Citrus reticulata cv. Suavissima by combination of macroporous resin and high-speed counter-current chromatography.

Journal: Journal of separation science 20120101

Title: Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin.

Journal: Journal of biomedicine & biotechnology 20120101

Title: LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration.

Journal: Natural product research 20120101

Title: Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Influence of hesperidin on renal cell surface glycoprotein content, nucleic acids, lysosomal enzymes and macromolecules against 7, 12-dimethylbenz [a] anthracene induced experimental breast carcinoma.

Journal: Journal of experimental therapeutics & oncology 20120101

Title: Hesperidin a citrus bioflavonoid modulates hepatic biotransformation enzymes and enhances intrinsic antioxidants in experimental breast cancer rats challenged with 7, 12-dimethylbenz (a) anthracene.

Journal: Journal of experimental therapeutics & oncology 20120101

Title: Enzymatic modification of chitosan with quercetin and its application as antioxidant edible films.

Journal: Prikladnaia biokhimiia i mikrobiologiia 20120101

Title: In vitro effect of hesperidin on root dentin collagen and de/re-mineralization.

Journal: Dental materials journal 20120101

Title: Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats.

Journal: Redox report : communications in free radical research 20120101

Title: [On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20120101

Title: Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats.

Journal: Vascular pharmacology 20120101

Title: Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells.

Journal: Biochemical and biophysical research communications 20111202

Title: Anti-platelet effects of yuzu extract and its component.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111201

Title: Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells.

Journal: Biopharmaceutics & drug disposition 20111201

Title: Analysis of flavonoids by capillary zone electrophoresis with electrokinetic supercharging.

Journal: The Analyst 20111107

Title: Evaluation of binding and thermodynamic characteristics of interactions between a citrus flavonoid hesperitin with protein and effects of metal ions on binding.

Journal: Molecular biology reports 20111101

Title: A novel application of α-glucosyl hesperidin for nanoparticle formation of active pharmaceutical ingredients by dry grinding.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20111101

Title: Differential effects of two citrus flavanones on bone quality in senescent male rats in relation to their bioavailability and metabolism.

Journal: Bone 20111101

Title: [Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20111101

Title: Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination.

Journal: Analytica chimica acta 20111031

Title: Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke.

Journal: Brain research 20111028

Title: α-Rhamnosyl-β-glucosidase-catalyzed reactions for analysis and biotransformations of plant-based foods.

Journal: Journal of agricultural and food chemistry 20111026

Title: Development and validation of a reliable high-performance liquid chromatographic method for determination of nodakenin in rat plasma and its application to pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20111001

Title: Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats.

Journal: Ecotoxicology and environmental safety 20111001

Title: Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin.

Journal: Cell biology and toxicology 20111001

Title: Microbial metabolism. Part 13. Metabolites of hesperetin.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats.

Journal: The British journal of nutrition 20111001

Title: Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7.

Journal: Molecular and cellular endocrinology 20110915

Title: HPLC determination of hesperidin, diosmin and eriocitrin in Iranian lime juice using polyamide as an adsorbent for solid phase extraction.

Journal: Journal of pharmaceutical and biomedical analysis 20110910

Title: Hesperidin promotes cyclobutane pyrimidine dimer repair in UVB-exposed mice epidermis.

Journal: Irish journal of medical science 20110901

Title: Purification and characterization of a novel alkaline α-L-rhamnosidase produced by Acrostalagmus luteo albus.

Journal: Journal of industrial microbiology & biotechnology 20110901

Title: Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat.

Journal: Cardiovascular toxicology 20110901

Title: Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents.

Journal: Pharmacology, biochemistry, and behavior 20110901

Title: Proline betaine and its biotransformation products in fasting urine samples are potential biomarkers of habitual citrus fruit consumption.

Journal: The British journal of nutrition 20110901

Title: Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study.

Journal: European review for medical and pharmacological sciences 20110901

Title: Optimized enzymatic synthesis of hesperidin fatty acid esters in a two-phase system containing ionic liquid.

Journal: Molecules (Basel, Switzerland) 20110823

Title: Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.

Journal: European journal of medicinal chemistry 20110801

Title: Possible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats.

Journal: Indian journal of experimental biology 20110801

Title: Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey.

Journal: Molecules (Basel, Switzerland) 20110727

Title: [Synthesis and anti-inflammatory activities of methylhesperetin-7-alkyl ether analogues].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110701

Title: Hesperedin promotes MyoD-induced myogenic differentiation in vitro and in vivo.

Journal: British journal of pharmacology 20110601

Title: Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort).

Journal: International angiology : a journal of the International Union of Angiology 20110601

Title: α-Glucosyl hesperidin induced an improvement in the bioavailability of pranlukast hemihydrate using high-pressure homogenization.

Journal: International journal of pharmaceutics 20110530

Title: Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells.

Journal: Journal of agricultural and food chemistry 20110525

Title: Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice.

Journal: Journal of photochemistry and photobiology. B, Biology 20110503

Title: Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110501

Title: Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.

Journal: The Journal of clinical endocrinology and metabolism 20110501

Title: Effect of hesperidin in vitro on root dentine collagen and demineralization.

Journal: Journal of dentistry 20110501

Title: Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFκB, p38 and caspase-3.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110401

Title: [Studies on the chemical constituents of Codonopsis pilosula].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401

Title: Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis.

Journal: Acta bio-medica : Atenei Parmensis 20110401

Title: Hesperetin, a potential therapy for carcinoid cancer.

Journal: American journal of surgery 20110301

Title: Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice.

Journal: Fundamental & clinical pharmacology 20110201

Title: Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats.

Journal: Pharmacology, biochemistry, and behavior 20110201

Title: Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animals.

Journal: Oncology reports 20110201

Title: Simultaneous determination of liquiritin, hesperidin, and glycyrrhizin by HPLC-photodiode array detection and the anti-inflammatory effect of Pyungwi-san.

Journal: Archives of pharmacal research 20110201

Title: [Separation and determination of hesperidin in huoxiangzhengqi water by hollow fiber ultrafiltration-high performance liquid chromatography].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110201

Title: Genotoxicity assessment of Pyungwi-san (PWS), a traditional herbal prescription.

Journal: Journal of ethnopharmacology 20110127

Title: Inactivation of nuclear factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells.

Journal: European journal of pharmacology 20110115

Title: Identification of chemical constituents in extracts and rat plasma from Fructus Aurantii by UPLC-PDA-Q-TOF/MS.

Journal: Phytochemical analysis : PCA 20110101

Title: Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.

Journal: Lipids in health and disease 20110101

Title: [Determination of liquiritin, naringin, hesperidin and glycyrrhizic acid in extractive of Wendan formula by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110101

Title: Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.

Journal: International journal of medical sciences 20110101

Title: C-kit binding properties of hesperidin (a major component of KMP6) as a potential anti-allergic agent.

Journal: PloS one 20110101

Title: Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma.

Journal: Mediators of inflammation 20110101

Title: Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Tissue distribution of hesperetin in rats after a dietary intake.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Effects of hesperidin on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats.

Journal: Journal of pharmacological sciences 20110101

Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

Journal: Journal of biomedical science 20110101

Title: Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a randomized controlled cross-over study.

Journal: PloS one 20110101

Title: Hesperidin protects renal and hepatic tissues against free radical-mediated oxidative stress during DMBA-induced experimental breast cancer.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20110101

Title: Antiviral activity of four types of bioflavonoid against dengue virus type-2.

Journal: Virology journal 20110101

Title: Binding capacity of ER-α ligands and SERMs: comparison of the human, dog and cat.

Journal: Asian Pacific journal of cancer prevention : APJCP 20110101

Title: Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9.

Journal: European journal of pharmacology 20101215

Title: 7,3'-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation.

Journal: Phytotherapy research : PTR 20101201

Title: Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study).

Journal: International angiology : a journal of the International Union of Angiology 20101201

Title: Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.

Journal: Acta tropica 20101101

Title: On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme.

Journal: Journal of agricultural and food chemistry 20101013

Title: Transglycosylated stevia and hesperidin as pharmaceutical excipients: dramatic improvement in drug dissolution and bioavailability.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101001

Title: Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101001

Title: Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design.

Journal: Journal of separation science 20101001

Title: Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners.

Journal: The British journal of nutrition 20100901

Title: UV-B modulates the interplay between terpenoids and flavonoids in peppermint (Mentha x piperita L.).

Journal: Journal of photochemistry and photobiology. B, Biology 20100802

Title: Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters.

Journal: Journal of medicinal food 20100801

Title: Synergistic and antagonistic interactions of phenolic compounds found in navel oranges.

Journal: Journal of food science 20100801

Title: Passive asymmetric transport of hesperetin across isolated rabbit cornea.

Journal: International journal of pharmaceutics 20100715

Title: Synthesis, characterization, DNA binding properties, fluorescence studies and antioxidant activity of transition metal complexes with hesperetin-2-hydroxy benzoyl hydrazone.

Journal: Journal of fluorescence 20100701

Title: Effect of added citrus fibre and spice essential oils on quality characteristics and shelf-life of mortadella.

Journal: Meat science 20100701

Title: Hesperidin and hesperetin membrane interaction: understanding the role of 7-O-glycoside moiety in flavonoids.

Journal: Archives of biochemistry and biophysics 20100701

Title: Protective effects of silybin and analogues against X-ray radiation-induced damage.

Journal: Acta biochimica et biophysica Sinica 20100701

Title: [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100701

Title: Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with alpha-glucosyl hesperidin.

Journal: International journal of pharmaceutics 20100615

Title: Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects.

Journal: The British journal of nutrition 20100601

Title: The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers.

Journal: Molecular nutrition & food research 20100601

Title: Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.

Journal: Journal of agricultural and food chemistry 20100526

Title: Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro.

Journal: Journal of agricultural and food chemistry 20100526

Title: In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr.

Journal: Bioorganic & medicinal chemistry 20100515

Title: Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway.

Journal: The Journal of nutritional biochemistry 20100501

Title: Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100501

Title: Extracellular monoenzyme deglycosylation system of 7-O-linked flavonoid beta-rutinosides and its disaccharide transglycosylation activity from Stilbella fimetaria.

Journal: Archives of microbiology 20100501

Title: The effect of component of cream for topical delivery of hesperetin.

Journal: Chemical & pharmaceutical bulletin 20100501

Title: Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.

Journal: Natural product communications 20100501

Title: Homoisoflavonoids from the fibrous roots of Polygonatum odoratum with glucose uptake-stimulatory activity in 3T3-L1 adipocytes.

Journal: Journal of natural products 20100423

Title: Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.

Journal: Journal of natural products 20100423

Title: Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.

Journal: Journal of ethnopharmacology 20100421

Title: The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells.

Journal: Toxicology letters 20100415

Title: The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.

Journal: Biochemical and biophysical research communications 20100409

Title: Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100401

Title: Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.

Journal: European journal of clinical nutrition 20100401

Title: Chiral separation of hesperidin and naringin and its analysis in a butanol extract of Launeae arborescens.

Journal: Natural product research 20100401

Title: In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system.

Journal: International journal of pharmaceutics 20100330

Title: Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells.

