Home Amines 521-78-8
521-78-8,MFCD00082376
Catalog No.:AA003V22

521-78-8 | Trimipramine Maleate, BP

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003V22
Chemical Name:
Trimipramine Maleate, BP
CAS Number:
521-78-8
Molecular Formula:
C24H30N2O4
Molecular Weight:
410.5060
MDL Number:
MFCD00082376
SMILES:
CN(CC(CN1c2ccccc2CCc2c1cccc2)C)C.OC(=O)/C=C\C(=O)O
NSC Number:
758386
Properties
Properties
 
Form:
Solid  
MP:
140-142°C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
436  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route

[1]OrganicPreparationsandProceduresInternational,1991,vol.23,p.365-372

521-78-8   
2-hydroxy-trimipramine 

[1]OrganicPreparationsandProceduresInternational,1991,vol.23,p.365-372

521-78-8   
formicacid5-(3-dimethylamino-2-methyl-propyl)-10,11-dihydro-5<i>H</i>-dibenzo<i>b</i>,<i>f</i>azepin-2-ylester 

[1]OrganicPreparationsandProceduresInternational,1991,vol.23,p.365-372

Literature

Title: Antidepressants for patients with tinnitus.

Journal: The Cochrane database of systematic reviews 20120912

Title: Electromembrane extraction combined with cyclodextrin-modified capillary electrophoresis for the quantification of trimipramine enantiomers.

Journal: Electrophoresis 20120201

Title: Two polymorphs and the diethylammonium salt of the barbiturate eldoral.

Journal: Acta crystallographica. Section C, Crystal structure communications 20120201

Title: Venlafaxine in somatopsychic and autopsychic depersonalization.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20111201

Title: FPIN's clinical inquiries: Antidepressants for the treatment of insomnia in patients with depression.

Journal: American family physician 20111101

Title: Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters.

Journal: Psychopharmacology 20110901

Title: Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples.

Journal: Analytical and bioanalytical chemistry 20110401

Title: Determination of imipramine and trimipramine by capillary electrophoresis with electrochemiluminescence detection.

Journal: Talanta 20110215

Title: The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20110117

Title: Styryl-based and tricyclic compounds as potential anti-prion agents.

Journal: PloS one 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Persistent tinnitus induced by tricyclic antidepressants.

Journal: Journal of psychopharmacology (Oxford, England) 20100801

Title: Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501

Title: Radiopaque stomach contents in postmortem CT in suicidal oral medication intoxication: report of three cases.

Journal: Journal of forensic and legal medicine 20100401

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: The effect of trimipramine on dream recall and dream emotions in depressive outpatients.

Journal: Psychiatry research 20090530

Title: Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial.

Journal: Journal of psychiatric research 20090401

Title: Metabolism in adipose tissue in response to citalopram and trimipramine treatment--an in situ microdialysis study.

Journal: Journal of psychiatric research 20080601

Title: Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman.

Journal: Forensic science international 20071220

Title: Receptor occupancy of mirtazapine determined by PET in healthy volunteers.

Journal: Psychopharmacology 20071101

Title: Heart rate variability reveals risk of arrhythmias after intoxication with antidepressants.

Journal: Intensive care medicine 20070101

Title: Shifts in metabolic parameters surrounding glucose homoeostasis resulting from tricyclic antidepressant therapy: implications of insulin resistance?

Journal: The Journal of pharmacy and pharmacology 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine.

Journal: Pharmacology, biochemistry, and behavior 20060401

Title: Trimipramine for refractory panic attacks.

Journal: The American journal of psychiatry 20060301

Title: Galactorrhea during treatment with trimipramine. A case report.

Journal: Pharmacopsychiatry 20051101

Title: [Multiple fibromas in systemic mastocytosis].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20050501

Title: Protonation of trimipramine salts of maleate, mesylate and hydrochloride observed by 1H, 13C and 15N NMR spectroscopy.

Journal: Magnetic resonance in chemistry : MRC 20050201

Title: Fluoxetine versus trimipramine in the treatment of depression in geriatric patients.

Journal: Pharmacopsychiatry 20050101

Title: Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG.

Journal: Psychoneuroendocrinology 20041001

Title: [Hypotensive cardio-circulatory failure and metabolic acidosis after suicidal intoxication with trimipramine and quetiapine. Case report and background].

Journal: Der Anaesthesist 20040101

Title: Trimipramine determination in pharmaceutical preparations with an automated multicommutated reversed-flow system.

