Home Bromides 53251-94-8
53251-94-8,MFCD01713435
Catalog No.:AA00I9FG

53251-94-8 | Pinaverium bromide

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25mg
>98%(HPLC)
in stock  
$34.00   $24.00
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100mg
>98%(HPLC)
in stock  
$75.00   $53.00
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1g
>98%(HPLC)
in stock  
$150.00   $105.00
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25g
97%
in stock  
$2,511.00   $1,758.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I9FG
Chemical Name:
Pinaverium bromide
CAS Number:
53251-94-8
Molecular Formula:
C26H41Br2NO4
Molecular Weight:
591.4160
MDL Number:
MFCD01713435
SMILES:
COc1cc(C[N+]2(CCOCCC3CCC4CC3C4(C)C)CCOCC2)c(cc1OC)Br.[Br-]
Properties
Properties
 
Form:
Solid  
MP:
159-1640C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
596  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:BEIJINGWINSUNNYPHARMACEUTICAL-CN104650005,2018,BLocationinpatent:Paragraph0076;0080;0081;0084;0085;0088

[2]Baronnet;FoussardBlanpin;Bretaudeau;Hubert[EuropeanJournalofMedicinalChemistry,1974,vol.9,#2,p.182-187]

[1]CurrentPatentAssignee:BEIJINGWINSUNNYPHARMACEUTICAL-CN104650005,2018,B

[1]CurrentPatentAssignee:BEIJINGWINSUNNYPHARMACEUTICAL-CN104650005,2018,B

[1]CurrentPatentAssignee:BEIJINGWINSUNNYPHARMACEUTICAL-CN104650005,2018,B

Literature

Title: Pinaverium Reduces Symptoms of Irritable Bowel Syndrome in a Multicenter, Randomized, Controlled Trial.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20150701

Title: [Comparative observation on therapeutic effects between acupuncture and western medication for diarrhea-predominant irritable bowel syndrome].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20120801

Title: Exfoliative erythrodermia induced by pantoprazole.

Journal: Allergologia et immunopathologia 20120101

Title: A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of pinaverium bromide in human plasma: application to a pharmacokinetic study in healthy volunteers.

Journal: Biomedical chromatography : BMC 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: The stapled hemorrhoidopexy syndrome: a new clinical entity?

Journal: Techniques in coloproctology 20111001

Title: [Effect of jianpi tiaogan wenshen recipe in treating diarrhea-predominant irritable bowel syndrome].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100101

Title: Effect of four medications associated with gastrointestinal motility on Oddi sphincter in the rabbit.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20090101

Title: [Pinaverium bromide-induced esophageal ulcerations].

Journal: Therapie 20080101

Title: [Drug treatment of irritable bowel syndrome: an unmet need].

Journal: Gastroenterologia y hepatologia 20070301

Title: [New approaches to diagnosing and treating hyperkinetic biliary dyskinesia associated with chronic acalculous cholecystitis].

Journal: Klinicheskaia meditsina 20040101

Title: Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome.

Journal: Current pharmaceutical design 20040101

Title: [Randomized controlled clinical study on effect of Chinese compound changjitai in treating diarrheic irritable bowel syndrome].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20031101

Title: Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats.

Journal: World journal of gastroenterology 20030315

Title: [Effects of dicetel on gastrointestinal motility and vegetative dysfunction in patients with duodenal ulcer].

Journal: Klinicheskaia meditsina 20030101

Title: Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide.

Journal: Cell calcium 20010601

Title: [Current approaches to the diagnosis and treatment of irritable bowel syndrome].

Journal: Likars'ka sprava 20010101

Title: Irritable bowel syndrome treatment using pinaverium bromide as a calcium channel blocker. A randomized double-blind placebo-controlled trial.

Journal: Acta gastroenterologica Latinoamericana 19950101

Title: Effect of pinaverium and other calcium channel blockers on contraction of isolated gastric antral smooth muscle cells caused by gastrointestinal hormones.

Journal: Life sciences 19940101

Title: Interaction of pinaverium (a quaternary ammonium compound) with 1,4-dihydropyridine binding sites in rat ileum smooth muscle.

Journal: British journal of pharmacology 19920201

Title: Action of pinaverium bromide, a calcium-antagonist, on gastrointestinal motility disorders.

Journal: General pharmacology 19900101

Title: Effects of pinaverium bromide and verapamil on the motility of the rat isolated colon.

Journal: British journal of pharmacology 19850901

Title: Inhibitory effect of pinaverium bromide on gastrointestinal contractile activity in conscious dogs.

Journal: Arzneimittel-Forschung 19810101

Title: Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61.

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