Journal: Journal of agricultural and food chemistry 20100324

Title: Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions.

Journal: Drug development and industrial pharmacy 20100301

Title: Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography.

Journal: Journal of chromatography. A 20100212

Title: Preserving hesperetin nanosuspensions for dermal application.

Journal: Die Pharmazie 20100201

Title: [Study on the contents of flavonoids in Citrus reticulata 'Chachi' from various habitats and different collecting periods].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100201

Title: Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.

Journal: Nutrients 20100201

Title: Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation.

Journal: Journal of agricultural and food chemistry 20100113

Title: Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide.

Journal: Behavioural brain research 20100105

Title: Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20100105

Title: Structural activity relationship of flavonoids with estrogen-related receptor gamma.

Journal: FEBS letters 20100104

Title: Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

Journal: Bioorganic & medicinal chemistry 20100101

Title: Simultaneous quantification of 14 bioactive constituents in Forsythia suspensa by liquid chromatography-electrospray ionisation-mass spectrometry.

Journal: Phytochemical analysis : PCA 20100101

Title: Effect of hesperidin on expression of inducible nitric oxide synthase in cultured rabbit retinal pigment epithelial cells.

Journal: Advances in experimental medicine and biology 20100101

Title: [Study on the flavonoids constituents of Trachelospermum jasminoides].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100101

Title: Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells.

Journal: Cellular immunology 20100101

Title: Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction.

Journal: Pharmacological reports : PR 20100101

Title: [Monitoring the quality of life in patients with varicose disease of the lower extremities in the use of venarus].

Journal: Khirurgiia 20100101

Title: Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats.

Journal: Journal of toxicology and environmental health. Part A 20100101

Title: Hesperidin, a flavanone glycoside, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats.

Journal: Redox report : communications in free radical research 20100101

Title: [Conservative treatment of patients with varicose esophagus veins cirrhosis].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20100101

Title: Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components.

Journal: World journal of gastroenterology 20091221

Title: Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease.

Journal: Phytotherapy research : PTR 20091201

Title: Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes.

Journal: Bioscience, biotechnology, and biochemistry 20091201

Title: Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone.

Journal: European journal of medicinal chemistry 20091101

Title: [Study on the optimal extraction process of chaihushugan powder].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091101

Title: Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20091001

Title: Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats.

Journal: The British journal of nutrition 20091001

Title: Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice.

Journal: Journal of natural medicines 20091001

Title: Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091001

Title: Effect of 4G-alpha-glucopyranosyl hesperidin on brown fat adipose tissue- and cutaneous-sympathetic nerve activity and peripheral body temperature.

Journal: Neuroscience letters 20090911

Title: Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin.

Journal: Free radical research 20090901

Title: Exploring the effect of Hesperetin-HSPC complex--a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics.

Journal: AAPS PharmSciTech 20090901

Title: Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods.

Journal: Analytica chimica acta 20090901

Title: Treatment of rat adjuvant arthritis with flavonoid (Detralex), methotrexate, and their combination.

Journal: Annals of the New York Academy of Sciences 20090901

Title: Physiological and biochemical characterization of the two alpha-L-rhamnosidases of Lactobacillus plantarum NCC245.

Journal: Microbiology (Reading, England) 20090801

Title: Assessment of quality of life in Mexican patients suffering from chronic venous disorder - impact of oral Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid treatment - 'QUALITY Study'.

Journal: Phlebology 20090801

Title: Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis.

Journal: Chemico-biological interactions 20090715

Title: Glucosyl hesperidin prevents influenza a virus replication in vitro by inhibition of viral sialidase.

Journal: Biological & pharmaceutical bulletin 20090701

Title: Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.

Journal: Journal of natural products 20090701

Title: Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance.

Journal: Toxicology and industrial health 20090701

Title: Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.

Journal: Investigational new drugs 20090601

Title: Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.

Journal: Investigational new drugs 20090601

Title: Hesperidin gastroresistant microparticles by spray-drying: preparation, characterization, and dissolution profiles.

Journal: AAPS PharmSciTech 20090601

Title: Bioactivation of flavonoid diglycosides by chicken cecal bacteria.

Journal: FEMS microbiology letters 20090601

Title: Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats.

Journal: The Journal of pharmacy and pharmacology 20090601

Title: Changes on venous diameter and leg perimeter with different clinical treatments for moderate chronic venous disease: evaluation using Duplex scanning and perimeter measurements.

Journal: International angiology : a journal of the International Union of Angiology 20090601

Title: [Anti-inflammatory effects and quantitative study of the combinations of active ingredients of Painong powder in mice].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090601

Title: Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats.

Journal: Journal of the Egyptian National Cancer Institute 20090601

Title: Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes.

Journal: Mutation research 20090531

Title: Solubility, stability, physicochemical characteristics and in vitro ocular tissue permeability of hesperidin: a natural bioflavonoid.

Journal: Pharmaceutical research 20090501

Title: Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans.

Journal: Molecular nutrition & food research 20090501

Title: Production and characterization of Hesperetin nanosuspensions for dermal delivery.

Journal: International journal of pharmaceutics 20090417

Title: Untargeted metabolite analysis of healthy and Huanglongbing-infected orange leaves by CE-DAD.

Journal: Electrophoresis 20090401

Title: Sulfation of dietary flavonoids by human sulfotransferases.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090401

Title: [Effects of Hesperetin on cell activation and proliferation of murine T lymphocytes in vitro].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20090401

Title: The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.

Journal: Archives of biochemistry and biophysics 20090401

Title: The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.

Journal: Biomedical chromatography : BMC 20090301

Title: Evaluation of antioxidant activity of hesperidin and its protective effect on H2O2 induced oxidative damage on pBR322 DNA and RBC cellular membrane.

Journal: Molecular and cellular biochemistry 20090301

Title: Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers.

Journal: Planta medica 20090301

Title: Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells.

Journal: Toxicology letters 20090210

Title: Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.

Journal: Biomedical chromatography : BMC 20090201

Title: [Studies on chemical components of Lobelia chinensis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

Title: Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids.

Journal: Molecular and cellular biochemistry 20090101

Title: Effect of constituents from Fructus Aurantii Immaturus and Radix Paeoniae Alba on gastrointestinal movement.

Journal: Planta medica 20090101

Title: Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.

Journal: Bioorganic & medicinal chemistry 20090101

Title: [Study on the interaction of hesperidin or icariin with lysozyme by fluorescence spectroscopy].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20090101

Title: Discrimination of three medicinal materials from the Citrus genus by HPLC fingerprint coupled with two complementary software.

Journal: Phytochemical analysis : PCA 20090101

Title: Liquid chromatographic determination of narirutin and hesperidin in Zhi Ke (Citrus aurantium L.) in the form of the raw herb and of the dried aqueous extract.

Journal: Journal of AOAC International 20090101

Title: Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection.

Journal: Journal of pharmaceutical and biomedical analysis 20081215

Title: Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt.

Journal: Journal of agricultural and food chemistry 20081210

Title: Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism.

Journal: Phytotherapy research : PTR 20081201

Title: Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.

Journal: Nutrition research (New York, N.Y.) 20081201

Title: Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes.

Journal: Journal of agricultural and food chemistry 20081126

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Enantiomeric separation of some flavanones using shinorhizobial linear octasaccharides in CE.

Journal: Electrophoresis 20081101

Title: Neuroprotective effects of chronic hesperetin administration in mice.

Journal: Archives of pharmacal research 20081101

Title: Characterization of an alpha-L-rhamnosidase from Aspergillus kawachii and its gene.

Journal: Applied microbiology and biotechnology 20081001

Title: Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin.

Journal: Phytotherapy research : PTR 20081001

Title: Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.

Journal: The Journal of pharmacy and pharmacology 20081001

Title: Chemical characterization of Citrus sinensis grafted on C. limonia and the effect of some isolated compounds on the growth of Xylella fastidiosa.

Journal: Journal of agricultural and food chemistry 20080910

Title: Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080901

Title: Effects of hesperidin on cyclic strain-induced endothelin-1 release in human umbilical vein endothelial cells.

Journal: Clinical and experimental pharmacology & physiology 20080801

Title: Effects of calcium dobesilate and diosmin-hesperidin on apoptosis of venous wall in primary varicose veins.

Journal: VASA. Zeitschrift fur Gefasskrankheiten 20080801

Title: In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts.

Journal: Journal of agricultural and food chemistry 20080723

Title: Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry.

Journal: Biomedical chromatography : BMC 20080701

Title: Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.

Journal: Neuroscience letters 20080613

Title: Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats.

Journal: European journal of pharmacology 20080610

Title: Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation.

Journal: Cell biology and toxicology 20080601

Title: Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.

Journal: Gastroenterology 20080601

Title: Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice.

Journal: Life sciences 20080523

Title: Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle.

Journal: Journal of cellular biochemistry 20080501

Title: Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20080501

Title: Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells.

Journal: International immunopharmacology 20080501

Title: Use of microcirculatory parameters to evaluate clinical treatments of chronic venous disorder (CVD).

Journal: Microvascular research 20080501

Title: Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats.

Journal: The Israel Medical Association journal : IMAJ 20080501

Title: HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines.

Journal: Journal of pharmaceutical and biomedical analysis 20080414

Title: Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.

Journal: The Journal of biological chemistry 20080404

Title: Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.

Journal: Bioorganic & medicinal chemistry 20080401

Title: Hesperidin in orange juice reduces the absorption of celiprolol in rats.

Journal: Biopharmaceutics & drug disposition 20080401

Title: Anti-allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride-induced contact dermatitis in mice.

Journal: Journal of natural medicines 20080401

Title: Enhanced bioavailability of verapamil after oral administration with hesperidin in rats.

Journal: Archives of pharmacal research 20080401

Title: Ultrasound-assisted extraction of hesperidin from Penggan (Citrus reticulata) peel.

Journal: Ultrasonics sonochemistry 20080301

Title: Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices.

Journal: Biopharmaceutics & drug disposition 20080301

Title: Glycosylation of hesperetin by plant cell cultures.

Journal: Phytochemistry 20080301

Title: Hesperidin inhibits ovariectomized-induced osteopenia and shows differential effects on bone mass and strength in young and adult intact rats.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20080301

Title: Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells.

Journal: Journal of agricultural and food chemistry 20080213

Title: Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.

Journal: European journal of pharmacology 20080212

Title: Different flavonoids present in the micronized purified flavonoid fraction (Daflon 500 mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch microcirculation.

Journal: International angiology : a journal of the International Union of Angiology 20080201

Title: Effect of adding extracted hesperetin, naringenin and pectin on egg cholesterol, serum traits and antioxidant activity in laying hens.

Journal: Archives of animal nutrition 20080201

Title: Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.

Journal: Journal of nutritional science and vitaminology 20080201

Title: High-performance liquid chromatography as a tool for the chemical standardisation of Triphala--an Ayurvedic formulation.

Journal: Phytochemical analysis : PCA 20080101

Title: Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20080101

Title: Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers.

Journal: Biochimica et biophysica acta 20080101

Title: Effects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans.

Journal: Immunopharmacology and immunotoxicology 20080101

Title: Flavonoid glycosides and limonoids from Citrus molasses.

