Title: Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes.
Journal: The Journal of pharmacology and experimental therapeutics 20160801
Title: Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
Journal: PloS one 20150101
Title: Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium.
Journal: Nuclear receptor signaling 20150101
Title: Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice.
Journal: The Journal of biological chemistry 20140808
Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: Role of Peroxisome Proliferator-Activated Receptor β/δ and B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells.
Journal: PPAR research 20130101
Title: Hormonal and chemical regulation of paraoxonases in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20120901
Title: Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
Journal: Bioorganic & medicinal chemistry letters 20120401
Title: Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics.
Journal: BMC genomics 20120101
Title: PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways.
Journal: PPAR research 20120101
Title: Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study.
Journal: Cardiovascular diabetology 20120101
Title: The renoprotective actions of peroxisome proliferator-activated receptors agonists in diabetes.
Journal: PPAR research 20120101
Title: Cardiovascular events in patients received combined fibrate/statin treatment versus statin monotherapy: Acute Coronary Syndrome Israeli Surveys data.
Journal: PloS one 20120101
Title: AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells.
Journal: PPAR research 20120101
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Mechanisms of cardiovascular remodeling in hyperhomocysteinemia.
Journal: Antioxidants & redox signaling 20111001
Title: Ciprofibrate quantification in human plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry for pharmacokinetic studies.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110815
Title: Peroxisome proliferator-activated receptor α agonists modulate Th1 and Th2 chemokine secretion in normal thyrocytes and Graves' disease.
Journal: Experimental cell research 20110701
Title: Nutritional and metabolic status of HIV-positive patients with lipodystrophy during one year of follow-up.
Journal: Clinics (Sao Paulo, Brazil) 20110301
Title: Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function.
Journal: PloS one 20110101
Title: Dyslipidaemia of obesity, metabolic syndrome and type 2 diabetes mellitus: the case for residual risk reduction after statin treatment.
Journal: The open cardiovascular medicine journal 20110101
Title: Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies.
Journal: PloS one 20110101
Title: Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells.
Journal: Nutrition & metabolism 20110101
Title: Rhabdomyolysis associated with fenofibrate monotherapy in a patient with chronic myelogenous leukemia.
Journal: Case reports in gastroenterology 20110101
Title: Medicinal Chemistry and Actions of Dual and Pan PPAR Modulators.
Journal: The open medicinal chemistry journal 20110101
Title: Low incidence of paradoxical reductions in HDL-C levels in dyslipidemic patients treated with fenofibrate alone or in combination with ezetimibe or ezetimibe/simvastatin.
Journal: Lipids in health and disease 20110101
Title: CXCL9 and CXCL11 chemokines modulation by peroxisome proliferator-activated receptor-alpha agonists secretion in Graves' and normal thyrocytes.
Journal: The Journal of clinical endocrinology and metabolism 20101201
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice.
Journal: The pharmacogenomics journal 20100601
Title: Effect of a Large Dose of Di (2-ethylhexyl) phthalate (DEHP) on Hepatic Peroxisome in Cynomolgus Monkeys (Macaca Fascicularis).
Journal: Journal of toxicologic pathology 20100601
Title: Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse.
Journal: Carcinogenesis 20100201
Title: Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors.
Journal: European heart journal 20100101
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.
Journal: Nuclear receptor signaling 20100101
Title: Fenofibric acid: a new fibrate approved for use in combination with statin for the treatment of mixed dyslipidemia.
Journal: Vascular health and risk management 20100101
Title: Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acid.
Journal: Vascular health and risk management 20100101
Title: Coactivators in PPAR-Regulated Gene Expression.
Journal: PPAR research 20100101
Title: Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation.
Journal: PPAR research 20100101
Title: PPARα in Obesity: Sex Difference and Estrogen Involvement.
Journal: PPAR research 20100101
Title: Methods of chromatographic determination of medicines decreasing the level of cholesterol.
Journal: Acta poloniae pharmaceutica 20100101
Title: PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex.
