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13241-33-3,MFCD16661259
Catalog No.:AA0010LH

13241-33-3 | Neohesperidin

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100mg
98%
in stock  
$6.00   $4.00
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250mg
98%
in stock  
$7.00   $5.00
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1g
98%
in stock  
$9.00   $7.00
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5g
95%
in stock  
$18.00   $13.00
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25g
95%
in stock  
$40.00   $28.00
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100g
95%
in stock  
$96.00   $67.00
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500g
95%
in stock  
$381.00   $267.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0010LH
Chemical Name:
Neohesperidin
CAS Number:
13241-33-3
Molecular Formula:
C28H34O15
Molecular Weight:
610.5606
MDL Number:
MFCD16661259
SMILES:
OC[C@H]1O[C@@H](Oc2cc3O[C@@H](CC(=O)c3c(c2)O)c2ccc(c(c2)O)OC)[C@@H]([C@H]([C@@H]1O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
940  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
7  
XLogP3:
-0.5  

Literature

Title: Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells.

Journal: Food chemistry 20121201

Title: Degreening and postharvest storage influences 'Star Ruby' grapefruit (Citrus paradisi Macf.) bioactive compounds.

Journal: Food chemistry 20121201

Title: The influence of compatibility of traditional Chinese medicine on the pharmacokinetic of main components in Fructus aurantii.

Journal: Journal of ethnopharmacology 20121121

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells.

Journal: Journal of agricultural and food chemistry 20120926

Title: Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques.

Journal: Journal of food science 20120901

Title: The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines.

Journal: Journal of agricultural and food chemistry 20120815

Title: Phenolic composition and antioxidant effect of aqueous extract of Arisaema cum Bile, the Oriental Herb Medicine, in human fibroblast cells.

Journal: Immunopharmacology and immunotoxicology 20120801

Title: Protective effects of an extract from Citrus bergamia against inflammatory injury in interferon-γ and histamine exposed human keratinocytes.

Journal: Life sciences 20120627

Title: In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.

Journal: Molecular nutrition & food research 20120601

Title: Characterization and quantification of major constituents of Xue Fu Zhu Yu by UPLC-DAD-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20120325

Title: Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20120125

Title: Separation and purification of neohesperidin from the albedo of Citrus reticulata cv. Suavissima by combination of macroporous resin and high-speed counter-current chromatography.

Journal: Journal of separation science 20120101

Title: Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Soybean Knowledge Base (SoyKB): a web resource for soybean translational genomics.

Journal: BMC genomics 20120101

Title: Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Journal: Frontiers in microbiology 20120101

Title: The content of high-intensity sweeteners in different categories of foods available on the Polish market.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101

Title: Evaluation of the antioxidant properties of fruit and flavoured black teas.

Journal: European journal of nutrition 20111201

Title: [Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20111101

Title: Optimization of flavanones extraction by modulating differential solvent densities and centrifuge temperatures.

Journal: Talanta 20110715

Title: Analysis of isoflavones and flavonoids in human urine by UHPLC.

Journal: Analytical and bioanalytical chemistry 20110301

Title: Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: [Comprehensive quality control method for total flavonoid of Fructus Aurantii].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20110101

Title: Development and validation of a UHPLC method for the determination of flavonoids in red wine.

Journal: Journal of AOAC International 20110101

Title: Secondary metabolites of ponderosa lemon (Citrus pyriformis) and their antioxidant, anti-inflammatory, and cytotoxic activities.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101

Title: Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice.

Journal: Pharmacognosy research 20110101

Title: Dihydrochalcone glycosides from Oxytropis myriophylla.

Journal: Chemistry Central journal 20110101

Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

Journal: Journal of biomedical science 20110101

Title: Antitumor Activity of Citrus maxima (Burm.) Merr. Leaves in Ehrlich's Ascites Carcinoma Cell-Treated Mice.

Journal: ISRN pharmacology 20110101

Title: Binding capacity of ER-α ligands and SERMs: comparison of the human, dog and cat.

Journal: Asian Pacific journal of cancer prevention : APJCP 20110101

Title: Study of the polyphenolic composition and antioxidant activity of new sherry vinegar-derived products by maceration with fruits.

Journal: Journal of agricultural and food chemistry 20101124

Title: [Intestinal absorption properties of flavones and extract of fructus aurantii immaturus in rats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100701

Title: Application of an efficient strategy based on MAE, HPLC-DAD-MS/MS and HSCCC for the rapid extraction, identification, separation and purification of flavonoids from Fructus Aurantii Immaturus.

Journal: Biomedical chromatography : BMC 20100301

Title: Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography.

Journal: Journal of chromatography. A 20100212

Title: Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.

Journal: Nutrients 20100201

Title: Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines.

Journal: European journal of pharmacology 20100125

Title: [Flavonoids--bioactive compounds in fruits juice].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101

Title: Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease.

Journal: Phytotherapy research : PTR 20091201

Title: Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells.

Journal: Journal of agricultural and food chemistry 20091125

Title: Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice.

Journal: Journal of natural medicines 20091001

Title: Major phytochemical composition of 3 native Korean citrus varieties and bioactive activity on V79-4 cells induced by oxidative stress.

Journal: Journal of food science 20090801

Title: An updated review of tyrosinase inhibitors.

Journal: International journal of molecular sciences 20090601

Title: [Anti-inflammatory effects and quantitative study of the combinations of active ingredients of Painong powder in mice].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090601

Title: Inhibitory effects of Citrus hassaku extract and its flavanone glycosides on melanogenesis.