Journal: Journal of natural medicines 20080101

Title: Inhibition of oral carcinogenesis by citrus flavonoids.

Journal: Nutrition and cancer 20080101

Title: [Certain aspects of pathogenesis of hemorheological and trophic disturbances and their pharmacological correction in patients with chronic venous insufficiency].

Journal: Vestnik khirurgii imeni I. I. Grekova 20080101

Title: Development of a potential reference material for evaluating antioxidant activity.

Journal: Journal of AOAC International 20080101

Title: Suppressive effects of the flavonoids quercetin and luteolin on the accumulation of lipid rafts after signal transduction via receptors.

Journal: Immunopharmacology and immunotoxicology 20080101

Title: Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain.

Journal: Journal of biochemical and molecular toxicology 20080101

Title: Antagonistic interactions between the flavonoids hesperetin and naringenin and beta-lactam antibiotics against Staphylococcus aureus.

Journal: British journal of biomedical science 20080101

Title: [Edema as a measure for severity of chronic venous insufficiency and efficacy of its treatment].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20080101

Title: Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.

Journal: Journal of applied microbiology 20071201

Title: Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients.

Journal: International angiology : a journal of the International Union of Angiology 20071201

Title: Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20071101

Title: Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells.

Journal: Molecular and cellular biochemistry 20071101

Title: [Inhibitory effect of isorhamnetin and hesperidin on the oxidation of high-density lipoproteins (HDL) induced by Cu2+].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20071101

Title: Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

Title: Antioxidant properties of hesperidin in nicotine-induced lung toxicity.

Journal: Fundamental & clinical pharmacology 20071001

Title: [Immunological aspects of aphthous stomatitis].

Journal: Georgian medical news 20071001

Title: [Study on chemical constituents of Portulaca oleracea].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071001

Title: Effect of hesperidin on matrix metalloproteinases and antioxidant status during nicotine-induced toxicity.

Journal: Toxicology 20070905

Title: Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity.

Journal: Atherosclerosis 20070901

Title: Functional characteristics of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. BL-31 highly specific for intermolecular transglycosylation of bioflavonoids.

Journal: Journal of microbiology and biotechnology 20070901

Title: High-performance liquid chromatographic determination and pharmacokinetic study of vitexin-2''-O-rhamnoside in rat plasma after intravenous administration.

Journal: Journal of pharmaceutical and biomedical analysis 20070727

Title: Flavanone plasma pharmacokinetics from blood orange juice in human subjects.

Journal: The British journal of nutrition 20070701

Title: [Inhibitory effect of Isorhamnetin and Hesperidin on LDL oxidation induced by Cu2+].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070601

Title: [Microwave-assisted extraction of Hesperidin from pericarpium citri reticulate].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070601

Title: Thermal degradation of antioxidant micronutrients in citrus juice: kinetics and newly formed compounds.

Journal: Journal of agricultural and food chemistry 20070516

Title: The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.

Journal: Life sciences 20070424

Title: Enantioseparation of some chiral flavanones using microbial cyclic beta-(1-->3),(1-->6)-glucans as novel chiral additives in capillary electrophoresis.

Journal: Carbohydrate research 20070409

Title: Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.

Journal: European journal of clinical nutrition 20070401

Title: Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.

Journal: Clinical pharmacology and therapeutics 20070401

Title: Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS.

Journal: Journal of separation science 20070401

Title: Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death.

Journal: Biological & pharmaceutical bulletin 20070201

Title: Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.

Journal: Journal of enzyme inhibition and medicinal chemistry 20070201

Title: Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.

Journal: Journal of enzyme inhibition and medicinal chemistry 20070201

Title: Protective effect of hesperidin on nicotine induced toxicity in rats.

Journal: Indian journal of experimental biology 20070201

Title: [Congenital anomalies of the inferior vena cava: diagnosis and medical treatment].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20070101

Title: Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21.

Journal: Nutrition and cancer 20070101

Title: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

Journal: BMC structural biology 20070101

Title: Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS).

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20070101

Title: Effects of citrus flavonoids on redox homeostasis of toxin-injured liver in rat.

Journal: Acta biologica Hungarica 20061201

Title: Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods.

Journal: Journal of chromatography. A 20061117

Title: A new method for fabrication of an integrated indium tin oxide electrode on electrophoresis microchips with amperometric detection and its application for determination of synephrine and hesperidin in pericarpium citri reticulatae.

Journal: Electrophoresis 20061101

Title: Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061101

Title: Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20061011

Title: Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin.

Journal: Aging cell 20061001

Title: [Prevention of osteoporosis by foods and dietary supplements. Hesperidin and bone metabolism].

Journal: Clinical calcium 20061001

Title: Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity.

Journal: Toxicology 20060921

Title: Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.

Journal: Biochemical and biophysical research communications 20060908

Title: Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20060901

Title: [Determination of three chemical components in Fructus aurantii immaturus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901

Title: Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin.

Journal: Archives of pharmacal research 20060801

Title: Use of NIRS for quantification of mangiferin and hesperidin contents of dried green honeybush (Cyclopia genistoides) plant material.

Journal: Journal of agricultural and food chemistry 20060726

Title: Bioavailability of glucosyl hesperidin in rats.

Journal: Bioscience, biotechnology, and biochemistry 20060601

Title: Suppression of apolipoprotein B secretion from HepG2 cells by glucosyl hesperidin.

Journal: Journal of nutritional science and vitaminology 20060601

Title: A new method for express analysis of flavonoid fraction in nephrophite plant extract and prediction of its antioxidant effects.

Journal: Bulletin of experimental biology and medicine 20060601

Title: Identification of linear plasmid pAM1 in the flavonoid degrading strain Actinoplanes missouriensis(T) (DSM 43046).

Journal: Plasmid 20060501

Title: Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells.

Journal: The British journal of radiology 20060501

Title: Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060401

Title: The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites.

Journal: European journal of nutrition 20060301

Title: Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20060301

Title: Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro.

Journal: The Journal of pharmacy and pharmacology 20060301

Title: Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans.

Journal: Journal of nutritional science and vitaminology 20060201

Title: Quantitative and qualitative analysis of flavonoid markers in Frucus aurantii of different geographical origin by capillary electrophoresis with electrochemical detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

Title: Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice.

Journal: The international journal of biochemistry & cell biology 20060101

Title: [Risk factors of chronic venous insufficiency of the lower extremities and possibilities of its medication in therapeutic practice].

Journal: Terapevticheskii arkhiv 20060101

Title: [Flavonoids as effective protectors of urease from ultrasonic inactivation in solutions].

Journal: Bioorganicheskaia khimiia 20060101

Title: Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC.

Journal: Journal of agricultural and food chemistry 20051214

Title: Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormality.

Journal: Journal of nutritional science and vitaminology 20051201

Title: Prokinetic activity of an aqueous extract from dried immature fruit of Poncirus trifoliata (L.) Raf.

Journal: Journal of ethnopharmacology 20051114

Title: Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.

Journal: Antiviral research 20051001

Title: Separation of some chiral flavonoids by microbial cyclosophoraoses and their sulfated derivatives in micellar electrokinetic chromatography.

Journal: Electrophoresis 20051001

Title: Determination of active components in rosemary by capillary electrophoresis with electrochemical detection.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-beta-cyclodextrin.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials.

Journal: Journal of natural products 20050901

Title: HPLC separation of hesperidin and the C-2 epimer in commercial hesperidin samples and herbal medicines.

Journal: Chirality 20050801

Title: Flavonoids to reduce bleeding and pain after stapled hemorrhoidopexy: a randomized controlled trial.

Journal: Wiener klinische Wochenschrift 20050801

Title: [Analysis of surgical procedures on the vena saphena magna in the Czech Republic and an effect of Detralex during its stripping].

Journal: Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20050801

Title: Analysis of flavanone-7-O-glycosides in citrus juices by short-end capillary electrochromatography.

Journal: Journal of chromatography. A 20050715

Title: Interaction between hesperetin and human serum albumin revealed by spectroscopic methods.

Journal: Biochimica et biophysica acta 20050620

Title: Antioxidant activity of the flavonoid hesperidin in chemical and biological systems.

Journal: Journal of agricultural and food chemistry 20050615

Title: Effects of rikkunshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by N(G)-nitro-L-arginine.

Journal: Journal of pharmacological sciences 20050601

Title: Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids.

Journal: The British journal of nutrition 20050501

Title: Venous ulcers: pathophysiology and treatment options.

Journal: Ostomy/wound management 20050501

Title: Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.

Journal: European journal of pharmacology 20050411

Title: [Study on quality control of effective fraction in qixue bingzhi decoction].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

Title: Degradation of neohesperidin dihydrochalcone by human intestinal bacteria.

Journal: Journal of agricultural and food chemistry 20050309

Title: Stereospecific high-performance liquid chromatographic analysis of hesperetin in biological matrices.

Journal: Journal of pharmaceutical and biomedical analysis 20050309

Title: Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages.

Journal: Journal of cellular physiology 20050201

Title: Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system.

Journal: Analytical and bioanalytical chemistry 20050201

Title: Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.

Journal: Atherosclerosis 20050101

Title: HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study.

Journal: Angiology 20050101

Title: Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney.

Journal: BMC pharmacology 20050101

Title: Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression.

Journal: Anticancer research 20050101

Title: [Quercetin and hesperidin decrease the formation of nitric oxide radicals in rat liver and heart under the conditions of hepatosis].

Journal: Biofizika 20050101

Title: Antiradical and anti-H2O2 properties of polyphenolic compounds from an aqueous peppermint extract.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

Title: Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041201

Title: Monitoring the self-assembly of chitosan/glutaraldehyde/cysteamine/Au-colloid and the binding of human serum albumin with hesperidin.

Journal: Biomaterials 20041101

Title: Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma.

Journal: Journal of agricultural and food chemistry 20041020

Title: Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars.

Journal: Journal of agricultural and food chemistry 20040922

Title: A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine.

Journal: Journal of pharmaceutical and biomedical analysis 20040921

Title: Reactions of the flavonoid hesperetin with chlorine: a spectroscopic study of the reaction pathways.

Journal: Environmental science & technology 20040901

Title: The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.

Journal: Molecular nutrition & food research 20040901

Title: Crystal architecture and conformational properties of the inclusion complex, neohesperidin dihydrochalcone-cyclomaltoheptaose (beta-cyclodextrin), by X-ray diffraction.

Journal: Carbohydrate research 20040823

Title: Antiallergic activity of hesperidin is activated by intestinal microflora.

Journal: Pharmacology 20040801

Title: Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats.

Journal: Regulatory toxicology and pharmacology : RTP 20040801

Title: Determination of extracellular hesperidin in blood and bile of anaesthetized rats by microdialysis with high-performance liquid chromatography: a pharmacokinetic application.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705

Title: Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats.

Journal: Bioorganic & medicinal chemistry 20040701

Title: Hesperetin: a potent antioxidant against peroxynitrite.

Journal: Free radical research 20040701

Title: Determination of hesperetin, cinnamic acid and nicotinic acid in propolis with micellar electrokinetic capillary chromatography.