Journal: PPAR research 20100101
Title: Role of PPARα in Hepatic Carbohydrate Metabolism.
Journal: PPAR research 20100101
Title: Peroxisome proliferator-activated receptor alpha target genes.
Journal: PPAR research 20100101
Title: Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects.
Journal: PPAR research 20100101
Title: Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism.
Journal: PPAR research 20100101
Title: Effects of fenofibrate on lipid profiles, cholesterol ester transfer activity, and in-stent intimal hyperplasia in patients after elective coronary stenting.
Journal: Lipids in health and disease 20100101
Title: PPARs and xenobiotic-induced adverse effects: relevance to human health.
Journal: PPAR research 20100101
Title: Rhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case report.
Journal: European journal of clinical pharmacology 20091201
Title: Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats.
Journal: Archives of toxicology 20091001
Title: Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20091001
Title: Probing the fibrate binding specificity of rat liver fatty acid binding protein.
Journal: Journal of medicinal chemistry 20090910
Title: Antidiabetic action of bezafibrate in a large observational database.
Journal: Diabetes care 20090401
Title: Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090401
Title: Cancer biomarker AKR1B10 and carbonyl metabolism.
Journal: Chemico-biological interactions 20090316
Title: Differential regulation of peroxisome proliferator-activated receptor (PPAR)-alpha1 and truncated PPARalpha2 as an adaptive response to fasting in the control of hepatic peroxisomal fatty acid beta-oxidation in the hibernating mammal.
Journal: Endocrinology 20090301
Title: Activation of hepatic lipase expression by oleic acid: possible involvement of USF1.
Journal: Nutrients 20090201
Title: Differences in transcriptional activation by the two allelic (L162V Polymorphic) variants of PPARα after Omega-3 fatty acids treatment.
Journal: PPAR research 20090101
Title: Systems biology for identifying liver toxicity pathways.
Journal: BMC proceedings 20090101
Title: Peroxisome proliferator-activated receptors in HCV-related infection.
Journal: PPAR research 20090101
Title: Safety and efficacy of rosiglitazone in the elderly diabetic patient.
Journal: Vascular health and risk management 20090101
Title: Kidney function and estimated vascular risk in patients with primary dyslipidemia.
Journal: The open cardiovascular medicine journal 20090101
Title: Regulation of bile acid and cholesterol metabolism by PPARs.
Journal: PPAR research 20090101
Title: Hypothyroidism enhances tumor invasiveness and metastasis development.
Journal: PloS one 20090101
Title: Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.
Journal: PPAR research 20090101
Title: Ciprofibrate increases cholesteryl ester transfer protein gene expression and the indirect reverse cholesterol transport to the liver.
Journal: Lipids in health and disease 20090101
Title: Sensitivity of liver metabolism in jerboa (Jaculus orientalis) to ciprofibrate, a peroxisome proliferator.
Journal: Molecular medicine reports 20090101
Title: Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20081201
Title: Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARalpha.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080701
Title: Role of the p50 subunit of NF-kappaB in vitamin E-induced changes in mice treated with the peroxisome proliferator, ciprofibrate.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080601
Title: Administration of ciprofibrate to lactating mothers induces PPARalpha-signaling pathway in the liver and kidney of suckling rats.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080601
Title: Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
Journal: European journal of pharmacology 20080428
Title: Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha.
Journal: Bioorganic & medicinal chemistry 20080401
Title: Vascular and metabolic effects of treatment of combined hyperlipidemia: focus on statins and fibrates.
Journal: International journal of cardiology 20080227
Title: Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells.
Journal: Toxicology 20080203
Title: Update on the use of fibrates: focus on bezafibrate.
Journal: Vascular health and risk management 20080201
Title: High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease.
Journal: Vascular health and risk management 20080201
Title: Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.
Journal: Stem cells (Dayton, Ohio) 20080101
Title: Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080101
Title: Peroxisome proliferator activated receptors and lipoprotein metabolism.