Journal: Journal of pharmaceutical and biomedical analysis 20031204

Title: Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity.

Journal: Pharmacogenetics 20031201

Title: Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine pharmacokinetics.

Journal: Journal of clinical psychopharmacology 20031001

Title: Clinical outcome after trimipramine in patients with delusional depression - a pilot study.

Journal: Pharmacopsychiatry 20030101

Title: abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice.

Journal: Journal of psychiatric research 20030101

Title: Antipsychotic efficacy of the antidepressant trimipramine: a randomized, double-blind comparison with the phenothiazine perazine.

Journal: Pharmacopsychiatry 20030101

Title: Prescribing cyclic antidepressants for vitiligo patients: which agents are superior, which are not?

Journal: Psychotherapy and psychosomatics 20030101

Title: Enantiomers' potential in psychopharmacology--a critical analysis with special emphasis on the antidepressant escitalopram.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

Title: Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study.

Journal: Pharmacopsychiatry 20020901

Title: Hydrophobia as a rare presentation of Cotard's syndrome: a case report.

Journal: Acta psychiatrica Scandinavica 20020801

Title: [Delusional depression as differential dementia of the Alzheimer type diagnosis].

Journal: Der Nervenarzt 20020501

Title: Effects of the atypical antidepressant trimipramine on neuronal excitability and long-term potentiation in guinea pig hippocampal slices.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020201

Title: Effects of REM sleep awakenings and related wakening paradigms on the ultradian sleep cycle and the symptoms in depression.

Journal: Journal of psychiatric research 20020101

Title: [Chronic sleep disorders. Masked depression].

Journal: MMW Fortschritte der Medizin 20011018

Title: Separation of basic drug enantiomers by capillary electrophoresis using ovoglycoprotein as a chiral selector: comparison of chiral resolution ability of ovoglycoprotein and completely deglycosylated ovoglycoprotein.

Journal: Electrophoresis 20010901

Title: Seizure during combination of trimipramine and bupropion.

Journal: The Journal of clinical psychiatry 20010601

Title: Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine.

Journal: Pharmacopsychiatry 20010301

Title: Differential effects of trimipramine and fluoxetine on sleep in geriatric depression.

Journal: Pharmacopsychiatry 20010301

Title: [Instead of benzodiazepines. An antidepressant as sleep aid].

Journal: MMW Fortschritte der Medizin 20010118

Title: Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study.

Journal: Neurochemistry international 20010101

Title: Seizures associated with therapeutic doses of venlafaxine and trimipramine.

Journal: The Annals of pharmacotherapy 20001201

Title: [Tourette's syndrome and antidepressant therapy: exacerbation of nervous tics with paroxetine].

Journal: Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie 20000501

Title: Clomipramine and related structures as inhibitors of the skeletal sarcoplasmic reticulum Ca2+ pump.

Journal: Journal of bioenergetics and biomembranes 20000401

Title: Repeated trimipramine induces dopamine D2/D3 and alpha1-adrenergic up-regulation.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 19980101

Title: Rapid cycling following antidepressant in an adolescent.

Journal: Biological psychiatry 19900515

Title: Trimipramine-induced neuroleptic malignant syndrome after transient psychogenic polydipsia in one patient.

Journal: The Journal of clinical psychiatry 19890401

Title: Intractable manic-depressive psychosis with rapid cycling in an 18-year-old woman successfully treated with electroconvulsive therapy.

Journal: The Journal of nervous and mental disease 19870401

Title: Trimipramine-induced acute renal failure.

Journal: The New Zealand medical journal 19860409

Title: A comparative trial of the antidepressant, anxiolytic, and cardiovascular effects of trimipramine and doxepin in depressed hospitalized patients.

Journal: The Journal of clinical psychiatry 19850301

Title: Epilepsy as an adverse reaction to combined therapy of MAOIs and tricyclics.

Journal: Journal of the Royal Society of Medicine 19840401

Title: Jenck F, et al. Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur J Pharmacol. 1993 Feb 9;231(2):223-9.

Title: Haenisch B, et al. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl). 2011 Sep. 217(2):289-95.

Title: Juorio AV, et al. The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain. Gen Pharmacol. 1990;21(5):759-62.

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Tags:521-78-8 Molecular Formula|521-78-8 MDL|521-78-8 SMILES|521-78-8 Trimipramine Maleate, BP