Journal: Fitoterapia 20040601

Title: Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level.

Journal: Journal of nutritional science and vitaminology 20040601

Title: Double-strand break of giant DNA: protection by glucosyl-hesperidin as evidenced through direct observation on individual DNA molecules.

Journal: FEBS letters 20040521

Title: Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia.

Journal: Journal of agricultural and food chemistry 20040519

Title: Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora.

Journal: Journal of agricultural and food chemistry 20040407

Title: Adsorption of flavonoids on resins: cyanidin 3-glucoside.

Journal: Journal of agricultural and food chemistry 20040407

Title: Effects of betaine, coumarin and flavonoids on mucin release from cultured hamster tracheal surface epithelial cells.

Journal: Phytotherapy research : PTR 20040401

Title: Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040305

Title: Micronization enhances the protective effect of purified flavonoid fraction against postischaemic microvascular injury in the hamster cheek pouch.

Journal: Clinical and experimental pharmacology & physiology 20040301

Title: [Effect of hesperidin and rutin on oxidative modification of high density lipoprotein in vitro].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20040301

Title: [Studies on chemical constitutents in roots of Jasminum sambac].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040301

Title: LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii.

Journal: Journal of pharmaceutical and biomedical analysis 20040127

Title: Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice.

Journal: Toxicologic pathology 20040101

Title: [The principles of action and use of phlebotropic agents].

Journal: Klinicheskaia meditsina 20040101

Title: The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury.

Journal: Acta chirurgica Belgica 20040101

Title: Comparative study of flavonoids in experimental models of inflammation.

Journal: Pharmacological research 20031201

Title: Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature.

Journal: Journal of nutritional science and vitaminology 20031201

Title: Adsorption of flavonoids on resins: hesperidin.

Journal: Journal of agricultural and food chemistry 20031119

Title: Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores.

Journal: American journal of physiology. Cell physiology 20031101

Title: Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.

Journal: Biochemical pharmacology 20031001

Title: Inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation.

Journal: Archives of pharmacal research 20031001

Title: Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line.

Journal: Cancer letters 20030925

Title: Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20030919

Title: Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts.

Journal: Photochemistry and photobiology 20030901

Title: Hypocholesterolemic activity of hesperetin derivatives.

Journal: Bioorganic & medicinal chemistry letters 20030818

Title: Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars.

Journal: Journal of agricultural and food chemistry 20030604

Title: Polyacylated neohesperidosides from Geranium caespitosum: bacterial multidrug resistance pump inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20030602

Title: Pro-oxidative properties of flavonoids in human lymphocytes.

Journal: Bioscience, biotechnology, and biochemistry 20030601

Title: Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells.

Journal: Planta medica 20030601

Title: The compositional characterisation and antioxidant activity of fresh juices from sicilian sweet orange (Citrus sinensis L. Osbeck) varieties.

Journal: Free radical research 20030601

Title: 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS.

Journal: Pharmacology, biochemistry, and behavior 20030601

Title: Influence of industrial processing on orange juice flavanone solubility and transformation to chalcones under gastrointestinal conditions.

Journal: Journal of agricultural and food chemistry 20030507

Title: Interaction between flavonoids and the blood-brain barrier: in vitro studies.

Journal: Journal of neurochemistry 20030401

Title: Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver.

Journal: Life sciences 20030221

Title: Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice.

Journal: European journal of clinical nutrition 20030201

Title: Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats.

Journal: Clinica chimica acta; international journal of clinical chemistry 20030101

Title: Anti-Sindbis activity of flavanones hesperetin and naringenin.

Journal: Biological & pharmaceutical bulletin 20030101

Title: [The theory of lymphangion and current approaches to the pathogenesis, diagnosis and treatment of lymphedema of the lower extremities].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20030101

Title: [Efficacy and safety of treatment with methotrexate, leflunomide, detralex, and their combination of patients with rheumatoid arthritis].

Journal: Likars'ka sprava 20030101

Title: [Microcirculation end effect of detralex in patients with chronic venous insufficiency of the lower extremities].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20030101

Title: Flavonoids and nitric oxide synthase.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201

Title: [Prediction of eluotropic sequence of solutes in countercurrent chromatography].

Journal: Se pu = Chinese journal of chromatography 20021101

Title: [Determination of hesperidin and naringin in Fructus Aurantii Immaturus and Fructus Aurantii by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20021101

Title: Kinetic evaluation of the reactivity of flavonoids as radical scavengers.

Journal: SAR and QSAR in environmental research 20021001

Title: Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats.

Journal: Journal of nutritional science and vitaminology 20021001

Title: Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.

Journal: European journal of clinical nutrition 20020901

Title: Effect of exogenous flavonoids on nodulation of pea (Pisum sativum L.).

Journal: Journal of experimental botany 20020801

Title: Determination of hesperidin and synephrine in Pericarpium Citri Reticulatae by capillary electrophoresis with electrochemical detection.

Journal: Analytical and bioanalytical chemistry 20020601

Title: Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.

Journal: Clinical pharmacology and therapeutics 20020101

Title: Hydrolytic properties of crude alpha-L-rhamnosidases produced by several wild strains of mesophilic fungi.

Journal: Letters in applied microbiology 20020101

Title: Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease.

Journal: Advances in experimental medicine and biology 20020101

Title: Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin.

Journal: Advances in experimental medicine and biology 20020101

Title: Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice.

Journal: Cancer letters 20011228

Title: Isolation of antioxidant compounds from orange juice by using countercurrent supercritical fluid extraction (CC-SFE).

Journal: Journal of agricultural and food chemistry 20011201

Title: Chemistry and pharmacology of the Citrus bioflavonoid hesperidin.

Journal: Phytotherapy research : PTR 20011201

Title: [Studies on chemical constituents from the flower of Citrus aurantium].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20011201

Title: Improved LC methods for the determination of diosmin and/or hesperidin in plant extracts and pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20011101

Title: Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.

Journal: Farmaco (Societa chimica italiana : 1989) 20010901

Title: Cofermentation of rutin and hesperidin during two-stage anaerobic pre-treatment of high-loaded brewery wastewater.

Journal: Water research 20010801

Title: Flavanone glycosides from Citrus junos and their anti-influenza virus activity.

Journal: Planta medica 20010801

Title: Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.

Journal: Journal of lipid research 20010501

Title: [Lymphocytic colitis in a women with Biermer's disease treated with Cirkan].

Journal: Presse medicale (Paris, France : 1983) 20010501

Title: [Studies on antiviral flavonoids in yinqiaosan powder].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010501

Title: [Determination of neohesperidin dihydrochalcone in foods].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20010201

Title: PROP (6-n-Propylthiouracil) tasting and sensory responses to caffeine,sucrose, neohesperidin dihydrochalcone and chocolate.

Journal: Chemical senses 20010101

Title: Improved water solubility of neohesperidin dihydrochalcone in sweetener blends.

Journal: Journal of agricultural and food chemistry 20010101

Title: Interactive effect of hesperidin and vitamin E supplements on cholesterol metabolism in high cholesterol-fed rats.

Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20010101

Title: [Effect of daflon on the transcapillary fluid exchange in hindlimbs of anesthesized Wistar rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: Effect of a venotonic agent on the main arteries and veins during a 5 day HDT.

Journal: Acta astronautica 20010101

Title: Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20010101

Title: Antimicrobial activity of prenylflavanones.

Journal: In vivo (Athens, Greece) 20010101

Title: The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase.

Journal: Molecular microbiology 20000101

Title: Inhibition of HIV activation in latently infected cells by flavonoid compounds.

Journal: AIDS research and human retroviruses 19960101

Title: Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

Journal: Journal of natural products 19940101

Title: Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.

Journal: European journal of biochemistry 19900705

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SDS
Tags:520-26-3 Molecular Formula|520-26-3 MDL|520-26-3 SMILES|520-26-3 (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one
Catalog No.: AA003959
520-26-3,MFCD00075663
520-26-3 | (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one
Pack Size: 1mg
Purity:
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Purity: 97%
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Pack Size: 1g
Purity: 97%
in stock
$7.00 $5.00
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Purity:
in stock
$9.00 $6.00
Pack Size: 10g
Purity: 97%
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$16.00 $12.00
Pack Size: 25g
Purity: 97%
in stock
$29.00 $20.00
Pack Size: 100g
Purity: 97%
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$67.00 $47.00
Pack Size: 250g
Purity: ≥ 91% (HPLC)
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Technical Information
Catalog Number: AA003959
Chemical Name: (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one
CAS Number: 520-26-3
Molecular Formula: C28H34O15
Molecular Weight: 610.5606
MDL Number: MFCD00075663
SMILES: COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O1)cc(cc2O)O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@@H]([C@H]([C@H]2O)O)O)[C@H]([C@@H]([C@H]1O)O)O
Properties
Complexity: 940  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 11  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 43  
Hydrogen Bond Acceptor Count: 15  
Hydrogen Bond Donor Count: 8  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -1.1  
Literature fold

Title: Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats.

Journal: Chemico-biological interactions20180801

Title: Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice.

Journal: Chemico-biological interactions20180401

Title: Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson's disease.

Journal: Chemico-biological interactions20180105

Title: Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation.

Journal: Chemico-biological interactions20171101

Title: Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl(4)-induced acute liver injury and LPS-treated RAW264.7 cells.

Journal: Toxicology letters20170515

Title: Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway.

Journal: Toxicology20170415

Title: Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.

Journal: Chemico-biological interactions20151205

Title: Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis.

Journal: Journal of biochemical and molecular toxicology20150301

Title: Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB.

Journal: Chemico-biological interactions20150225

Title: Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes.

Journal: Journal of biochemical and molecular toxicology20141101

Title: Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity.

Journal: Pharmacology, biochemistry, and behavior20140901

Title: Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor.

Journal: Chemico-biological interactions20140805

Title: Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro.

Journal: Chemico-biological interactions20140425

Title: Mangiferin has an additive effect on the apoptotic properties of hesperidin in Cyclopia sp. tea extracts.

Journal: PloS one20140101

Title: Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.

Journal: Mediators of inflammation20140101

Title: Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

Journal: Journal of pharmaceutical sciences20130901

Title: Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori.

Journal: Food chemistry20121215

Title: Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells.

Journal: Food chemistry20121201

Title: Effect of natural cross-linkers incorporation in a self-etching primer on dentine bond strength.

Journal: Journal of dentistry20121201

Title: Synthesis and anti-hyperglycemic activity of hesperidin derivatives.

Journal: Bioorganic & medicinal chemistry letters20121201

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: The flavonoids hesperidin and rutin promote neural crest cell survival.

Journal: Cell and tissue research20121101

Title: Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability.

Journal: Journal of molecular recognition : JMR20121101

Title: Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats.

Journal: Molecules (Basel, Switzerland)20121101

Title: The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.

Journal: The Journal of nutritional biochemistry20121001

Title: The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent.

Journal: Journal of vascular surgery20121001

Title: Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells.

Journal: Food & function20121001

Title: Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats.

Journal: Neurotoxicology20121001

Title: Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart.

Journal: The Journal of pharmacy and pharmacology20121001

Title: Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells.