Journal: PPAR research 20080101
Title: PPAR Agonists and Cardiovascular Disease in Diabetes.
Journal: PPAR research 20080101
Title: Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
Journal: Advances in experimental medicine and biology 20080101
Title: Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders.
Journal: PPAR research 20080101
Title: Statin induced myopathy and myalgia: time trend analysis and comparison of risk associated with statin class from 1991-2006.
Journal: PloS one 20080101
Title: The Role of PPARs in Cancer.
Journal: PPAR research 20080101
Title: Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats.
Journal: Arzneimittel-Forschung 20080101
Title: The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products.
Journal: PPAR research 20080101
Title: PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis.
Journal: PPAR research 20080101
Title: PPAR Regulation of Inflammatory Signaling in CNS Diseases.
Journal: PPAR research 20080101
Title: The Role of PPARs in the Endothelium: Implications for Cancer Therapy.
Journal: PPAR research 20080101
Title: The Role of NF-kappaB in PPARalpha-Mediated Hepatocarcinogenesis.
Journal: PPAR research 20080101
Title: Development and Validation of RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Forms.
Journal: Indian journal of pharmaceutical sciences 20080101
Title: Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.
Journal: Bioorganic & medicinal chemistry letters 20071215
Title: Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
Journal: The Journal of biological chemistry 20071214
Title: Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071001
Title: Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration.
Journal: Toxicology and applied pharmacology 20070915
Title: Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.
Journal: Journal of lipid research 20070801
Title: Transcriptional regulation of Cidea, mitochondrial cell death-inducing DNA fragmentation factor alpha-like effector A, in mouse liver by peroxisome proliferator-activated receptor alpha and gamma.
Journal: The Journal of biological chemistry 20070622
Title: The clinical significance of the size of low-density-lipoproteins and the modulation of subclasses by fibrates.
Journal: Current medical research and opinion 20070501
Title: P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPARalpha-dependent peroxisomal proliferation.
Journal: Journal of lipid research 20070401
Title: Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels.
Journal: Vascular health and risk management 20070201
Title: Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis.
Journal: BMC genomics 20070101
Title: PPARs, Obesity, and Inflammation.
Journal: PPAR research 20070101
Title: Ciprofibrate treatment decreases non-high density lipoprotein cholesterol and triglycerides and increases high density lipoprotein cholesterol in patients with Frederickson type IV dyslipidemia phenotype.
Journal: American journal of therapeutics 20070101
Title: Clofibrate treatment in pigs: effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents.
Journal: BMC pharmacology 20070101
Title: A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways.
Journal: BMC bioinformatics 20070101
Title: Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells.
Journal: BMC genomics 20070101
Title: Radiation injury is a potentially serious complication to fluoroscopically-guided complex interventions.
Journal: Biomedical imaging and intervention journal 20070101
Title: Consumption costs of inappropriate medicines estimated from bulk purchase data: The example of NSAids in Guatemala.
Journal: International journal of clinical pharmacology and therapeutics 20061101
Title: Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells.
Journal: Toxicology and applied pharmacology 20060901
Title: Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.
Journal: Environmental health perspectives 20060901
Title: Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801
Title: Effects of ciprofibrate on testicular and adrenal steroidogenic enzymes in the rat.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20060701
Title: Ciprofibrate increases paraoxonase activity in patients with metabolic syndrome.
Journal: British journal of clinical pharmacology 20060601
Title: Fenofibrate: a novel formulation (Triglide) in the treatment of lipid disorders: a review.
Journal: International journal of nanomedicine 20060601
Title: PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex.
Journal: Biochemical and biophysical research communications 20060505
Title: Separation of fibrate-type antihyperlipidemic drugs by capillary electrophoresis and their quantitation in pharmaceuticals.
Journal: Journal of pharmaceutical and biomedical analysis 20060503
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060401
Title: Workgroup report: Review of genomics data based on experience with mock submissions--view of the CDER Pharmacology Toxicology Nonclinical Pharmacogenomics Subcommittee.
