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524-17-4,MFCD26960929
Catalog No.:AA00DEG8

524-17-4 | Dauricine

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Purity
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5mg
98% by HPLC
in stock  
$156.00   $109.00
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10mg
98% by HPLC
in stock  
$219.00   $153.00
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25mg
98% by HPLC
in stock  
$392.00   $274.00
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50mg
98% by HPLC
in stock  
$622.00   $435.00
- +
100mg
98% by HPLC
in stock  
$1,029.00   $720.00
- +
500mg
98% by HPLC
in stock  
$3,179.00   $2,226.00
- +
1000mg
98% by HPLC
in stock  
$5,049.00   $3,534.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DEG8
Chemical Name:
Dauricine
CAS Number:
524-17-4
Molecular Formula:
C38H44N2O6
Molecular Weight:
624.7658
MDL Number:
MFCD26960929
SMILES:
COc1cc2c(cc1OC)CCN([C@@H]2Cc1ccc(cc1)Oc1cc(ccc1O)C[C@H]1N(C)CCc2c1cc(OC)c(c2)OC)C
Properties
Computed Properties
 
Complexity:
933  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
6.7  

Downstream Synthesis Route

[1]Sugimoto,Yukihiro;Yoshida,Akihiko;Uchida,Shinji;Inanaga,Shinobu;Yamada,Yasuyuki[Phytochemistry,1994,vol.36,#3,p.679-684]

[1]Zhou,Xiaobo;Qu,YuanQing;Zheng,Zhiyuan;Law,BettyYuenKwan;Mok,SimonWingFai;Jiang,Zhi-Hong;Wong,VincentKamWai;Bai,Li-Ping[BioorganicChemistry,2019,vol.83,p.450-460]

83-01-2    524-17-4   
C51H53N3O7 

[1]BioorganicChemistry,2019,vol.83,p.450-460

[2]Patent:US2019/202802,2019,A1.Locationinpatent:Paragraph0087;0089;0090;0091

[1]Zhou,Xiaobo;Qu,YuanQing;Zheng,Zhiyuan;Law,BettyYuenKwan;Mok,SimonWingFai;Jiang,Zhi-Hong;Wong,VincentKamWai;Bai,Li-Ping[BioorganicChemistry,2019,vol.83,p.450-460]

[1]Zhou,Xiaobo;Qu,YuanQing;Zheng,Zhiyuan;Law,BettyYuenKwan;Mok,SimonWingFai;Jiang,Zhi-Hong;Wong,VincentKamWai;Bai,Li-Ping[BioorganicChemistry,2019,vol.83,p.450-460]

Literature

Title: CYP3A-mediated apoptosis of dauricine in cultured human bronchial epithelial cells and in lungs of CD-1 mice.

Journal: Toxicology and applied pharmacology 20120615

Title: Inhibitory effects of a bisbenzylisoquinline alkaloid dauricine on HERG potassium channels.

Journal: Journal of ethnopharmacology 20120601

Title: Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells.

Journal: Pharmacognosy magazine 20110101

Title: Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells.

Journal: Journal of cellular physiology 20101001

Title: Predictable and linear scale-up of four phenolic alkaloids separation from the roots of Menispermum dauricum using high-performance counter-current chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100715

Title: [Studies on the chemical constituents of Callicarpa kochiana].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

Title: Validated liquid chromatography-tandem mass spectrometry method for quantitative determination of dauricine in human plasma and its application to pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100501

Title: Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice.

Journal: The Journal of pharmacology and experimental therapeutics 20100301

Title: Neuroprotective effect of dauricine after transient middle cerebral artery occlusion in rats: involvement of Bcl-2 family proteins.

Journal: The American journal of Chinese medicine 20100101

Title: Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.

Journal: Chinese medicine 20100101

Title: Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia.

Journal: International journal of molecular sciences 20100101

Title: Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current.

Journal: Canadian journal of physiology and pharmacology 20091101

Title: Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1alpha protein accumulation and vascular endothelial growth factor expression in human breast cancer cells.

Journal: Acta pharmacologica Sinica 20090501

Title: Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile.

Journal: Chemical research in toxicology 20090501

Title: [Effect of dauricine on apoptosis and expression of apoptogenic protein after transient focal cerebral ischemia-reperfusion injury in rats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090101

Title: Improved RP-HPLC method to determine neferine in dog plasma and its application to pharmacokinetics.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

Title: Identification of dauricine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

Title: Neuroprotective effect of dauricine in cortical neuron culture exposed to hypoxia and hypoglycemia: involvement of correcting perturbed calcium homeostasis.

Journal: Canadian journal of physiology and pharmacology 20070601

Title: Neuroprotective effects of dauricine against apoptosis induced by transient focal cerebral ischaemia in rats via a mitochondrial pathway.

Journal: Clinical and experimental pharmacology & physiology 20070301

Title: Inhibitory effect of dauricine on inflammatory process following focal cerebral ischemia/reperfusion in rats.

Journal: The American journal of Chinese medicine 20070101

Title: Genetic and alkaloid analysis of Menispermum dauricum DC. by RAPD and HPLC.

Journal: Phytochemical analysis : PCA 20070101

Title: [Study on the chemical constituents of Mitragyna rotundifolia].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060601

Title: [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051001

Title: Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell.

Journal: British journal of pharmacology 20041201

Title: [Protective effects of phenolic alkaloids from Menispermum dauricum on inflammatory injury following focal cerebral ischemia-reperfusion in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801

Title: Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs.

Journal: Acta pharmacologica Sinica 20031001

Title: Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives.

Journal: Acta pharmacologica Sinica 20021201

Title: Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells.

Journal: Acta pharmacologica Sinica 20020701

Title: Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier.

Journal: Acta pharmacologica Sinica 20020501

Title: Dauricine-induced changes in monophasic action potentials and effective refractory period of rabbit left ventricle in situ.

Journal: Acta pharmacologica Sinica 20020401

Title: [Poteintation of vincristine-induced apoptosis by tetrandrine, neferine and dauricine in the human mammary MCF-7 multidrug-resistant cells].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010201

Title: Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75.

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