Journal: Journal of agricultural and food chemistry20120926

Title: Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats.

Journal: Phytotherapy research : PTR20120901

Title: Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

Journal: Chinese journal of integrative medicine20120901

Title: Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques.

Journal: Journal of food science20120901

Title: Hesperidin attenuates brain biochemical changes of irradiated rats.

Journal: International journal of radiation biology20120801

Title: Bioevaluation of human serum albumin-hesperidin bioconjugate: insight into protein vector function and conformation.

Journal: Journal of agricultural and food chemistry20120725

Title: Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie20120701

Title: Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie20120701

Title: Simultaneous determination of six active components in traditional herbal medicine 'Oyaksungisan' by HPLC-DAD.

Journal: Journal of natural medicines20120701

Title: Simultaneous UPLC analysis of three major flavonoids in granule decoctions of Fructus aurantii-type formulae.

Journal: Die Pharmazie20120701

Title: Effects of the flavonoid hesperidin in cerebral cortical progenitors in vitro: indirect action through astrocytes.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience20120601

Title: Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

Journal: Toxicology mechanisms and methods20120601

Title: An investigation on the interaction of DNA with hesperetin/apigenin in the presence of CTAB by resonance Rayleigh light scattering technique and its analytical application.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20120501

Title: Protective effect of hesperidin, a citrus flavanoglycone, against γ-radiation-induced tissue damage in Sprague-Dawley rats.

Journal: Journal of medicinal food20120501

Title: Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin.

Journal: Experimental dermatology20120501

Title: Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.

Journal: Journal of natural products20120427

Title: Interaction of antioxidant flavonoids with calf thymus DNA analyzed by spectroscopic and electrochemical methods.

Journal: Journal of pharmaceutical and biomedical analysis20120407

Title: Intravitreal kinetics of hesperidin, hesperetin, and hesperidin G: effect of dose and physicochemical properties.

Journal: Journal of pharmaceutical sciences20120401

Title: Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites.

Journal: Food & function20120401

Title: Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy.

Journal: Molecular nutrition & food research20120401

Title: Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20120301

Title: Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20120301

Title: Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.

Journal: Inflammation20120201

Title: The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism.

Journal: European journal of nutrition20120201

Title: Alleviation of allergic rhinitis symptoms with Pyeongwee-San extract (KMP6).

Journal: Immunopharmacology and immunotoxicology20120201

Title: Neuroprotective effects of citrus flavonoids.

Journal: Journal of agricultural and food chemistry20120201

Title: Phytonutrient intake by adults in the United States in relation to fruit and vegetable consumption.

Journal: Journal of the Academy of Nutrition and Dietetics20120201

Title: Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20120125

Title: Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation.

Journal: Toxicology letters20120125

Title: Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach.

Journal: Journal of agricultural and food chemistry20120111

Title: UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices.

Journal: Journal of pharmaceutical and biomedical analysis20120105

Title: Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study.

Journal: International journal of biological macromolecules20120101

Title: Separation and purification of neohesperidin from the albedo of Citrus reticulata cv. Suavissima by combination of macroporous resin and high-speed counter-current chromatography.

Journal: Journal of separation science20120101

Title: Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin.

Journal: Journal of biomedicine & biotechnology20120101

Title: LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration.

Journal: Natural product research20120101

Title: Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.

Journal: Bioscience, biotechnology, and biochemistry20120101

Title: Influence of hesperidin on renal cell surface glycoprotein content, nucleic acids, lysosomal enzymes and macromolecules against 7, 12-dimethylbenz [a] anthracene induced experimental breast carcinoma.

Journal: Journal of experimental therapeutics & oncology20120101

Title: Hesperidin a citrus bioflavonoid modulates hepatic biotransformation enzymes and enhances intrinsic antioxidants in experimental breast cancer rats challenged with 7, 12-dimethylbenz (a) anthracene.

Journal: Journal of experimental therapeutics & oncology20120101

Title: Enzymatic modification of chitosan with quercetin and its application as antioxidant edible films.

Journal: Prikladnaia biokhimiia i mikrobiologiia20120101

Title: In vitro effect of hesperidin on root dentin collagen and de/re-mineralization.

Journal: Dental materials journal20120101

Title: Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats.

Journal: Redox report : communications in free radical research20120101

Title: [On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery20120101

Title: Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats.

Journal: Vascular pharmacology20120101

Title: Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells.

Journal: Biochemical and biophysical research communications20111202

Title: Anti-platelet effects of yuzu extract and its component.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20111201

Title: Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells.

Journal: Biopharmaceutics & drug disposition20111201

Title: Analysis of flavonoids by capillary zone electrophoresis with electrokinetic supercharging.

Journal: The Analyst20111107

Title: Evaluation of binding and thermodynamic characteristics of interactions between a citrus flavonoid hesperitin with protein and effects of metal ions on binding.

Journal: Molecular biology reports20111101

Title: A novel application of α-glucosyl hesperidin for nanoparticle formation of active pharmaceutical ingredients by dry grinding.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20111101

Title: Differential effects of two citrus flavanones on bone quality in senescent male rats in relation to their bioavailability and metabolism.

Journal: Bone20111101

Title: [Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20111101

Title: Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination.

Journal: Analytica chimica acta20111031

Title: Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke.

Journal: Brain research20111028

Title: α-Rhamnosyl-β-glucosidase-catalyzed reactions for analysis and biotransformations of plant-based foods.

Journal: Journal of agricultural and food chemistry20111026

Title: Development and validation of a reliable high-performance liquid chromatographic method for determination of nodakenin in rat plasma and its application to pharmacokinetic study.

Journal: Biomedical chromatography : BMC20111001

Title: Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats.

Journal: Ecotoxicology and environmental safety20111001

Title: Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin.

Journal: Cell biology and toxicology20111001

Title: Microbial metabolism. Part 13. Metabolites of hesperetin.

Journal: Bioorganic & medicinal chemistry letters20111001

Title: Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats.

Journal: The British journal of nutrition20111001

Title: Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7.

Journal: Molecular and cellular endocrinology20110915

Title: HPLC determination of hesperidin, diosmin and eriocitrin in Iranian lime juice using polyamide as an adsorbent for solid phase extraction.

Journal: Journal of pharmaceutical and biomedical analysis20110910

Title: Hesperidin promotes cyclobutane pyrimidine dimer repair in UVB-exposed mice epidermis.

Journal: Irish journal of medical science20110901

Title: Purification and characterization of a novel alkaline α-L-rhamnosidase produced by Acrostalagmus luteo albus.

Journal: Journal of industrial microbiology & biotechnology20110901

Title: Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat.

Journal: Cardiovascular toxicology20110901

Title: Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents.

Journal: Pharmacology, biochemistry, and behavior20110901

Title: Proline betaine and its biotransformation products in fasting urine samples are potential biomarkers of habitual citrus fruit consumption.

Journal: The British journal of nutrition20110901

Title: Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study.

Journal: European review for medical and pharmacological sciences20110901

Title: Optimized enzymatic synthesis of hesperidin fatty acid esters in a two-phase system containing ionic liquid.

Journal: Molecules (Basel, Switzerland)20110823

Title: Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.

Journal: European journal of medicinal chemistry20110801

Title: Possible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats.

Journal: Indian journal of experimental biology20110801

Title: Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey.

Journal: Molecules (Basel, Switzerland)20110727

Title: [Synthesis and anti-inflammatory activities of methylhesperetin-7-alkyl ether analogues].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20110701

Title: Hesperedin promotes MyoD-induced myogenic differentiation in vitro and in vivo.

Journal: British journal of pharmacology20110601

Title: Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort).

Journal: International angiology : a journal of the International Union of Angiology20110601

Title: α-Glucosyl hesperidin induced an improvement in the bioavailability of pranlukast hemihydrate using high-pressure homogenization.

Journal: International journal of pharmaceutics20110530

Title: Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells.

Journal: Journal of agricultural and food chemistry20110525

Title: Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice.

Journal: Journal of photochemistry and photobiology. B, Biology20110503

Title: Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20110501

Title: Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.

Journal: The Journal of clinical endocrinology and metabolism20110501

Title: Effect of hesperidin in vitro on root dentine collagen and demineralization.

Journal: Journal of dentistry20110501

Title: Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFκB, p38 and caspase-3.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20110401

Title: [Studies on the chemical constituents of Codonopsis pilosula].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20110401

Title: Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis.

Journal: Acta bio-medica : Atenei Parmensis20110401

Title: Hesperetin, a potential therapy for carcinoid cancer.

Journal: American journal of surgery20110301

Title: Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice.

Journal: Fundamental & clinical pharmacology20110201

Title: Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats.

Journal: Pharmacology, biochemistry, and behavior20110201

Title: Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animals.

Journal: Oncology reports20110201

Title: Simultaneous determination of liquiritin, hesperidin, and glycyrrhizin by HPLC-photodiode array detection and the anti-inflammatory effect of Pyungwi-san.

Journal: Archives of pharmacal research20110201

Title: [Separation and determination of hesperidin in huoxiangzhengqi water by hollow fiber ultrafiltration-high performance liquid chromatography].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20110201

Title: Genotoxicity assessment of Pyungwi-san (PWS), a traditional herbal prescription.

Journal: Journal of ethnopharmacology20110127

Title: Inactivation of nuclear factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells.

Journal: European journal of pharmacology20110115

Title: Identification of chemical constituents in extracts and rat plasma from Fructus Aurantii by UPLC-PDA-Q-TOF/MS.

Journal: Phytochemical analysis : PCA20110101

Title: Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.

Journal: Lipids in health and disease20110101

Title: [Determination of liquiritin, naringin, hesperidin and glycyrrhizic acid in extractive of Wendan formula by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20110101

Title: Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.

Journal: International journal of medical sciences20110101

Title: C-kit binding properties of hesperidin (a major component of KMP6) as a potential anti-allergic agent.

Journal: PloS one20110101

Title: Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.

Journal: Journal of biomedicine & biotechnology20110101

Title: Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma.

Journal: Mediators of inflammation20110101

Title: Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin.

Journal: Drug metabolism and pharmacokinetics20110101

Title: Tissue distribution of hesperetin in rats after a dietary intake.

Journal: Bioscience, biotechnology, and biochemistry20110101

Title: Effects of hesperidin on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats.

Journal: Journal of pharmacological sciences20110101

Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

Journal: Journal of biomedical science20110101

Title: Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a randomized controlled cross-over study.

Journal: PloS one20110101

Title: Hesperidin protects renal and hepatic tissues against free radical-mediated oxidative stress during DMBA-induced experimental breast cancer.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer20110101

Title: Antiviral activity of four types of bioflavonoid against dengue virus type-2.

Journal: Virology journal20110101

Title: Binding capacity of ER-α ligands and SERMs: comparison of the human, dog and cat.

Journal: Asian Pacific journal of cancer prevention : APJCP20110101

Title: Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9.

Journal: European journal of pharmacology20101215

Title: 7,3'-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation.

Journal: Phytotherapy research : PTR20101201

Title: Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study).

Journal: International angiology : a journal of the International Union of Angiology20101201

Title: Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.

Journal: Acta tropica20101101

Title: On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme.