Journal: Environmental health perspectives 20060401
Title: Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms.
Journal: Journal of cardiovascular pharmacology 20060401
Title: Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain.
Journal: The FEBS journal 20060301
Title: [Changes in serum lipids, plasma fibrinogen and other haemostatic parameters induced by ciprofibrate action in hyperlipidemic patients with and without coronary artery disease].
Journal: Investigacion clinica 20060301
Title: Characterization of liver function in transdifferentiated hepatocytes.
Journal: Journal of cellular physiology 20060101
Title: Flow cytometric assessment of peroxisome proliferation from frozen liver of fibrate-treated monkeys.
Journal: International journal of toxicology 20060101
Title: [AIP--atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice].
Journal: Vnitrni lekarstvi 20060101
Title: Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.
Journal: International journal of toxicology 20060101
Title: Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha).
Journal: PPAR research 20060101
Title: Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-alpha.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20051201
Title: Optimal lipid modification: the rationale for combination therapy.
Journal: Vascular health and risk management 20051201
Title: Fibrates inhibit aldose reductase activity in the forward and reverse reactions.
Journal: Biochemical pharmacology 20051125
Title: Severe rhabdomyolysis during a hypersensitivity reaction to abacavir in a patient treated with ciprofibrate.
Journal: AIDS (London, England) 20051104
Title: Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20051101
Title: Differential associations of statin and fibrate treatment with carotid arterial remodeling.
Journal: American journal of hypertension 20051101
Title: Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050901
Title: Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates.
Journal: Journal of cardiovascular pharmacology 20050901
Title: Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.
Journal: Journal of neuroscience research 20050801
Title: Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050701
Title: Induction of pancreatic acinar cell proliferation by thyroid hormone.
Journal: The Journal of endocrinology 20050601
Title: Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate.
Journal: Cancer letters 20050526
Title: Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters.
Journal: Journal of agricultural and food chemistry 20050504
Title: Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.
Journal: Molecular pharmacology 20050401
Title: Study of the liquid chromatography retention of some fibrate-type antihyperlipidemic drugs on C18 and CN columns: application for quantitation in pharmaceutical formulations.
Journal: Journal of AOAC International 20050101
Title: [A case of Parkinsonian syndrome, cognitive impairment and hyperammonemia induced by divalproate sodium prescribed for bipolar disorder].
Journal: L'Encephale 20050101
Title: The effect of ciprofibrate on flow-mediated dilation and inflammatory markers in patients with combined hyperlipidemia.
Journal: Endothelium : journal of endothelial cell research 20050101
Title: Single and chronic administration of ciprofibrate or of ciprofibrate-glycinate in male Fischer 344 rats: comparison of the effects on morphological and biochemical parameters in liver and blood.
Journal: European journal of drug metabolism and pharmacokinetics 20050101
Title: Plasmalogens in rat liver chromatin: new molecules involved in cell proliferation.
Journal: Journal of cellular physiology 20041201
Title: Application of comparative functional genomics to identify best-fit mouse models to study human cancer.
Journal: Nature genetics 20041201
Title: Peroxisome proliferator-activated receptors as regulators of lipid metabolism; tissue differential expression in adipose tissues during cold acclimatization and hibernation of jerboa (Jaculus orientalis).
Journal: Biochimie 20041101
Title: Activation of peroxisome proliferator-activated receptor alpha in rat spinal cord after peripheral noxious stimulation.
Journal: Neuroscience letters 20041007
Title: Fenofibrate impairs rat mitochondrial function by inhibition of respiratory complex I.
Journal: The Journal of pharmacology and experimental therapeutics 20041001
Title: The effect of statins and fibrates on interferon-gamma and interleukin-2 release in patients with primary type II dyslipidemia.
Journal: Atherosclerosis 20041001
Title: Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys.
Journal: Carcinogenesis 20040901
Title: PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Journal: Regulatory peptides 20040815
Title: Effects of vitamin E on the NF-kappaB pathway in rats treated with the peroxisome proliferator, ciprofibrate.