Journal: Biological & pharmaceutical bulletin 20090301

Title: [Studies on chemical constituents in stems of Zanthoxylum dissitum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

Title: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.

Journal: Analytica chimica acta 20090202

Title: Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids.

Journal: Molecular and cellular biochemistry 20090101

Title: Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry.

Journal: Chinese medicine 20090101

Title: Evaluation of flavonoids and furanocoumarins from Citrus bergamia (Bergamot) juice and identification of new compounds.

Journal: Molecules (Basel, Switzerland) 20080918

Title: Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.

Journal: Journal of agricultural and food chemistry 20080813

Title: Estimating bergamot juice adulteration of lemon juice by high-performance liquid chromatography (HPLC) analysis of flavanone glycosides.

Journal: Journal of agricultural and food chemistry 20080709

Title: Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome P450 isoform activities.

Journal: Biological & pharmaceutical bulletin 20080501

Title: HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines.

Journal: Journal of pharmaceutical and biomedical analysis 20080414

Title: Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells.

Journal: Journal of agricultural and food chemistry 20080213

Title: Inhibition of oral carcinogenesis by citrus flavonoids.

Journal: Nutrition and cancer 20080101

Title: Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet.

Journal: Journal of agricultural and food chemistry 20071226

Title: Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.

Journal: Journal of applied microbiology 20071201

Title: Origin identification on the commercial samples of Aurantii Fructus.

Journal: Journal of separation science 20070601

Title: Racemization at C-2 of naringin in sour oranges with increasing maturity determined by chiral high-performance liquid chromatography.

Journal: Journal of agricultural and food chemistry 20070516

Title: [Identification of jizhi syrup using HPLC fingerprint].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death.

Journal: Biological & pharmaceutical bulletin 20070201

Title: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

Journal: BMC structural biology 20070101

Title: Medicinal importance of grapefruit juice and its interaction with various drugs.

Journal: Nutrition journal 20070101

Title: Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods.

Journal: Journal of chromatography. A 20061117

Title: Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20061011

Title: An HPLC/MS method for identifying major constituents in the hypocholesterolemic extracts of Chinese medicine formula 'Xue-Fu-Zhu-Yu decoction'.

Journal: Biomedical chromatography : BMC 20060801

Title: Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20060601

Title: Stereoisomeric separation of flavanones and flavanone-7-O-glycosides by capillary electrophoresis and determination of interconversion barriers.

Journal: Analytical chemistry 20060515

Title: Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20060301

Title: Flavonoid composition of fruit tissues of citrus species.

Journal: Bioscience, biotechnology, and biochemistry 20060101

Title: Application of LC/MS and ICP/MS for establishing the fingerprint spectrum of the traditional Chinese medicinal preparation Gan-Lu-Yin.

Journal: Journal of separation science 20060101

Title: Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC.

Journal: Journal of agricultural and food chemistry 20051214

Title: Separation of some chiral flavonoids by microbial cyclosophoraoses and their sulfated derivatives in micellar electrokinetic chromatography.

Journal: Electrophoresis 20051001

Title: HPLC separation of hesperidin and the C-2 epimer in commercial hesperidin samples and herbal medicines.

Journal: Chirality 20050801

Title: [Study on quality control of effective fraction in qixue bingzhi decoction].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

Title: Antioxidant activity of citrus limonoids, flavonoids, and coumarins.

Journal: Journal of agricultural and food chemistry 20050323

Title: Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney.

Journal: BMC pharmacology 20050101

Title: Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP.

Journal: In vivo (Athens, Greece) 20050101

Title: [Historical and pharmalogical study of Citrus hassaku.].

Journal: Yakushigaku zasshi 20050101

Title: Separation of flavanone-7-O-glycoside diastereomers and analysis in citrus juices by multidimensional liquid chromatography coupled with mass spectrometry.

Journal: Journal of agricultural and food chemistry 20040825

Title: LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii.

Journal: Journal of pharmaceutical and biomedical analysis 20040127

Title: High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara.

Journal: Phytochemical analysis : PCA 20040101

Title: [History and therapeutic evaluation of Citrus hassaku HORT. Tanaka].

Journal: Yakushigaku zasshi 20040101

Title: Separation of some chiral flavanones by micellar electrokinetic chromatography.

Journal: Electrophoresis 20030801

Title: Influence of solvents on the antioxidant property of flavonoids.

Journal: Die Nahrung 20030601

Title: Sweetener preference of C57BL/6ByJ and 129P3/J mice.

Journal: Chemical senses 20010901

Title: Chiral separation of six diastereomeric flavanone-7-O-glycosides by capillary electrophoresis and analysis of lemon juice.

Journal: Journal of chromatography. A 20010803

Title: Purification and identification of active antibacterial components in Carpobrotus edulis L.

Journal: Journal of ethnopharmacology 20010601

Title: Lee JH, et al. Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease. Phytother Res. 2009 Dec;23(12):1748-53.

Title: Xu F, et al. Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. Nat Prod Commun. 2012 Nov;7(11):1475-8.

Title: Jia S, et al. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A(y) mice. Food Funct. 2015 Mar;6(3):878-86.

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Tags:13241-33-3 Molecular Formula|13241-33-3 MDL|13241-33-3 SMILES|13241-33-3 Neohesperidin