Journal: Journal of agricultural and food chemistry20101013

Title: Transglycosylated stevia and hesperidin as pharmaceutical excipients: dramatic improvement in drug dissolution and bioavailability.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20101001

Title: Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20101001

Title: Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design.

Journal: Journal of separation science20101001

Title: Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners.

Journal: The British journal of nutrition20100901

Title: UV-B modulates the interplay between terpenoids and flavonoids in peppermint (Mentha x piperita L.).

Journal: Journal of photochemistry and photobiology. B, Biology20100802

Title: Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters.

Journal: Journal of medicinal food20100801

Title: Synergistic and antagonistic interactions of phenolic compounds found in navel oranges.

Journal: Journal of food science20100801

Title: Passive asymmetric transport of hesperetin across isolated rabbit cornea.

Journal: International journal of pharmaceutics20100715

Title: Synthesis, characterization, DNA binding properties, fluorescence studies and antioxidant activity of transition metal complexes with hesperetin-2-hydroxy benzoyl hydrazone.

Journal: Journal of fluorescence20100701

Title: Effect of added citrus fibre and spice essential oils on quality characteristics and shelf-life of mortadella.

Journal: Meat science20100701

Title: Hesperidin and hesperetin membrane interaction: understanding the role of 7-O-glycoside moiety in flavonoids.

Journal: Archives of biochemistry and biophysics20100701

Title: Protective effects of silybin and analogues against X-ray radiation-induced damage.

Journal: Acta biochimica et biophysica Sinica20100701

Title: [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20100701

Title: Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with alpha-glucosyl hesperidin.

Journal: International journal of pharmaceutics20100615

Title: Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects.

Journal: The British journal of nutrition20100601

Title: The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers.

Journal: Molecular nutrition & food research20100601

Title: Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.

Journal: Journal of agricultural and food chemistry20100526

Title: Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro.

Journal: Journal of agricultural and food chemistry20100526

Title: In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr.

Journal: Bioorganic & medicinal chemistry20100515

Title: Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway.

Journal: The Journal of nutritional biochemistry20100501

Title: Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.

Journal: American journal of physiology. Gastrointestinal and liver physiology20100501

Title: Extracellular monoenzyme deglycosylation system of 7-O-linked flavonoid beta-rutinosides and its disaccharide transglycosylation activity from Stilbella fimetaria.

Journal: Archives of microbiology20100501

Title: The effect of component of cream for topical delivery of hesperetin.

Journal: Chemical & pharmaceutical bulletin20100501

Title: Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.

Journal: Natural product communications20100501

Title: Homoisoflavonoids from the fibrous roots of Polygonatum odoratum with glucose uptake-stimulatory activity in 3T3-L1 adipocytes.

Journal: Journal of natural products20100423

Title: Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.

Journal: Journal of natural products20100423

Title: Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.

Journal: Journal of ethnopharmacology20100421

Title: The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells.

Journal: Toxicology letters20100415

Title: The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.

Journal: Biochemical and biophysical research communications20100409

Title: Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

Journal: Drug metabolism and disposition: the biological fate of chemicals20100401

Title: Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.

Journal: European journal of clinical nutrition20100401

Title: Chiral separation of hesperidin and naringin and its analysis in a butanol extract of Launeae arborescens.

Journal: Natural product research20100401

Title: In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system.

Journal: International journal of pharmaceutics20100330

Title: Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells.

Journal: Journal of agricultural and food chemistry20100324

Title: Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions.

Journal: Drug development and industrial pharmacy20100301

Title: Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography.

Journal: Journal of chromatography. A20100212

Title: Preserving hesperetin nanosuspensions for dermal application.

Journal: Die Pharmazie20100201

Title: [Study on the contents of flavonoids in Citrus reticulata 'Chachi' from various habitats and different collecting periods].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20100201

Title: Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.

Journal: Nutrients20100201

Title: Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation.

Journal: Journal of agricultural and food chemistry20100113

Title: Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide.

Journal: Behavioural brain research20100105

Title: Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20100105

Title: Structural activity relationship of flavonoids with estrogen-related receptor gamma.

Journal: FEBS letters20100104

Title: Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

Journal: Bioorganic & medicinal chemistry20100101

Title: Simultaneous quantification of 14 bioactive constituents in Forsythia suspensa by liquid chromatography-electrospray ionisation-mass spectrometry.

Journal: Phytochemical analysis : PCA20100101

Title: Effect of hesperidin on expression of inducible nitric oxide synthase in cultured rabbit retinal pigment epithelial cells.

Journal: Advances in experimental medicine and biology20100101

Title: [Study on the flavonoids constituents of Trachelospermum jasminoides].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20100101

Title: Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells.

Journal: Cellular immunology20100101

Title: Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.

Journal: Drug metabolism and pharmacokinetics20100101

Title: Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction.

Journal: Pharmacological reports : PR20100101

Title: [Monitoring the quality of life in patients with varicose disease of the lower extremities in the use of venarus].

Journal: Khirurgiia20100101

Title: Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats.

Journal: Journal of toxicology and environmental health. Part A20100101

Title: Hesperidin, a flavanone glycoside, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats.

Journal: Redox report : communications in free radical research20100101

Title: [Conservative treatment of patients with varicose esophagus veins cirrhosis].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology20100101

Title: Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components.

Journal: World journal of gastroenterology20091221

Title: Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease.

Journal: Phytotherapy research : PTR20091201

Title: Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes.

Journal: Bioscience, biotechnology, and biochemistry20091201

Title: Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone.

Journal: European journal of medicinal chemistry20091101

Title: [Study on the optimal extraction process of chaihushugan powder].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20091101

Title: Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20091001

Title: Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats.

Journal: The British journal of nutrition20091001

Title: Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice.

Journal: Journal of natural medicines20091001

Title: Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20091001

Title: Effect of 4G-alpha-glucopyranosyl hesperidin on brown fat adipose tissue- and cutaneous-sympathetic nerve activity and peripheral body temperature.

Journal: Neuroscience letters20090911

Title: Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin.

Journal: Free radical research20090901

Title: Exploring the effect of Hesperetin-HSPC complex--a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics.

Journal: AAPS PharmSciTech20090901

Title: Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods.

Journal: Analytica chimica acta20090901

Title: Treatment of rat adjuvant arthritis with flavonoid (Detralex), methotrexate, and their combination.

Journal: Annals of the New York Academy of Sciences20090901

Title: Physiological and biochemical characterization of the two alpha-L-rhamnosidases of Lactobacillus plantarum NCC245.

Journal: Microbiology (Reading, England)20090801

Title: Assessment of quality of life in Mexican patients suffering from chronic venous disorder - impact of oral Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid treatment - 'QUALITY Study'.

Journal: Phlebology20090801

Title: Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis.

Journal: Chemico-biological interactions20090715

Title: Glucosyl hesperidin prevents influenza a virus replication in vitro by inhibition of viral sialidase.

Journal: Biological & pharmaceutical bulletin20090701

Title: Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.

Journal: Journal of natural products20090701

Title: Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance.

Journal: Toxicology and industrial health20090701

Title: Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.

Journal: Investigational new drugs20090601

Title: Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.

Journal: Investigational new drugs20090601

Title: Hesperidin gastroresistant microparticles by spray-drying: preparation, characterization, and dissolution profiles.

Journal: AAPS PharmSciTech20090601

Title: Bioactivation of flavonoid diglycosides by chicken cecal bacteria.

Journal: FEMS microbiology letters20090601

Title: Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats.

Journal: The Journal of pharmacy and pharmacology20090601

Title: Changes on venous diameter and leg perimeter with different clinical treatments for moderate chronic venous disease: evaluation using Duplex scanning and perimeter measurements.

Journal: International angiology : a journal of the International Union of Angiology20090601

Title: [Anti-inflammatory effects and quantitative study of the combinations of active ingredients of Painong powder in mice].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine20090601

Title: Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats.

Journal: Journal of the Egyptian National Cancer Institute20090601

Title: Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes.

Journal: Mutation research20090531

Title: Solubility, stability, physicochemical characteristics and in vitro ocular tissue permeability of hesperidin: a natural bioflavonoid.

Journal: Pharmaceutical research20090501

Title: Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans.

Journal: Molecular nutrition & food research20090501

Title: Production and characterization of Hesperetin nanosuspensions for dermal delivery.

Journal: International journal of pharmaceutics20090417

Title: Untargeted metabolite analysis of healthy and Huanglongbing-infected orange leaves by CE-DAD.

Journal: Electrophoresis20090401

Title: Sulfation of dietary flavonoids by human sulfotransferases.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20090401

Title: [Effects of Hesperetin on cell activation and proliferation of murine T lymphocytes in vitro].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology20090401

Title: The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.

Journal: Archives of biochemistry and biophysics20090401

Title: The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.

Journal: Biomedical chromatography : BMC20090301

Title: Evaluation of antioxidant activity of hesperidin and its protective effect on H2O2 induced oxidative damage on pBR322 DNA and RBC cellular membrane.

Journal: Molecular and cellular biochemistry20090301

Title: Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers.

Journal: Planta medica20090301

Title: Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells.

Journal: Toxicology letters20090210

Title: Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.

Journal: Biomedical chromatography : BMC20090201

Title: [Studies on chemical components of Lobelia chinensis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090201

Title: Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids.

Journal: Molecular and cellular biochemistry20090101

Title: Effect of constituents from Fructus Aurantii Immaturus and Radix Paeoniae Alba on gastrointestinal movement.

Journal: Planta medica20090101

Title: Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.

Journal: Bioorganic & medicinal chemistry20090101

Title: [Study on the interaction of hesperidin or icariin with lysozyme by fluorescence spectroscopy].

Journal: Guang pu xue yu guang pu fen xi = Guang pu20090101

Title: Discrimination of three medicinal materials from the Citrus genus by HPLC fingerprint coupled with two complementary software.

Journal: Phytochemical analysis : PCA20090101

Title: Liquid chromatographic determination of narirutin and hesperidin in Zhi Ke (Citrus aurantium L.) in the form of the raw herb and of the dried aqueous extract.

Journal: Journal of AOAC International20090101

Title: Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection.

Journal: Journal of pharmaceutical and biomedical analysis20081215

Title: Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt.

Journal: Journal of agricultural and food chemistry20081210

Title: Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism.

Journal: Phytotherapy research : PTR20081201

Title: Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.

Journal: Nutrition research (New York, N.Y.)20081201

Title: Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes.

Journal: Journal of agricultural and food chemistry20081126

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Enantiomeric separation of some flavanones using shinorhizobial linear octasaccharides in CE.

Journal: Electrophoresis20081101

Title: Neuroprotective effects of chronic hesperetin administration in mice.

Journal: Archives of pharmacal research20081101

Title: Characterization of an alpha-L-rhamnosidase from Aspergillus kawachii and its gene.

Journal: Applied microbiology and biotechnology20081001

Title: Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin.

Journal: Phytotherapy research : PTR20081001

Title: Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.

Journal: The Journal of pharmacy and pharmacology20081001

Title: Chemical characterization of Citrus sinensis grafted on C. limonia and the effect of some isolated compounds on the growth of Xylella fastidiosa.