Journal: Toxicology and applied pharmacology 20040815
Title: Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.
Journal: Biochimica et biophysica acta 20040705
Title: The peroxisome proliferator-activated receptor alpha (PPARalpha) agonist ciprofibrate inhibits apolipoprotein B mRNA editing in low density lipoprotein receptor-deficient mice: effects on plasma lipoproteins and the development of atherosclerotic lesions.
Journal: The Journal of biological chemistry 20040702
Title: Visualization and quantitation of peroxisomes using fluorescent nanocrystals: treatment of rats and monkeys with fibrates and detection in the liver.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040701
Title: Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells.
Journal: The Journal of nutrition 20040701
Title: Effects of antihypertensive and hypolipidemic drugs on plasma and high-density lipoprotein-associated platelet activating factor-acetylhydrolase activity.
Journal: Journal of cardiovascular pharmacology and therapeutics 20040601
Title: Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040501
Title: Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040401
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents.
Journal: The Journal of steroid biochemistry and molecular biology 20040201
Title: Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation.
Journal: Nutrition journal 20040101
Title: Miniaturized fluorescent RNA dot blot method for rapid quantitation of gene expression.
Journal: BMC biotechnology 20040101
Title: Application of UV-derivative spectra for determination of four antihyperlipidaemic drugs in pharmaceutical formulations.
Journal: Acta poloniae pharmaceutica 20040101
Title: Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study).
Journal: Cardiovascular diabetology 20040101
Title: The levels of soluble adhesion molecules in diabetic and nondiabetic patients with combined hyperlipoproteinemia and the effect of ciprofibrate therapy.
Journal: Angiology 20040101
Title: Overexpression of SR-BI by adenoviral vector reverses the fibrateinduced hypercholesterolemia of apolipoprotein E-deficient mice.
Journal: The Journal of biological chemistry 20031226
Title: Cell proliferation and apoptosis are altered in mice deficient in the NF-kappaB p50 subunit after treatment with the peroxisome proliferator ciprofibrate.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031001
Title: Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition.
Journal: Journal of bioenergetics and biomembranes 20031001
Title: Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-alpha agonist ciprofibrate.
Journal: Physiological genomics 20030929
Title: The peroxisome-proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E.
Journal: The Biochemical journal 20030801
Title: Chromatin sphingomyelin changes in cell proliferation and/or apoptosis induced by ciprofibrate.
Journal: Journal of cellular physiology 20030801
Title: Lipid-lowering drugs and serum liver enzymes: the effects of body weight and baseline enzyme levels.
Journal: Fundamental & clinical pharmacology 20030801
Title: Action of ciprofibrate in type IIb hyperlipoproteinemia: modulation of the atherogenic lipoprotein phenotype and stimulation of high-density lipoprotein-mediated cellular cholesterol efflux.
Journal: The Journal of clinical endocrinology and metabolism 20030801
Title: [Long-term hypolipidemic treatment of mixed hyperlipidemia with a combination of statins and fibrates].
Journal: Casopis lekaru ceskych 20030801
Title: Fibrates and renal function.
Journal: Clinical nephrology 20030701
Title: LDL-cholesterol, HDL-cholesterol or triglycerides--which is the culprit?
Journal: Diabetes research and clinical practice 20030701
Title: Changes of peroxisomal fatty acid metabolism during cold acclimatization in hibernating jerboa (Jaculus orientalis).
Journal: Biochimie 20030701
Title: [Efficacy and safety of combined statin-fenofibrates therapy compared with monotherapy in patients with mixed hyperlipidemia and high risk of coronary heart disease].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030701
Title: Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells.
Journal: The Journal of pharmacology and experimental therapeutics 20030601
Title: Serum lipid comparison in patients treated by statins or fibrates: existence of bad HDL-C responders to statins.