Journal: Journal of agricultural and food chemistry20080910

Title: Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.

Journal: Drug metabolism and disposition: the biological fate of chemicals20080901

Title: Effects of hesperidin on cyclic strain-induced endothelin-1 release in human umbilical vein endothelial cells.

Journal: Clinical and experimental pharmacology & physiology20080801

Title: Effects of calcium dobesilate and diosmin-hesperidin on apoptosis of venous wall in primary varicose veins.

Journal: VASA. Zeitschrift fur Gefasskrankheiten20080801

Title: In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts.

Journal: Journal of agricultural and food chemistry20080723

Title: Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry.

Journal: Biomedical chromatography : BMC20080701

Title: Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.

Journal: Neuroscience letters20080613

Title: Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats.

Journal: European journal of pharmacology20080610

Title: Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation.

Journal: Cell biology and toxicology20080601

Title: Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.

Journal: Gastroenterology20080601

Title: Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice.

Journal: Life sciences20080523

Title: Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle.

Journal: Journal of cellular biochemistry20080501

Title: Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)20080501

Title: Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells.

Journal: International immunopharmacology20080501

Title: Use of microcirculatory parameters to evaluate clinical treatments of chronic venous disorder (CVD).

Journal: Microvascular research20080501

Title: Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats.

Journal: The Israel Medical Association journal : IMAJ20080501

Title: HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines.

Journal: Journal of pharmaceutical and biomedical analysis20080414

Title: Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.

Journal: The Journal of biological chemistry20080404

Title: Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.

Journal: Bioorganic & medicinal chemistry20080401

Title: Hesperidin in orange juice reduces the absorption of celiprolol in rats.

Journal: Biopharmaceutics & drug disposition20080401

Title: Anti-allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride-induced contact dermatitis in mice.

Journal: Journal of natural medicines20080401

Title: Enhanced bioavailability of verapamil after oral administration with hesperidin in rats.

Journal: Archives of pharmacal research20080401

Title: Ultrasound-assisted extraction of hesperidin from Penggan (Citrus reticulata) peel.

Journal: Ultrasonics sonochemistry20080301

Title: Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices.

Journal: Biopharmaceutics & drug disposition20080301

Title: Glycosylation of hesperetin by plant cell cultures.

Journal: Phytochemistry20080301

Title: Hesperidin inhibits ovariectomized-induced osteopenia and shows differential effects on bone mass and strength in young and adult intact rats.

Journal: Journal of applied physiology (Bethesda, Md. : 1985)20080301

Title: Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells.

Journal: Journal of agricultural and food chemistry20080213

Title: Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.

Journal: European journal of pharmacology20080212

Title: Different flavonoids present in the micronized purified flavonoid fraction (Daflon 500 mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch microcirculation.

Journal: International angiology : a journal of the International Union of Angiology20080201

Title: Effect of adding extracted hesperetin, naringenin and pectin on egg cholesterol, serum traits and antioxidant activity in laying hens.

Journal: Archives of animal nutrition20080201

Title: Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.

Journal: Journal of nutritional science and vitaminology20080201

Title: High-performance liquid chromatography as a tool for the chemical standardisation of Triphala--an Ayurvedic formulation.

Journal: Phytochemical analysis : PCA20080101

Title: Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20080101

Title: Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers.

Journal: Biochimica et biophysica acta20080101

Title: Effects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans.

Journal: Immunopharmacology and immunotoxicology20080101

Title: Flavonoid glycosides and limonoids from Citrus molasses.

Journal: Journal of natural medicines20080101

Title: Inhibition of oral carcinogenesis by citrus flavonoids.

Journal: Nutrition and cancer20080101

Title: [Certain aspects of pathogenesis of hemorheological and trophic disturbances and their pharmacological correction in patients with chronic venous insufficiency].

Journal: Vestnik khirurgii imeni I. I. Grekova20080101

Title: Development of a potential reference material for evaluating antioxidant activity.

Journal: Journal of AOAC International20080101

Title: Suppressive effects of the flavonoids quercetin and luteolin on the accumulation of lipid rafts after signal transduction via receptors.

Journal: Immunopharmacology and immunotoxicology20080101

Title: Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain.

Journal: Journal of biochemical and molecular toxicology20080101

Title: Antagonistic interactions between the flavonoids hesperetin and naringenin and beta-lactam antibiotics against Staphylococcus aureus.

Journal: British journal of biomedical science20080101

Title: [Edema as a measure for severity of chronic venous insufficiency and efficacy of its treatment].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery20080101

Title: Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.

Journal: Journal of applied microbiology20071201

Title: Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients.

Journal: International angiology : a journal of the International Union of Angiology20071201

Title: Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD20071101

Title: Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells.

Journal: Molecular and cellular biochemistry20071101

Title: [Inhibitory effect of isorhamnetin and hesperidin on the oxidation of high-density lipoproteins (HDL) induced by Cu2+].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20071101

Title: Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20071001

Title: Antioxidant properties of hesperidin in nicotine-induced lung toxicity.

Journal: Fundamental & clinical pharmacology20071001

Title: [Immunological aspects of aphthous stomatitis].

Journal: Georgian medical news20071001

Title: [Study on chemical constituents of Portulaca oleracea].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20071001

Title: Effect of hesperidin on matrix metalloproteinases and antioxidant status during nicotine-induced toxicity.

Journal: Toxicology20070905

Title: Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity.

Journal: Atherosclerosis20070901

Title: Functional characteristics of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. BL-31 highly specific for intermolecular transglycosylation of bioflavonoids.

Journal: Journal of microbiology and biotechnology20070901

Title: High-performance liquid chromatographic determination and pharmacokinetic study of vitexin-2''-O-rhamnoside in rat plasma after intravenous administration.

Journal: Journal of pharmaceutical and biomedical analysis20070727

Title: Flavanone plasma pharmacokinetics from blood orange juice in human subjects.

Journal: The British journal of nutrition20070701

Title: [Inhibitory effect of Isorhamnetin and Hesperidin on LDL oxidation induced by Cu2+].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20070601

Title: [Microwave-assisted extraction of Hesperidin from pericarpium citri reticulate].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20070601

Title: Thermal degradation of antioxidant micronutrients in citrus juice: kinetics and newly formed compounds.

Journal: Journal of agricultural and food chemistry20070516

Title: The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.

Journal: Life sciences20070424

Title: Enantioseparation of some chiral flavanones using microbial cyclic beta-(1-->3),(1-->6)-glucans as novel chiral additives in capillary electrophoresis.

Journal: Carbohydrate research20070409

Title: Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.

Journal: European journal of clinical nutrition20070401

Title: Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.

Journal: Clinical pharmacology and therapeutics20070401

Title: Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS.

Journal: Journal of separation science20070401

Title: Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death.

Journal: Biological & pharmaceutical bulletin20070201

Title: Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.

Journal: Journal of enzyme inhibition and medicinal chemistry20070201

Title: Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.

Journal: Journal of enzyme inhibition and medicinal chemistry20070201

Title: Protective effect of hesperidin on nicotine induced toxicity in rats.

Journal: Indian journal of experimental biology20070201

Title: [Congenital anomalies of the inferior vena cava: diagnosis and medical treatment].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery20070101

Title: Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21.

Journal: Nutrition and cancer20070101

Title: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

Journal: BMC structural biology20070101

Title: Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS).

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery20070101

Title: Effects of citrus flavonoids on redox homeostasis of toxin-injured liver in rat.

Journal: Acta biologica Hungarica20061201

Title: Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods.

Journal: Journal of chromatography. A20061117

Title: A new method for fabrication of an integrated indium tin oxide electrode on electrophoresis microchips with amperometric detection and its application for determination of synephrine and hesperidin in pericarpium citri reticulatae.

Journal: Electrophoresis20061101

Title: Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20061101

Title: Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20061011

Title: Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin.

Journal: Aging cell20061001

Title: [Prevention of osteoporosis by foods and dietary supplements. Hesperidin and bone metabolism].

Journal: Clinical calcium20061001

Title: Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity.

Journal: Toxicology20060921

Title: Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.

Journal: Biochemical and biophysical research communications20060908

Title: Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)20060901

Title: [Determination of three chemical components in Fructus aurantii immaturus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20060901

Title: Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin.

Journal: Archives of pharmacal research20060801

Title: Use of NIRS for quantification of mangiferin and hesperidin contents of dried green honeybush (Cyclopia genistoides) plant material.

Journal: Journal of agricultural and food chemistry20060726

Title: Bioavailability of glucosyl hesperidin in rats.

Journal: Bioscience, biotechnology, and biochemistry20060601

Title: Suppression of apolipoprotein B secretion from HepG2 cells by glucosyl hesperidin.

Journal: Journal of nutritional science and vitaminology20060601

Title: A new method for express analysis of flavonoid fraction in nephrophite plant extract and prediction of its antioxidant effects.

Journal: Bulletin of experimental biology and medicine20060601

Title: Identification of linear plasmid pAM1 in the flavonoid degrading strain Actinoplanes missouriensis(T) (DSM 43046).

Journal: Plasmid20060501

Title: Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells.

Journal: The British journal of radiology20060501

Title: Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20060401

Title: The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites.

Journal: European journal of nutrition20060301

Title: Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry.

Journal: Journal of mass spectrometry : JMS20060301

Title: Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro.

Journal: The Journal of pharmacy and pharmacology20060301

Title: Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans.

Journal: Journal of nutritional science and vitaminology20060201

Title: Quantitative and qualitative analysis of flavonoid markers in Frucus aurantii of different geographical origin by capillary electrophoresis with electrochemical detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20060118

Title: Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice.

Journal: The international journal of biochemistry & cell biology20060101

Title: [Risk factors of chronic venous insufficiency of the lower extremities and possibilities of its medication in therapeutic practice].

Journal: Terapevticheskii arkhiv20060101

Title: [Flavonoids as effective protectors of urease from ultrasonic inactivation in solutions].

Journal: Bioorganicheskaia khimiia20060101

Title: Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC.

Journal: Journal of agricultural and food chemistry20051214

Title: Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormality.

Journal: Journal of nutritional science and vitaminology20051201

Title: Prokinetic activity of an aqueous extract from dried immature fruit of Poncirus trifoliata (L.) Raf.

Journal: Journal of ethnopharmacology20051114

Title: Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.

Journal: Antiviral research20051001

Title: Separation of some chiral flavonoids by microbial cyclosophoraoses and their sulfated derivatives in micellar electrokinetic chromatography.

Journal: Electrophoresis20051001

Title: Determination of active components in rosemary by capillary electrophoresis with electrochemical detection.

Journal: Journal of pharmaceutical and biomedical analysis20050915

Title: The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-beta-cyclodextrin.

Journal: Journal of pharmaceutical and biomedical analysis20050915

Title: Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials.

Journal: Journal of natural products20050901

Title: HPLC separation of hesperidin and the C-2 epimer in commercial hesperidin samples and herbal medicines.

Journal: Chirality20050801

Title: Flavonoids to reduce bleeding and pain after stapled hemorrhoidopexy: a randomized controlled trial.

Journal: Wiener klinische Wochenschrift20050801

Title: [Analysis of surgical procedures on the vena saphena magna in the Czech Republic and an effect of Detralex during its stripping].

Journal: Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti20050801

Title: Analysis of flavanone-7-O-glycosides in citrus juices by short-end capillary electrochromatography.

Journal: Journal of chromatography. A20050715

Title: Interaction between hesperetin and human serum albumin revealed by spectroscopic methods.

Journal: Biochimica et biophysica acta20050620

Title: Antioxidant activity of the flavonoid hesperidin in chemical and biological systems.

Journal: Journal of agricultural and food chemistry20050615

Title: Effects of rikkunshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by N(G)-nitro-L-arginine.

Journal: Journal of pharmacological sciences20050601

Title: Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids.

Journal: The British journal of nutrition20050501

Title: Venous ulcers: pathophysiology and treatment options.

Journal: Ostomy/wound management20050501

Title: Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.

Journal: European journal of pharmacology20050411

Title: [Study on quality control of effective fraction in qixue bingzhi decoction].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20050401

Title: Degradation of neohesperidin dihydrochalcone by human intestinal bacteria.

Journal: Journal of agricultural and food chemistry20050309

Title: Stereospecific high-performance liquid chromatographic analysis of hesperetin in biological matrices.

Journal: Journal of pharmaceutical and biomedical analysis20050309

Title: Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages.

Journal: Journal of cellular physiology20050201

Title: Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system.

Journal: Analytical and bioanalytical chemistry20050201

Title: Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.

Journal: Atherosclerosis20050101

Title: HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study.

Journal: Angiology20050101

Title: Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney.

Journal: BMC pharmacology20050101

Title: Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression.

Journal: Anticancer research20050101

Title: [Quercetin and hesperidin decrease the formation of nitric oxide radicals in rat liver and heart under the conditions of hepatosis].

Journal: Biofizika20050101

Title: Antiradical and anti-H2O2 properties of polyphenolic compounds from an aqueous peppermint extract.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20050101

Title: Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20041201

Title: Monitoring the self-assembly of chitosan/glutaraldehyde/cysteamine/Au-colloid and the binding of human serum albumin with hesperidin.

Journal: Biomaterials20041101

Title: Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma.

Journal: Journal of agricultural and food chemistry20041020

Title: Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars.

Journal: Journal of agricultural and food chemistry20040922

Title: A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine.

Journal: Journal of pharmaceutical and biomedical analysis20040921

Title: Reactions of the flavonoid hesperetin with chlorine: a spectroscopic study of the reaction pathways.

Journal: Environmental science & technology20040901

Title: The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.

Journal: Molecular nutrition & food research20040901

Title: Crystal architecture and conformational properties of the inclusion complex, neohesperidin dihydrochalcone-cyclomaltoheptaose (beta-cyclodextrin), by X-ray diffraction.

Journal: Carbohydrate research20040823

Title: Antiallergic activity of hesperidin is activated by intestinal microflora.

Journal: Pharmacology20040801

Title: Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats.

Journal: Regulatory toxicology and pharmacology : RTP20040801

Title: Determination of extracellular hesperidin in blood and bile of anaesthetized rats by microdialysis with high-performance liquid chromatography: a pharmacokinetic application.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20040705

Title: Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats.

Journal: Bioorganic & medicinal chemistry20040701

Title: Hesperetin: a potent antioxidant against peroxynitrite.

Journal: Free radical research20040701

Title: Determination of hesperetin, cinnamic acid and nicotinic acid in propolis with micellar electrokinetic capillary chromatography.

Journal: Fitoterapia20040601

Title: Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level.

Journal: Journal of nutritional science and vitaminology20040601

Title: Double-strand break of giant DNA: protection by glucosyl-hesperidin as evidenced through direct observation on individual DNA molecules.

Journal: FEBS letters20040521

Title: Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia.

Journal: Journal of agricultural and food chemistry20040519

Title: Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora.

Journal: Journal of agricultural and food chemistry20040407

Title: Adsorption of flavonoids on resins: cyanidin 3-glucoside.

Journal: Journal of agricultural and food chemistry20040407

Title: Effects of betaine, coumarin and flavonoids on mucin release from cultured hamster tracheal surface epithelial cells.

Journal: Phytotherapy research : PTR20040401

Title: Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20040305

Title: Micronization enhances the protective effect of purified flavonoid fraction against postischaemic microvascular injury in the hamster cheek pouch.

Journal: Clinical and experimental pharmacology & physiology20040301

Title: [Effect of hesperidin and rutin on oxidative modification of high density lipoprotein in vitro].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine20040301

Title: [Studies on chemical constitutents in roots of Jasminum sambac].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20040301

Title: LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii.

Journal: Journal of pharmaceutical and biomedical analysis20040127

Title: Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice.

Journal: Toxicologic pathology20040101

Title: [The principles of action and use of phlebotropic agents].

Journal: Klinicheskaia meditsina20040101

Title: The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury.

Journal: Acta chirurgica Belgica20040101

Title: Comparative study of flavonoids in experimental models of inflammation.

Journal: Pharmacological research20031201

Title: Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature.

Journal: Journal of nutritional science and vitaminology20031201

Title: Adsorption of flavonoids on resins: hesperidin.

Journal: Journal of agricultural and food chemistry20031119

Title: Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores.

Journal: American journal of physiology. Cell physiology20031101

Title: Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.

Journal: Biochemical pharmacology20031001

Title: Inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation.

Journal: Archives of pharmacal research20031001

Title: Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line.

Journal: Cancer letters20030925

Title: Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis20030919

Title: Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts.

Journal: Photochemistry and photobiology20030901

Title: Hypocholesterolemic activity of hesperetin derivatives.

Journal: Bioorganic & medicinal chemistry letters20030818

Title: Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars.

Journal: Journal of agricultural and food chemistry20030604

Title: Polyacylated neohesperidosides from Geranium caespitosum: bacterial multidrug resistance pump inhibitors.

Journal: Bioorganic & medicinal chemistry letters20030602

Title: Pro-oxidative properties of flavonoids in human lymphocytes.

Journal: Bioscience, biotechnology, and biochemistry20030601

Title: Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells.

Journal: Planta medica20030601

Title: The compositional characterisation and antioxidant activity of fresh juices from sicilian sweet orange (Citrus sinensis L. Osbeck) varieties.

Journal: Free radical research20030601

Title: 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS.

Journal: Pharmacology, biochemistry, and behavior20030601

Title: Influence of industrial processing on orange juice flavanone solubility and transformation to chalcones under gastrointestinal conditions.

Journal: Journal of agricultural and food chemistry20030507

Title: Interaction between flavonoids and the blood-brain barrier: in vitro studies.

Journal: Journal of neurochemistry20030401

Title: Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver.

Journal: Life sciences20030221

Title: Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice.

Journal: European journal of clinical nutrition20030201

Title: Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats.

Journal: Clinica chimica acta; international journal of clinical chemistry20030101

Title: Anti-Sindbis activity of flavanones hesperetin and naringenin.

Journal: Biological & pharmaceutical bulletin20030101

Title: [The theory of lymphangion and current approaches to the pathogenesis, diagnosis and treatment of lymphedema of the lower extremities].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery20030101

Title: [Efficacy and safety of treatment with methotrexate, leflunomide, detralex, and their combination of patients with rheumatoid arthritis].

Journal: Likars'ka sprava20030101

Title: [Microcirculation end effect of detralex in patients with chronic venous insufficiency of the lower extremities].

Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery20030101

Title: Flavonoids and nitric oxide synthase.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20021201

Title: [Prediction of eluotropic sequence of solutes in countercurrent chromatography].

Journal: Se pu = Chinese journal of chromatography20021101

Title: [Determination of hesperidin and naringin in Fructus Aurantii Immaturus and Fructus Aurantii by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography20021101

Title: Kinetic evaluation of the reactivity of flavonoids as radical scavengers.

Journal: SAR and QSAR in environmental research20021001

Title: Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats.

Journal: Journal of nutritional science and vitaminology20021001

Title: Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.

Journal: European journal of clinical nutrition20020901

Title: Effect of exogenous flavonoids on nodulation of pea (Pisum sativum L.).

Journal: Journal of experimental botany20020801

Title: Determination of hesperidin and synephrine in Pericarpium Citri Reticulatae by capillary electrophoresis with electrochemical detection.

Journal: Analytical and bioanalytical chemistry20020601

Title: Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.

Journal: Clinical pharmacology and therapeutics20020101

Title: Hydrolytic properties of crude alpha-L-rhamnosidases produced by several wild strains of mesophilic fungi.

Journal: Letters in applied microbiology20020101

Title: Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease.

Journal: Advances in experimental medicine and biology20020101

Title: Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin.

Journal: Advances in experimental medicine and biology20020101

Title: Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice.

Journal: Cancer letters20011228

Title: Isolation of antioxidant compounds from orange juice by using countercurrent supercritical fluid extraction (CC-SFE).

Journal: Journal of agricultural and food chemistry20011201

Title: Chemistry and pharmacology of the Citrus bioflavonoid hesperidin.

Journal: Phytotherapy research : PTR20011201

Title: [Studies on chemical constituents from the flower of Citrus aurantium].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20011201

Title: Improved LC methods for the determination of diosmin and/or hesperidin in plant extracts and pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis20011101

Title: Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.

Journal: Farmaco (Societa chimica italiana : 1989)20010901

Title: Cofermentation of rutin and hesperidin during two-stage anaerobic pre-treatment of high-loaded brewery wastewater.

Journal: Water research20010801

Title: Flavanone glycosides from Citrus junos and their anti-influenza virus activity.

Journal: Planta medica20010801

Title: Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.

Journal: Journal of lipid research20010501

Title: [Lymphocytic colitis in a women with Biermer's disease treated with Cirkan].

Journal: Presse medicale (Paris, France : 1983)20010501

Title: [Studies on antiviral flavonoids in yinqiaosan powder].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20010501

Title: [Determination of neohesperidin dihydrochalcone in foods].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan20010201

Title: PROP (6-n-Propylthiouracil) tasting and sensory responses to caffeine,sucrose, neohesperidin dihydrochalcone and chocolate.

Journal: Chemical senses20010101

Title: Improved water solubility of neohesperidin dihydrochalcone in sweetener blends.

Journal: Journal of agricultural and food chemistry20010101

Title: Interactive effect of hesperidin and vitamin E supplements on cholesterol metabolism in high cholesterol-fed rats.

Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition20010101

Title: [Effect of daflon on the transcapillary fluid exchange in hindlimbs of anesthesized Wistar rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia20010101

Title: Effect of a venotonic agent on the main arteries and veins during a 5 day HDT.

Journal: Acta astronautica20010101

Title: Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands)20010101

Title: Antimicrobial activity of prenylflavanones.

Journal: In vivo (Athens, Greece)20010101

Title: The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase.

Journal: Molecular microbiology20000101

Title: Inhibition of HIV activation in latently infected cells by flavonoid compounds.

Journal: AIDS research and human retroviruses19960101

Title: Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

Journal: Journal of natural products19940101

Title: Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.

Journal: European journal of biochemistry19900705

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