Journal: Acta cardiologica 20030601
Title: Fibrates and their newly synthesized glycinate or glycinate-methylester derivatives: comparison of the interactions with liver cytochrome P450 dependent monooxygenase- and oxidase-functions in vitro.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030601
Title: [Ciprofibrate-induced acute cholestatic hepatitis].
Journal: Annales d'endocrinologie 20030601
Title: Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.
Journal: Carcinogenesis 20030501
Title: Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030301
Title: Antral G cells in rats during dosing with a PPAR alpha agonist: a morphometric and immunocytochemical study.
Journal: Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan 20030301
Title: The hypolipidemic drug metabolites nafenopin-CoA and ciprofibroyl-CoA are competitive P2Y1 receptor antagonists.
Journal: FEBS letters 20030211
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
Journal: The Biochemical journal 20030201
Title: Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia.
Journal: American journal of physiology. Lung cellular and molecular physiology 20030201
Title: Fibrates and C-reactive protein.
Journal: Clinica chimica acta; international journal of clinical chemistry 20030201
Title: Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation.
Journal: Blood 20030115
Title: Different effects of the liver mitogens triiodo-thyronine and ciprofibrate on the development of rat hepatocellular carcinoma.
Journal: Toxicologic pathology 20030101
Title: [Conjugation reactions of ciprofibrate with human and laboratory animals].
Journal: Arzneimittel-Forschung 20030101
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Title: Effects of various fibrates on serum alkaline phosphatase activity.
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Title: Combined treatment with fibrates and small doses of atorvastatin in patients with mixed hyperlipidemia.
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Title: Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes.
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Title: Nafenopin-, ciprofibroyl-, and palmitoyl-CoA conjugation in vitro: kinetic and molecular characterization of marmoset liver microsomes and expressed MLCL1.
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Title: Ciprofibrate increases plasma concentration of platelet-derived growth factor AB in patients with advanced atherosclerosis and hyperlipidemia independently of its hypolipidemic effects.
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Title: Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
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Title: Fibrate treatment can increase serum creatinine levels.
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Title: Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: an open-label, multicenter study.
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Title: Statin-fibrate combinations in patients with combined hyperlipedemia.
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Title: Differential induction of stearoyl-CoA desaturase and acyl-CoA oxidase genes by fibrates in HepG2 cells.
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Title: Fibrate-induced increase in blood urea and creatinine: is gemfibrozil the only innocuous agent?
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Title: Statin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease.
Journal: International journal of cardiology 19990601
Title: Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes.
Journal: The Journal of pharmacology and experimental therapeutics 19990501
Title: Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha.
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Title: Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
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Title: Mechanisms of peroxisome proliferation by perfluorooctanoic acid and endogenous fatty acids.
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Title: Activation of hepatic NF-kappaB by the herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) in female and male rats.
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Title: Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol 12,13-myristate-type tumor promoters in immortalized mouse liver cells.
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Title: Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention.
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Title: Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes.
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Title: The herbicide dicamba (2-methoxy-3,6-dichlorobenzoic acid) is a peroxisome proliferator in rats.
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Title: Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.
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Title: Effect of the peroxisome proliferators ciprofibrate and perfluorodecanoic acid on hepatic cell proliferation and toxicity in Sprague-Dawley rats.
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Title: Antihyperlipidaemic agents. Drug interactions of clinical significance.
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Title: A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids.
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Title: Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator.
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Title: Mechanism of action of fibrates.
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Title: Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.
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Title: Effect of different hypolipemic agents on rat liver peroxisomal and mitochondrial functions and biogenesis.
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Title: Peroxisome proliferation in neoplastic nodules and hepatocellular carcinomas induced by ciprofibrate in the rat.
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Title: Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strain. Co-induction of microsomal cytochrome P-450 IVA1 and peroxisome proliferation.
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Title: Absence of gamma-glutamyltranspeptidase activity in lung metastasis in rats with hepatocellular carcinomas induced by ciprofibrate, a peroxisome proliferator.
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Title: Thing-Fong Tzeng, et al. 6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolism. Nutrients. 2015 Feb 4;7(2):999-1020.
